Master of science (physics and mathematics), Copenhagen University 1980.Thesis on experimental microdosimetry.

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1 1 Curriculum vitae for: Søren Holm, born 18. Feb in Copenhagen Degrees: Danish Baccalaureate (science), Ballerup Gymnasium 1971 Master of science (physics and mathematics), Copenhagen University 1980.Thesis on experimental microdosimetry. Lic.scient (ph.d.) in medical physics 1987, Copenhagen University. Thesis on dynamic SPECT of the brain Supplementary education, courses etc: Health Physics, DTH Isotope course, Finsen Institute Summerschool on Advances in Radiation Protection and Dosimetry in Medicine, Erice, Italien Professional postgraduate teacher training (math and physics) 1981 NMR, NOVO, November VMS, Digital A/S, PET techniques, GEMS PET, Uppsala, 1992 MR for physicists, MR-department, University of Lund, 1996 ESI International week on radiation detectors and imaging in life sciences, Archamps, France 1998 Internal Dosimetry, Radiophysics department, University of Lund, 1999 Audit course, Frederiksberg, 2003 Safety and risk analysis in medical physics. Limassol, 2004 MATLAB-course, DIKU, 2005 MicroPET and microct, Siemens Preclinical, Knoxville, 2006 Dosimetry Internal radiation course DSMF, SIS Herlev, NACP-course: CT dosimetry and image optimization for medical physicists, Århus, 2010 MR-course, RH, st PET/MR Workshop, Tübingen, March 2012 Additional courses for medical doctors specializing in Neurology or Nuclear Medicine, contributing by teaching in SPECT/PET, kinetics, and radiation protection. Participation in international meetings, workshops, symposia, congresses as listed below. Positions: Instructor/teaching assistant in physics for students at Copenhagen University in medicine, biology, and chemistry , and for master students in physics (course in health physics) Professional postgraduate teacher training in math and physics, Metropolitanskolen, Copenhagen 1981 Research grant from the Danish Technical Research Council at department of Neurology, Rigshospitalet,

2 2 Consultant (scientific advisor) for Novo Diagnostic Systems and Scan Detectronics , stationed at Dept. of Clinical Physiology, Finsen Institute 1986 Scientific assistant to professor Niels A Lassen at Dept. of Clinical Physiology, Bispebjerg Hospital (grants from the Lundbeck Foundation and the Medical Research Council) Scientific assistant to professor Olaf Paulson, Dept. of Neurology, Rigshospitalet Medical Physicist at the PET centre, Rigshospitalet, (grants from The John and Birthe Meyer Foundation) Medical Physicist at dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet Chief Physicist at Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet Associate Professor ( ekstern lektor ) at Copenhagen University Other scientific tasks Reviewer for Phys Med Biol, NeuroImage, J Nucl Med, J Cereb Blood Flow Metab, Eur J Nucl Med Mol Imaging, Acta Oncologica, Ugeskrift for Læger Participant in EU-project (performed ). Evaluation of a new type of positron emission tomograph scanner for high resolution images. Organizer (scientific secretary) Human Brain Mapping 1997, Copenhagen Editorial Board Member, Clinical Physiology, Member of the Sundhedsfaglige råd for klinisk fysiologi og nuklearmedicin i HS Delegate to EFOMP (Eur Fed Org Med Physics) from the Danish Society for Medical Physics (DSMF) Member of EFOMP s scientific committee Board member of DSKFNM, the Danish Society for Clinical Physiology and Nuclear Medicine Member of the Sundhedsfaglige råd for klinisk fysiologi og nuklearmedicin i Region Hovedstaden (the Capitol region) Member of the education council of the Danish Society for Medical Physics, DSMF President of the Danish Society for Medical Physics, DSMF Head of national user group for PET/CT, preparing a nationwide tender for PET/CT Member of a working group under IAEA addressing artifacts in PET/CT Participant in a NKS-sponsored project (Nordisk kernesikkerhedsforskning, Nordic nuclear safety research) about calibration of whole-body counters Board member of NSFS (Nordisk Selskab for Strålebeskyttelse, Nordic Society of Radiation Protection) Organizer of symposium celebrating the 100-anniversary of Niels Bohr s atomic model: Bohrs atommodel og nuklearmedicinen. Rigshospitalet, November 2013 Award: Prize of honour from DSKFNM 2008.

3 3 Participation in meetings, workshops, symposia, congresses etc. (normally with poster or oral presentation): Repeated (e.g., yearly) events are listed with *, place and year under first appearance International Symposium on CBF and Metabolism in Man, Heidelberg 1983 Eur Soc of Clin Inv, Toulouse 1985 *International Symposium on CBF and Metabolism ( Brain ) Lund/Ronneby 1985, Montreal 1987, Bologna 1989, Miami 1991, Sendai 1993, Köln 1995 *European Nuclear Medicine Congress Goslar 1986, Budapest 1987, Strasbourg 1989, Lissabon 1992, Copenhagen 1996, Barcelona 1999, Paris 2000, Wien 2002, Amsterdam 2003, Helsinki 2004, Istanbul 2005, Athen 2006, Copenhagen 2007, München 2008, Barcelona 2009, Wien 2010, Birmingham 2011, Milano 2012, Lyon 2013 *Society of Nuclear Medicine annual meeting Washington 1986, St. Louis 1989, Washington 1990, Minneapolis 1995, Toronto 2001, Los Angeles 2002, Philadelphia 2004, New Orleans 2008, Miami Beach 2012, Vancouver 2013 *Nordisk CBF-møde Fåborg 1989, Lund 1990, Sørup 1991, Malmø 1992, Hillerød 1993, Höör 1994, Helsingør 1995, 1997 NordPET, Copenhagen, December 1989 International meeting on iodinated receptor ligands, Bruxelles, October Invited talk: "Acquisition requirements for SPECT with I-123". Brain Work Imaging (Alfred Benzon symp. no 31) Vid. Selskab, Copenhagen, Aug Symposium on Migraine and other headaches, Copenhagen, November 1990 Symposium om Retained brain tracers, Firenze, November 1991 Invited talk: "Quantitation of brain perfusion with SPECT using brain retained tracers". Benzodiazepin-receptormeeting, Vid. Selskab, Copenhagen, May Invited talk: "Is quantitation possible with SPECT and PET?" ECD symposium, Copenhagen, July 1992 Brain and Mind symposium, Vid. Selskab, Copenhagen, August 1992 *GE PET users meeting: Jülich, Oct. 1992, Duke NC, USA March 1993, Tübingen Oct. 1994, New York April 1996, Bethesda Md USA Sept st European workshop on epilepsy surgery, Copenhagen, April 1993.

4 4 Invited talk: "Methodological considerations. SPECT and PET-machines." *Brain PET Akita 1993, Oxford 1995, Bethesda 1997, Copenhagen 1999 X Scandinavian Congress in Clinical Physiology. Copenhagen, August 1993 *Human Brain Project Workshop, Minneapolis August 1993, Boston November 1994, Copenhagen April *Small animal scanner network meeting, Hammersmith February 1994, Bruxelles February 1996 EC-meeting on 3D PET, Louvain la Neuve April 1994 *IEEE NS and MIC Norfolk 1994, San Francisco 1995, Seattle 1999, Dresden 2008, Orlando 2009 Workshop on Dopamin transporter quantitation, RH, 5.May 1995 Workshop on PET instrumentation for animal imaging, San Francisco 1995 *Human Brain Mapping Boston 1996, Copenhagen 1997, Montreal 1998 Hypoxia in malignant tumors, RH, November International workshop on non-invasive imaging of tumor hypoxia, Århus, November The VIII symposium on the medical application of cyclotrons. Turku, May HiRes '99, High resolution in small animals with PET, MR, and other modalities. Amsterdam, September ESPR (Eur Soc Pediatr Res) congress. Copenhagen, June Invited talk: The principle of SPECT and PET for measurement of rcbf Symposium on Mechanisms to secure tissue oxygenation in humans; adaptive and evolutionary aspects. Vid. Selskab, Copenhagen, November 2000 XII Scandinavian Congress of Clinical Physiology and Nuclear Medicine, Århus, April 2001 Molecular Imaging Symposium, Zürich, May 2001 Barcelona PET Conference, Barcelona, October 2001 *DSKFNM årsmøder (yearly meetings of the Danish Society of Clinical Physiology and Nucl Med) Karrebæksminde 2001, Rebild 2002, Helsingør 2003, Rebild 2004, Helsingør 2005 (mødeleder: Billedbehandling), Rebild 2008, Helsingør 2009, Vingsted 2010, Vingsted 2012, Korsør 2013

5 5 The IX symposium on the medical application of cyclotrons. Turku, May DSMF symposium. Dalum, March 2003 Scandinavian PET Winter symposium. Lillehammer, March 2003 Invited talk: The PET scanner Reconstruction of images. VIII European Congress on Medical Physics and Engineering, Eindhoven Holland, May Malmö-mötet om Kvalitet i Strålskyddsarbetet. Malmø, February DSMF symposium. Dalum, April Invited talk: New experimental techniques, PET-CT. II EFOMP Mediterranean Conference on Medical Physics, Limassol Cypern, April 2004 Segerfalk Symposium. Lund, May 2004 The X Turku PET symposium. Turku, May *DSKFMN ½-års møde. Odense, June 2005, June Risø, June 2007, Odense, May 2008 Nordic Society for Radiation Protection (XIV). Radiological Protection in Transition. Rättvik, September st AAPM/EFOMP scientific symposium. Advances in imaging and radiation therapy. Nürnberg, September International Conference of Medical Physics. Nürnberg, September Röntgenveckan. Malmø, September Invited talk: PET-CT, technique and physics First Danish Workshop on particle therapy (Danlite). Siemens Danmark, November GE Medical Advisory Board. Milano, November Brain Storm Symposium Birthday symposium for Albert Gjedde. Århus, January DSMF symposium. Odense, March Workshop on Medical Applications of the X-ray Compact Light Source. Panum, June th International symposium on Functional Neuroreceptor Mapping. Rigshopitalet, July 2006 EFOMP/SEFM European Day on Medical Physics Training. Màlaga, October 2006 *RSNA. Chicago, November 2006, November DSMF symposium. Odense, March 2007

6 6 EFOMP X Congress, Pisa, September 2007 Nordic Society for Radiation Protection (XV). Ålesund, May 2008 NACP/IGRT symposium, Århus, June 2008 European Conference on Medical Physics and Engineering, Krakow, September 2008 Siemens Biograph User Club, Göteborg March DSMF symposium. Odense, May rd Malmö Conference on Medical Imaging: Optimization in x-ray and molecular imaging. Malmö, June Advanced Intra-operative Imaging of Radioisotopes. (8th international thematic workshop). Presymposium on TOF-PET. Baia delle Zagare, Italien, September DSMF symposium. Odense, April 2010 Third European IRPA Congress, Helsinki, Finland, June Invited talk: "Optimization of Protection in Paediatric PET-CT. DSR/DSKFNM Scientific meeting, Odense, January 2011 DSMMR Årsmøde, Middelfart, 12. April 2011 Acta/NACP (9. DSMF) Symposium), Uppsala, Sverige, April 2011 EU/EFOMP workshop: European Commission guidelines on Medical Physics Expert, Sevilla, Spanien, May 2011 XII Turku PET symposium, Turku, Finland, May 2011 Nordic Society for Radiation Protection (XVI). Reykjavik, August 2011 European Workshop to introduce RP162 (Acceptability criteria for medical equipment...), Malahide, Dublin, Irland, September 2011 PIANOLIB workshop, Göteborg, September DSMF Symposium, Nyborg Strand, April 2012 IRPA 13, Glasgow, May 2012 DSR/DSKFNM scientific meeting, Århus, January DSMF Symposium, Odense, May 2013

7 7 PSMR2013, Aachen, May 2013 Siemens Biograph user meeting, Århus, January 2014 DSR/DSKFNM Scientific meeting, Odense, January 2014

8 8 Other presentations (scientific societies, colloquia etc.) Colloquium at Service Frederic Joliot, Orsay, March SPECT with Tomomatic Invited talk at Amersham International, Amersham, May Dynamic SPECT. Symposium, High resolution scintitomography of cerebral blood flow, Gasthuisberg, Leuven, November Invited talk: "Performance analysis of the NOVO multidetector brain SPECT scanner." Scientific meeting, RH afd. B, January Invited talk: Nuclear cardiology methods. PET. Invited talk in Dansk Selskab for Neurovidenskab, April PET og SPECT. Invited talks in DSKFNM (Dansk Selskab for Klinisk Fysiologi og Nuklear Medicin): 28. Nov about SPECT 5. March 1992, PET with FDG 30. Oct. 1992, about PET at Rigshospitalet Invited talk at Århus Kommunehospital 21. June "Metodologiske problemer ved PET-skanning." Neurolite launch symposium, Herlev, December Invited talk: "Split-dose/activation." Invited talk at Sokoloff s laboratory at NIH, April "The lumped constant of the PET-FDG method: A reevaluation by different techniques" (with Steen Hasselbalch) Invited talk at UTHSC Dallas, June "Radioisotope based methods for determination of CBF in man." Invited talk at Turku PET center, January "Physical aspects of brain PET activation studies with H 2 15 O bolus injection." Invited talk (paid by Nycomed Amersham) at Hedmark Sentralsjukehus, Elverum, Norge November "Måling af CBF på gammakamera, fysiske aspekter". Invited talk at Symposium for prof. Olaf B. Paulson, RH August Kritisk evaluering af Kety- Schmidt teknikken. Invited talk at the 40 years anniversary of the Dept. of Clinical Physiology at Bispebjerg Hospital: Metoder og apparatur; nuværende og fremtidige krav/ønsker. October Invited talk at DSKFNM ½-års meeting, Odense, June 2004 (with Lars Thorbjørn Jensen). Akutte stråleuheld på skadestuer og nuklearmedicinske afdelinger.

9 9 Teaching: Repeated events are listed with *, ( place and) year at first appearance. (Most courses are given in Danish language, and the Danish titles are kept here) Kursus om hjernens gennemblødning og blod-hjerne barriere. RH, December Flow kinetik. Kursus i cerebral hæmodynamik, RH 1986 *Kursus i Matematik for Kliniske Fysiologer (A-kursus), April-May 1990, Oct.-Nov. 1993, 1996, 1999, March-April 2003, Oct.-Nov. 2006, March-April 2009, Sept.-Nov Brain Imaging Kursus i hjernens patofysiologi for neurologer og kliniske fysiologer, Neurologisk afd. RH September Tomografisk billeddannelse af hjernen. Basale principper, relevante isotoper. Videregående Isotopkursus for Klin. Fysiologer (A-kursus), KAS Glostrup, November 1990 Nordisk kursus i hjernens patofysiologi. Gilleleje, May SPECT og PET. Cyklotron og isotoper. "Nyere diagnostiske metoder i Neurologi" (A-kursus) October 1991 Kursus i 3-D billedbehandling. Efterudd.kursus i Dansk selskab for Med. Fysik, October 1991 Brain Imaging Kursus (receptorer), Neurologisk afd. RH November 1991 Kurser i "Radioaktivitet og Strålehygiejne" for laboranter March/April 1992 Kursus i "Radioaktivitet og Strålehygiejne" for laboranter March 1993 Brain Imaging Kursus, Neurologisk afd. RH, March Isotoper og principper for SPECT og PET. Billeddiagnostiske metoder i neurologi (A-kursus), RH, September PET, principper og anvendelse i neurologisk forskning. Videregående isotopkursus (A-kursus), March SPECT. Brain Imaging Kursus, Neurologisk afd. RH October PET kursus, RH December PET og SPECT, principper og teknik. Kursus i Arbejde med radioaktive isotoper for personale i Finsencentret, November *Medical Imaging Course (Humanbiologer) Panum og RH. Jan. 96, Aug/Sept , Jan/Feb : Nuklearmedicinske undersøgelser. Fysiske principper. Tracere og kinetik. Brain Imaging Kursus, Neurologisk afd. RH, March 1996 Ph.D. kursus i isotopteknik, RH, March Radioaktivitet og stråling, vekselvirkning og detektion. *Videregående isotopkursus (A-kursus), Hvidovre, April 1997, April SPECT og PET. Isotopkursus for laboranter, RH, May 1998 (*2). Basal strålefysik. *Kursus i nuklearkardiologi (A-kursus), Frederiksberg October 1998, September Partial volume, betydning for myokardie-spect. Brain Imaging Kursus, neurologisk afd. RH, October 1998 Ph.D. kursus, BBH October Undersøgelsesmetoder i kredsløbsforskning. Hjernegennemblødning. CME-kursus i nuklearkardiologi (efteruddannelse for speciallæger, RH January 1999). Partial volume. PET pharmacokinetic course, Copenhagen 1999 (ved Brain '99) *PET og FDG. Kursus (DSKFNM) for laboranter, sygeplejersker mv. May og August 1999 A-kursus: Hjernen, Bispebjerg, March SPECT datahåndtering. DSMF efteruddannelseskursus, Herlev, March PET instrumentering mm. * Isotopkursus ("øvelse" på RH for A-kursus, August Krogh Inst. v/ Jørgen Gomme).March *Ph.D. Kursus, Functional Imaging, Rigshospitalet November 2000, March 2003, February 2007 SPECT-kursus (DSKFNM), Frederiksberg, September 2002 (arrangør og underviser) *A-kursus i onkologi for nuklearmedicinere, Kamerakrav til PET-undersøgelser, September 2002, 2005, 2008, 2011 *Kursus i PET og PET/CT. Scannere. Strålehygiejne. Rigshospitalet, January 2003, January 2006, March Videregående isotopkursus (A-kursus). PET. Frederiksberg October Metodekursus (A-kursus). Attenuationskorrektion. PET og PET/CT, Bispebjerg November 2003.

10 *DTU November Kursus i medicinsk billedbehandling, PET og PET/CT. *Grundlæggende isotopkursus (1 dag). RH, January 2004, June 2006, August 2007, November 2009, September 2010 Kursus i GMP for bioanlytikere, arr. DSKFNM. Strålehygiejniske overvejelser. RH, May 2004 *A-kursus i Hjertepatofysiologi. Kvalitetskontrol og korrektionsmuligheder. FH, September 2004, RH October Rekonstruktioner/korrektioner i SPECT/PET, RH October 2010, Panum October 2013 Temadag i PET. Dosis til personalet ved PET-undersøgelser. RH, September Iskæmisk hjertesygdom og myocardiescintigrafi (for bioanalytikere). Attenuationskorrektion, Princip og Praksis. KAS Gentofte, September 2006 (*2) *CT-kursus. Grundlæggende strålefysik og røntgenteknik, kvalitetssikring, February 2005, September/November 2005, December 2006/January 2007, February/April 2008, December 2008/February 2009, January/March 2010, December 2010/March 2011 *ENMS Technologist course (Wien). PET and PET/CT. March 2006, June 2007, March 2008, June 2009, March 2010, March 2011, April 2012, April 2013 Beredskabsøvelser i traumecentret (Nukleart beredskab). Rigshospitalet, May Internal radiation dosimetry course. DSMF, SIS Herlev, June 2006.MIRD, Mirdos3, OLINDA. *MAIS, Medicinsk anvendelse af ioniserende stråling. Kursus for Civilingeniører i Medicin og Teknik. Efterår 2007, 2008, 2009, 2010, 2011, 2012, 2013 EANM, CTE course. Quality control and radiation protection issues in PET and PET/CT facilities. Barcelona, October 2009 Introduktion til medikoteknik 1, Kursus for Civilingeniører i Medicin og Teknik, DTU, September 2010, 2011 Ph.D. kursus: Physics of ionizing radiation. Appl. in Nuclear Medicine Imaging, Panum, October 2010 Videregående isotopkursus (for bioanalytikere m.fl.), Gentofte, January 2011, May 2012, May 2013 PET og PET/CT, 2-dages kursus for diplomingeniører, RH February 2011 Medical Imaging: PET. I patofysiologikursus for Humanbiologi, March 2012 *Videregående isotopkursus (A-kursus). PET og Hybridteknologi. Gentofte, September 2012 CT-kursus. Grundlæggende strålefysik og røntgenteknik. Prof.Højskolen Metropol, Nov PET kursus for bioanalytikere og radiografer, RH March 2013 Ph.d. kursus: PET technique and application for molecular imaging. Dosimetry. Panum, March 2013 Kursus for bioanalytikere (DBio): kend dit gammakamera. Glostrup, September 2013 Strålehygiejne ved DEXA-skanning. (Blandet målgruppe). Panum, October

11 11 Supervision: Supervisor for bachelor- og master students in Medicine and Technology Anders Nymark Christensen Pernille Thomsen Louise Scheibel Susanne Bekke Martin Lyngby Lassen Joakim Bay Simonsen Cecilie Louise Klyver Katrine B Albrektsen Stina Møller Supervisor for Medical Physicists according to Danish legislation, Sundhedsstyrelsens vejledning nr. 122 af 20/07/1995, recently replaced by Bekendtgørelse 1252 af 11. November 2010 Markus Nowak ( ) Stefan Fuglsang ( ) Thomas Levin Klausen ( ) Troels Jørgensen ( ) Lasse Rye Aarup ( ) Bryan Haddock (2012-

12 Informal supervisor, providing method development and experimental support as reflected in publication list, for Masters (theses in human biology og physics) Minna W Pedersen (2002) Troels Jørgensen (2005) ph.d: Klaus Børch (1996) Ian Law (1996) Morten Blinkenberg (1997) Klaus Fuglsang Kofoed (1998) Ulrik Lassen (1998) Christian Meyer (1999) Francisco Alves (2000) Markus Nowak (2001) Annika Eigtved (2001) Kirsten Møller (2001) Michael J Schueller (2001) Jens Hove (2002) Yan Cai (2002) Karen Husted Adams (2004) Malene Fischer (2006) Steven Haugbøl (2007) - and doctoral theses (dr. med.) Sissel Vorstrup (1988) Allan Andersen (1990) Peter Lund Madsen (1993) Gunhild Waldemar (1996) Pia Rubin (1997) Charlotte Videbæk (2002) Steen Hasselbalch (2003) Klaus Fuglsang Kofoed (2005) Egill Rostrup (2006) Kirsten Møller (2007) Ian Law (2007) Lars H Pinborg (2009) 12

13 13 Ph.d. thesis ( licentiatafhandling ) Holm S. Dynamic SPECT of the Human Brain for measurement of rcbf. A critical appraisal. PhD thesis, Physics Laboratory, University of Copenhagen 1987 (ISBN ) Delivered to Faculty of Science at Copenhagen University 1. May Public defense at the H.C.Ørsted Institute 30. October List of Publications, papers with peer review. H-index ( ): Lassen NA, Henriksen L, Holm S, Barry DI, Paulson OB, Vorstrup S, Rapin J, Poncin-Lafitte M, Moretti JL, Askienazy S, Raynaud C: Cerebral blood-flow tomography: xenon-133 compared with isopropylampetamine-iodine-123: Concise communication. J Nucl Med 1983;24: Lassen NA, Henriksen L, Holm S, Barry DI, Paulson OB, Vorstrup S, Rapin J, Poncin-Lafitte M, Moretti JL, Askienazy S, Raynaud C: Cerebral blood-flow tomography by SPECT: xenon-133 compared to isopropylampetamine-iodine-123: Ann Radiol Paris 1983;26: Holm S, Andersen AR, Vorstrup S, Lassen NA, Paulson OB, Holmes RA. Dynamic SPECT of the brain using a lipophilic Technetium-99m complex, PnAO. J Nucl Med 1985;26: Holm S, Vorstrup S, Lassen NA. Tomographic cerebral blood flow calculation. J Cereb Blood Flow Metabol 1985;5: Shirahata N, Henriksen L, Vorstrup S, Holm S, Lauritzen M, Paulson OB, Lassen NA. Regional cerebral blood flow by xenon-133 inhalation and emission tomography. Normal values and illustrative clinical cases. J Comp Assist Tomogr 1985;9: Paulson OB, Jarden JO, Vorstrup S, Holm S, Godtfredsen J: Effect of Captopril on the cerebral circulation in chronic heart failure. Eur J Clin Invest 1986;16; Hemmingsen R, Vorstrup S, Clemmesen L, Holm S, Tfelt-Hansen P, Sørensen AS, Hansen C, Sommer W, Bolwig TG: Cerebral Blood Flow during Delirium Tremens and related clinical states studied with xenon-133 inhalation tomography. Am J Psychiatry 1988;145: Gram L, Diemer H, Kjaer L, Fuglsang-Frederiksen A, Holm S, Herning GM, Dam M. Sammenlignende undersøgelser imellem forskellige neurologiske billed-(neuroimaging)-teknikker og EEG til lokalisation af focus ved partiel epilepsi. Ugeskrift for Læger 1988;150(40): Rubin P, Holm S, Friberg L, Videbech P, Andersen HS, Bendsen BB, Strømsø N, Larsen JK, Lassen NA, Hemmingsen R: Altered modulation of prefrontal and subcortical brain activity in novel diagnosed schizophrenia and schizophreniform disorder: A regional cerebral blood flow study. Arch Gen Psych 1991;48: Madsen PL, Holm S, Vorstrup S, Friberg L, Lassen NA, Wildschiødtz G: Human regional cerebral blood flow during rapid eye-movement sleep. J Cereb Blood Flow Metabol 1991;11:

14 11. Madsen PL, Schmidt JF, Wildschiødtz G, Friberg L, Holm S, Vorstrup S, Lassen NA: Cerebral O2 metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep. J Appl Physiol 1991;70: Madsen PL, Schmidt JF, Holm S, Vorstrup S, Lassen NA, Wildschiødtz G: Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage II). Brain Res. 1991;557: Madsen PL, Schmidt JF, Holm S, Jørgensen H, Wildschiødtz, Christensen NJ, Friberg L, Vorstrup S, Lassen NA: Mental stress and cognitive performance do not increase overall level of cerebral O 2 uptake in humans. J Appl Physiol 1992;73: Madsen PL, Sperling BK, Warming T, Schmidt JF, Secher NH, Wildschiødtz G, Holm S, Lassen NA: Middle cerebral artery blood velocity, and cerebral blood flow and O 2 -uptake during dynamic exercise. J Appl Physiol 1993:74: Madsen PL, Holm S, Herning M, Lassen NA: Average blood flow and oxygen uptake in brain during resting wakefulness. A critical appraisal of the Kety-Schmidt technique. J Cereb Blood Flow Metab 1993:13: Hasselbalch SG, Knudsen GM, Jakobsen J, Holm S, Paulson OB. Estimation of unidirectional clearance of FDG and glucose across the blood-brain barrier in man. Adv Exp Med Biol 1993:331: Videbæk C, Friberg L, Holm S, Wammen S, Foged C, Andersen JV, Dalgaard L, Lassen NA. Benzodiazepine receptor equilibrium constants for flumazenil and midazolam determined in humans with the single photon emission computer tomography tracer [ 123 I]iomazenil. European Journal of Pharmacology 1993:249: Friberg L, Andersen AR, Lassen NA, Holm S, Dam M. Retension of Tc-99m-bicisate in the human brain after intracarotid injection. J Cereb Blood Flow Metab 1994 (Suppl. 1): S19-S Holm S, Madsen PL, Sperling B, Lassen NA. Use of Tc-99m-bicisate in activation studies by splitdose technique. J Cereb Blood Flow Metab 1994 (Suppl. 1):S115-S Hasselbalch SG, Knudsen GM, Jakobsen J, Pinborg Hagemann L, Holm S, Paulson OB. Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 1994:14: Holm S. Methodological considerations. An overview of SPECT and PET. Acta Neurol Scand 1994: Suppl 152: (1. European Workshop on Epilepsy Surgery) 22. Rubin P, Hemmingsen R, Holm S, Møller-Madsen S, Hertel C, Povlsen UJ, Karle A. Relationship between brain structure and function in disorders of the schizophrenic spectrum: SPECT, CT and psychopathology of first episodes. Acta Psychiatr Scand 1994:90: Rubin P, Holm S, Madsen PL, Friberg L, Videbech P, Andersen HS, Bentsen BB, Strømsø N, Larsen JK, Lassen NA, Hemmingsen R: rcbf distribution in newly diagnosed schizophrenia and schizophreniform disorder. Psychiatr Res 1994:53:

15 24. Fogh T, Nielsen LH, Hansen LK, Holm S, Law I, Svarer C, Paulson OB. Neural estimation of kinetic rate constants from dynamic PET-scans. In: Vlontzos J et al., eds. Neural Networks for Signal Processing IV. IEEE, Piscataway, New Jersey, USA, 1994: Hasselbalch SG, Knudsen GM, Jakobsen J, Hageman LP, Holm S, Paulson OB. Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans. Am J Physiol 1995:268: E1161-E Madsen PL, Hasselbalch SG, Hagemann-LP, Olsen KS, Bülow J, Holm S, Wildschiøtz G, Paulson OB, Lassen NA. Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab 1995:15: Tedeschi E, Hasselbalch SG, Waldemar G, Juhler M, Høgh P, Holm S, Garde L, Knudsen LL, Klinken L, Gjerris F, Paulson OB. Heterogenous cerebral glucose metabolism in normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry 1995;59: Svarer C, Law I, Holm S, Mørch N, Paulson OB, Hansen LK, Fog T. Estimation of the glucose metabolism from dynamic PET-scans using neural networks. In: Girosi F et al., eds. IEEE Workshop on Neural Networks for Signal Processing (NNSP '95) 1995: Holm S, Toft PA and Jensen M. Estimation of the noise contributions from blank, transmission and emission scans in PET. IEEE Trans Nucl Sci 1996:43: Hasselbalch SG, Knudsen GM, Holm S, Hageman LP, Capaldo B, Paulson OB. Transport of D- glucose and 2-fluordeoxyglucose across the blood-brain barrier in humans. J Cereb Blood Flow Metab 1996:16: Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB. Changes in brain metabolism and cerebral blood flow during acute hyperketonemia. Am J Physiol 1996:33:E746-E Hasselbalch S, Knudsen GM, Toft PB, Høgh P, Tedeschi E, Holm S, Videbæk C, Henriksen O, Lou HC, Paulson OB. Cerebral glucose metabolism is decreased in white matter changes in patients with phenylketonuria. Pediatr Res 1996:40: Blinkenberg M, Bonde C, Holm S, Svarer C, Andersen J, Paulson OB, Law I. Rate dependence of regional cerebral activation during performance of a repetitive motor task: a PET study. J Cereb Blood Flow Metab 1996:16: Blinkenberg M, Rune K, Jønsson A, Holm S, Jensen CV, Paulson OB, Sørensen PS. Cerebral metabolism in a case of multiple sclerosis with acute mental disorder. Acta Neurol Scand 1996:94: Law I, Svarer C, Holm S, Paulson OB. The activation pattern during suppression, imagination and performance of saccadic eye movements. Acta Physiol Scand 1997:161: Hasselbalch SG, Madsen PL, Knudsen GM, Holm S, Paulson OB. Calculation of the FDG lumped constant by simultaneous measurements of global glucose and FDG metabolism in humans. J Cereb Blood Flow Metabol 1998:18:

16 Børch K, Pryds O, Holm S, Lou H, Greisen G. Regional cerebral blood flow during seizures in neonates. J Pediatrics 1998:132: Kofoed KF, Carstensen S, Hesse B, Hove JD, Holm S, Jensen M, Haunsø S, Kelbæk H. Fluorodeoxyglucose uptake in dysfunctional myocardium subtended by an occluded coronary artery. Relation to dobutamine contractile reserve and Sestamibi uptake. Int J of Cardiac Imaging 1998:14: Lassen U, Andersen P, Daugaard G, Holm S, Jensen M, Svarer C, Poulsen HS, Paulson OB. Metabolic and hemodynamic evaluation of brain metastases from small cell lung cancer with positron emission tomography. Clinical Cancer Research 1998:4: Lou HC, Kjær TW, Friberg L, Wildschiødtz G, Holm S, Nowak M. A 15 O-H 2 O PET study of meditation and the resting state of normal consciousness. Human Brain Mapping 1999:7: Nowak M, Olsen KS, Law I, Holm S, Paulson OB, Secher NH. Command related distribution of regional cerebral blood flow during attempted handgrip. J Appl Physiol 1999:3: Blinkenberg M, Jensen CV, Holm S, Paulson OB, Sørensen PS. A longitudinal study of cerebral glucose metabolism, MRI, and disability in patients with multiple sclerosis. Neurology 1999;53; Hasselbalch SG, Knudsen GM, Videbæk C, Hageman LP, Schmidt JF, Holm S, Paulson OB. No effect of insulin on blood-brain barrier transport and brain metabolism of glucose in humans. Diabetes 1999;48: Eigtved A, Andersson AP, Dahlstrøm K, Rabøl A, Jensen M, Holm S, Sørensen SS, Drzewiecki KT, Højgaard L, Friberg L. Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of silent metastates from malignant melanoma. Eur J Nucl 2000;27: Rostrup E, Law I, Blinkenberg M, Larsson HBW, Born AP, Holm S, Paulson OB. Regional differences in the CBF and BOLD response to hypercapnia. A combined PET and MR study. NeuroImage 2000;11: Blinkenberg M, Rune K, Jensen CV, Ravnborg M, Kyllingsbæk S, Holm S, Paulson OB, Sørensen PS. Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS. Neurology 2000;54: Alves F, Jensen M, Jensen HJ, Nickles RJ, Holm S. Determination of the excitation function for the 10 B(p,n) 10 C reaction with implications for the production of [ 10 C]carbon dioxide for use as a PET tracer. Appl Rad Isotop 2000;52: Nickles RJ, Jensen M, Paans AMJ, Holm S, Schuller MJ, Vaalburg W. Doppler broadening as a probe of the chemical environment following oxygen-14 decay. Radiochim Acta 2000; 49. Lapela M, Eigtved A, Jyrkkiö S, Grénman R, Kurki T, Lindholm P, Nuutinen J, Sutinen E, Solin O, Bjornskov I, Bretlav P, Friberg L, Holm S, Jensen M, Hansen HH, Minn H. Experience in

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