Supplementary Material
|
|
- Angel Fowler
- 7 years ago
- Views:
Transcription
1 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 1 Supplementary Material NMR spectra ( 1 H and 13 C), infrared and the typical procedure for preparation of the compounds. GENERAL PROCEDURE FOR THE ANTHRANILIC ACIDS SYNTHESIS All anthranilic acids were synthesized following the same procedure. A mixture of isatin (1 mmol), 5 ml of sodium hydroxide solution 5% w/w and 5 ml of hydrogen peroxide 30% w/v was allowed to stir at room temperature for 15 or 45 minutes (Table I). The end of the reactions was confirmed by TLC, employing 50% hexane ethyl acetate as eluent. After total consumption of the substrate, hydrochloric acid 6 M was added dropwise until precipitation of the product, which was filtered under vacuum. The final ph of the resulting solution was 1 to 3 and was measured with an universal indicator paper. The yields, reaction times and solution ph values are shown in Table I. SPECTROSCOPIC AND SPECTROMETRIC METHODS 1 H and 13 C NMR were obtained on a Bruker DRX-200 model, operating at 200 MHz for 1 H nuclei and 50 MHz for 13 C in DMSO-d 6. Chemical shifts (δ) are expressed in parts per million (ppm) and values of coupling constants (J), in Hertz (Hz). IR spectra were recorded on a Nicolet Magna 760 (KBr). 1 H and 13 C NMR data and melting point of the products 5-BROMO-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3493, 3379, 3060, 2991, 2879, 2838, 2706, 2625, 1671, 1610, 1584, 1547, 1480, 1421, 1312, 1292, 1239, 1159, 1127, 1083, 903, 812, 789, 688, 628, 554, 516, 441; NMR 1 H δ H (200 MHz, DMSO): 7.61 (1H, d, J 4 Hz), 7.21 (1H, dd, J 4 and 8 Hz), 6.76 (1H, d, J 8 Hz). NMR 13 C δ C (50 MHz, DMSO-d 6 ): , , , , , , ; Melting Point: 212 C 5-CHLORO-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3504, 3470, 3390, 3359, 3011, 2884, 2840, 1674, 1613, 1589,1552, 1483, 1421, 1291, 1238, 1157, 1133, 1088, 882, 810, 788, 705, 651, 655, 518, 442; NMR ¹H δ H (200 MHz, DMSO): 7.61 (1H, d, J 4 Hz), 7.21 (1H, dd, J 4 and 8 Hz), 6.72 (1H, d, J 8 Hz); NMR 13 C δ C (50 MHz, DMSO-d 6 ): , , , , , , ; Melting Point: 212 C 5-NITRO-ANTHRANILIC ACID IV ν max (KBr), cm -1 : 3542, 3482, 3414, 3368, 3305, 3216, 3088, 1694, 1639, 1629, 1491, 1428, 1327, 1290, 1245, 1168, 1141,1075, 920, 827, 749, 696, 644, 569, 521, 505; NMR 1 H δ H (200 MHz, DMSO): 8.56 (1H, d, J 2 Hz), 8.04 (1H, dd, J 2 and 10 Hz); 7.85 (2H, s); 6.83 (1H, d, J 10 Hz); NMR 13 C δ C (50 MHz, DMSO-d 6 ): , , , , , , ; Melting Point: 280 C 5-METHYL-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3425, 3325, 3022, 2953, 2926, 1674, 1599, 1569, 1493, 1421, 1303, 1241, 1214, 1162, 913, 818, 792, 758, 675, 620, 553, 524, 475, 439; NMR 1 H δ H (200 MHz, DMSO-d 6 ): 7.49 (1H, d, J 2 Hz),
2 2 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO 7.04 (1H, dd, J 2 and 8 Hz), 6.64 (1H, d, J 8 Hz), 2.12 (3H, s); NMR 13 C δ C (50 MHz, DMSO): , , , , , , , 19.84; Melting Point: 173 C 5-IODO-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3501, 3416, 3388, 3008, 2934, 2891, 2843, 2724, 2624, 1898, 1759, 1678, 1614, 1578, 1542, 1476, 1419, 1321, 1290, 1228, 1162, 1124, 1076, 1043, 914, 865, 811, 786, 688, 620, 558, 517, 448, 421; NMR 1 H δh (200 MHz, DMSO): 7.91 (1H, d, J 2 Hz), 7.44 (1H, dd, J 2 and 8 Hz); 6.60 (1H, d, J 8 Hz); NMR 13 C δc (50 MHz, DMSO-d6): , , , , , , 74.09; Melting Point: 210 C 5-FLUORO-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3503, 3381, 3078, 2893, 2587, 1674, 1591, 1562, 1491, 1434, 1417, 1310, 1291, 1238, 1199, 1151, 935, 883, 828, 799, 788, 757, 676, 559; NMR 1 H δh (200 MHz, DMSO): 7.36 (1H, dd, J 4 and 10 Hz), 7.14 (1H, ddd, J 2, 4 and 10 Hz), 6.75 (1H, dd, J 4 and 10 Hz); NMR 13 C δc (50 MHz, DMSO-d6): , (d, J Hz), , (d, J 22 Hz), (d, J 7 Hz), (d, J 22 Hz), (d, J 7 Hz); Melting Point: 180 C 4-FLUORO-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3506, 3385, 3064, 2911, 2854, 2720, 2647, 2614, 2538, 1664, 1600, 1570, 1497, 1429, 1324, 1254, 1179, 1142, 1114, 979, 892, 837, 762, 688, 613, 530, 462, 447; NMR 1 H δh (200 MHz, DMSO): (1H, m), 6.48 (1H, dd, J 2 e 10 Hz), 6.29 (1H, td, J 2 and 10 Hz); NMR 13 C δc (50 MHz, DMSO-d6): , (d, J 246 Hz), (d, J 13 Hz), (d, J 13 Hz), , (d, J 23 Hz), (d, J 23 Hz); Melting Point: 196 C 3-CHLOROANTHRANILIC ACID IV ν max (KBr), cm 1 : 3478, 3366, 3100, 3057, 3006, 2907, 2864, 2825, 2715, 2632, 2567, 2539, 1667, 1610, 1586, 1547, 1454, 1420, 1337, 1311, 1250, 1164, 1092, 1077, 919, 892, 855, 749, 708, 612, 574, 547, 459; NMR 1 H δh (200 MHz, DMSO-d6): 7.73 (1H, dd, J 2 and 8 Hz), 7.46 (1H, dd, J 2 and 8 Hz), 6.56 (1H, t, J 8). NMR 13 C δc (50 MHz, DMSO): , , , , , , ; Melting Point: 190 C 3,5-DICHLORO-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3490, 3371, 3081, 2706, 1678, 1615, 1573, 1541, 1424, 1402, 1250, 1219, 1152, 1075, 876, 839, 788, 702, 600, 552, 461; NMR 1 H δh (200 MHz, DMSO): 7.68 (1H, d, J 2 Hz), 7.59 (1H, d, J 2 Hz); NMR 13 C δc (50 MHz, DMSO-d6): , , , , , , ; Melting Point: 230 C 3,5-DIBROMO-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3467, 3363, 3083, 1784, 1682, 1599, 1564, 1537, 1452, 1420, 1326, 1306, 1265, 1243, 1223, 1063, 881, 789, 710, 689, 590, 544, 456; NMR 1 H δ H (200 MHz, DMSO): 7.84 (1H, d, J 2 Hz), 7.81 (1H, d, J 2 Hz); NMR 13 C δ C (50 MHz, DMSO-d 6 ): , , , , , , ; Melting Point: 234 C
3 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 3 3-BROMO-5-METHYL-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3480, 3365, 2921, 2716, 2604, 1780, 1675, 1620, 1578, 1545, 1480, 1461, 1423, 1332, 1310, 1274, 1235, 1105, 1075, 1001, 938, 893, 868, 789, 705, 593, 553, 481, 456; NMR 1 H δ H (200 MHz, DMSO): 7.58 (1H, d, J 2 Hz), 7.47 (1H, d, J 2 Hz); 2.15 (3H, s); NMR ¹³C δ C (50 MHz, DMSO-d 6 ): , , , , , , , 19.33; Melting Point: 205 C N-ACETYL-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3481, 3376, 3181, 3123, 2927, 2918, 2609, 2798, 2789, 2595, 2667, 2539, 2502, 2474, 1702, 1655, 1605, 1581, 1522, 1453, 1430, 1377, 1327, 1312, 1298, 1268, 1243, 1164, 1149, 1088, 1042, 968, 881, 845, 792, 769, 755, 699, 651, 604, 558, 527; NMR 1 H δ H (200 MHz, DMSO-d 6 ): (1H, s), 8.45 (1H, d, J 8 Hz), 7.96 (1H, dd, J 2 e 8 Hz), 7.55 (1H, td, J 2 and 8 Hz), 7.11 (1H, td, J 2 and 8 Hz), 2.11 (3H, s); NMR 13 C δ C (50 MHz, DMSO): , , , , , , , , 24.96; Melting Point: 184 C N-ALLYL-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3376, 3084, 3014, 2855, 2855, 2642, 2562, 1668, 1574, 1517, 1443, 1420, 1411, 1319, 1252, 1172, 932, 912, 753, 742, 668, 523; NMR ¹H δ H (200 MHz, DMSO-d 6 ): 7.79 (1 H, dd, J 2 and 8 Hz), 7.33 (1H, td, J 2 and 8 Hz); 6.67 (1 H, d, J 8 Hz); 6.55 (1H, t, J 8 Hz), (1H, m), (2 H, m), 3.85 (2 H, J 4 Hz); NMR 13 C δ C (50 MHz, DMSO-d 6 ): , (C-NH 2 ), , , , , , , 44.38; Melting Point: 119 C N-BENZYL-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3376, 3029, 2916, 2865, 1663, 1576, 1518, 1495, 1441, 1411, 1363, 1625, 1277, 1249, 1236, 1176, 1166, 1154, 907, 836, 753, 728, 694, 658, 556, 527, 488, 457; NMR 1 H δ H (200 MHz, DMSO-d 6 ): 7.81 (1H, dd, J 2 and 8 Hz), (5H, m), 6.65 (1H, d, J 8 Hz), 6.55 (1H, t, J 8 Hz), 4.44 (2H, s); NMR 13 C δ C (50 MHz, DMSO-d 6 ): , , , , , , , , , , 45.85; Melting Point: 182 C 5-IODO-N-ALLYL-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3372, 3075, 2923, 2851, 2623, 2543, 1668, 1567, 1503, 1441, 1422, 1402, 1310, 1233, 1168, 1105, 991, 932, 899, 807, 787, 688, 585, 516; NMR 1 H δ H (200 MHz, DMSO-d 6 ): 8.00 (1 H, d, J 2 Hz), 7.56 (1 H, dd, J 2 and 8 Hz), 6.54 (1H, d, J 8 Hz), (1H, m), (1H, m), 3.85 (2 H, J 6 Hz); NMR 13 C δ C (50 MHz, DMSO-d 6 ): , , , , , , , , 74.33, 44.27; Melting Point: 163 C 5-IODO- N-BENZYL-ANTHRANILIC ACID IV ν max (KBr), cm 1 : 3370, 3082, 3066, 3028, 2921, 2892, 2856, 2721, 2621, 2539, 1902, 1671, 1564, 1499, 1466, 1440, 1402, 1360, 1312, 1238, 1165, 1105, 1078, 1026, 898, 837, 809, 786, 749, 697, 684, 642, 594, 560, 517, 505, 426; NMR 1 H δ H (200 MHz, DMSO-d 6 ): 8.2 (1H, d, J 2 Hz), 7.52 (1H, dd, J 2 and 10 Hz); (5H, m), 6.52 (1H, d, J 10 Hz), 4.44 (1H, s); NMR 13 C δ C (50 MHz, DMSO-d 6 ): , , , , , , , , , , 45.66; Melting Point: 163 C
4 4 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 1 - IR of 5-chloro-anthranilic acid.
5 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 5 Figure 2-1 H NMR of 5-chloro-anthranilic acid.
6 6 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 3-13 C NMR of 5-chloro-anthranilic acid.
7 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 7 Figure 4 - IR of 5-bromo-anthranilic acid.
8 8 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 5-1 H NMR of 5-bromo-anthranilic acid.
9 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 9 Figure 6-13 C NMR of 5-bromo-anthranilic acid.
10 10 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 7 - IR of 5-nitro-anthranilic acid.
11 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 11 Figure 8-1 H NMR of 5-nitro-anthranilic acid.
12 12 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 9-13 C NMR of 5-nitro-anthranilic acid.
13 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 13 Figure 10 - IR of 5-methyl-anthranilic acid.
14 14 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 11-1 H NMR of 5-methyl-anthranilic acid.
15 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 15 Figure C NMR of 5-methyl-anthranilic acid.
16 16 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 13 - IR of 5-iodo-anthranilic acid.
17 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 17 Figure 14-1 H NMR of 5-iodo-anthranilic acid.
18 18 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure C NMR of 5-iodo-anthranilic acid.
19 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 19 Figure 16 - IR of 5-fluoro-anthranilic acid.
20 20 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 17-1 H NMR of 5-fluoro-anthranilic acid.
21 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 21 Figure C NMR of 5-fluoro-anthranilic acid.
22 22 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 19 - IR of 4-fluoro-anthranilic acid.
23 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 23 Figure 20-1 H NMR of 4-fluoro-anthranilic acid.
24 24 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure C NMR of 4-fluoro-anthranilic acid.
25 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 25 Figure 22 - IR of 3-chloro-anthranilic acid.
26 26 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 23-1 H NMR of 3-chloro-anthranilic acid.
27 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 27 Figure C NMR of 3-chloro-anthranilic acid.
28 28 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 25 - IR of 3,5-dichloro-anthranilic acid.
29 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 29 Figure 26-1 H NMR of 3,5-dichloro-anthranilic acid.
30 30 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure C NMR of 3,5-dichloro-anthranilic acid.
31 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 31 Figure 28 - IR of 3,5-dibromo-anthranilic acid.
32 32 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 29-1 H NMR of 3,5-dibromo-anthranilic acid.
33 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 33 Figure C NMR of 3,5-bromo-anthranilic acid.
34 34 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 31 - IR of 3-bromo-5-methyl-anthranilic acid.
35 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 35 Figure 32-1 H NMR of 3-bromo-5-methyl-anthranilic acid.
36 36 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure C NMR of 3-bromo-5-methyl-anthranilic acid.
37 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 37 Figure 34 - IR of N-acetyl-anthranilic acid.
38 38 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 35-1 H NMR of N-acetyl-anthranilic acid.
39 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 39 Figure C NMR of N-acetyl-anthranilic acid.
40 40 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 37 - IR of N-allyl-anthranilic acid.
41 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 41 Figure 38-1 H NMR of N-allyl-anthranilic acid.
42 42 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure C NMR of N-allyl-anthranilic acid.
43 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 43 Figure 40 - IR of ácido N-benzyl-anthranilic acid.
44 44 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 41-1 H NMR of N-benzyl-anthranilic acid.
45 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 45 Figure C NMR of N-benzyl-anthranilic acid.
46 46 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 43 - IR of N-allyl-5-iodo-anthranilic acid.
47 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 47 Figure 44-1 H NMR of N-allyl-5-iodo-anthranilic acid.
48 48 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure C NMR of N-benzyl-5-iodo-anthranilic acid.
49 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 49 Figure 46 - IR of N-benzyl-5-iodo-anthranilic acid.
50 50 GABRIEL F. RIO, BÁRBARA V. SILVA, SABRINA T. MARTINEZ and ANGELO C. PINTO Figure 47-1 H NMR of N-benzyl-5-iodo-anthranilic acid.
51 SYNTHESIS OF A SERIES OF ANTHRANILIC ACIDS 51 Figure C NMR of N-benzyl-5-iodo-anthranilic acid.
Supporting Information
Copyright WILEY VCH Verlag GmbH & Co. KGaA, 69469 Weinheim, Germany, 2012. Supporting Information for Adv. Funct. Mater., DOI: 10.1002/adfm.201102486 Colorimetric Detection of Warfare Gases by Polydiacetylenes
More informationA prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supporting Information A prochelator with a modular masking group featuring hydrogen peroxide activation
More information4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol
4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol OH + HCl Cl + H 2 O C 4 H 10 O C 4 H 9 Cl (74.1) (36.5) (92.6) Classification Reaction types and substance classes nucleophilic
More informationThe D-glucosamine-derived pyridyl-triazole@palladium recoverable catalyst for Mizoroki-Heck reactions under solvent-free conditions
Electronic Supplementary Material (ESI) for Green Chemistry. This journal is The Royal Society of Chemistry 204 Supporting Information The D-glucosamine-derived pyridyl-triazole@palladium recoverable catalyst
More informationOnline edition for students of organic chemistry lab courses at the University of Colorado, Boulder, Dept of Chem and Biochem.
u Experiment 9 Aromatic Chemistry: Synthesis of o-nitroaniline and p-nitroaniline via a Multi-Step Sequence Reading: Introduction to rganic Chemistry by Streitwieser, Heathcock, and Kosower, pp. 695-696
More informationand its application in the synthesis of Nilotinib intermediate
Electronic upplementary Material (EI) for RC Advances. This journal is The Royal ociety of Chemistry 204 upporting Information An efficient D-glucosamine-based copper catalyst for C-X couplings and its
More informationExperimental procedures. Solid phase peptide synthesis (SPPS)
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is The Royal Society of Chemistry 214 Experimental procedures Solid phase peptide synthesis (SPPS) Solid phase
More informationSYNTHETIC STUDIES ON TULEARIN MACROLIDES. M.Montserrat Martínez, Luis A. Sarandeses, José Pérez Sestelo
SYNTHETIC STUDIES N TULEARIN MACRLIDES M.Montserrat Martínez, Luis A. Sarandeses, José Pérez Sestelo Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain E-mail: mmartinezc@udc.es
More informationCH243: Lab 4 Synthesis of Artificial Flavorings by Fischer Esterification
H243: Lab 4 Synthesis of Artificial Flavorings by Fischer Esterification PURPSE: To prepare esters by reaction of carboxylic acids and alcohols. To modify a known procedure to prepare an unknown. DISUSSIN:
More informationAlkoxycarbonylation of Ethylene with Cellulose in Ionic Liquids
Supplementary data Alkoxycarbonylation of Ethylene with Cellulose in Ionic Liquids Anna sichow and Stefan Mecking* Chair of Chemical Materials Science, Dept. of Chemistry, University of Konstanz, 78464
More informationStructure-Based Design of Covalent Siah Inhibitors
Chemistry & Biology, Volume 20 Supplemental Information Structure-Based Design of Covalent Siah Inhibitors John L. Stebbins, Eugenio Santelli, Yongmei Feng, Surya K. De, Angela Purves, Khatereh Motamedchaboki,
More informationProton Nuclear Magnetic Resonance Spectroscopy
CHEM 334L Organic Chemistry Laboratory Revision 2.0 Proton Nuclear Magnetic Resonance Spectroscopy In this laboratory exercise we will learn how to use the Chemistry Department's Nuclear Magnetic Resonance
More informationSupporting Information
Supporting Information Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT Chao Wang +, Daniel Abegg +, Dominic G. Hoch, and Alexander Adibekian* ange_201511301_sm_miscellaneous_information.pdf
More informationA Ratiometric NMR ph Sensing Strategy Based on Slow- Proton-Exchange (SPE) Mechanism
Electronic Supplementary Material (ESI) for Chemical Science. This journal is The Royal Society of Chemistry 2015 A Ratiometric NMR ph Sensing Strategy Based on Slow- Proton-Exchange (SPE) Mechanism Loïse
More informationA Grignard reagent formed would deprotonate H of the ethyl alcohol OH.
216 S11-E2 Page 2 Name Key I. (9 points) Answer in the boxes below the following questions for the Grignard reagent C 3 -Mg. (1) (2 points) Is the carbon atom associated with magnesium electrophilic or
More informationCeric ammonium nitrate catalyzed mild and efficient α-chlorination of ketones by acetyl chloride
Issue in Honor of Prof. (Mrs.) Asima Chatterjee ARKIVC 2003 (ix) 34-38 Ceric ammonium nitrate catalyzed mild and efficient α-chlorination of ketones by acetyl chloride Subhas Chandra Roy,* Kalyan Kumar
More informationSupplementary Information for
Electronic Supplementary Material (ESI) for Polymer Chemistry. This journal is The Royal Society of Chemistry 2015 Supplementary Information for Doubly Responsive Polymersomes towards Monosaccharides and
More informationEnantiomers: Synthesis, characterization, and resolution of tris(ethylenediamine)cobalt(iii) chloride Introduction:
Enantiomers: Synthesis, characterization, and resolution of tris(ethylenediamine)cobalt(iii) chloride Introduction: The development of coordination chemistry prior to 1950 involved the synthesis and characterization
More informationA Simple and efficient method for mild and selective oxidation of propargylic alcohols using TEMPO and calcium hypochlorite
A Simple and efficient method for mild and selective oxidation of propargylic alcohols using TEMPO and calcium hypochlorite Sabbasani Rajasekhara Reddy, a,b Anju Chadha b,c* a School of Advanced Sciences,
More informationIdentification of Unknown Organic Compounds
Identification of Unknown Organic Compounds Introduction The identification and characterization of the structures of unknown substances are an important part of organic chemistry. Although it is often
More informationConvenient and robust one-pot synthesis of symmetrical and unsymmetrical benzyl thioethers from benzyl halides using thiourea
Convenient and robust one-pot synthesis of symmetrical and unsymmetrical benzyl thioethers from benzyl halides using thiourea Kevin S. Eccles, a Curtis J. Elcoate, a Simon E. Lawrence, a and Anita R. Maguire*
More informationPage 1 of 5. Purification of Cholesterol An Oxidative Addition-Reductive Elimination Sequence
Page 1 of 5 Purification of Cholesterol An Oxidative Addition-Reductive Elimination Sequence From your lectures sessions in CEM 2010 you have learned that elimination reactions may occur when alkyl halides
More informationSyntheses of partially hydrogenated [1,2,4]triazolo[4,5-a] pyrimidine-4-ones through cyclisation of 2-arylidenehydrazino- 6-methyl-4-pyrimidones
Issue in onor of Prof. Sándor Antus ARKIVC 2004 (vii) 24-252 Syntheses of partially hydrogenated [1,2,4]triazolo[4,5-a] pyrimidine-4-ones through cyclisation of 2-arylidenehydrazino- 6-methyl-4-pyrimidones
More informationSyllabus CHM 2202 Organic Chemistry Laboratory II Spring 2011
Villanova University Department of Chemistry Syllabus CHM 2202 Organic Chemistry Laboratory II Spring 2011 Text: C.E. Bell, D.F. Taber and A.K. Clark, Organic Chemistry Laboratory with Qualitative Analysis,
More informationExperiment 6 Qualitative Tests for Alcohols, Alcohol Unknown, IR of Unknown
Experiment 6 Qualitative Tests for Alcohols, Alcohol Unknown, I of Unknown In this experiment you are going to do a series of tests in order to determine whether or not an alcohol is a primary (1 ), secondary
More informationPROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (H-NMR)
PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (H-NMR) WHAT IS H-NMR SPECTROSCOPY? References: Bruice 14.1, 14.2 Introduction NMR or nuclear magnetic resonance spectroscopy is a technique used to determine
More informationHOMEWORK PROBLEMS: IR SPECTROSCOPY AND 13C NMR. The peak at 1720 indicates a C=O bond (carbonyl). One possibility is acetone:
HMEWRK PRBLEMS: IR SPECTRSCPY AND 13C NMR 1. You find a bottle on the shelf only labeled C 3 H 6. You take an IR spectrum of the compound and find major peaks at 2950, 1720, and 1400 cm -1. Draw a molecule
More informationSynthesis and Antimicrobial Activity of 7-Amino cephalosporanic Acid Derivatives of Amino Acids and Peptides
Asian Journal of Chemistry Vol. 22, No. 4 (2010), 2914-2918 Synthesis and Antimicrobial Activity of 7-Amino cephalosporanic Acid Derivatives of Amino Acids and Peptides M. HIMAJA*, SIDDHARTH DESAI, A.
More informationSupporting information. Cyclic peptide-polymer conjugates: grafting to VS grafting from
Supporting information Cyclic peptide-polymer conjugates: grafting to VS grafting from Sophie C. Larnaudie, a Johannes C. Brendel, a,c Katrina A. Jolliffe* b and Sébastien Perrier* a,c a Department of
More informationAPPENDIX 2: A BRIEF GUIDE TO WRITING IN CHEMISTRY
Writing Guide - 1 APPENDIX 2: A BRIEF GUIDE TO WRITING IN CHEMISTRY This document is a guide to assist students in chemistry courses with writing and formatting laboratory reports and research reports.
More informationSupporting Information. Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2008
Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2008 Titanosilsesquioxane Anchored on Mesoporous Silicas. A Novel Approach for the preparation of Heterogeneous Catalysts
More informationNMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities
7512 J. Org. Chem. 1997, 62, 7512-7515 NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities Hugo E. Gottlieb,* Vadim Kotlyar, and Abraham Nudelman* Department of Chemistry, Bar-Ilan University,
More informationEXPERIMENT Aspirin: Synthesis and NMR Analysis
EXPERIMENT Aspirin: Synthesis and NMR Analysis Introduction: When salicylic acid reacts with acetic anhydride in the presence of an acid catalyst, acetylsalicylic acid, or aspirin, is produced according
More informationEnzyme Pre-Lab. Using the Enzyme worksheet and Enzyme lab handout answer the Pre-Lab questions the pre-lab must be complete before beginning the lab.
Enzyme Pre-Lab Using the Enzyme worksheet and Enzyme lab handout answer the Pre-Lab questions the pre-lab must be complete before beginning the lab. Background: In this investigation, you will study several
More informationFigure 8. Example of simple benzene naming with chlorine and NO 2 as substituents.
BENZENE NAMING EXPLAINED. This was excerpted from CHEM WIKI and is used with appreciation to the authors. http://chemwiki.ucdavis.edu/organic_chemistry/hydrocarbons/aromatics/naming_the_benzenes. Simple
More informationSupplementary Information. Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes.
This journal is (c) The Royal Society of Chemistry 8 Supplementary Information Primary amino acid lithium salt as a catalyst for asymmetric Michael addition of isobutyraldehyde with β-nitroalkenes. Atsushi
More informationOrganic Chemistry Tenth Edition
Organic Chemistry Tenth Edition T. W. Graham Solomons Craig B. Fryhle Welcome to CHM 22 Organic Chemisty II Chapters 2 (IR), 9, 3-20. Chapter 2 and Chapter 9 Spectroscopy (interaction of molecule with
More informationDetermination of the amount of sodium carbonate and sodium hydroxide in a mixture by titration.
Module 9 : Experiments in Chemistry Lecture 38 : Titrations : Acid-Base, Redox and Complexometric Objectives In this lecture you will learn the techniques to do following Determination of the amount of
More informationSynthesis of Fragrant Esters
Synthesis of Fragrant Esters Introduction: An ester is an organic compound that is formed when a carboxylic acid reacts with an alcohol. In addition to an ester being form, water is another product of
More informationExperiment 3: Extraction: Separation of an Acidic, a Basic and a Neutral Substance
1 Experiment 3: Extraction: Separation of an Acidic, a Basic and a Neutral Substance Read pp 142-155, 161-162, Chapter 10 and pp 163-173, Chapter 11, in LTOC. View the videos: 4.2 Extraction (Macroscale);
More informationNuclear Magnetic Resonance
Nuclear Magnetic Resonance NMR is probably the most useful and powerful technique for identifying and characterizing organic compounds. Felix Bloch and Edward Mills Purcell were awarded the 1952 Nobel
More informationGreen Principles Atom Economy Solventless Reactions Catalysis
Lab 5: The Aldol Reaction Solventless vs Traditional Reactions: (Melting Point Study & Recrystallization) (adapted from Doxsee, K.M. and Hutchison, J.E., Green Organic Chemistry and John Thompson; Lane
More informationSynthesis and Analysis of Acetyl Salicylic Acid
Chan 0 Synthesis and Analysis of Acetyl Salicylic Acid Amy Chan CHEM 290 - Section 1 November 25, 2002 Chan 1 Introduction Acetyl salicylic acid, commonly known as aspirin, is one of the most common synthetic
More informationCHEMISTRY 338 THE SYNTHESIS OF LIDOCAINE
CHEMISTRY 338 THE SYTHESIS F LIDCAIE Lidocaine (1) is the common name of an important member of a category of drugs widely used as local anesthetics. Trade names for this substance include Xylocaine, Isocaine,
More informationph-induced outward Movement of Star Centers within Coumarin-Centered Star-Block Polymer Micelles Supporting Information
ph-induced outward Movement of Star Centers within Coumarin-Centered Star-Block Polymer Micelles Supporting Information Jinqiang Jiang,* a, b Yan Liu, a Yunhua Gong, b Qiaozhen Shu, b Ming Yin, b Xiaoya
More informationSelf-Propelled Chemotactic Ionic Liquid Droplets
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Supporting Information Self-Propelled Chemotactic Ionic Liquid Droplets Wayne Francis, Cormac Fay,
More informationNeutralization Reactions. Evaluation copy
Neutralization Reactions Computer 6 If an acid is added to a base, a chemical reaction called neutralization occurs. An example is the reaction between nitric acid, HNO 3, and the base potassium hydroxide,
More informationLight-driven Nanoscale Chiral Molecular Switch: Reversible Dynamic Full Range Color Phototuning
This journal is (c) The Royal Society of Chemistry Supporting Information Light-driven Nanoscale Chiral Molecular Switch: Reversible Dynamic Full Range Color Phototuning Ji Ma, Yannian Li, Timothy White,
More informationMASS SPECTROMETRIC IDENTIFICATION OF SOME SULPHUR CONTAINING PHENALKYLAMINE DESIGNER DRUGS *
MASS SPECTROMETRIC IDENTIFICATION OF SOME SULPHUR CONTAINING PHENALKYLAMINE DESIGNER DRUGS * Ingrid J. BOSMAN 1, Douwe DE BOER 2, Edwin B. SIDERIUS 1, Lesseps J. A. L. DOS REYS 2, Robert A. A. MAES 1 1
More informationLiquid phase. Balance equation Moles A Stoic. coefficient. Aqueous phase
STOICHIOMETRY Objective The purpose of this exercise is to give you some practice on some Stoichiometry calculations. Discussion The molecular mass of a compound is the sum of the atomic masses of all
More informationPET Recycling. Nicholas Robusto Maggie Ifarraguerri Nathaniel Lawton Isabel Hefner
PET Recycling Nicholas Robusto Maggie Ifarraguerri Nathaniel Lawton Isabel Hefner OBJECTIVES Hydrolyze a sample of Polyethylene Terephthalate (PET) obtained from used soda bottles, and synthesize a dimer
More informationSYNTHESIS AND ANALYSIS OF A COORDINATION COMPOUND OF COPPER
Chemistry 111 Lab: Synthesis of a Copper Complex Page H-1 SYNTHESIS AND ANALYSIS OF A COORDINATION COMPOUND OF COPPER In this experiment you will synthesize a compound by adding NH 3 to a concentrated
More informationAlkanes. Chapter 1.1
Alkanes Chapter 1.1 Organic Chemistry The study of carbon-containing compounds and their properties What s so special about carbon? Carbon has 4 bonding electrons. Thus, it can form 4 strong covalent bonds
More informationSummer Holidays Questions
Summer Holidays Questions Chapter 1 1) Barium hydroxide reacts with hydrochloric acid. The initial concentration of the 1 st solution its 0.1M and the volume is 100ml. The initial concentration of the
More informationOXIDATION-REDUCTION TITRATIONS-Permanganometry
Experiment No. Date OXIDATION-REDUCTION TITRATIONS-Permanganometry INTRODUCTION Potassium permanganate, KMnO 4, is probably the most widely used of all volumetric oxidizing agents. It is a powerful oxidant
More information#9 Condensation Polymerization: Preparation of Nylon 6/10
#9 Condensation Polymerization: Preparation of Nylon 6/10 Submitted by: Arturo Contreras, Visiting Scholar, Center for Chemical Education, Miami University, Middletown, OH; 1996 1997. I. INTRODUCTION Description
More informationChemistry: Chemical Equations
Chemistry: Chemical Equations Write a balanced chemical equation for each word equation. Include the phase of each substance in the equation. Classify the reaction as synthesis, decomposition, single replacement,
More informationAcid-Base Extraction.
Acid-Base Extraction. Extraction involves dissolving a compound or compounds either (1) from a solid into a solvent or (2) from a solution into another solvent. A familiar example of the first case is
More informationCERTIFICATE OF ANALYSIS Methyl 4-Hydroxybenzoate
CERTIFICATE OF ANALYSIS Methyl 4-Hydroxybenzoate C8H8O3 Molecular Weight 152.15 1. Description White crystalline powder or colorless crystals. 2. Solubility Slightly soluble in water, freely soluble in
More informationNMR and other Instrumental Techniques in Chemistry and the proposed National Curriculum.
NMR and other Instrumental Techniques in Chemistry and the proposed National Curriculum. Dr. John Jackowski Chair of Science, Head of Chemistry Scotch College Melbourne john.jackowski@scotch.vic.edu.au
More information1. Read P. 368-375, P. 382-387 & P. 429-436; P. 375 # 1-11 & P. 389 # 1,7,9,12,15; P. 436 #1, 7, 8, 11
SCH3U- R.H.KING ACADEMY SOLUTION & ACID/BASE WORKSHEET Name: The importance of water - MAKING CONNECTION READING 1. Read P. 368-375, P. 382-387 & P. 429-436; P. 375 # 1-11 & P. 389 # 1,7,9,12,15; P. 436
More informationChemiluminescence: Synthesis of Cyalume 3 Chemiluminescence: Synthesis of Cyalume and Making it Glow
Chemiluminescence: Synthesis of Cyalume 3 Chemiluminescence: Synthesis of Cyalume and Making it Glow Intro Chemiluminescence is the process whereby light is produced by a chemical reaction. The flashes
More informationQ1: What is the ph Scale? Q6: As acids become more acidic, their ph values
Q1: What is the ph Scale? Q6: As acids become more acidic, their ph values increase or decrease? Q2: The range of values of the ph scale is: Q7: As bases become more alkaline, their ph values increase
More informationA Greener Synthesis of Creatine
A Greener Synthesis of Creatine Carl S Lecher 1 and Ryan J Bernhardt, 2 Marian College, Indianapolis, I Chemical Concepts Addition to nitriles, vacuum filtration, melting point determination Green Lessons
More informationUnit title: Chemical Laboratory Techniques
Unit title: Chemical Laboratory Techniques Unit code: H/601/0355 QCF level: 4 Credit value: 15 Aim This unit gives learners the opportunity to practise and become proficient in a range of practical skills
More informationName Lab #3: Solubility of Organic Compounds Objectives: Introduction: soluble insoluble partially soluble miscible immiscible
Lab #3: Solubility of rganic Compounds bjectives: - Understanding the relative solubility of organic compounds in various solvents. - Exploration of the effect of polar groups on a nonpolar hydrocarbon
More informationEUDRAGIT E 100, EUDRAGIT E PO and
Technical Information EUDRAGIT E 100, and Specification and Test Methods Ph. Eur. USP/NF JPE Basic Butylated Methacrylate Copolymer Amino Methacrylate Copolymer - NF Aminoalkyl Methacrylate Copolymer E
More informationCHM1 Review for Exam 12
Topics Solutions 1. Arrhenius Acids and bases a. An acid increases the H + concentration in b. A base increases the OH - concentration in 2. Strong acids and bases completely dissociate 3. Weak acids and
More informationRecovery of Elemental Copper from Copper (II) Nitrate
Recovery of Elemental Copper from Copper (II) Nitrate Objectives: Challenge: Students should be able to - recognize evidence(s) of a chemical change - convert word equations into formula equations - perform
More informationEXPERIMENT 3 (Organic Chemistry II) Nitration of Aromatic Compounds: Preparation of methyl-m-nitrobenzoate
EXPERIMENT 3 (Organic Chemistry II) Nitration of Aromatic Compounds: Preparation of methyl-m-nitrobenzoate Pahlavan/Cherif Purpose a) Study electrophilic aromatic substitution reaction (EAS) b) Study regioselectivity
More informationSynthesis of Isopentyl Acetate
Experiment 8 Synthesis of Isopentyl Acetate Objectives To prepare isopentyl acetate from isopentyl alcohol and acetic acid by the Fischer esterification reaction. Introduction Esters are derivatives of
More informationCHEMICAL REACTIONS AND REACTING MASSES AND VOLUMES
CHEMICAL REACTIONS AND REACTING MASSES AND VOLUMES The meaning of stoichiometric coefficients: 2 H 2 (g) + O 2 (g) 2 H 2 O(l) number of reacting particles 2 molecules of hydrogen react with 1 molecule
More informationNuclear Magnetic Resonance Spectroscopy
Nuclear Magnetic Resonance Spectroscopy Nuclear magnetic resonance spectroscopy is a powerful analytical technique used to characterize organic molecules by identifying carbonhydrogen frameworks within
More informationHonors 227 Fall 2007 Laboratory with Ms. Clark. Enzymes, Reactions, Metabolism and Homeostasis
1 Name: Honors 227 Fall 2007 Laboratory with Ms. Clark Enzymes, Reactions, Metabolism and Homeostasis Background Enzymes, which are comprised of amino acids, are very important macromolecules found in
More informationSolvent-free, catalyst-free Michael-type addition of amines to electron-deficient alkenes
Solvent-free, catalyst-free Michael-type addition of amines to electron-deficient alkenes Brindaban C. Ranu,* Suvendu S. Dey, and Alakananda Hajra Department of Organic Chemistry, Indian Association for
More informationTABLE OF CONTENTS CHAPTER TITLE PAGE DECLARATION ACKNOWLEDGEMENT ABSTRACT LIST OF TABLES LIST OF FIGURES LIST OF SYMBOLS LIST OF APPENDICES
vii TABLE OF CONTENTS CHAPTER TITLE PAGE DECLARATION ii ACKNOWLEDGEMENT iv ABSTRACT v TABLE OF CONTENTS vii LIST OF TABLES xii LIST OF FIGURES xiv LIST OF SYMBOLS xvii LIST OF APPENDICES xviii 1 INTRODUCTION
More informationSupporting Information
Supporting Information Wiley-VCH 2008 69451 Weinheim, Germany Pseudo Polyanions based on Poly [NIPAAM-co-β-Cyclodextrin methacrylate] and Ionic Liquids Sadik Amajjahe, Soowhan Choi, Maricica Munteanu,
More informationUnit 2: Quantities in Chemistry
Mass, Moles, & Molar Mass Relative quantities of isotopes in a natural occurring element (%) E.g. Carbon has 2 isotopes C-12 and C-13. Of Carbon s two isotopes, there is 98.9% C-12 and 11.1% C-13. Find
More informationNomenclature and Household Items
Nomenclature and Household Items NAME: DATE: PERIOD: Background: Many household items contain chemicals that are commonly used in everyday life. Some chemicals are edible while other compounds would be
More informationEnvironmental Water Testing: Surface Water, Groundwater, Hard Water, Wastewater, & Seawater
Document: AND Sol Env 08 2013 Environmental Water Testing: Surface Water, Groundwater, Hard Water, Wastewater, & Seawater Matrix specific sample preparation and testing methods for environmental waters
More informationNumber of moles of solute = Concentration (mol. L ) x Volume of solution (litres) or n = C x V
44 CALCULATIONS INVOLVING SOLUTIONS INTRODUCTION AND DEFINITIONS Many chemical reactions take place in aqueous (water) solution. Quantities of such solutions are measured as volumes, while the amounts
More informationThe Grignard Reaction. Preparation of Benzoic Acid
The Grignard Reaction. Preparation of Benzoic Acid References: Bruice, Chapter 11, section 11.8 Background Grignard reagents are prepared (eq. 1) from alkyl halides by treatment with magnesium metal in
More informationEXPERIMENT Oil of Wintergreen: Synthesis and NMR Analysis
EXPERIMENT il of Wintergreen: Synthesis and NMR Analysis Introduction: When salicylic acid reacts with methanol in the presence of an acid catalyst, methyl salicylate, or oil of wintergreen, is produced
More informationReactions of Aldehydes and Ketones
Reactions of Aldehydes and Ketones Structure Deduction using lassification Tests 1 Determination of Structure Determining the structure of an unknown organic compound is an exercise in deductive reasoning.
More informationEXPERIMENT 9 (Organic Chemistry II) Pahlavan - Cherif Synthesis of Aspirin - Esterification
EXPERIMENT 9 (rganic hemistry II) Pahlavan - herif Materials Hot plate 125-mL Erlenmeyer flask Melting point capillaries Melting point apparatus Büchner funnel 400-mL beaker Stirring rod hemicals Salicylic
More informationSynthesis of tetraamminecopper(ii) sulfate, [Cu(NH 3 ) 4 ]SO 4 The reaction for making tetraamminecopper(ii) sulfate and some molar masses are:
Experiment 9 Synthesis of a opper oordination omplex and Aspirin with Demonstrations of the Synthesis of Nylon, Bakelite, and Polyvinyl Alcohol Slime Synthesis of tetraamminecopper(ii) sulfate, [u(n 3
More informationPreparation of frequently used solutions
Preparation of frequently used solutions Content 1. Diluting Concentrated Acids (Last Login: 08/08/2009) 2. Indicators (Last Login: 27/07/2009) 3. Standard Buffer Solutions (Last Login: 27/07/2009) 4.
More informationCORK INSTITUTE OF TECHNOLOGY INSTITIÚID TEICNEOLAÍOCHTA CHORCAÍ
CORK INSTITUTE OF TECHNOLOGY INSTITIÚID TEICNEOLAÍOCHTA CHORCAÍ Module Title: Topics in Organic Chemistry Module Code: CHEO 7003 School : Science Programme Title: Bachelor of Science in Analytical & Pharmaceutical
More informationSeparation by Solvent Extraction
Experiment 3 Separation by Solvent Extraction Objectives To separate a mixture consisting of a carboxylic acid and a neutral compound by using solvent extraction techniques. Introduction Frequently, organic
More informationSorbents. [ A] [ A] aq. Strong affinity = large K D. Digital chromatography: all-or. or-nothing LC mechanism to extremes K =
Theory of SPE 1 SPE Nonequilibrium,, exhaustive removal of chemical constituents from a flowing liquid sample via retention on a contained solid sorbent and subsequent recovery of selected constituents
More informationLABORATORY OF ORGANIC CHEMISTRY
LABRATRY F RGANIC CHEMISTRY NATURAL PRDUCTS AND PHARMACEUTICALS Anna K. Przybył Joanna Kurek Edited by Jan Milecki UAM, Poznań 2013 CNSTENTS I. Synthesis of compounds 1. Aspirin (synthesis)...... 2. Paracetamol
More informationEXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT
EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT Pre-Lab Questions: None. 64 I. Background Information DIPEPTIDE RESEARCH PROJECT Methods developed by organic chemists for the synthesis of biopolymers have had
More informationSolving Spectroscopy Problems
Solving Spectroscopy Problems The following is a detailed summary on how to solve spectroscopy problems, key terms are highlighted in bold and the definitions are from the illustrated glossary on Dr. Hardinger
More informationWorking with Hazardous Chemicals
A Publication of Reliable Methods for the Preparation of Organic Compounds Working with Hazardous Chemicals The procedures in Organic Syntheses are intended for use only by persons with proper training
More information1. Qualitative Analysis of Chromium, Iron, and Copper
1. Qualitative Analysis of Chromium, Iron, and Copper Introduction We have used copper and iron as basic materials since the Bronze and Iron Ages, but our extensive use of chromium began only after the
More informationExperiment 5: Column Chromatography
Experiment 5: Column Chromatography Separation of Ferrocene & Acetylferrocene by Column Chromatography Reading: Mohrig, Hammond & Schatz Ch. 18 pgs 235-253 watch the technique video on the course website!
More informationPRODUCT DATA SHEET PDS A115_E. Metric thread M 1.5 pitch CEI EN 60423 CEI EN 50262
reduced cable entry Metric thread M 1.5 pitch CEI EN 60423 CEI EN 50262 Ref. P Fixing A B C L Light Hole min-max Spanner min-max Quantity Grey (mm) (mm) (mm) (mm) (mm) 1900S.M16N M16x1,5 16,5 6-9,5 19
More informationPECTINS. SYNONYMS INS No. 440 DEFINITION DESCRIPTION. FUNCTIONAL USES Gelling agent, thickener, stabilizer, emulsifier CHARACTERISTICS
PECTINS SYNONYMS INS No. 440 Prepared at the 71 st JECFA (2009) and published in FAO JECFA Monographs 7 (2009), superseding specifications prepared at the 68 th JECFA (2007) and published in FAO JECFA
More informationSolid-phase Synthesis of Homodimeric Peptides: Preparation of Covalently-linked Dimers of Amyloid-beta Peptide
Electronic Supplementary Information Solid-phase Synthesis of Homodimeric Peptides: Preparation of Covalently-linked Dimers of Amyloid-beta Peptide W. Mei Kok, a,b,c Denis B. Scanlon, b John A. Karas,
More informationPRODUCT DATA SHEET PDS A17_E
Multi-entry seal plugs Ref. A L Suitable Quantity for Box/Bag Seal (mm) (mm) TGM38 36A3M1623 3 8 5.000/100 TGM48 36A3M1624 + 36A3M2034 + 36A3M2554 4 8 5.000/100 TGM58 36A3M2025 5 8 5.000/100 TGM513 36A3M2545
More information