Bone Marrow Donors Worldwide Annual Report 2012

Transcription

1 Bone Marrow Donors Worldwide Annual Report 2012

2 Bone Marrow Donors Worldwide Annual Report 2012 Contact address Bone Marrow Donors Worldwide Europdonor Foundation Plesmanlaan 1B 2333 BZ Leiden The Netherlands Tel: +31 (0) Fax: +31 (0) Acknowledgements Graphic Design: Five Spices b.v., The Hague. Leiden, 2013

3 page I Preface Two thousand twelve was an important year, as we passed the 20th million mark of stem cell donors. It is also the year that the China Marrow Donor Program (CMDP) joined BMDW. Furthermore the numbers of cord blood units in BMDW are still increasing and there are now over half a million cord blood units in BMDW. There have been many discussions on the future of registries and their IT networks. The main conclusions concerning BMDW were the following. The enduring role of BMDW is to present a comprehensive and open access global file of searchable data that will permit rapid determination of the likelihood of an individual patient being able to find, or just as importantly not to find, a match donor. BMDW will thus need to enhance its search systems and governance structure to achieve this role. Convergence of technology of EMDIS and BMDW should remain a long-term goal. With respect to the first topic BMDW is the only system which provides you the most complete overview on potential donors in a single report. Five new donor registries and four cord blood banks joined BMDW in 2012 and we expect more to join in In order to enhance the BMDW search system, the high resolution HLA-A, -B, -C, -DRB1, -DQB1 haplotype frequencies need to be established. This is not an easy task due to the often incomplete typing of the donors and lack of knowledge on the ethnicity of donors. The WMDA Registry Diversity Working Group under the guidance of Martin Maiers, Carlheinz Müller and Steven Marsh are working on this topic. The registries will receive a letter asking them to participate in this project and we hope and trust that you will all respond positively thus helping to improve the search system of BMDW. Concerning the second topic discussions have already been started. One of the important points to tackle in order to make this convergence possible is the use of a unique identifier for the different registries. This is a task of the WMDA Information Technology Working Group. Dr. M. Oudshoorn Chairman of Bone Marrow Donors Worldwide April 2013

4 page II Index page Preface I Index II 1 Introduction to Bone Marrow Donors Worldwide (BMDW) Participating Stem Cell Donor Registries and Cord Blood Banks Participating stem cell donor registries Participating cord blood banks/registries 4 3 Number of Stem Cell Donors and Cord Blood Units Number of stem cell donors Number of cord blood units 10 4 Distribution of Stem Cell Donors and Cord Blood Units in the World Distribution of stem cell donors Distribution of cord blood units 15 5 Number of HLA Phenotypes Information Technology Developments in Change Request Registry / third party support and other topics 6.2 Use of BMDW 21 On-line services 7 Financial overview 23 7 Board and Staff 24 8 Advisory Committee 25

5 1Introduction to Bone Marrow Donors Worldwide (BMDW) page 1 Bone Marrow Donors Worldwide (BMDW) started as an initiative of the Immunobiology Working Party of the European Group for Blood and Marrow Transplantation (EBMT) in In February 1989 the first edition was distributed, which contained the donor files of eight registries with a total of 150,000 volunteer stem cell donors. The pioneer registries were: Anthony Nolan Research Centre (UK) France Greffe de Moelle (France) National Marrow Donor Program (USA) Europdonor Foundation (The Netherlands) German Registry of Bone Marrow Donors (Germany) Italian Bone Marrow Donor Registry (Italy) Austrian Bone Marrow Donors (Austria) Marrow Donor Program Belgium (Belgium) The original goals of BMDW are still adhered to, but new initiatives have been added. The main goals are: To maximize the chance of finding a stem cell donor/cord blood unit by providing access to all donors and cord blood units available in the world. To minimize the effort put into stem cell donor/cord blood unit searches: only registries/ banks with potential stem cell donors/cord blood units need to be contacted. To provide an estimate of the chance of finding a stem cell donor/cord blood unit for a given patient. To provide advanced search programs to identify partially matched stem cell donors and/ or cord blood units. To facilitate search request advices via Internet. To provide relevant general information for the benefit of the patient. To provide statistics on the increase of donors of different registries, the number of DNA typed donors etc. What is BMDW? BMDW Bone Marrow Donors Worldwide is a service provided by Europdonor Foundation. It provides a listing of HLA phenotypes and other relevant data of unrelated volunteer stem cell donors and cord blood units from participating stem cell donor registries and cord blood banks (CBB s) combined with matching programs. The participants pay an operational fee to have the right to have their own data files uploaded in BMDW and to consult those from other registries and cord blood banks in a secure fashion. BMDW can be used by transplant centres and search coordinators. The procedure for authorisation can be found on BMDW Office The office consists of Europdonor (ED) staff, responsible for keeping BMDW operational, but also to improve the operation as decided by the Editorial Board (EB). Note: the staff size is flexible, which has meant in practical terms that if necessary, extra staff is provided to BMDW by ED.

6 page 2 Editorial Board (EB) of BMDW The Editorial Board is a forum of one representative from each of the registries and cord blood banks, which meets at least once a year. It approves the budget and is authorized by the Europdonor Board to decide on new developments. Advisory Committee (AC) The Advisory Committee consists of seven members elected from and by the EB to assist the BMDW Office and the chair of the Editorial Board to select and prepare topics to be discussed and decided upon by the EB. How is the relationship between the individual registries and/or cord blood banks in relation to BMDW as part of Europdonor regulated? The requirements the registries or CBB s must meet in order to participate in BMDW are described in the house rules (see The services to be delivered by the BMDW Office are defined there as well. They are in brief as follows: The registries/cbb s will submit their data according to a format as determined by the BMDW Office. The participants pay an annual fee which is agreed upon by the Editorial Board. BMDW verifies the submitted data and makes it available on the website together with matching programs. The BMDW budget depends on the tasks to be performed and is approved in advance by the Editorial Board. How is the relationship between the BMDW Office, the Editorial Board, the Advisory Committee and Europdonor regulated? Briefly the following has been agreed upon: The Board of Europdonor has authorized the Editorial Board to decide on new features and improvements to be developed. The Editorial Board will decide with the BMDW Office as part of Europdonor, the necessary budget to keep BMDW running and to develop the requested new features. The Advisory Committee assists the BMDW Office in preparing the agenda of the Editorial Board meeting and the items the Editorial Board has to decide upon. It will report to the Editorial Board not only the opinions of the majority of the Advisory Committee members, but also minority opinions. The Advisory Committee has the option to consult the IT Working Group of the WMDA. Figure 1 Advisory Committee (AC) Advises IT WG WMDA Advises Europdonor Board (ED) Authorizes Editorial Board (EB) Decides on New developments to be implemented by the BMDW office and the necessary budget

7 2Participating Stem Cell Donor Registries and Cord Blood Banks page Participating stem cell donor registries At the end of 2012, 67 stem cell donor registries from 49 countries participated in BMDW (Table 1). Five new stem cell donor registries joined in BMDW, China Marrow Donor Program from China, Bharat Stem Cells from India, Bone Marrow Donor Registry Nigeria from Nigeria, Romanian National Registry of Hematopoietic Stem Cells Voluntary Donors from Romania and Serbian Bone Marrow Donor Registry from Serbia. Together the new registries added 160,214 donors to BMDW. The Russian Bone Marrow Donor Registry, San Marino Bone marrow Donor Registry and American Bone Marrow Donor Registry have been deleted from BMDW in Table 1 PARTICIPATING STEM CELL DONOR REGISTRIES Registry (N = 67) City Country (N = 49) Argentine CPH Donors Registry Buenos Aires Argentina Armenian Bone Marrow Donor Registry Charitable Trust Yerevan Armenia Australian Bone Marrow Donor Registry * Sydney Australia Austrian Bone Marrow Donors Vienna Austria Marrow Donor Program Belgium Mechelen Belgium INCA/REDOME Rio de Janeiro Brazil Bulgarian Bone Marrow Donor Registry Sofia Bulgaria OneMatch Stem Cell and Marrow Network * Ottawa Canada China Marrow Donor Program (CMDP) Beijing China Hong Kong Bone Marrow Donor Registry (HKBMDR) Hong Kong China New Sunshine Charity Foundation (NSCF) Beijing China Croatian Bone Marrow Donor Registry Zagreb Croatia Cyprus Paraskevaidio Bone Marrow Donor Registry (CPBMDR) Nicosia Cyprus Cyprus Bone Marrow Donor Registry (CBMDR) * Nicosia Cyprus Czech Stem Cells Registry (CSCR) Prague Czech Republic Czech National Marrow Donor Registry (CNMDR) * Plzen Czech Republic The Danish Bone Marrow Donor Registry (DBMDR) Aarhus Denmark Bone Marrow Donors Copenhagen (BMDC) Copenhagen Denmark Finnish Bone Marrow Donor Registry Helsinki Finland France Greffe de Moelle * St-Denis la Plaine France ZKRD German National Registry of Blood Stem Cell Donors* Ulm Germany Unrelated Hematopoietic Stem Cell Donor Registry Greece Athens Greece Hungarian Bone Marrow Donor Registry Budapest Hungary Bharat Stem Cells (BSC) New Delhi India DATRI Blood Stem Cell Donors Registry Chennai India Iranian Stem Cell Donor Program (ISCDP) Tehran Iran Irish Unrelated Bone Marrow Registry * Dublin Ireland Hadassah Bone Marrow Donor Registry (HBMDR) Jerusalem Israel Ezer Mizion Bone Marrow Donor Registry (EMBMDR) * Petach Tikvah Israel Sheba Medical Center Donor Registry (SMCDR) Tel-Hashomer Israel Italian Bone Marrow Donor Registry * Genova Italy Japan Marrow Donor Program * Tokyo Japan Lithuanian National Bone Marrow Donor Registry Vilnius Lithuania Mexican Bone Marrow Donor Registry (DONORMO) Mexico City Mexico Europdonor Foundation * Leiden The Netherlands New Zealand Bone Marrow Donor Registry * Auckland New Zealand Bone Marrow Donor Registry Nigeria Enugu Nigeria The Norwegian Bone Marrow Donor Registry * Oslo Norway Against Leukemia Foundation Marrow Donor Registry (ALF-MDR) Warsaw Poland Fundacja DKMS Baza Dawcow Komorek Macierzystych Polska Warsaw Poland Central Bone Marrow Donor Registry (POLTransplant) Warsaw Poland Portuguese Bone Marrow Donors Registry (CEDACE) Lisbon Portugal Romanian Nat. Registry of Hematopoietic Stem Cells Voluntary Donors Bucharest Romania Karelian Registry of Unrel. Donors of Hematopoietic Stem Cells Petrozavodsk Russian Federation

8 page 4 Figure 2 Participating Stem Cell Donor Registries Mexican Bone Marrow Donor Registry (DONORMO) Mexico City Mexico Europdonor Foundation * Leiden The Netherlands New Zealand Bone Marrow Donor Registry * Auckland New Zealand Bone Marrow Donor Registry Nigeria Enugu Nigeria PARTICIPATING The Norwegian Bone STEM Marrow CELL Donor DONOR Registry REGISTRIES * Registry Against Leukemia (N = 67) Foundation Marrow Donor Registry (ALF-MDR) Oslo City Warsaw Norway Country Poland (N = 49) Argentine Fundacja DKMS CPH Donors Baza Dawcow Registry Komorek Macierzystych Polska Buenos Warsaw Aires Argentina Poland Armenian Central Bone Bone Marrow Donor Donor Registry (POLTransplant) Charitable Trust Yerevan Warsaw Armenia Poland Australian Portuguese Bone Marrow Donors Registry * (CEDACE) Sydney Lisbon Australia Portugal Austrian Romanian Bone Nat. Marrow Registry Donors of Hematopoietic Stem Cells Voluntary Donors Vienna Bucharest Austria Romania Marrow Karelian Donor Registry Program of Unrel. Belgium Donors of Hematopoietic Stem Cells Mechelen Petrozavodsk Belgium Russian Federation INCA/REDOME Bone Marrow Donors Registry Blood Banks of Russia Rio St. Petersburg de Janeiro Russian Brazil Federation NP Bulgarian HPC Registry Bone Marrow Donor Registry Sofia Samara Bulgaria Russian Federation OneMatch Serbian Bone Stem Marrow Cell and Donor Marrow Registry Network * Ottawa Belgrade Serbia Canada China Singapore Marrow Bone Donor Marrow Program Donor (CMDP) Programme (BMDP) Beijing Singapore Singapore China Hong Slovak Kong National Bone Bone Marrow Marrow Donor Donor Registry Registry (HKBMDR) Hong Bratislava Kong China Slovakia New Slovenia Sunshine Donor Charity Foundation (NSCF) Beijing Ljubljana China Slovenia Croatian South African Bone Bone Marrow Marrow Donor Registry (SABMR) Zagreb Cape Town Croatia South Africa Cyprus REDMO, Paraskevaidio Jose Carreras Bone International Marrow Donor Leukemia Registry Foundation (CPBMDR) Nicosia Barcelona Cyprus Spain Cyprus DKMS España Bone Marrow Donor Registry (CBMDR) * Nicosia Cyprus Spain Czech The Tobias Stem Registry Cells Registry (CSCR) Prague Stockholm Czech Sweden Republic Czech Swiss Blood National Stem Marrow Cells Donor Registry (CNMDR) * Plzen Bern Czech Switzerland Republic The Buddhist Danish Tzu Bone Chi Stem Marrow Cells Donor Center Registry * (DBMDR) Aarhus Hualien City Denmark Taiwan Bone Thai Stem Marrow Cell Donors Registry Copenhagen (TSCDR) (BMDC) Copenhagen Bangkok Denmark Thailand Finnish Ankara University Bone Marrow School Donor of Medicine Registry Unrelated Blood and Helsinki Finland France Marrow Greffe Donor de Registry Moelle * St-Denis Ankara la Plaine France Turkey ZKRD Blood and German Bone Marrow National Donor Registry Registry of Blood of Istanbul Stem Cell Medical Donors* Fac. Ulm Istanbul Germany Turkey Unrelated Emirates Bone Hematopoietic Marrow Donor Stem Registry Cell Donor Registry Greece Athens Sharjah Greece United Arab Emirates Hungarian Anthony Nolan Bone * Marrow Donor Registry Budapest London Hungary United Kingdom Bharat British Bone Stem Marrow Cells (BSC) Registry (BBMR) * New Bristol Delhi India United Kingdom DATRI Welsh Blood Bone Marrow Stem Cell Donors Registry Registry * Chennai Pontyclun India United Kingdom Iranian National Stem Marrow Cell Donor Program (NMDP) (ISCDP)* Tehran Minneapolis, MN Iran USA Irish Caitlin Unrelated Raymond Bone International Marrow Registry *(CRIR) * Dublin Worcester, MA Ireland USA Hadassah Gift of Life Bone Marrow Donor Foundation Registry (GOL) (HBMDR) * Jerusalem Boca Raton, FL Israel USA Ezer SINDOME Mizion Bone Marrow Donor Registry (EMBMDR) * Petach Montevideo Tikvah Israel Uruguay Sheba *) Registry Medical accredited Center by Donor the World Registry Marrow (SMCDR) Donors Association (WMDA) Tel-Hashomer Israel Italian Bone Marrow Donor Registry * Genova Italy Japan Marrow Donor Program * Tokyo Japan Lithuanian National Bone Marrow Donor Registry Vilnius Lithuania The number of participating stem cell donor registries is shown in Figure 2. Mexican Bone Marrow Donor Registry (DONORMO) Mexico City Mexico Europdonor Foundation * Leiden The Netherlands New Number Zealand of registries Bone Marrow Donor Registry * Auckland New Zealand 80 Bone Marrow Donor Registry Nigeria Enugu Nigeria 70 The Norwegian Bone Marrow Donor Registry * Oslo Norway Against Leukemia Foundation Marrow Donor Registry (ALF-MDR) Warsaw Poland 60 Fundacja DKMS Baza Dawcow Komorek Macierzystych Polska Warsaw Poland 50 Central Bone Marrow Donor Registry (POLTransplant) Warsaw Poland 40 Portuguese Bone Marrow Donors Registry (CEDACE) Lisbon Portugal Romanian Nat. Registry of Hematopoietic Stem Cells Voluntary Donors Bucharest Romania 30 Karelian Registry of Unrel. Donors of Hematopoietic Stem Cells Petrozavodsk Russian Federation 20 Bone Marrow Donors Registry Blood Banks of Russia St. Petersburg Russian Federation 10 NP HPC Registry Samara Russian Federation Serbian Bone Marrow Donor Registry Belgrade Serbia 0 Singapore Bone Marrow Donor Programme (BMDP) Singapore Year Singapore Slovak National Bone Marrow Donor Registry Bratislava Slovakia Slovenia Donor Ljubljana Slovenia South African Bone Marrow Registry (SABMR) Cape Town South Africa Participating REDMO, Jose Carreras cord blood International banks/registries Leukemia Foundation Barcelona Spain DKMS España Spain In The 2012, Tobias 46 Registry cord blood banks/registries from 30 countries participated Stockholm in BMDW Sweden(Table 2). Four Swiss new Blood cord Stem blood Cells banks joined BMDW, Hema-Quebec Cord Bern Blood Bank Switzerland from Canada, Thessaloniki Buddhist Tzu Chi Public Stem Cells Cord Center Blood * Bank from Greece, Royal Institute Hualien Cord City Blood Taiwan Bank from Iran Thai and Stem Slovenia Cell Donor Cord Registry from (TSCDR) Slovenia. These new banks supplied Bangkok data of 7,857 Thailand units to BMDW. Ankara University The Austrian School of Cord Medicine Blood Unrelated Registry Blood has and withdrawn its data from BMDW in Marrow Donor Registry Ankara Turkey Blood and Bone Marrow Donor Registry of Istanbul Medical Fac. Istanbul Turkey Emirates Bone Marrow Donor Registry Sharjah United Arab Emirates Anthony Nolan * London United Kingdom British Bone Marrow Registry (BBMR) * Bristol United Kingdom Welsh Bone Marrow Donor Registry * Pontyclun United Kingdom 2012

9 page 5 Table 2 PARTICIPATING CORD BLOOD BANKS/REGISTRIES Registry (N = 46) City Country (N = 30) Argentina National Cord Blood Bank Buenos Aires Argentina Australian Cord Blood Registry Sydney Australia Belgium Cord Blood Registry (BCBR) Mechelen Belgium Hema-Quebec Cord Blood Bank Quebec Canada Croatian Cord Blood Bank Zagreb Croatia Cyprus Cord Blood Bank Nicosia Cyprus Czech Cord Blood Registry Prague Czech Republic Finnish Cord Blood Registry Helsinki Finland France Greffe de Moelle Cord Blood Registry St-Denis La Plaine France Jose Carreras Stem Cell Bank Duesseldorf Duesseldorf Germany ZKRD - German National Registry of Blood Stem Cell Donors Ulm Germany Hellenic Cord Blood Bank Athens Greece Thessaloniki Public Cord Blood Bank Thessaloniki Greece Hadassah-MDA Cord Blood Bank (H-MDACBB) Jerusalem Israel Sheba Medical Centre Cord Blood Registry (SMCCBR) Tel-Hashomer Israel Iranian Stem Cell Donor Program (ISCDP) Tehran Iran Royan Institute Cord Blood Bank Tehran Iran Italian Cord Blood Bank Network Genova Italy Tokyo Cord Blood Bank Tokyo Japan Catholic Hematopoietic Stem Cell Bank (KCHSCB) Seoul Republic of Korea Korea Cord Blood Bank (KCBB) Seoul Republic of Korea Mexican Unrelated Cord Blood Bank (BACECU) Mexico City Mexico Europdonor Foundation Leiden The Netherlands Central Cord Blood Registry (POLTransplant) Warsaw Poland NP HPC Registry Samara Russian Federation Eurocord Slovakia Slovak Placental Stem Cell Registry Bratislava Slovakia Slovenia Cord Ljubljana Slovenia REDMO Spanish Cord Blood Registry Barcelona Spain The Tobias Registry Stockholm Sweden Swiss Cord Blood Registry Bern Switzerland Alarvita BioLife Corporation Wugu Shiang Taiwan BIONET Corp. Hualien City Taiwan Buddhist Tzu Chi Stem Cells Center Taipei City Taiwan Healthbanks Biotech Co. Ltd. Taipei Taiwan StemCyte, Inc. Taiwan LinKou, Taipei Hsien Taiwan Thai National Cord Blood Bank Bangkok Thailand Ankara University School of Medicine Unrelated Blood and Marrow Donor Registry Ankara Turkey Anthony Nolan Cord Blood Registry London United Kingdom British Bone Marrow Registry Cord Blood Bank Bristol United Kingdom StemCyte Inc. Covina, CA USA Gift of Life Cord Blood Program (GOL) Boca Raton, FL USA Celgene Cord Blood Bank Cedar Knolls, NJ USA Cleveland Cord Blood Center (CCBC) Cleveland, OH USA National Marrow Donor Program Cord Blood Bank (NMDP) Minneapolis, MN USA National Cord Blood Program, New York Blood Center (NCBP-NYBC) Long Island City, NY USA New Jersey Cord Blood Allendale, NJ USA

10 page 6 The number of participating cord blood banks/registries are shown in Figure 3. Figure 3 Participating Cord Blood Banks/Registries Number of registries Year

11 page 7 3Number of Stem Cell Donors and Cord Blood Units 3.1 Number of stem cell donors The number of HLA-A, -B and HLA-A, -B, -DR typed stem cell donors per registry is shown in Table 3. In Figure 4 the total number of HLA-A, -B and HLA-A, -B, -DR typed stem cell donors per year is given. The number of stem cell donors increased by 1,613,741 from 18,613,122 to 20,226,863 in The percentage of HLA-DR typed donors has increased by 1%, from 87% in 2011 to 88% in In the total group of donors the percentage of HLA class I DNA typed donors is 76% and HLA class II DNA typed donors is 85%. Table 3 THE NUMBER OF HLA-A, -B AND HLA-A, -B, -DR AND DNA TYPED STEM CELL DONORS PER REGISTRY Number of Percentage Number of Number of Total HLA-A, -B, of HLA-A, -B, class I class II number -DR typed -DR typed DNA typed DNA typed Registry Country of donors donors donors donors donors Argentine CPH Donors Registry Argentina 33,589 29, ,588 29,442 Armenian Bone Marrow Donor Registry Charitable Trust Armenia 21,073 21,072 >99 21,073 21,073 Australian Bone Marrow Donor Registry Australia 175, , , ,488 Austrian Bone Marrow Donors Austria 63,274 30, ,628 21,857 Marrow Donor Program Belgium Belgium 61,366 53, ,185 40,427 INCA/REDOME Brazil 2,855,244 2,847,603 >99 2,713,843 2,841,965 Bulgarian Bone Marrow Donor Registry Bulgaria OneMatch Stem Cell and Marrow Network Canada 336, , , ,854 China Marrow Donor Program (CMDP) China 156, , , ,794 Hong Kong Bone Marrow Donor Registry (HKBMDR) China 76,497 62, ,307 45,242 New Sunshine Charity Foundation (NSCF) China 2,670 2, ,670 2,517 Croatian Bone Marrow Donor Registry Croatia 31,758 30, ,191 30,189 Cyprus Paraskevaidio Bone Marrow Donor Registry (CPBMDR) Cyprus 5, , Cyprus Bone Marrow Donor Registry (CBMDR) Cyprus 117,139 68, ,786 56,751 Czech National Marrow Donor Registry Czech (CNMDR) Republic 39,715 35, ,681 34,982 Czech Stem Cells Registry (CSCR) Czech Republic 21,568 10, ,446 10,615 The Danish Bone Marrow Donor Registry (DBMDR) Denmark 27,012 25, ,590 25,928 Bone Marrow Donors Copenhagen (BMDC) Denmark 13,575 12, ,635 Finnish Bone Marrow Donor Registry Finland 20,649 20, ,246 6,677 France Greffe de Moelle France 205, , , ,282 ZKRD-German National Registry of Blood Stem Cell Donors Germany 4,767,127 3,802, ,428,437 3,727,273 Unrelated Hematopoietic Stem Cell Donor Registry Greece Greece 33,737 18, ,379 2,378 Hungarian Bone Marrow Donor Registry Hungary 6,452 3, ,684 2,441 Bharat Stem Cells (BSC) India DATRI Blood Stem Cell Donors Registry India 14,654 14, ,654 14,146 Iranian Stem Cell Donor Program (ISCDP) Iran 2,191 1, ,856 1,855 Irish Unrelated Bone Marrow Registry Ireland 20,910 20, ,625 14,256 Hadassah Bone Marrow Donor Registry (HBMDR) Israel 118,181 87, ,455 87,125 Ezer Mizion Bone Marrow Donor

12 page 8 Finnish Bone Marrow Donor Registry Finland 20,649 20, ,246 6,677 France Greffe de Moelle France 205, , , ,282 ZKRD-German National Registry of Blood Stem Cell Donors Germany 4,767,127 3,802, ,428,437 3,727,273 THE Unrelated NUMBER Hematopoietic OF HLA-A, Stem Cell -B AND HLA-A, -B, -DR AND DNA TYPED STEM CELL DONORS PER REGISTRY Donor Registry Greece Greece 33,737 Number 18,038 of Percentage 53 Number 2,379 of Number 2,378 of Hungarian Bone Marrow Donor Registry Hungary Total 6,452 HLA-A, 3,643 -B, of HLA-A, 56 -B, class 1,684 I class 2,441 II Bharat Stem Cells (BSC) India number 114 -DR typed 114 -DR 100 typed DNA typed 111 DNA typed 111 DATRI Registry Blood Stem Cell Donors Registry Country India of donors 14,654 donors 14,028 donors 96 donors 14,654 donors 14,146 Iranian Argentine Stem CPH Cell Donors Registry Program (ISCDP) Iran Argentina 33,589 2,191 29,444 1, ,588 1,856 29,442 1,855 Irish Armenian Unrelated Bone Bone Marrow Marrow Donor Registry Ireland 20,910 20, ,625 14,256 Hadassah Registry Charitable Bone Marrow Trust Donor Registry Armenia 21,073 21,072 >99 21,073 21,073 Australian (HBMDR) Bone Marrow Donor Registry Israel Australia 118, , ,444 87, ,455 69, ,488 87,125 Austrian Ezer Mizion Bone Bone Marrow Marrow Donors Austria 63,274 30, ,628 21,857 Marrow Registry Donor (EMBMDR) Program Belgium Israel Belgium 650,465 61, ,542 53, ,426 22, ,994 40,427 INCA/REDOME Sheba Medical Center Donor Brazil 2,855,244 2,847,603 >99 2,713,843 2,841,965 Bulgarian Registry (SMCDR) Bone Marrow Donor Registry Israel Bulgaria 1, OneMatch Italian Bone Stem Marrow Cell Donor and Marrow Registry Italy 337, , , ,752 Network Japan Marrow Donor Program Canada Japan 336, , , , , , , ,233 Lithuanian China Marrow National Donor Bone Program Marrow (CMDP) China 156, , , ,794 Donor Hong Kong Registry Bone Marrow Donor Lithuania 7,762 7,760 >99 5,492 7,760 Registry Mexican (HKBMDR) Bone Marrow Donor Registry China 76,497 62, ,307 45,242 New (DONORMO) Sunshine Charity Foundation Mexico 11,896 11, ,889 Europdonor (NSCF) Foundation The China 2,670 2, ,670 2,517 Croatian Bone Marrow Donor Registry Netherlands Croatia 41,639 31,758 40,338 30, ,022 30,191 31,956 30,189 New Cyprus Zealand Paraskevaidio Bone Marrow Bone Donor Marrow Registry Donor Registry (CPBMDR) New Cyprus Zealand 10,541 5,884 4, ,183 3,421 4, Bone Cyprus Marrow Bone Marrow Donor Registry Donor Registry Nigeria Nigeria The (CBMDR) Norwegian Bone Marrow Donor Cyprus 117,139 68, ,786 56,751 Registry Czech National Marrow Donor Registry Norway Czech 30,029 29, ,190 28,712 Against (CNMDR) Leukemia Foundation Marrow Republic 39,715 35, ,681 34,982 Donor Czech Registry Stem Cells (ALF Registry MDR) (CSCR) Czech Poland 15,145 10, ,676 10,974 Fundacja DKMS Baza Dawcow Republic 21,568 10, ,446 10,615 Komorek The Danish Macierzystych Bone Marrow Polska Donor Poland 251, ,761 >99 251, ,768 Central Registry Bone (DBMDR) Marrow Donor Registry Denmark 27,012 25, ,590 25,928 (POLTransplant) Bone Marrow Donors Copenhagen Poland 115,565 99, ,187 99,365 Portuguese (BMDC) Bone Marrow Donors Denmark 13,575 12, ,635 Registry Finnish Bone (CEDACE) Marrow Donor Registry Portugal Finland 310,935 20, ,527 20, ,385 5, ,172 6,677 Romanian France Greffe Nat. de Registry Moelle of Hematopoietic France 205, , , ,282 ZKRD-German Stem Cells National Voluntary Registry Donors of Romania 1,058 1, ,058 1,036 Karelian Blood Stem Registry Cell Donors of Unrel. Donors of Germany 4,767,127 3,802, ,428,437 3,727,273 Hematopoietic Unrelated Hematopoietic Stem Cells Stem Cell Russian Fed. 2, , Bone Donor Marrow Registry Donors Greece Registry Blood Greece 33,737 18, ,379 2,378 Banks Hungarian of Russia Bone Marrow Donor Registry Russian Hungary Fed. 3,382 6,452 3, ,6840 2, NP Bharat HPC Stem Registry Cells (BSC) Russian India Fed. 1, , , , Serbian DATRI Blood Bone Stem Marrow Cell Donors Registry India Serbia 14,654 1,838 14,028 1, ,654 1,838 14,146 1,822 Singapore Iranian Stem Bone Cell Marrow Donor Program Donor (ISCDP) Iran 2,191 1, ,856 1,855 Irish Programme Unrelated (BMDP) Bone Marrow Registry Singapore Ireland 20,910 29,502 20,791 29,475 >99 13,625 29,502 14,256 29,475 Slovak Hadassah National Bone Bone Marrow Marrow Donor Registry Donor (HBMDR) Registry Slovakia Israel 118,181 3,544 87,664 3, ,455 2,984 87,125 3,369 Slovenia Ezer Mizion Donor Bone Marrow Donor Slovenia 15,568 15,559 >99 14,966 15,563 South Registry African (EMBMDR) Bone Marrow Registry Israel 650, , , ,994 (SABMR) Sheba Medical Center Donor South Africa 64,822 12, ,165 11,463 REDMO, Registry Jose (SMCDR) Carreras International Israel 1, Leukemia Italian Bone Foundation Marrow Donor Registry Spain Italy 106, , ,172 72, ,335 53, ,752 55,407 DKMS Japan Marrow España Donor Program Spain Japan 423,441 1, ,441 1, ,455 1, ,233 1,375 The Lithuanian Tobias National Registry Bone Marrow Sweden 39,878 24, ,779 23,461 Swiss Donor Blood Registry Stem Cells Switzerland Lithuania 41,741 7,762 41,576 7,760 > ,219 5,492 41,363 7,760 Buddhist Mexican Bone Tzu Chi Marrow Stem Donor Cells Center Registry Taiwan 303, , , ,989 Thai (DONORMO) Stem Cell Donor Registry (TSCDR) Mexico Thailand 130,058 11, ,513 11, , ,399 11,889 Europdonor Ankara University Foundation School of Medicine The Unrelated Blood and Marrow Donor Netherlands 41,639 40, ,022 31,956 New Registry Zealand (TRAN) Bone Marrow Donor Turkey 7,620 6, ,239 6,140 Registry Blood and Bone Marrow Donor Registry New Zealand 10,541 4, ,183 4,004 Bone of Istanbul Marrow Medical Donor Fac. Registry (BBMDR-IMF) Nigeria Turkey Nigeria 27, , , , The Anthony Norwegian Nolan Bone Marrow Donor United Kingdom 468, , , ,977 Registry British Bone Marrow Registry (BBMR) Norway United Kingdom 324,645 30, ,257 29, ,815 13, ,622 28,712 Against Welsh Bone Leukemia Marrow Foundation Donor Registry Marrow United Kingdom 51,669 51, ,094 51,669 Donor Emirates Registry Bone Marrow (ALF MDR) Donor Registry Poland United Arab 15,145 10, ,676 10,974 Fundacja DKMS Baza Dawcow Emirates

13 Figure 4 Total number of HLA-A, -B and HLA-A, -B, -DR typed stem cell donors Figure 5 The number of stem cell donors added to the database per year Leukemia Foundation Spain 106,521 72, ,184 55,407 DKMS España Spain 1,375 1, ,375 1,375 The Tobias Registry Sweden 39,878 24, ,779 23,461 page 9 Swiss Blood Stem Cells Switzerland 41,741 41, ,219 41,363 THE Buddhist NUMBER Tzu Chi Stem OF HLA-A, Cells Center -B AND HLA-A, Taiwan -B, -DR AND 303,328 DNA TYPED 272,976 STEM CELL 90 DONORS 180,151 PER REGISTRY 270,989 Thai Stem Cell Donor Registry (TSCDR) Thailand 130,058 Number 125,513 of Percentage 97 Number 125,025 of Number 125,399 of Ankara University School of Medicine Total HLA-A, -B, of HLA-A, -B, class I class II Unrelated Blood and Marrow Donor number -DR typed -DR typed DNA typed DNA typed Registry (TRAN) Country Turkey of donors 7,620 donors 6,236 donors 82 donors 4,239 donors 6,140 Argentine Blood and CPH Bone Donors Marrow Registry Donor Registry Argentina 33,589 29, ,588 29,442 Armenian of Istanbul Bone Medical Marrow Fac. (BBMDR-IMF) Donor Registry Anthony Nolan Charitable Trust Turkey Armenia United Kingdom 27, ,997 21,073 2, ,638 21,072 9 > , ,751 21,073 2, ,977 21,073 Australian British Bone Bone Marrow Marrow Registry Donor (BBMR) Registry United Australia Kingdom 324, , , , ,815 69, , ,622 Austrian Welsh Bone Bone Marrow Donors Registry United Austria Kingdom 51,669 63,274 51,669 30, ,628 50,094 21,857 51,669 Marrow Emirates Donor Bone Program Marrow Donor Belgium Registry Belgium United Arab 61,366 53, ,185 40,427 INCA/REDOME Brazil Emirates 2,855, ,847, > ,713,8430 2,841,9650 Bulgarian SINDOME Bone Marrow Donor Registry Uruguay Bulgaria OneMatch Caitlin Raymond Stem Cell International and Marrow Registry Network (CRIR) Canada USA 336, , , , , , , ,780 China Gift of Marrow Life Bone Donor Marrow Program Foundation (CMDP) China 156, , , ,794 Hong (GOL) Kong Bone Marrow Donor USA 214, , , ,853 Registry National (HKBMDR) Marrow Donor Program (NMDP) China USA 6,744,512 76,497 6,170,835 62, ,137,59 35,307 6,070,143 45,242 New Total Sunshine Charity Foundation 20,226,863 17,881, ,362,489 17,265,661 (NSCF) China 2,670 2, ,670 2,517 Croatian Bone Marrow Donor Registry Croatia 31,758 30, ,191 30,189 Cyprus Paraskevaidio Bone Marrow Donor Number Registry of stem (CPBMDR) cell donors (x million) Cyprus 5, , Cyprus Number Bone Marrow above bars Donor is % HLA-A, Registry -B, -DR typed stem cell donors HLA-A,-B,-DR (CBMDR) Cyprus 117,139 68, ,786 56, Czech National Marrow Donor Registry Czech 87 HLA-A,-B (CNMDR) Republic 39,715 35, ,681 34, Czech Stem Cells Registry (CSCR) Czech Republic 77 21, , ,446 10, The Danish Bone Marrow Donor Registry (DBMDR) 49 Denmark 53 27,012 25, ,590 25, Bone Marrow Donors Copenhagen (BMDC) Denmark 13,575 12, , Finnish Bone Marrow Donor Registry Finland 20,649 20, ,246 6,677 0 France Greffe de Moelle France 205, ,226 Year , ,282 ZKRD-German National Registry of Blood Stem Cell Donors Germany 4,767,127 3,802, ,428,437 3,727,273 Unrelated Hematopoietic Stem Cell The Donor increase Registry Greece of the number of stem Greece cell donors 33,737 per year 18,038 is given in 53 Figure 5. The 2,379 number 2,378 of additional Hungarian Bone donors Marrow (1,613,741) Donor Registry in Hungary the database in 6, is less 3,643 than in (3,739,176). 1,684 2,441 On Bharat average Stem Cells there (BSC) has been an increase India of 1,739, donors 114 per year 100 over the last 111 five years 111 ( ). DATRI Blood Stem Cell Donors Registry India 14,654 14, ,654 14,146 Iranian Stem Cell Donor Program (ISCDP) Iran 2,191 1, ,856 1,855 Irish Unrelated Bone Marrow Registry Ireland 20,910 20, ,625 14,256 Hadassah Number Bone of Marrow stem cell Donor donors Registry (x thousand) added per year 4000 (HBMDR) Israel 118,181 87, ,455 87, Ezer Mizion Bone Marrow Donor Registry (EMBMDR) Israel 650, , , , Sheba Medical Center Donor 2500 Registry (SMCDR) Israel 1, Italian Bone Marrow Donor Registry Italy 337, , , ,752 Japan Marrow Donor Program Japan 423, , , , Lithuanian National Bone Marrow 1000 Donor Registry Lithuania 7,762 7,760 >99 5,492 7, Mexican Bone Marrow Donor Registry (DONORMO) Mexico 11,896 11, ,889 0 Europdonor Foundation The Year Netherlands 41,639 40, ,022 31,956 New Zealand Bone Marrow Donor Registry New Zealand 10,541 4, ,183 4,004 Bone Marrow Donor Registry Nigeria Nigeria The Norwegian Bone Marrow Donor Registry Norway 30,029 29, ,190 28,712 Against Leukemia Foundation Marrow Donor Registry (ALF MDR) Poland 15,145 10, ,676 10,974 Fundacja DKMS Baza Dawcow

14 page Number of cord blood units The number of HLA-A, -B and HLA-A, -B, -DR typed cord blood units per cord blood bank/ registry is shown in Table 4. In ,523 cord blood units are listed in BMDW. The cord blood units are practically all fully typed for HLA-A, -B and -DR, in addition 76% is class I DNA typed and 93% of the units is class II DNA typed. The total nucleated cell count is given for over 99% of the units and for 84% of the units the net volume collected is provided. In Table 5 the mean number of total nucleated cells (TNC) of the cord blood units in the cord bloodbanks is given. For all cord blood units in BMDW the mean number of TNC is x 10 7 and the median of TNC is x There has been only a slight increase in both the mean and median TNC since Table 4 THE NUMBER OF HLA-A, -B AND HLA-A, -B, -DR TYPED CORD BLOOD UNITS PER CORD BLOOD BANK/REGISTRY Number of Total HLA-A, -B, number -DR typed Number of class I DNA typed Number of class II DNA typed Registry Country of units units units units Argentina National Cord Blood Bank Argentina 1,962 1,959 1,962 1,959 Australian Cord Blood Registry Australia 25,085 25,085 19,841 25,085 Belgium Cord Blood Registry (BCBR) Belgium 16,952 16,952 14,734 16,902 Hema-Quebec Cord Canada 6,025 6,024 6,025 6,024 Croatian Cord Blood Bank Croatia 2,026 2,026 2,026 2,026 Cyprus Cord Blood Bank (CCBB) Cyprus 1,535 1,535 1,535 1,535 Czech Cord Blood Registry (CSCR) Czech Republic 3,923 3,923 3,808 3,921 Finnish Cord Blood Registry Finland 3,369 3,369 1,596 3,369 France Greffe de Moelle Cord Blood Registry France 22,960 22,960 17,661 22,477 Jose Carreras Stem Cell Bank Duesseldorf Germany 17,852 17,852 14,178 17,851 German National Registry of Blood Stem Cell Donors (ZKRD) Germany 15,375 15,375 14,006 15,368 Hellenic Cord Blood Bank (HCBB) Greece 1,251 1, Thessaloniki Public Cord Blood Bank Greece Iranian Stem Cell Donor Program (ISCDP) Iran 1,625 1,615 1,625 1,615 Royan Institute Cord Blood Bank Iran 1,125 1,121 1,125 1,121 Hadassah-MDA Cord Blood Bank (H-MDACBB) Israel 7,594 7,592 7,592 7,591 Sheba Medical Centre Cord Blood Registry (SMCCBR) Israel 2,475 2,251 2,475 2,251 Italian Cord Blood Bank Network Italy 28,430 28,428 20,112 28,426 Tokyo Cord Blood Bank Japan 4,698 4, ,698 Catholic Hematopoietic Stem Cell Bank (KCHSCB) Korea 2,247 2, ,247 Korea Cord Blood Bank (KCBB) Korea 21,775 21, Mexican Unrelated Cord Blood Bank (BACECU) Mexico Europdonor Foundation The Netherlands 3,237 3,237 2,637 3,232 Central Cord Blood Registry (POLTransplant) Poland NP HPC Registry Russian Federation 4,596 4,596 4,596 4,596 Eurocord Slovakia - Slovak Placental Stem Cell Registry Slovakia 1,724 1,724 1,171 1,178 Slovenia Cord Slovenia REDMO Spanish Cord Blood Registry Spain 55,424 55,424 42,617 51,455 The Tobias Registry Sweden 2,526 2,526 2,526 2,526 Swiss Cord Blood Registry Switzerland 3,828 3,828 3,823 3,828 Alarvita BioLife Corporation Taiwan BIONET Corp. Taiwan 29,895 29,895 29,895 29,894 Buddhist Tzu Chi Stem Cells Center Taiwan 14,108 14,106 12,551 12,620 Healthbanks Biotech Co. Ltd. Taiwan 6,237 6,237 6,237 6,237 StemCyte, Inc. Taiwan Taiwan 9,509 9,501 9,509 9,501 Thai National Cord Blood Bank Thailand 2,040 2, Ankara University School of Medicine Unrelated Blood and Marrow Donor Registry Turkey Anthony Nolan Cord Blood Registry United Kingdom 1,520 1,520 1,520 1,520 British Bone Marrow Registry Cord Blood Bank United Kingdom 17,334 17,334 17,270 17,334 StemCyte Inc. USA 19,281 19,280 19,281 19,280 Gift of Life Cord Blood Program (GOL) USA Celgene Cord Blood Bank USA 3,859 3,859 3,859 3,859

15 Figure 6 Total numbers of cord blood units Figure 7 The number of cord blood units added to the database per year The Tobias Registry Sweden 2,526 2,526 2,526 2,526 Swiss Cord Blood Registry Switzerland 3,828 3,828 3,823 3,828 Alarvita BioLife Corporation Taiwan page 11 0 BIONET Corp. Taiwan 29,895 29,895 29,895 29,894 THE Buddhist NUMBER Tzu Chi Stem OF HLA-A, Cells Center -B AND HLA-A, -B, Taiwan -DR TYPED CORD 14,108 BLOOD UNITS 14,106 12,551 12,620 PER Healthbanks CORD Biotech BLOOD Co. BANK/REGISTRY Ltd. Taiwan 6,237 6,237 6,237 6,237 StemCyte, Inc. Taiwan Taiwan 9,509 Number 9,501 of Number 9,509 of Number 9,501 of Thai National Cord Blood Bank Thailand Total 2,040 HLA-A, 2,040 -B, class I 0 class II 0 Ankara University School of Medicine Unrelated Blood number -DR typed DNA typed DNA typed Registry and Marrow Donor Registry Turkey Country of units 332 units323 units332 units323 Argentina Anthony Nolan National Cord Cord Blood Blood Registry Bank Argentina United Kingdom 1,962 1,520 1,959 1,520 1,962 1,520 1,959 1,520 Australian British Bone Cord Marrow Blood Registry Cord Blood Bank Australia United Kingdom 25,085 17,334 25,085 17,334 19,841 17,270 25,085 17,334 Belgium StemCyte Cord Inc. Blood Registry (BCBR) Belgium USA 16,952 19,281 16,952 19,280 14,734 19,281 16,902 19,280 Hema-Quebec Gift of Life Cord Cord Blood Program (GOL) Canada USA 6, , , , Croatian Celgene Cord Blood Bank Croatia USA 2,026 3,859 2,026 3,859 2,026 3,859 2,026 3,859 Cyprus Cleveland Cord Cord Blood Blood Bank Center (CCBB) (CCBC) Cyprus USA 1, , , , Czech National Cord Marrow Blood Donor Registry Program (CSCR) Czech Republic 3,923 3,923 3,808 3,921 Cord Finnish Blood Cord Bank Blood (NMDP) Registry USA Finland 133,783 3, ,783 3, ,469 1, ,725 3,369 Nat. France Cord Greffe Blood de Program, Moelle Cord New Blood York Blood Registry Center France 22,960 22,960 17,661 22,477 (NCBP-NYBC) Jose Carreras Stem Cell Bank Duesseldorf USA Germany 57,745 17,852 57,745 17,852 14,178 2,394 51,056 17,851 New German Jersey National Cord Registry Blood of Blood Stem Cell Donors Total (ZKRD) USA Germany 1, ,523 15,375 1, ,255 15,375 1, ,092 14,006 1, ,103 15,368 Hellenic Cord Blood Bank (HCBB) Greece 1,251 1, Thessaloniki Public Cord Blood Bank Greece Iranian Stem Cell Donor Program (ISCDP) Iran 1,625 1,615 1,625 1,615 The Royan steady Institute increase Cord Blood Bank of cord blood units in Iran BMDW is shown 1,125 in Figure 1, The total 1,125 number 1,121 of cord Hadassah-MDA blood units Cord Blood at the Bank end (H-MDACBB) of 2012 is 560,523. Israel 7,594 7,592 7,592 7,591 Sheba Medical Centre Cord Blood Registry (SMCCBR) Israel 2,475 2,251 2,475 2,251 Italian Number Cord Blood of cord Bank blood Network units (x thousand) Italy 28,430 28,428 20,112 28, Tokyo Cord Blood Bank Japan 4,698 4, ,698 Catholic Hematopoietic Stem Cell Bank (KCHSCB) Korea 2,247 2, , Korea Cord Blood Bank (KCBB) Korea 21,775 21, Mexican Unrelated Cord Blood Bank (BACECU) Mexico Europdonor Foundation The 300 Netherlands 3,237 3,237 2,637 3,232 Central Cord Blood Registry (POLTransplant) Poland NP HPC Registry Russian Federation 4,596 4,596 4,596 4, Eurocord Slovakia - Slovak Placental Stem Cell Registry Slovakia 1,724 1,724 1,171 1,178 Slovenia Cord Slovenia REDMO Spanish Cord Blood Registry Spain 55,424 55,424 Year 42,617 51,455 The Tobias Registry Sweden 2,526 2,526 2,526 2,526 Swiss Cord Blood Registry Switzerland 3,828 3,828 3,823 3,828 Alarvita BioLife Corporation Taiwan The BIONET number Corp. of cord blood units that have Taiwan been added per 29,895 year is given 29,895 in Figure 29, ,894 The Buddhist number Tzu Chi of Stem cord Cells blood Center units added to Taiwan the database in 14, is 53, ,106 12,551 12,620 Healthbanks Biotech Co. Ltd. Taiwan 6,237 6,237 6,237 6,237 StemCyte, Number Inc. of Taiwan cord blood units (x thousand) added per Taiwan year 9,509 9,501 9,509 9, Thai National Cord Blood Bank Thailand 2,040 2, Ankara University School of Medicine Unrelated Blood and Marrow Donor Registry Turkey Anthony Nolan Cord Blood Registry United Kingdom 1,520 1,520 1,520 1, British Bone Marrow Registry Cord Blood Bank United Kingdom 17,334 17,334 17,270 17, StemCyte Inc. USA 19,281 19,280 19,281 19,280 Gift of Life Cord Blood Program (GOL) USA Celgene Cord Blood Bank USA 3,859 3,859 3,859 3, Cleveland Cord Blood Center (CCBC) USA National Marrow Donor Program Cord Blood Bank (NMDP) USA 133, , , ,725 0 Nat. Cord Blood Program, New York Blood Center Year (NCBP-NYBC) USA 57,745 57,745 2,394 51,056 New Jersey Cord Blood USA 1,732 1,732 1,732 1,732 Total 560, , , ,

16 page 12 Table 5 THE MEAN NUMBER OF TOTAL NUCLEATED CELLS OF THE CORD BLOOD UNITS IN THE CORD BLOOD BANKS/REGISTRIES Registry Country Total number of units Mean number of TNC x 10 7 Eurocord Slovakia Slovak Placental Stem Cell Registry Slovakia 1, NP HPC Registry Russian Federation 4, Cleveland Cord Blood Center (CCBC) USA The Tobias Registry Sweden 2, France Greffe de Moelle Cord Blood Registry France 23, Anthony Nolan Cord Blood Registry United Kingdom 1, StemCyte Inc. USA 19, Sheba Medical Centre Cord Blood Registry (SMCCBR) Israel 2, Italian Cord Blood Bank Network Italy 28, Czech Cord Blood Registry Czech Republic 3, Hema-Quebec Cord Blood Bank Canada 6, REDMO Spanish Cord Blood Registry Spain 55, Jose Carreras Stem Cell Bank Duesseldorf Germany 17, National Marrow Donor Program Cord Blood Bank (NMDP) USA 133, Hadassah-MDA Cord Blood Bank (H-MDACBB) Israel 7, Europdonor Foundation The Netherlands 3, Swiss Cord Blood Registry Switzerland 3, Belgium Cord Blood Registry (BCBR) Belgium 16, Australian Cord Blood Registry Australia 25, Hellenic Cord Blood Bank Greece 1, Cyprus Cord Blood Bank Cyprus 1, Croatian Cord Blood Bank Croatia 2, National Cord Blood Program, New York Blood Center (NCBP-NYBC) USA 57, StemCyte, Inc. Taiwan Taiwan 9, Catholic Hematopoietic Stem Cell Bank (KCHSCB) Korea 2, British Bone Marrow Registry Cord Blood Bank United Kingdom 17, Central Cord Blood Registry (POLTransplant) Poland Argentina National Cord Blood Bank Argentina 1, Finnish Cord Blood Registry Finland 3, New Jersey Cord Blood USA 1, ZKRD - German National Registry of Blood Stem Cell Donors Germany 15, Gift of Life Cord Blood Program (GOL) USA Slovenia Cord Slovenia Korea Cord Blood Bank (KCBB) Korea 21, Ankara University School of Medicine Unrelated Blood and Marrow Donor Registry Turkey Thessaloniki Public Cord Blood Bank Greece Royan Institute Cord Blood Bank Iran 1, Iranian Stem Cell Donor Program (ISCDP) Iran 1, Celgene Cord Blood Bank USA 3, BIONET Corp. Taiwan 29, Mexican Unrelated Cord Blood Bank (BACECU) Mexico Buddhist Tzu Chi Stem Cells Center Taiwan 14, Thai National Cord Blood Bank Thailand 2, Tokyo Cord Blood Bank Japan 4, Alarvita BioLife Corporation Taiwan Healthbanks Biotech Co. Ltd. Taiwan 6,

17 page 13 4Distribution of Stem Cell Donors and Cord Blood Units in the World 4.1 Distribution of stem cell donors As shown in Figure 8, 37% of the donors reside in North America, 37% in Europe, 14% in South America, 11% in Asia and the remaining 1% originates from other continents (Africa and Australia/Oceania). Figure 8 The distribution of stem cell donors per continent Other 1% South America 14% Asia 11% Europe 37% North America 37% Figure 9 shows the distribution of stem cell donors in the world and in Europe. Figure 9 Distribution of stem cell donors in the world < 20,000 donors Bulgaria, Hungary, India, Iran, Lithuania, Mexico, New Zealand, Nigeria, Romania, Russian Federation, Serbia, Slovakia, Slovenia, United Arab Emirates, Uruguay 20, ,000 donors Argentina, Armenia, Austria, Belgium, Croatia, Czech Republic, Denmark, Finland, Greece, Ireland, Norway, Singapore, South Africa, Sweden, Switzerland, The Netherlands, Turkey > 100,000 donors Australia, Canada, China, Cyprus, France, Israel, Italy, Japan, Poland, Portugal, Spain, Taiwan, Thailand, United Kingdom > 1,000,000 donors Brazil, Germany and USA

18 page 14 Table 6 Table 6 contains the number of stem cell donors per 10,000 inhabitants sorted by HLA-A, -B, -DR. The mean number of HLA-A, -B, -DR typed donors per 10,000 inhabitants in the participating countries is 85.2 and median is 33.2; for HLA-A, -B plus HLA-A, -B, -DR typed donors the mean is and median is It is obvious that there are still large differences in the number of donors per 10,000 inhabitants between countries. Of the world population 0.3% is registered as a hematopoietic stem cell donor. THE NUMBER OF STEM CELL DONORS PER 10,000 INHABITANTS (SORTED BY HLA-A, -B, -DR PER 10,000 INHABITANTS) Number of Percentage Number of inhabitants HLA-A, Number -B, of of HLA-A, -B, -DR stem typedcell donors -DR typed Number of of donors Number per of class 10,000 I DNA inhabitants class II DNA Country x 10 6 ABDR Total ABDR Total Cyprus , , ,537.8 Israel , , Germany ,802,731 4,767, Portugal , , ,943.3 United States of America ,540,502 8,046, Brazil ,847,603 2,855, ,471.8 United Kingdom , , Taiwan, Province of China , , Poland , , Canada , , Slovenia ,559 15, Croatia ,403 31, Denmark ,771 40, Armenia ,072 21, Australia , , Norway ,140 30, Singapore ,475 29, Switzerland ,576 41, Belgium ,283 61, Ireland ,791 20, Czech Republic ,683 61, Italy , , Finland ,162 20, Austria ,712 63, Japan , , France , , Lithuania 3.0 7,760 7, Sweden ,566 39, The Netherlands ,338 41, Thailand , , Greece ,038 33, Spain , , New Zealand 4.5 4,108 10, Argentina ,444 33, Slovakia 5.4 3,369 3, Hungary ,643 6, Serbia 7.2 1,822 1, South Africa ,731 64, China 1, , , Uruguay Turkey ,721 35, Mexico ,896 11, Bulgaria Romania ,028 1, Iran, Islamic Republic of ,855 2, Russian Federation ,251 7, United Arab Emirates India 1, ,142 14, Nigeria

19 page Distribution of cord blood units As shown in Figure 10, the majority of the cord blood units is stored in North American (39%) and European (36%) cord blood banks. The remaining cord blood units are from Asia (20%), Australia/Oceania (4.5%) and South America (0.5%). Figure 10 Distribution of cord blood units per continent South America 0,5% Australia / Oceania 4,5% Asia 20% North America 39% Europe 36% Figure 11 shows the distribution of unrelated cord blood units in the world and in Europe. Figure 11 Distribution of cord blood units in the world < 10,000 units Argentina, Canada, Croatia, Cyprus, Czech Republic, Finland, Greece, Iran, Japan, Mexico, the Netherlands, Poland, Russian Federation, Slovakia, Slovenia, Sweden, Switzerland, Thailand, Turkey 10,000-20,000 units Belgium, France, Israel, United Kingdom > 20,000 units Australia, Germany, Italy, Republic of Korea, Spain, Taiwan, USA

20 page 16 The number of cord blood units per 10,000 inhabitants per country is given in Table 7. The data is sorted by the number of cord blood units per 10,000 inhabitants, starting with the highest number. The mean number of cord blood units per 10,000 inhabitants in the participating countries is 3.6 and the median is 3.4. Table 7 THE NUMBER OF CORD BLOOD UNITS PER 10,000 INHABITANTS Number of inhabitants Number of cord blood Number of cord blood units per 10,000 Country x 10 6 units inhabitants Taiwan, Province of China , Cyprus 0.8 1, Belgium , Israel , Spain , Australia , United States of America , Finland 5.4 3, Republic of Korea , Switzerland 8.0 3, Croatia 4.3 2, Italy , Germany , Czech Republic , France , Slovakia 5.4 1, United Kingdom , Sweden 9.6 2, The Netherlands , Canada , Greece , Slovenie Argentina , Japan , Iran, Islamic Republic of , Russian Federation , Thailand , Poland Turkey Mexico < 0.03