PATENT PORTFOLIO 2013

Transcription

1 PATENT PORTFOLIO 2013

2 n Title Inventors Applicants Status Field of use Description Suggested Applications Probes for the genomic typing of erytrocyte system, oligonucleotide methods and relative diagnostic kit Apparatus for treating neurological disorders by brain stimulation Poli Francesca Crespiatico Loretta Drago Francesca Espandas De Aras Alejandro Villa Maria Antonietta Priori Alberto Foffani Guglielmo Rossi Lorenzo 50% UNIMI 50% application (CA) (IT, EP, US, IL) application (CA) (IT, EP, US, IL) The present invention provides methods for the oligonucleotide specific probes for genomic typing of erytrocyte system and relative diagnostic kit. This method can be used for medical-biotechnology. The invention relates to an innovative system for Deep Brain Stimulation (DBS, which is able to correlate the typical EEG of certain neurodegenerative diseases with the therapeutic stimulation delivered at the nervous tissues. In this way the stimulation will be always regulated according to the patient need. The advantage related to the use of molecular techniques is economic and fast genomic typing of samples blood. The therapy is optimized and specifically adapted to each patient. The system installation procedure is safe, poorly invasive and it can be carried out under local anesthesia in the case of Parkinson s desease. 09 Process for reducing neuromuscolar fatigue caused by exercise Priori Alberto Cogia Manian Filippo Marceglia Sara (EP) The present invention is relates to a process for reducing neuromuscolar fatigue caused by exercise, in particular in a rehabilitation exercises and secondary syndromes of tireless To provide an alternative process for reducing neuromuscolar fatigue, in a healty person submit at phisical exercise. 11 Method for the genomic typing of erythrocyte systems, oligonucleotide probes and relative diagnostic kits. Poli Francesca Drago Francesca Karpasitou Katerina application (US, CA, IL) (IT, EP) The present invention relates to a method for the genomic typing of erythrocyte system, oligonucleotide probes and relative diagnostic kits. The advantage related to the use of molecular techniques is economic and fast genomic typing of samples blood

3 n Title Inventors Applicants Status Field of use 12 Method of stem cells expansion ex-vivo 13 Kit for voice audiometry with praxis control " Innovative method of Porphyria diagnosis Piastrinic fraction deriving from placentar blood Lazzari Lorenza Montemurro Tiziana Giordano Rosaria Rebulla Paolo Sirchia Girolamo Cesarani Antonio Di Bernardino Federica Di Pierro Elena Cappellini Maria Besana Valeria Brancaleoni Valentina Rebulla Paolo Lazzari Lorena Parazzi Valentina Greppi Noemi 50% UNIMI 50% application (US, IL) (IT, MX) (IT, EP) application (EP) (IT, US) Clinic Description The present invention relates to a colture inclusive of growth means and a combination of cytokines for expanding ex-vivo stem cells or progenic cells and cells differentiated, and use of this cells. The present invention relates to a kit for audiometry, in particular for voice audiometry with movement coordination control. The invention applies to the analysis and study in depth of the degree of hearing disturbance in a subject with suspected reduction in the auditory sensitivity (hipacusia) Porphyrias are a group of heterogeneous disorders caused by genetic defects of enzymes involved in heme biosynthetic pathway The present invention offers seven panels of probes able to recognize the seven genes of heme pathway involved in porphyrias and their surrounding regions. The present invention relates to a piastrinic fractions deriving from placentar blood with high concentration of piastrinic factors and gel. Moreover the invention relates methods to prepare this piastrinic fraction from placentar blood and they applications. Suggested Applications To provide an easy, standardized and reproducible ex vivo expansion system based on a proper mixture of cytokines in a animal-free medium that defines optimal culture conditions able either to expand and maintain stem cells and to amplify progenitor cells from different cell sources. This protocol has been already successfully tested in a clinical setting. To provide a kit for audiometry that is also able to evaluate the semantic-oral comprehension of a subject affected by hypocusia thought the Porphyria is often misdiagnosed because the symptoms are common with several other disorders. So far only point mutations or small deletions-insertions in the coding regions of heme genes have been described. The use of these probes will allow a fast and simple diagnosis, detecting deletion or duplication of genes involved in the pathway. Furthermore, this method is easier to use, faster and cheaper than other methods. To provide a medicament made of a piastrinic fraction to treat damaged tissues and other application.

4 n Title Inventors Applicants Status Field of use 16 New melanocortins with antimicrobial activity Catania Anna Bonino Ferruccio Grieco Paolo Novellino Ettore application (CA, IL, IN, JP) (EP, US) Description The present invention finds application in the therapeutic fields. In particular, it concerns new syntetic melanocortin peptides having improved antimicrobial activity. Suggested Applications Compound with major anti-inflammatory, anti-infective and antimicrobial activity for therapeutic use, especially against Candida albicans and Staphilococcus aureus. 17/18 Tecnosalute Bonino Ferruccio Italian trademark Education Figurative for educational and medical services. A new approach of multidisciplinary educational courses. 19 Method of threedimensional co-culture of podocytes and endothelial cells and in-vitro co-culture system thereof Rastaldi Maria Pia Li Min application (EP, US, IL) Method for dental pulp cryopreservation Gioventù Silvia, Frasca Stefania, Rebulla Paolo, Bonino Ferruccio, Lazzari Lorenza, Montelattici Tiziana, Andriolo Gabriella application (EP, US, IL) Center for the Prevention and Diagnosis of Celiac Disease 22 Method for determining inhomogeneity in animal Tissue and Equipment to Elli Luca Gattinoni Luciano Cadringer Paolo CressoniMassimo Italian trademark Education Figurative for

5 implement it Collecting Device for Analysis of biological Material 24 Method and diagnostic Kit to detect Gluten Sensitivity Messa Pier Giorgio Spinardi Laura Provasi Stefano Elli Luca Bardella Maria Teresa Tomba Carolina Roncoroni Leda 50% Tecnoline 50% Data deposito: Clinica/Diagno stica Method for determining whether a subject is sensitive to gluten and a kit for carrying out said method. 25 Method of noninvasive prenatal diagnosis Debora Lattuada application Data deposito: Clinica/Diagno stica Method for the isolation of intact fetal erythroblasts from a sample of peripheral blood of a pregnant woman and diagnostic kit thereof.