New treatments in MS What s here and what s nearly here

Size: px
Start display at page:

Download "New treatments in MS What s here and what s nearly here"

Transcription

1 5 th MS Research Day, June 14 th 2014 New treatments in MS What s here and what s nearly here David Miller Queen Square MS Centre at UCL and UCLH

2 Course of MS and its treatment Relapsing remitting Disability Secondary progressive Primary progressive Progressive relapsing Time in years

3 Aims of treatment Prevent relapses and associated disability Prevent progressive disability Reverse persistent disability

4 Aims of treatment Prevent relapses and associated disability Prevent progressive disability X Reverse persistent disability X

5 Current treatments are for relapsing remitting MS Relapsing remitting Secondary progressive Primary progressive Progressive relapsing Time in years Time

6 Problems measuring relapses Insensitive measure: tip of the iceberg Large and expensive treatment trials Trials don t address very long-term effects

7 Relapsing remitting MS: Monthly MRI: new lesions 10 new lesions per one relapse

8 New MRI lesions = good surrogate for relapses in more than 50 MS trials Decreasing MRI lesions Decreasing relapses Sormani et al Lancet Neurology 2013

9 Treatments work by impeding the immune cells that cause new lesions and relapses Immunomodulation Less effective Fewer side effects Immunosuppression More effective More side effects

10 What s here β-(beta)-interferons Avonex Injection into muscle once a week Rebif Injection under skin 3 times a week Betaferon Injection under skin every second day Extavia Injection under skin every second day Glatiramer acetate Copaxone Injection under skin every day Natalizumab Tysabri Injection into vein once a month Fingolimod Gilenya Tablet once a day

11 ß-interferon Immunomodulation Reduces relapse rate by 30% Reduces new MRI lesions by 60% Good long term safety

12 Glatiramer acetate Immunomodulation Reduces relapse rate by 30% Reduces new MRI lesions by 40% Good long term safety

13 NHS risk sharing scheme for β-interferon & glatiramer acetate Criteria for treatment Two relapses in two years Able to walk 6-year analysis = cost-effective

14 Natalizumab (Tysabri) Immunosuppression (novel) Prevents immune cells going from the blood to the brain Reduces relapse rate by 70% Reduced new MRI lesions by 90% Reduces disability by 40% Recommended by NICE for NHS (2007)

15 Blood-brain barrier Brain

16 Natalizumab: side effects Allergic reactions Progressive multifocal leucoencephalopathy (PML)

17 PML Risk Stratification* JC Anti-JCV Virus antibody Antibody Status test Negative (50%) Positive (50%) 1 in 10, / % CI in in in 1,429 Natalizumab Exposure No No Prior IS Use 1 24 months 0.7/ % CI months 5.3/ % CI months 6.1/ % CI Prior IS Use Yes Prior IS Use 1.8/ % CI / % CI Insufficient data Data beyond 6 years of treatment are limited. There are insufficient data to adequately determine PML risk in anti-jcv antibody positive patients with prior IS use and >48 months of natalizumab exposure. 1 in 556 *Based on natalizumab exposure and 343 confirmed PML cases as of 5 th March Prior IS data in overall natalizumab-treated patients based on proportion of patients with IS use prior to natalizumab therapy in TYGRIS as of May 2011; and prior IS data in PML patients as of 5 th March The analysis assumes that 55% of natalizumab-treated MS patients were anti-jcv antibody positive and that all PML patients test positive for anti-jcv antibodies prior to the onset and diagnosis of PML. The estimate of PML incidence in anti-jcv antibody negative patients is based on the assumption that all patients received at least 1 dose of natalizumab. Assuming that all patients received at least 18 doses of natalizumab, the estimate of PML incidence in anti-jcv antibody negative patients was generally consistent (0.16/1000; 95% CI ). 1 in 89 Biogen Idec, data on file.

18 NICE Criteria for natalizumab treatment 2 disabling relapses in 12 months + new MRI lesions

19 Fingolimod (Gilenya) Immunosuppression (novel) Traps immune cells in lymph nodes Reduces relapse rate by 50% Reduces new MRI lesions by 75% Reduces disability by 30% Recommended by NICE for NHS (2012)

20 Fingolimod: mechanism of action (Sphingosine)

21 Fingolimod: side effects Herpes infections (can be severe) Heart block with first dose (ECG monitoring) Blurred vision (swelling back of eye) Abnormal liver function High blood pressure

22 NHS England criteria for fingolimod Relapses on β-interferon or glatiramer acetate High PML risk on natalizumab

23 What s nearly here Teriflunomide Aubagio Tablet once a day Dimethylfumarate Tecfidera Tablet twice a day Alemtuzumab Lemtrada Injection into vein every day for 5 days then again one year later for 3 days

24 Teriflunomide (Aubagio) Immunomodulation Reduces relapse rate by 30% Reduces new MRI lesions by 50% Recommended by NICE for NHS (2014)

25 Teriflunomide: side effects Nausea, diarrhoea Hair thinning Abnormal liver function Must avoid in pregnancy

26 NICE criteria for teriflunomide treatment Two relapses in two years

27 Dimethyfumarate (Tecfidera) Immunomodulation Reduces relapse rate by 50% Reduces new MRI lesions by 75% NICE appraisal: on-going

28 Dimethylfumarate: side effects Flushing Nausea, abdominal pain, diarrhoea Abnormal liver function Low white blood cell count

29 Alemtuzumab (Lemtrada) Immunosuppression Depletes immune cells from the blood Reduces relapses, disability and new lesions by 50% compared to β-interferon Recommended by NICE for NHS (2014) Active relapsing remitting MS

30 Alemtuzumab: side effects Infusion reactions Infections (including herpes) Overactive thyroid Internal bleeding (low platelets) Kidney failure (rare)

31 Effectiveness and risks of treatments Natalizumab Alemtuzumab Increasing risks β-interferon Glatiramer acetate Teriflunomide Fingolimod Dimethylfumarate Increasing effectiveness

32 Options for treating relapsing remitting MS There will very soon be 10 different treatments Their benefits and side effects vary More benefit more side effects Different treatments will benefit different people Should be able to control relapses in most people

33 Future treatment of relapsing remitting MS More new treatments on the way Combination treatments Personalised treatment Long term benefit and safety

Progress in MS: Current and Emerging Therapies

Progress in MS: Current and Emerging Therapies Progress in MS: Current and Emerging Therapies Presented by: Dr. Kathryn Giles, MD MSc FRCPC The MS Society gratefully acknowledges the grant received from Biogen Idec Canada, which makes possible the

More information

Disease Modifying Therapies for MS

Disease Modifying Therapies for MS Disease Modifying Therapies for MS The term disease-modifying therapy (DMT) means a drug that can modify or change the course of a disease. In other words a DMT should be able to reduce the number of attacks

More information

Personalised Medicine in MS

Personalised Medicine in MS Personalised Medicine in MS Supportive Evidence from Therapeutic Trials Ludwig Kappos Neurology and Department of Biomedicine University Hospital CH-4031 Basel LKappos@uhbs.ch Established partially effective

More information

Treatments for MS: Immunotherapy. Gilenya (fingolimod) Glatiramer acetate (Copaxone )

Treatments for MS: Immunotherapy. Gilenya (fingolimod) Glatiramer acetate (Copaxone ) Treatments for MS: Immunotherapy There are currently several disease-modifying therapies approved for people with MS in Australia. These therapies, called immunotherapies, work to reduce disease activity

More information

A neurologist would assess your eligibility and suitability for the DMTs.

A neurologist would assess your eligibility and suitability for the DMTs. Choices Disease Modifying Treatments Disease modifying treatments (DMTs) are medications which modify the disease course. They target inflammation and are designed to reduce the damage caused by relapses.

More information

Disease modifying drug therapy

Disease modifying drug therapy Disease modifying drug therapy New edition for 2014-15 We hope you find the information in this book helpful. If you would like to speak with someone about any aspect of MS, contact the MS Trust information

More information

Committee Approval Date: December 12, 2014 Next Review Date: December 2015

Committee Approval Date: December 12, 2014 Next Review Date: December 2015 Medication Policy Manual Policy No: dru299 Topic: Tecfidera, dimethyl fumarate Date of Origin: May 16, 2013 Committee Approval Date: December 12, 2014 Next Review Date: December 2015 Effective Date: January

More information

Multiple sclerosis disease-modifying drugs second line treatments

Multiple sclerosis disease-modifying drugs second line treatments Great Ormond Street Hospital for Children NHS Foundation Trust: Information for Families Multiple sclerosis disease-modifying drugs second line treatments The following information should be read in conjunction

More information

Treatment guidelines for relapsing MS and the two step approach for disease modifying therapy

Treatment guidelines for relapsing MS and the two step approach for disease modifying therapy Treatment guidelines for relapsing MS and the two step approach for disease modifying therapy Klaus Schmierer, PhD FRCP Blizard Institute, Barts and The London School of Medicine & Dentistry Barts Health

More information

Medication Policy Manual. Topic: Aubagio, teriflunomide Date of Origin: November 9, 2012

Medication Policy Manual. Topic: Aubagio, teriflunomide Date of Origin: November 9, 2012 Medication Policy Manual Policy No: dru283 Topic: Aubagio, teriflunomide Date of Origin: November 9, 2012 Committee Approval Date: December 11, 2015 Next Review Date: December 2016 Effective Date: January

More information

Medication Policy Manual. Topic: Gilenya, fingolimod Date of Origin: November 22, 2010

Medication Policy Manual. Topic: Gilenya, fingolimod Date of Origin: November 22, 2010 Medication Policy Manual Policy No: dru229 Topic: Gilenya, fingolimod Date of Origin: November 22, 2010 Committee Approval Date: December 11, 2015 Next Review Date: December 2016 Effective Date: January

More information

Information About Medicines for Multiple Sclerosis

Information About Medicines for Multiple Sclerosis Information About Medicines for Multiple Sclerosis Information About Medicines for Multiple Sclerosis What is multiple sclerosis? 1 Multiple sclerosis (MS) is a lifelong disease that affects your brain

More information

Medication Policy Manual. Topic: Aubagio, teriflunomide Date of Origin: November 9, 2012

Medication Policy Manual. Topic: Aubagio, teriflunomide Date of Origin: November 9, 2012 Medication Policy Manual Policy No: dru283 Topic: Aubagio, teriflunomide Date of Origin: November 9, 2012 Committee Approval Date: December 12, 2014 Next Review Date: December 2015 Effective Date: January

More information

Disease modifying drug therapy

Disease modifying drug therapy Disease modifying drug therapy what you need to know Third Edition Karen Alldus Simon Webster SECTION 2 We hope you find the information in this book helpful. If you would like to speak with someone about

More information

CNS DEMYLINATING DISORDERS

CNS DEMYLINATING DISORDERS CNS DEMYLINATING DISORDERS Multiple sclerosis A Dutch saint named Lidwina, who died in 1433, may have been one of the first known MS patients. After she fell while ice skating, she developed symptoms such

More information

Disease Modifying Therapies for MS

Disease Modifying Therapies for MS Disease Modifying Therapies for MS The term disease-modifying therapy means a drug that can modify or change the course of a disease. In other words a DMT should be able to reduce the number of attacks

More information

Information about medicines for multiple sclerosis

Information about medicines for multiple sclerosis Information about medicines for multiple sclerosis Information about medicines for multiple sclerosis What is multiple sclerosis? 1 Multiple sclerosis (MS) is a lifelong disease that affects your brain

More information

National Multiple Sclerosis Society. Disease Modification in Multiple Sclerosis. Current as of January 2, 2013

National Multiple Sclerosis Society. Disease Modification in Multiple Sclerosis. Current as of January 2, 2013 National Multiple Sclerosis Society Disease Modification in Multiple Sclerosis Current as of January 2, 2013 Since 1993, the U.S. Food and Drug Administration (FDA) has approved several medications for

More information

Integrating New Treatments: A Case Based Approach

Integrating New Treatments: A Case Based Approach Integrating New Treatments: A Case Based Approach JILL CONWAY, MD, MA, MSCE DIRECTOR, MS CENTER DIRECTOR, NEUROLOGY CLERKSHIP AT UNCSOM- CHARLOTTE CAMPUS CAROLINAS HEALTHCARE CENTER Objectives Provide

More information

Resources for the Primary Care Provider. Please print these out for reference

Resources for the Primary Care Provider. Please print these out for reference Resources for the Primary Care Provider Please print these out for reference Resources for providers American Academy of Neurology www.aan.com Provides education and resources, such as guidelines for clinical

More information

Uncertainty in Benefit and Risk: Tysabri (natalizumab)

Uncertainty in Benefit and Risk: Tysabri (natalizumab) Uncertainty in Benefit and Risk: Tysabri (natalizumab) Robert J. Temple, M.D. Deputy Center Director for Clinical Science Center for Drug Evaluation and Research U.S. Food and Drug Administration IOM Drug

More information

Which injectable medication should I take for relapsing-remitting multiple sclerosis?

Which injectable medication should I take for relapsing-remitting multiple sclerosis? Which injectable medication should I take for relapsing-remitting multiple sclerosis? A decision aid to discuss options with your doctor This decision aid is for you if you: Have multiple sclerosis Have

More information

The MS Disease- Modifying Medications GENERAL INFORMATION

The MS Disease- Modifying Medications GENERAL INFORMATION The MS Disease- Modifying Medications GENERAL INFORMATION Current as of March 2014. This online brochure is updated with breaking news as required. If you have a printed a copy of this publication, please

More information

Medication Policy Manual. Topic: Plegridy, peginterferon beta-1a Date of Origin: December 12, 2014

Medication Policy Manual. Topic: Plegridy, peginterferon beta-1a Date of Origin: December 12, 2014 Medication Policy Manual Policy No: dru376 Topic: Plegridy, peginterferon beta-1a Date of Origin: December 12, 2014 Committee Approval Date: December 11, 2015 Next Review Date: December 2016 Effective

More information

MEDICAL POLICY STATEMENT

MEDICAL POLICY STATEMENT MEDICAL POLICY STATEMENT Original Effective Date Next Annual Review Date Last Review / Revision Date 10/01/2013 10/1/2015 08/25/2015 Policy Name Policy Number Multiple Sclerosis Therapy Class SRx-0022

More information

New Treatment Options for MS Patients: Understanding risks versus benefits

New Treatment Options for MS Patients: Understanding risks versus benefits New Treatment Options for MS Patients: Understanding risks versus benefits By Michael A. Meyer, MD Department of Neurology, Sisters Hospital, Buffalo, NY Objectives: 1. to understand fundamentals of MS

More information

The MS Disease- Modifying Medications

The MS Disease- Modifying Medications The MS Disease- Modifying Medications National MS Society 1 Current as of November 2014. This online brochure is updated with breaking news as required. If you have a printed a copy of this publication,

More information

Oxford University Hospitals. NHS Trust. Department of Neurology Natalizumab (Tysabri) for Multiple Sclerosis. Information for patients

Oxford University Hospitals. NHS Trust. Department of Neurology Natalizumab (Tysabri) for Multiple Sclerosis. Information for patients Oxford University Hospitals NHS Trust Department of Neurology Natalizumab (Tysabri) for Multiple Sclerosis Information for patients page 2 What is Natalizumab and what is it used for? Natalizumab is an

More information

Disease Modifying Therapies (DMTs) in Multiple Sclerosis

Disease Modifying Therapies (DMTs) in Multiple Sclerosis Disease Modifying Therapies (DMTs) in Multiple Sclerosis Gary Stobbe, MD Medical Director, MS Project ECHO Clinical Assistant Professor, UW Neurology Conflict of Interest Dr. Stobbe has no conflicts of

More information

A blood sample will be collected annually for up to 2 years for JCV antibody testing.

A blood sample will be collected annually for up to 2 years for JCV antibody testing. Mellen Center Currently Enrolling Non-Treatment Trials STRATIFY-2 JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tysabri Primary Investigator:

More information

The MS Disease- Modifying Medications

The MS Disease- Modifying Medications The MS Disease- Modifying Medications National MS Society 1 Current as of January 2015. This online brochure is updated with breaking news as required. If you have a printed a copy of this publication,

More information

Cost-effectiveness of dimethyl fumarate (Tecfidera ) for the treatment of adult patients with relapsing remitting multiple sclerosis

Cost-effectiveness of dimethyl fumarate (Tecfidera ) for the treatment of adult patients with relapsing remitting multiple sclerosis Cost-effectiveness of dimethyl fumarate (Tecfidera ) for the treatment of adult patients with relapsing remitting multiple sclerosis The NCPE has issued a recommendation regarding the cost-effectiveness

More information

Natalizumab (Tysabri)

Natalizumab (Tysabri) Natalizumab (Tysabri) Spirella Building, Letchworth, SG6 4ET 01462 476700 www.mstrust.org.uk reg charity no. 1088353 Natalizumab (Tysabri) Date of issue: July 2010 Review date: July 2011 Contents Section

More information

NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE. Proposed Health Technology Appraisal

NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE. Proposed Health Technology Appraisal NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Proposed Health Technology Appraisal Daclizumab for treating relapsing-remitting multiple Draft scope (pre-referral) Draft remit/appraisal objective To

More information

Study Support Materials Cover Sheet

Study Support Materials Cover Sheet Study Support Materials Cover Sheet Document Title ESCALATE Patient Brochure Intended Audience This brochure is designed to be given to potentially eligible patients as a take-home summary of key information

More information

Clinical relevance of natalizumab tests for multiple sclerosis

Clinical relevance of natalizumab tests for multiple sclerosis 22-09-08 Clinical relevance of natalizumab tests for multiple sclerosis Theo Rispens Multiple Sclerosis Treatment of (relapsing-remitting) MS 1 st line IFN-β (Avonex, Rebif, Betaferon) Glatiramer acetate

More information

The MS Disease- Modifying Drugs. Gener al information

The MS Disease- Modifying Drugs. Gener al information The MS Disease- Modifying Drugs Gener al information Current as of October 30, 2009. This online version is updated as breaking news requires. If you have downloaded and printed a copy from the web, please

More information

Understanding How Existing and Emerging MS Therapies Work

Understanding How Existing and Emerging MS Therapies Work Understanding How Existing and Emerging MS Therapies Work This is a promising and hopeful time in the field of multiple sclerosis (MS). Many new and different therapies are nearing the final stages of

More information

Eastern Health MS Service. Tysabri Therapy. Information for People with MS and their Families

Eastern Health MS Service. Tysabri Therapy. Information for People with MS and their Families Eastern Health MS Service Tysabri Therapy Information for People with MS and their Families The Eastern Health MS Service has developed this information for you as a guide through what will happen to you

More information

Review Date: March 2012. Issue Status: Approved Issue No: 2 Issue Date: March 2010

Review Date: March 2012. Issue Status: Approved Issue No: 2 Issue Date: March 2010 Title: Multiple Sclerosis guidelines for the use of beta-interferon, glatiramer acetate, natalizumab, mitoxantrone and other disease Authors Name: Dr P Talbot Contact Name: Dr Paul Talbot Contact Phone

More information

fingolimod, 0.5mg, hard capsules (Gilenya ) SMC No. (992/14) Novartis Pharmaceuticals UK

fingolimod, 0.5mg, hard capsules (Gilenya ) SMC No. (992/14) Novartis Pharmaceuticals UK fingolimod, 0.5mg, hard capsules (Gilenya ) SMC No. (992/14) Novartis Pharmaceuticals UK 08 August 2014 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises

More information

ORAL MEDICATIONS FOR MS! Gilenya and Aubagio

ORAL MEDICATIONS FOR MS! Gilenya and Aubagio ORAL MEDICATIONS FOR MS! Gilenya and Aubagio Champions against MS 4/20/13 Alexandra Goodyear, MD Stanford University Oral Medications Since 2010, 3 new oral medications for MS: Gilenya 2010 Aubagio 2012

More information

Lemtrada (alemtuzumab)

Lemtrada (alemtuzumab) Lemtrada (alemtuzumab) Policy Number: 5.02.517 Last Review: 08/2015 Origination: 08/2015 Next Review: 08/2016 Policy BCBSKC will provide coverage for Lemtrada (alemtuzumab) when it is determined to be

More information

MS Treatments Gilenya

MS Treatments Gilenya 1 MSology Essentials Series Gilenya (fingolimod) Developed by MSology with the invaluable assistance of multiple sclerosis nurse advisors: Trudy Campbell Dalhousie MS Research Unit, Capital Health, Halifax,

More information

Multiple Sclerosis Update. Bridget A. Bagert, MD, MPH Director, Ochsner Multiple Sclerosis Center

Multiple Sclerosis Update. Bridget A. Bagert, MD, MPH Director, Ochsner Multiple Sclerosis Center Multiple Sclerosis Update Bridget A. Bagert, MD, MPH Director, Ochsner Multiple Sclerosis Center None Disclosures First of All. Why is my talk in the Neurodegenerative hour? I respectfully object! Case

More information

Disease modifying therapies (DMTs) for MS

Disease modifying therapies (DMTs) for MS Disease modifying therapies (DMTs) for MS Section headline The Multiple Sclerosis Society More than 100,000 people live with multiple sclerosis in the UK. Every one of them shares the uncertainty of life

More information

Disease modifying therapies (DMTs) for MS

Disease modifying therapies (DMTs) for MS Disease modifying therapies (DMTs) for MS Section headline Contents Section headline The Multiple Sclerosis Society More than 100,000 people live with multiple sclerosis in the UK. Every one of them shares

More information

J.P. Morgan Cazenove Therapeutic Seminar

J.P. Morgan Cazenove Therapeutic Seminar Jannan, MS J.P. Morgan Cazenove Therapeutic Seminar David Meeker - CEO, Genzyme June 25, 2012 Forward Looking Statements This presentation contains forward-looking statements as defined in the Private

More information

Growth in revenue from MS drugs has been driven largely by price increases over the last several years.

Growth in revenue from MS drugs has been driven largely by price increases over the last several years. March 4, 2013 Ben Weintraub, PhD Are Injectable MS Drugs Finished? Market Ready for Tecfidera Companies: Biogen (BIIB) Sanofi (SNY) Teva (TEVA) Novartis (NVS) Merck Serono Bayer Schering Products: Tecfidera

More information

Medication Update. Acknowledgement

Medication Update. Acknowledgement Medication Update Multiple Sclerosis Limited Acknowledgement We acknowledge and pay respect to the traditional custodians past and present on whose lands we meet today. We acknowledge the deep feelings

More information

Dimethyl fumarate for treating relapsing remitting multiple sclerosis

Dimethyl fumarate for treating relapsing remitting multiple sclerosis NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Final appraisal determination Dimethyl fumarate for treating relapsing remitting multiple sclerosis This guidance was developed using the single technology

More information

Medication Policy Manual. Topic: Betaseron, Extavia, interferon beta-1b Date of Origin: June 18, 2004

Medication Policy Manual. Topic: Betaseron, Extavia, interferon beta-1b Date of Origin: June 18, 2004 Medication Policy Manual Policy No: dru108 Topic: Betaseron, Extavia, interferon beta-1b Date of Origin: June 18, 2004 Committee Approval Date: December 12, 2014 Next Review Date: December 2015 Effective

More information

teriflunomide, 14mg, film-coated tablets (Aubagio ) SMC No. (940/14) Genzyme Ltd.

teriflunomide, 14mg, film-coated tablets (Aubagio ) SMC No. (940/14) Genzyme Ltd. teriflunomide, 14mg, film-coated tablets (Aubagio ) SMC No. (940/14) Genzyme Ltd. 10 January 2014 (Issued 07 February 2014) The Scottish Medicines Consortium (SMC) has completed its assessment of the above

More information

Relapsing-remitting multiple sclerosis Ambulatory with or without aid

Relapsing-remitting multiple sclerosis Ambulatory with or without aid AVONEX/BETASERON/COPAXONE/EXTAVIA/GILENYA/REBIF/TYSABRI Applicant must be covered on an Alberta Government sponsored drug program. Page 1 of 5 PATIENT INFMATION Surname First Name Middle Initial Sex Date

More information

Dimethyl fumarate for treating relapsing-remitting multiple sclerosis

Dimethyl fumarate for treating relapsing-remitting multiple sclerosis Dimethyl fumarate for treating relapsing-remitting multiple Issued: August 2014 guidance.nice.org.uk/ta320 NICE has accredited the process used by the Centre for Health Technology Evaluation at NICE to

More information

Treatment in Relapsing MS: Choosing Among the Options. Donald Negroski, MD

Treatment in Relapsing MS: Choosing Among the Options. Donald Negroski, MD Treatment in Relapsing MS: Choosing Among the Options Donald Negroski, MD Disclosures Research Grants Educational activities and lectures Consulting or other services including Continuing Medical Education

More information

MEDICAL ASSISTANCE BULLETIN

MEDICAL ASSISTANCE BULLETIN ISSUE DATE May 11, 2015 SUBJECT EFFECTIVE DATE May 18, 2015 MEDICAL ASSISTANCE BULLETIN NUMBER *See below BY Prior Authorization of Multiple Sclerosis Agents Pharmacy Service Leesa M. Allen, Deputy Secretary

More information

The Nuts and Bolts of Multiple Sclerosis. Rebecca Milholland, M.D., Ph.D. Center for Neurosciences

The Nuts and Bolts of Multiple Sclerosis. Rebecca Milholland, M.D., Ph.D. Center for Neurosciences The Nuts and Bolts of Multiple Sclerosis Rebecca Milholland, M.D., Ph.D. Center for Neurosciences Objectives Discuss which patients are at risk for Multiple Sclerosis Discuss the diagnostic criteria for

More information

Alemtuzumab for treating relapsing-remitting multiple sclerosis

Alemtuzumab for treating relapsing-remitting multiple sclerosis Alemtuzumab for treating relapsing-remitting multiple Issued: May 2014 guidance.nice.org.uk/ta NICE has accredited the process used by the Centre for Health Technology Evaluation at NICE to produce technology

More information

The submission positioned dimethyl fumarate as a first-line treatment option.

The submission positioned dimethyl fumarate as a first-line treatment option. Product: Dimethyl Fumarate, capsules, 120 mg and 240 mg, Tecfidera Sponsor: Biogen Idec Australia Pty Ltd Date of PBAC Consideration: July 2013 1. Purpose of Application The major submission sought an

More information

Literature Scan: Oral Multiple Sclerosis Drugs

Literature Scan: Oral Multiple Sclerosis Drugs Copyright 2012 Oregon State University. All Rights Reserved Drug Use Research & Management Program Oregon State University, 500 Summer Street NE, E35 Salem, Oregon 97301-1079 Phone 503-947-5220 Fax 503-947-1119

More information

Disease modifying drug therapy. what you need to know

Disease modifying drug therapy. what you need to know Disease modifying drug therapy what you need to know Contact information Neurologist s name: Neurologist s secretary: Telephone number: MS specialist nurse: Telephone number: Manufacturer helpline number:

More information

Teriflunomide (Aubagio) 14mg once daily tablet

Teriflunomide (Aubagio) 14mg once daily tablet Teriflunomide (Aubagio) 14mg once daily tablet Exceptional healthcare, personally delivered Your Consultant Neurologist has suggested that you may benefit from treatment with Teriflunomide. The decision

More information

Original Policy Date

Original Policy Date MP 5.01.20 Tysabri (natalizumab) Medical Policy Section Prescription Drug Issue 12:2013 Original Policy Date 12:2013 Last Review Status/Date Local Policy/12:2013 Return to Medical Policy Index Disclaimer

More information

Version History. Previous Versions. Policy Title. Drugs for MS.Drug facts box Glatiramer Acetate Version 1.0 Author

Version History. Previous Versions. Policy Title. Drugs for MS.Drug facts box Glatiramer Acetate Version 1.0 Author Version History Policy Title Drugs for MS.Drug facts box Glatiramer Acetate Version 1.0 Author West Midlands Commissioning Support Unit Publication Date Jan 2013 Review Date Supersedes/New (Further fields

More information

Resources for the Patient. Please print these out and give them to your patients with MS

Resources for the Patient. Please print these out and give them to your patients with MS Resources for the Patient Please print these out and give them to your patients with MS An internet program for persons with MS on the FCM website Multiple Sclerosis: A Toolbox of Information and Resources

More information

Multiple Sclerosis (MS) Class Update

Multiple Sclerosis (MS) Class Update Drug Use Research & Management Program Oregon State University, 500 Summer Street NE, E35, Salem, Oregon 97301-1079 Phone 503-947-5220 Fax 503-947-1119 Multiple Sclerosis (MS) Class Update Month/Year of

More information

Treatments-related side effects

Treatments-related side effects Treatments-related side effects MS: from the diagnosis to the disease management MSc, MD, José Flores Rivera Instituto Nacional de Neurología y Neurocirugía Safety issues: beta interferon Depression/suicidal

More information

Alemtuzumab (Lemtrada)

Alemtuzumab (Lemtrada) Alemtuzumab (Lemtrada) This factsheet is about alemtuzumab, a disease modifying therapy (DMT) for relapsing multiple sclerosis (MS). At the end of this factsheet you ll find out where you can get more

More information

MS Essentials. Disease modifying drugs

MS Essentials. Disease modifying drugs Fifth edition March 2012 Revised March 2013 06 MS Essentials For people living with MS This publication is available in large print (22 point) and audio CD Call 020 8438 0799 or email infoteam@mssociety.org.uk

More information

A Product and Pipeline Analysis of the Multiple Sclerosis Therapeutics Market

A Product and Pipeline Analysis of the Multiple Sclerosis Therapeutics Market A Product and Pipeline Analysis of the Multiple Sclerosis Therapeutics Market Launch of Several Pipeline Oral Products Could Diminish the Market for Injectable Therapies NEC3-52 November 2014 Contents

More information

Medical Information Services

Medical Information Services Medical Information Services (natalizumab) Safety Update: (17 August 2012) As part our commitment communicating information about (natalizumab), Biogen Idec wish inform you the following update. PML Incidence

More information

News on modifying diseases therapies. Michel CLANET CHU Toulouse France ECTRIMS

News on modifying diseases therapies. Michel CLANET CHU Toulouse France ECTRIMS News on modifying diseases therapies Michel CLANET CHU Toulouse France ECTRIMS Current treatment strategies Future oral treatments Future non oral treatments Drug safety and risks CIS at risk of MS Active

More information

Version History. Previous Versions. Drugs for MS.Drug facts box fingolimod Version 1.0 Author

Version History. Previous Versions. Drugs for MS.Drug facts box fingolimod Version 1.0 Author Version History Policy Title Drugs for MS.Drug facts box fingolimod Version 1.0 Author West Midlands Commissioning Support Unit Publication Date Jan 2013 Review Date Supersedes/New (Further fields as required

More information

Right treatment, right time?

Right treatment, right time? Right treatment, right time? How people with MS make decisions about disease modifying drugs Diane Redfern-Tofts, Ed Holloway Multiple Sclerosis Society April 2014 1 Contents Executive Summary... 5 Introduction...

More information

NHS BOURNEMOUTH AND POOLE AND NHS DORSET

NHS BOURNEMOUTH AND POOLE AND NHS DORSET NHS BOURNEMOUTH AND POOLE AND NHS DORSET COMMISSIONING STATEMENT ON THE USE OF BETA-INTERFERON IN RELAPSING-REMITTING MULTIPLE SCLEROSIS OR SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS, WHERE RELAPSES ARE

More information

Disclosures. Multiple Sclerosis: An Overview & Treatment options. Neurology Care Coordina/on, Nov. 16, 2013

Disclosures. Multiple Sclerosis: An Overview & Treatment options. Neurology Care Coordina/on, Nov. 16, 2013 Multiple Sclerosis: An Overview & Treatment options Bennett Myers, MD Dent Neurologic Institute March 19 th, 2016 NEUR-40695 Disclosures * Teva * Biogen * Novartis Multiple Sclerosis * Diagnosis generally

More information

SECTION 2. Section 2 Multiple Sclerosis (MS) Drug Coverage

SECTION 2. Section 2 Multiple Sclerosis (MS) Drug Coverage SECTION 2 Multiple Sclerosis (MS) Drug Coverage Section 2 Multiple Sclerosis (MS) Drug Coverage ALBERTA HEALTH AND WELLNESS DRUG BENEFIT LIST Selected Drug Products used in the treatment of patients with

More information

UTAH MEDICAID DUR REPORT FEBRUARY 2015 MULTIPLE SCLEROSIS (MS): ORAL DISEASE-MODIFYING DRUGS

UTAH MEDICAID DUR REPORT FEBRUARY 2015 MULTIPLE SCLEROSIS (MS): ORAL DISEASE-MODIFYING DRUGS UTAH MEDICAID DUR REPORT FEBRUARY 2015 MULTIPLE SCLEROSIS (MS): ORAL DISEASE-MODIFYING DRUGS Teriflunomide (Aubagio ) Fingolimod (Gilenya ) Dimethyl fumarate (Tecfidera ) Drug Regimen Review Center Joanita

More information

Progress in the field: therapeutic improvements for all patients?

Progress in the field: therapeutic improvements for all patients? Progress in the field: therapeutic improvements for all patients? Krzysztof Selmaj, Department of Neurology, Medical University of Lodz, PL Warsaw 15 May, 2015 Main features of MS Inflammation Demyelination

More information

Committee Approval Date: December 12, 2014 Next Review Date: December 2015

Committee Approval Date: December 12, 2014 Next Review Date: December 2015 Medication Policy Manual Policy No: dru381 Topic: Lemtrada TM, alemtuzumab Date of Origin: December 12, 2014 Committee Approval Date: December 12, 2014 Next Review Date: December 2015 Effective Date: January

More information

Gilenya. Exceptional healthcare, personally delivered

Gilenya. Exceptional healthcare, personally delivered Gilenya Exceptional healthcare, personally delivered Your Consultant Neurologist has suggested that you may benefit from treatment with Gilenya. The decision to start this form of treatment can be difficult.

More information

What is MS? 1. disease that affects the central nervous. Is a disease that affects both white and gray matter

What is MS? 1. disease that affects the central nervous. Is a disease that affects both white and gray matter What is MS? 1 Neuron Damaged myelin due to inflammation MS is a chronic immunemediated disease that affects the central nervous system (CNS) Is a disease that affects both white and gray matter Interrupted

More information

Multiple Sclerosis in Practice. An Expert Commentary With Jeffrey Cohen, MD, PhD A Clinical Context Report

Multiple Sclerosis in Practice. An Expert Commentary With Jeffrey Cohen, MD, PhD A Clinical Context Report Multiple Sclerosis in Practice An Expert Commentary With Jeffrey Cohen, MD, PhD A Clinical Context Report Clinical Context: Multiple Sclerosis in Practice Expert Commentary Jointly Sponsored by: and Clinical

More information

What is Multiple Sclerosis? Disease Modifying Therapies. Best of all. Why is treatment so important? Outline and Expectations.

What is Multiple Sclerosis? Disease Modifying Therapies. Best of all. Why is treatment so important? Outline and Expectations. What is Multiple Sclerosis? Disease Modifying Therapies for Relapsing Remitting MS Jeanie Lynn Cote, MD Chronic, auto immune disorder. As a consequence of immune attacks, there is loss of myelin (fatty

More information

Teriflunomide for treating relapsing remitting multiple sclerosis

Teriflunomide for treating relapsing remitting multiple sclerosis Teriflunomide for treating relapsing remitting multiple Issued: January 2014 last modified: June 2014 guidance.nice.org.uk/ta NICE has accredited the process used by the Centre for Health Technology Evaluation

More information

alemtuzumab, 12mg, concentrate for solution for infusion (Lemtrada ) SMC No. (959/14) Genzyme

alemtuzumab, 12mg, concentrate for solution for infusion (Lemtrada ) SMC No. (959/14) Genzyme alemtuzumab, 12mg, concentrate for solution for infusion (Lemtrada ) SMC No. (959/14) Genzyme 04 April 2014 (Issued 06 June 2014) The Scottish Medicines Consortium (SMC) has completed its assessment of

More information

Clinical Commissioning Policy: Disease Modifying Therapies For patients With Multiple Sclerosis (MS) December 2012. Reference : NHSCB/D4/c/1

Clinical Commissioning Policy: Disease Modifying Therapies For patients With Multiple Sclerosis (MS) December 2012. Reference : NHSCB/D4/c/1 Clinical Commissioning Policy: Disease Modifying Therapies For patients With Multiple Sclerosis (MS) December 2012 Reference : NHSCB/D4/c/1 NHS Commissioning Board Clinical Commissioning Policy: Disease

More information

Novel therapeutic approaches in multiple sclerosis Neuroprotective and remyelinating agents, the future of clinical trials in MS?

Novel therapeutic approaches in multiple sclerosis Neuroprotective and remyelinating agents, the future of clinical trials in MS? Novel therapeutic approaches in multiple sclerosis Neuroprotective and remyelinating agents, the future of clinical trials in MS? Marie Trad, M.D., Lynne Hughes, Cathy VanBelle, Amy Del Medico 3rd International

More information

Conflict of Interest Declaration. Overview of New Medications for Multiple Sclerosis. Assessment Question. Objectives 4/1/2011

Conflict of Interest Declaration. Overview of New Medications for Multiple Sclerosis. Assessment Question. Objectives 4/1/2011 Conflict of Interest Declaration Overview of New Medications for Multiple Sclerosis I or my spouse have no actual or potential conflict of interest in relation to this activity. Crystal Obering, Pharm.D.,

More information

FastTest. You ve read the book... ... now test yourself

FastTest. You ve read the book... ... now test yourself FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. The answers will refer you back to

More information

New Developments in the Treatment and Management of Multiple Sclerosis

New Developments in the Treatment and Management of Multiple Sclerosis New Developments in the Treatment and Management of Multiple Sclerosis Myla D. Goldman, MD, MS For a CME/CEU version of this article, please go to www.namcp.org/cmeonline.htm, and then click the activity

More information

Access to Medicines Campaign Handbook

Access to Medicines Campaign Handbook MS Ireland Campaign Handbook 1 Access to Medicines Campaign Handbook Contents Foreword Introduction MS Ireland and Access to Medicines About MS Medicines MS Medicines Approved For Use Access to MS Medicines

More information

Choices Drug Therapies

Choices Drug Therapies Choices Drug Therapies There are many prescription drugs available to treat MS. There are disease modifying drugs that affect the long-term course of MS and other medications to treat a particular symptom.

More information

Multiple Sclerosis Drug Discoveries - What the Future Holds

Multiple Sclerosis Drug Discoveries - What the Future Holds Brochure More information from http://www.researchandmarkets.com/reports/1408035/ Multiple Sclerosis Drug Discoveries - What the Future Holds Description: The recent approval in the US of Novartis' orally

More information

this 7^ day of September 2014 by Randall S. Gregg Special Deputy Director

this 7^ day of September 2014 by Randall S. Gregg Special Deputy Director r STATE OF MICHIGAN DEPARTMENT OF INSURANCE AND FINANCIAL SERVICES Before the Director of Insurance and Financial Services In the matter of: Petitioner, v File No. 143525-001 Health Alliance Plan of Michigan,

More information

Patient Group Input to CADTH

Patient Group Input to CADTH Patient Group Input to CADTH Section 1 General Information Name of the drug CADTH is reviewing and indication(s) of interest Name of patient group/author of submission Patient group s contact information:

More information

Economic Evaluation of Natalizumab (Tysabri) for the treatment of relapsing remitting multiple sclerosis that is rapidly evolving and severe or

Economic Evaluation of Natalizumab (Tysabri) for the treatment of relapsing remitting multiple sclerosis that is rapidly evolving and severe or Economic Evaluation of Natalizumab (Tysabri) for the treatment of relapsing remitting multiple sclerosis that is rapidly evolving and severe or sub-optimally treated Summary In January 2007 Biogen Idec

More information

Managing Relapsing Remitting MS Risks & benefits of emerging therapies. Dr Mike Boggild The Walton Centre

Managing Relapsing Remitting MS Risks & benefits of emerging therapies. Dr Mike Boggild The Walton Centre Managing Relapsing Remitting MS Risks & benefits of emerging therapies Dr Mike Boggild The Walton Centre MS: Facts and figures Affects 1 in 800 in the UK Commonest cause of acquired neurological disability

More information

Multiple Sclerosis Agents Step Therapy with Quantity Limit Program Summary

Multiple Sclerosis Agents Step Therapy with Quantity Limit Program Summary Multiple Sclerosis Agents Step Therapy with Quantity Limit Program Summary OBJECTIVE The intent of the Multiple Sclerosis (MS) Agents Step Therapy (ST) program is to encourage the use of preferred multiple

More information