AUDITORIUM ALFREDO KRAUS

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1 AUDITORIUM ALFREDO KRAUS LAS PALMAS DE GRAN CANARIA JUNE 27-29th 2014 Organized by: Activity accredited by the Catalan Council for Continuing Medical Education 09/10879-MD 1,6 Credits groupgem.org

2 Organizing Committee GEM Enrique Espinosa Salvador Martín Algarra Delvys Rodríguez WORKSHOP Josep Malvehy Susana Puig Antoni Ribas María S. Soengas Scientific Committee Robert Ballotti. Mediterranean Research Center for Molecular Medicine. Nice. France Boris Bastian. UCSF Cardiovascular Research Institute. San Francisco, U.S.A Alfonso Berrocal. Hospital Universitario General de Valencia. Valencia, Spain Corine Bertolotto. Institut National de la Santé et de la Recherche Médicale (INSERM). Nice, France Miguel Ángel Cabrera. Hospital Universitario Nuestra Sra. de La Candelaria. Tenerife, Spain Luis de la Cruz. Hospital Universitario Virgen de Macarena. Sevilla, Spain Irwin Davidson. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC). Strasbourg, France Enrique Espinosa. Hospital Universitario La Paz. Madrid, Spain Colin Goding. Nuffield Department of Clinical Medicine. Oxford, UK María González Cao. Instituto Oncológico Dr. Rosell. Barcelona, Spain Salvador González. Memorial Sloan Kettering Cancer Center. New York, U.S.A. Lionel Larue. Institute Curie. Paris, France Josep Malvehy. Hospital Clínico de Barcelona. Barcelona, Spain Iván Márquez. Hospital Universitario Gregorio Marañón. Madrid, Spain Salvador Martín Algarra. Clínica Universidad de Navarra. Pamplona, Spain Alain Mauviel. Institute Curie. Paris, France Martin McMahon. UCSF Helen Diller Family Comprehensive Cancer Center. San Francisco, U.S.A. Eduardo Nagore. Instituto Valenciano de Oncología (IVO). Valencia, Spain Juana Oramas. Hospital Universitario de Canarias. Tenerife, Spain Daniel Peeper. Netherlands Cancer Institute. Amsterdam, Netherlands Héctor Peinado. Cornell University. New York, U.S.A. Antoni Ribas. University of California. Los Angeles, U.S.A. Luis Ríos. Hospital Universitario Ramón y Cajal. Madrid, Spain Delvys Rodríguez. Hospital Universitario Insular de Gran Canaria. Las Palmas, Spain José Luis Rodríguez Peralto. Hospital Universitario 12 de Octubre. Madrid, Spain Ze'ev Ronai. Sanford-Burham Medical Research Institute. La Jolla, U.S.A Yardena Samuels. Weizmann Institute of Science. Rehovot, Israel Salvador Saura. Hospital Universitario Dr. Negrín. Las Palmas, Spain María S. Soengas. Centro Nacional de Investigaciones Oncológicas (CNIO). Madrid, Spain Ainara Soria. Hospital Universitario Ramón y Cajal. Madrid, Spain Eirikur Steingrimsson. University of Iceland. Reykjavík, Iceland Thomas Tüting. University of Bonn. Bonn, Germany

3 We are pleased to announce that the V International Symposium of GEM and the 6th European Melanoma Workshop will take place in the Auditorium Alfredo Kraus of Las Palmas de Gran Canaria, Spain, on the 27th, 28th & 29th of June The objective of the SYMPOSIUM is to offer better treatments for the patients by sharing new ideas, experiences and improving the prevention and investigation of new treatments for this pathology. VENUE AUDITORIUM ALFREDO KRAUS LAS PALMAS DE GRAN CANARIA Av. Príncipe de Asturias, s/n Las Palmas de Gran Ganaria Islas Canarias (Spain)

4 Friday, June 27th 15:00h - 16:20h GEM SYMPOSIUM 15:00h - 15:15h Opening Excma. Dña. Brígida Mendoza Bethencourt Salvador Martín Algarra & Delvys Rodríguez 15:15h - 15:35h Melanoma in Spain: Recent Progress Chair: Delvys Rodríguez Speaker: Luis de la Cruz 15:35h - 16:20h Oral Communications Chairs: Juana Oramas & Miguel Ángel Cabrera 16:20h - 16:25h MelaNet: Presentation Academic Course 2014 Salvador Martín Algarra 16:25h - 16:45h COFFEE BREAK Room Gran Canaria & Room Tenerife 16:45h - 17:45h GEM GENERAL ASSEMBLY 18:00h - 19:15h GEM - EUROPEAN MELANOMA WORKSHOP 18:00h - 18:15h Introduction Salvador Martín Algarra & María S. Soengas 18:15h - 19:15h Melanoma Immunotherapy Chair: Delvys Rodríguez 18:15-18:45h PD1/PDL1 Antoni Ribas 18:45-19:15h Combined Targeting of Immunological Checkpoints Iván Márquez

5 Saturday, June 28th 09:00h - 11:30h GEM - EUROPEAN MELANOMA WORKSHOP 09:00h - 10:00h ASCO 2014 Chair: Enrique Espinosa 09:00h - 09:30h ASCO Tyrosine-Kinase Inhibitors María González Cao 09:30h - 10:00h ASCO Immunotherapy Alfonso Berrocal 10:00h - 11:30h Melanoma Initiation Chair: Ze'ev Ronai 10:00h - 10:30h Risk Factors in Melanoma Development Josep Malvehy 10:30h - 11:00h Early Events in Melanoma Dissemination Boris Bastian 11:00h - 11:15h Phase II Study Evaluating Ipilimumab as a Single Agent in the First-line Treatment of Adult Patients with Metastatic Uveal Melanoma (MUM): The GEM-1 Trial Josep Mª Piulats 11:15h - 11:30h Re-routing of the Lymphatic Vasculature During Melanoma Progression Steven Proulx 11:30h - 12:00h COFFEE BREAK Room Gran Canaria & Room Tenerife 12:00h - 13:30h GEM - EUROPEAN MELANOMA WORKSHOP 13:30h - 15:00h LUNCH Room Alegranza POSTER VIEWING Exhibition Area Level -2 12:00h - 13:30h New Melanoma Drivers and Drug Targets (I) Chair: Josep Malvehy 12:00h - 12:30h Deciphering the Role of Melanoma Secreted Exosomes in Metastasis Héctor Peinado 12:30h - 13:00h Targeting the Lymphatic System María S. Soengas 13:00h - 13:30h Mutational and Functional Analysis in Melanoma-Looking for New Therapeutic Targets Yardena Samuels

6 Saturday, June 28th 15:00h - 16:15h GEM - EUROPEAN MELANOMA WORKSHOP 15:00h - 16:15h New Melanoma Drivers and Drug Targets (II) Chairs: Martin McMahon & María S. Soengas 15:00h - 15:30h In Vivo RNAi Screening for Novel Therapeutic Melanoma Daniel Peeper 15:30h - 16:00h PI3'-Kinase Isoform Selectivity in the Progression and Maintenance of BRAF Mutated Melanoma Martin McMahon 16:00h - 16:15h In Vivo Identification of Novel Determinants of Melanoma Progression Daniela Bossi 16:15h - 16:45h COFFEE BREAK Room Gran Canaria & Room Tenerife 16:45h - 18:45h Concurrent Session I 16:45h - 17:35h Challenges in the Diagnosis of Melanocytic Lesions Chairs: Salvador González & Luis Ríos 16:45h - 17:10h Dermoscopy, Confocal Microscopy and Other Imaging Techniques in the Early Diagnosis and Management of Melanoma Josep Malvehy 17:10h - 17:35h Molecular Markers for Melanoma Diagnosis José Luis Rodríguez Peralto 17:35h - 18:25h Familiar Melanoma. Discovering New Driver Somatic Mutations Chairs: Salvador Saura & Ainara Soria 17:35h - 18:00h TERT - Promoter Mutation Eduardo Nagore 18:00h - 18:25h The FAM-GEM Study Iván Márquez 18:25h - 18:45h Closure GEM Symposium Salvador Martín Algarra 16:45h - 18:45h Concurent Session II Room Atlántico 16:45h - 18:45h Lessons from Model Systems Chair: Corine Bertolotto 16:45h - 17:15h PDK1 and ATF2 - Lessons from Genetic Models Ze'ev Ronai 17:15h - 17:45h Caveolin Plays a Critical Role in PTEN-induced in Melanomagenesis Lionel Larue 17:45h - 18:15h UV Irradiation, TLR4-Dependent Neutrophilic Infammation and Melanoma Metastasis Thomas Tüting 18:15h - 18:30h Unraveling the Anticancer Mechanism of the Autophagy Inhibitor Chloroquine In Vivo Hannelore Maes 18:30h - 18:45h Proteomic Characterization of Exosomes Reflects Melanoma Aggressiveness Lazar Ikrame

7 Sunday, June 29th 09:00h - 13:00h GEM - EUROPEAN MELANOMA WORKSHOP 09:00h - 10:45h Melanoma Biology Chair: Robert Ballotti 09:00h - 09:25h Melanoma: Senescence and Stem Cell-Like Phenotypes Corine Bertolotto 09:25h - 09:50h Subcellular Localization of MITF Eirikur Steingrimsson 09:50h - 10:15h Using Single Cell Transcription Profiles to Investigate Melanoma Heterogeneity Irwin Davidson 10:15h - 10:30h G12DNRAS and Kinase-dead BRAF Cooperate to Drive Naevogenesis and Melanomagenesis Malin Padersen 10:30h - 10:45h ATF2 in BRAF Mutant Melanoma Giuseppina Claps 10:45h - 11:15h COFFEE BREAK Room Gran Canaria & Room Tenerife 11:15h - 12:20h Plasticity and Heterogeneity Chair: Alain Mauviel 11:15h - 11:40h The Role and Regulation of MITF in Melanoma Phenotype-Switching Colin Goding 11:40h - 12:00h Melanoma Therapy; MAPK Pathway and Beyond Robert Ballotti 12:00h - 12:20h Contribution of GLI2 to the Transcriptional Control of the Cadherin Switch in Melanoma Cells Alain Mauviel 12:20h - 13:00h CLOSING REMARKS María S. Soengas & Josep Malvehy For registration and additional information about accomodation or abstracts, please visit:

8 Golden Sponsor Silver Sponsor Bronze Sponsor Contributors Technical Secretariat MARKETING FARMACÉUTICO & INVESTIGACIÓN CLÍNICA, S.L. Secretari Coloma, 64-68, esc. B, entlo. 5ª Barcelona Mobile Phone: (34) Phone: (34) Fax: (34) Symposium held under the auspice of the Spanish Society of Medical Oncology Activity accredited by the Catalan Council for Continuing Medical Education 09/10879-MD 1,6 Credits

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