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1 2 ND INTERNATIONAL WORKSHOP ON DOSE OPTIMIZATION STRATEGIES FOR TARGETED DRUGS FOCUS ON ONCOLYTICS MADRID, SPAIN SEPTEMBER 2017 SPONSORSHIP REQUEST

2 INTRODUCTION & SIGNIFICANCE With this document, we would like to request your financial support and sponsor the International Workshop on Dose Optimization Strategies for Targeted Drugs - Focus on Oncolytics. Your contribution will make a very much needed conference possible. The field of targeted drugs is in continuous development. Given the many existing drugs with multiple unanswered pharmacological questions and with the introduction of the new group of targeted agents with their unique pharmacological properties many studies are being performed which will lead to new perspectives. Whereas there is a possibility to submit research in this area to major international conferences, there is usually limited time for in depth discussion and debate among experts on new data and their implications. Together with a group of international experts we feel there is a need for a state of the art, scientific and independent platform for international exchange between experts in this field. It is therefore that in 2014 we initiated an international abstract-driven workshop on dose optimisation strategies for targeted drugs, with focus on oncolytics. The meeting gathers a cross-disciplinary team of experts and trainees involved in targeted therapies research, in order to present and discuss the latest developments and strategies for the future, in an interactive and science-focused setting. MEETING OBJECTIVES To gather professionals in the field of pharmacology of targeted drugs in an interactive workshop setting; To provide a platform for presentation and discussion of the latest pharmacological developments in the field; To map all current studies and results; To translate new data to treatment guidelines; To educate clinicians on pharmacological challenges that need to be addressed with the implement of current and new drugs. TARGET AUDIENCE The targeted audience of this workshop will consist of medical oncologists, clinical pharmacologists, pharmacists, industry researchers, government representatives and other experts involved in this field of research. The expected number of participants is aimed to be EDITION The 2nd edition of the International Workshop on Dose Optimization Strategies for Targeted Drugs: Focus on Oncolytics will take place on September 2017 in Madrid, Spain, right after the ESMO.

3 INTRODUCTION & SIGNIFICANCE TARGET AUDIENCE The targeted audience of this workshop will consist of medical oncologists, clinical pharmacologists, pharmacists, industry researchers, government representatives and other experts involved in this field of research. The expected number of participants is aimed to be 100. DEMOGRAPHICS 2015 I am: Mainly employed by: Hospital Pharmacist 15% Student 5% Other 3% Clinical doctor 36% Other 1% Industry 30% University 45% Researcher 41% Hospital 24% Area of expertise: General Medicine 1% Other 14% Medical Oncology 32% Clinical Pharmacology 53%

4 PARTNERSHIPS & PREVIOUS SUPPORTERS ENDORSERS Study of the Liver (IASL) Is among the oldest professional associations of clinicians and scientists dedicated to translating liver research into clinical practice. PREVIOUS SUPPORTERS

5 THE WORLD S LEADING EXPERTS ORGANIZING COMMITTEE ETIENNE CHATELUT, PHARMD, PHD Institut Claudius-Regaud Toulouse, France GEORGE DEMETRI, MD Harvard Medical school Boston, MA, USA LENA FRIBERG, PHARMD, PHD Uppsala University Uppsala, Sweden NIELKA VAN ERP, PHARMD, PHD Radboud University Nijmegen Medical Center Nijmegen, the Netherlands HOWARD GURNEY, MB, BS, FRACP Macquarie University, Westmead Hospital, University of Sydney, Sydney, Australia RON MATHIJSSEN, MD, PHD Erasmus Medical Center Rotterdam, the Netherlands MICHELLE RUDEK, PHARMD, PHD Johns Hopkins University Baltimore, MD, USA 2 nd International Workshop on Dose Optimization Strategies for Targeted Drugs: Focus on Oncolytics

6 BROAD CONFERENCE GOALS Facilitate a neutral, scientific, knowledge exchange on dose optimisation of targeted oncolytics Promote dissemination and successful translation of new knowledge Foster new and lasting cross-disciplinary partnerships and collaborations between researchers, in order to improve the knowledge sharing, with the end goal of improving quality of life within the population of oncology patients Attract, showcase, and maintain new, early career, and underrepresented investigators to this multidisciplinary area of research. Facilitate a robust dialogue among participants through interactive networking and meal breaks, a networking reception, and distribution of participant list to all registrants during the conference. Host an interactive poster session; award young (early career) investigators Publish and promote conference proceedings. Summarize the current state of the science with regard to dose optimization of targeted oncolytics and assess their value in identifying at-risk patients and monitoring therapeutic modalities. PROJECTED CONFERENCE OUTCOMES After participating in this activity, the participants will demonstrate the ability to: Define issues related to the pharmacology of novel targeted drugs; Integrate the latest scientific research into daily clinical care to improve the quality of life of oncology patients; Understand the concepts of dose-efficacy/toxicity relationships and use this knowledge to guide clinical decision making e.g. dose reduction/elevation or switch from treatment regimen; Recognize the future challenges and strategies to personalize targeted therapy.

7 2016-EDITION The first edition of the International Workshop on Dose Optimization Strategies for Targeted Drugs took place on March 2015 at the Inntel Hotels Zaandam, Amsterdam, The Netherlands and managed to attract nearly 70 participants from 11 countries. The workshop was CME- accredited by EACCME for a maximum of 11 hours of European external CME credits. Professional Background Hospital Pharmacist 15% Student 5% Other 3% Clinical doctor 36% Researcher 41%

8 WORKSHOP FORMAT FORMAT The format of the workshop includes plenary expert presentations, discussion sessions on areas currently lacking consensus, abstract-driven presentations and a poster-viewing session. Experts in the area are invited to give state-of-the-art lectures and controversial patient cases are be discussed by expert panels. The duration of the workshop will be two full days. The workshop will be abstract-driven. To ensure the quality of accepted abstracts, all submitted abstracts go through a blind, peer-reviewed process conducted by the members of the Organizing and Scientific Committees. The below table shows the abstract submission statistics for Total number of accepted abstracts 25 (1 withdrawn) Oral presentations 12 Mini - oral presentation 7 Poster presentations 5 YOUNG INVESTIGATOR PARTICIPATION Virology Education seeks to attract the participation of young Investigators with accepted abstracts by waiving registration fees. Conference Participation Grants with sufficient funding, we can issue a call for applications and award a number of travel fellowships for young investigators. The committee will select the grantees, via a competitive application process, including submission of letters of recommendation and a poster abstract. Poster Session Participating scientists are invited to submit poster abstracts for presentation at a dedicated Poster Session, allowing poster presenters and attendees to exchange knowledge, interact, and establish new collaborations. Posters are set-up in highly visible areas with easy accessibility during registration, session breaks, and after closing on all days of the conference. This is the ideal time for researchers to present their posters to fellow scientists, expert faculty, and many others on multiple occasions. The compiled poster abstracts will be archived and made available to the global scientific community. Short Oral Presentations a number of investigators will be selected from the pool of submitted poster abstracts for podium Key Topic talks. Presenters will be selected from submitted abstracts by the scientific organizing committee in a competitive process open to all investigators in the field, with preference given to early career investigators.

9 JOIN US AND REACH THOUSANDS GLOBALLY WHY SUPPORT US? As a sponsor of this conference, you will have exclusive access to scientists from academia, government, and industry in search of the latest advancements and information about targeted oncolytics. Supporter benefits include: Extensive visibility to a highly targeted, expert audience via the conference s promotional campaign, on-site exposure during the event, press and media coverage, and post-event information dissemination. Unique one-on-one networking opportunities during the event. Exhibiting opportunities and complimentary passes to the event. PRE-EVENT MARKETING As a conference supporter, your organization will receive extensive exposure, enabling you to reach out to thousands of targeted researchers, clinicians, patients, and scientists. These channels include targeted print and campaigns, as well as web advertising. Your support delivers to you: Branding as a supporter on the event website, to which traffic is driven by: Banner ads strategically positioned on the homepages of relevant partners. Traffic from the Virology Education website, which receives thousands of visitors monthly. Advertisements placed in the Newsletters delivered to thousands opt-in subscribers. Electronic advertising posted on several calendars, which will link to the event website. ONSITE BENEFITS You will benefit as a supporter from many on-site marketing and networking opportunities at the event, including: Branding for your organization via on-site signage throughout the conference. Highlighted position in the conference program distributed to all attendees. Promotion option to display marketing materials such as pamphlets, flyers, postcards, and other materials on the marketing table (subject to approval). Complimentary passes to the event to increase your networking opportunities with attendees (quantity of complimentary passes dependent on level of support).

10 THIS MEETING IS BROUGHT TO YOU BY of the medical community. Expert Medical Events is a sister company of Virology Education, the industry leading provider of state of the art medical programs within the field of infectious diseases. With nearly 20 years of experience, we are committed to delivering highly acclaimed and CME accredited medical education workshops and conferences consistently. Our solid network of KOL s and rich database of HCP s enable us to develop highprofile programs specifically tailored to the educational needs CONTACT For more information, to sponsor our workshops, or to request a tailored proposal, please contact: Alice Posthumus- Plantinga Managing Director T: +31 (0) M: +31 (0) E: alice@vironet.com Goda Adomonis Senior Conference Manager T: +31 (0) M: +31 (0) E: goda@vironet.com