Amino Acids. Dr. Kevin Ahern
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1 Amino Acids Dr. Kevin Ahern
2 Part 1 - Amino Acids Structure and Chemistry
3 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins
4 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins Essential Amino Acids
5 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins Essential Amino Acids Basic Structure
6 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins Essential Amino Acids Basic Structure Stereochemistry
7 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins Essential Amino Acids Basic Structure Stereochemistry Side Chain Chemistry
8 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins Essential Amino Acids Basic Structure Stereochemistry Side Chain Chemistry Properties
9 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins Essential Amino Acids Basic Structure Stereochemistry Side Chain Chemistry Properties Ionization
10 Part 1 - Amino Acids Structure and Chemistry Building Blocks of Proteins Essential Amino Acids Basic Structure Stereochemistry Side Chain Chemistry Properties Ionization Bonding
11 Amino Acids & Proteins
12 Amino Acids & Proteins Workhorses of cell
13 Amino Acids & Proteins Workhorses of cell Catalysis
14 Amino Acids & Proteins Workhorses of cell Catalysis Signaling
15 Amino Acids & Proteins Workhorses of cell Catalysis Signaling Structure
16 Amino Acids & Proteins Workhorses of cell Catalysis Signaling Structure Energy/Gradient Generation
17 Amino Acids & Proteins Workhorses of cell Catalysis Signaling Structure Energy/Gradient Generation Proteins comprised of amino acids
18 Amino Acids Essential Amino Acids
19 Basics of Structure Elements
20 Basics of Structure Elements Alpha Amino Acids
21 Alpha Carbon Basics of Structure Elements Alpha Amino Acids
22 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids
23 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Alpha Amine
24 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine
25 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine Examples
26 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine Examples
27 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine Examples Alpha Carbon Alpha Carboxyl R Alpha Amine
28 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine Examples Asymmetric Center Alpha Carbon Alpha Carboxyl R Alpha Amine
29 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine Examples
30 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine Examples Alpha Carbon Alpha Carboxyl R Alpha Amine
31 Alpha Carbon Basics of Structure Elements Alpha Carboxyl Alpha Amino Acids Differences in R Groups Alpha Amine Examples Asymmetric Center Alpha Carbon Alpha Carboxyl R Alpha Amine
32 Amino Acids Stereochemistry D and L Isomers
33 Amino Acids Stereochemistry D and L Isomers
34 Amino Acids Stereochemistry D and L Isomers Asymmetric Carbon
35 Amino Acids Stereochemistry D and L Isomers Asymmetric Carbon
36 Amino Acids Stereochemistry D and L Isomers Asymmetric Carbon
37 Amino Acids Stereochemistry D and L Isomers Asymmetric Carbon Almost all biological amino acids are in the L- configuration
38 Categorizing Amino Acids Non-Polar Carboxyl Amine Aromatic Hydroxyl Other Alanine Aspartic Acid Arginine Phenylalanine Serine Asparagine Glycine Glutamic Acid Histidine Tryptophan Threonine Cysteine Isoleucine Lysine Tyrosine Tyrosine Glutamine Leucine Selenocysteine Methionine Pyrrolysine Proline Valine
39 Ionizable R- groups Name Charged R- group Approximate R- group pka Aspartic Acid Glutamic Acid - COO - - COO Lysine Arginine Histidine - NH 3 + =NH 2 + =- NH Cysteine - S Tyrosine - O
40 Amino Acids Aromatic R- Groups Tryptophan Tyrosine Phenylalanine
41 Amino Acids Aromatic R- Groups Alpha Carbon Tryptophan Alpha Amine Alpha Carboxyl Tyrosine Phenylalanine
42 Amino Acids Aromatic R- Groups R Tryptophan R R Tyrosine Phenylalanine
43 Amino Acids Aromatic R- Groups R Charges at Physiological ph Tryptophan R R Tyrosine Phenylalanine
44 Amino Acids Aromatic R- Groups R Charges at Physiological ph Tryptophan R R Ionizes at high ph Tyrosine Phenylalanine
45 Amino Acids Aliphatic R- Groups H Alanine Glycine Proline Isoleucine Leucine Valine Methionine
46 Amino Acids Aliphatic R- Groups H Alanine Glycine Proline Isoleucine Leucine Valine Methionine
47 Amino Acids Aliphatic R- Groups Charges at Physiological ph
48 Amino Acids Aliphatic R- Groups Charges at Physiological ph
49 Amino Acids Aliphatic R- Groups Charges at Physiological ph
50 Amino Acids Aliphatic R- Groups Charges at Physiological ph
51 Amino Acids Aliphatic R- Groups Charges at Physiological ph
52 Amino Acids Aliphatic R- Groups Charges at Physiological ph
53 Amino Acids Aliphatic R- Groups Charges at Physiological ph
54 Amino Acids Aliphatic R- Groups Charges at Physiological ph
55 Amino Acids R- Group Carboxyls Aspartic Acid Glutamic Acid
56 Amino Acids R- Group Carboxyls Aspartic Acid Glutamic Acid
57 Amino Acids R- Group Carboxyls Aspartic Acid Glutamic Acid
58 Amino Acids R- Group Carboxyls R R Aspartic Acid Glutamic Acid
59 Amino Acids R- Group Carboxyls Charges at physiological ph R R Aspartic Acid Glutamic Acid
60 Amino Acids Hydroxyl R- Groups Serine Threonine Tyrosine
61 Amino Acids Hydroxyl R- Groups Serine Threonine Tyrosine
62 Amino Acids Hydroxyl R- Groups Serine Threonine Tyrosine
63 Amino Acids Hydroxyl R- Groups Charges at Physiological ph Serine Threonine Ionizes at high ph Tyrosine
64 Amino Acids Hydroxyl R- Groups Charges at Physiological ph Serine Threonine Ionizes at high ph Tyrosine
65 Amino Acids Sulfhydryl R- Group Cysteine
66 Amino Acids Sulfhydryl R- Group Ionizes at about ph = 8 + Cysteine
67 Amino Acids Carboxamide R- Groups Asparagine Glutamine
68 Amino Acids Carboxamide R- Groups Asparagine Glutamine
69 Amino Acids Carboxamide R- Groups Asparagine Glutamine
70 Amino Acids Carboxamide R- Groups Asparagine Glutamine
71 Amino Acids Carboxamide R- Groups Asparagine Glutamine
72 Amino Acids Ionizable Amine R- Groups Arginine Lysine Histidine
73 Amino Acids Ionizable Amine R- Groups Arginine Lysine Histidine
74 Amino Acids Ionizable Amine R- Groups Charges at Physiological ph Arginine Lysine Histidine
75 Rare Amino Acids
76 Rare Amino Acids
77 Rare Amino Acids
78 Rare Amino Acids
79 Rare Amino Acids
80 Rare Amino Acids
81 Rare Amino Acids
82 Rare Amino Acids
83 Rare Amino Acids
84 Non- Protein Amino Acids
85 Non- Protein Amino Acids Carnitine
86 Non- Protein Amino Acids Carnitine Also - Citrulline, Ornithine, others
87 Amino Acids Ionization
88 Amino Acids Ionization - by pka Values
89 Amino Acids Ionization - by pka Values
90 Amino Acids Ionization - by pka Values
91 Amino Acids Ion Locations in Titration Charge = - 1
92 Amino Acids Ionization - by pka Values Charge = 0
93 Amino Acids Ionization - by pka Values Charge = - 1
94 Amino Acids Ionization - by pka Values Charge = - 2
95 Ionization Changes Charges Within Proteins
96 Ionization Changes Charges Within Proteins Changes in Charge Change Activities
97 Ionization Changes Charges Within Proteins Changes in Charge Change Activities
98 Post- translational Modifications
99 Post- translational Modifications
100 Post- translational Modifications
101 Post- translational Modifications
102 Post- translational Modifications
103 Phosphorylated Amino Acids
104 Phosphorylated Amino Acids
105 Phosphorylated Amino Acids
106 Phosphorylated Amino Acids
107 Phosphorylated Amino Acids
108 Breakdown of Amino Acids
109 Breakdown of Amino Acids
110 Peptide Bond Formation
111 Peptide Bond Formation
112 Metabolic Melody
113 The Amino Alphabet Song (to the tune of "The Alphabet Song") Copyright Kevin Ahern Lysine, arginine and his Basic ones you should not miss Ala, leu, val, ile, and met Fill the aliphatic set Proline bends and cys has 's' Glycine's 'R' is the smallest Then there's trp and tyr and phe Structured aromatically Asp and glu's side chains of R Say to protons "au revoir" Glutamine, asparagine Bear carboxamide amines Threonine and tiny ser Have hydroxyl groups to share These twen-ty amino A's Can combine a zillion ways
114 Metabolic Melody
115 You re Cysteine To the tune of You re Sixteen Copyright Kevin Ahern
116 You re Cysteine To the tune of You re Sixteen Copyright Kevin Ahern You re in every protein That I ve ever seen There s no need to debate You re cysteine, a building block, and you re great You give the hair waves It s something we crave Makes the food on my plate You re cysteine, a building block, and you re great Bridge That sulfhydryl in your chain Can oxidize, but I don t complain It gives support to all peptides So proteins need to have disulfides
117 You re Cysteine To the tune of You re Sixteen Copyright Kevin Ahern You re in every protein That I ve ever seen There s no need to debate You re cysteine, a building block, and you re great You give the hair waves It s something we crave Makes the food on my plate You re cysteine, a building block, and you re great Bridge That sulfhydryl in your chain Can oxidize, but I don t complain It gives support to all peptides So proteins need to have disulfides You re an acid it seems And have an amine Please don t ever mutate You re cysteine, a building block, and you re great Bridge A U-G-U or U-G-C In secret code at the cell's decree You re in my skin and in my bone And even in my glutathione You re in every protein That I ve ever seen There s no need to debate You re cysteine, a building block, and you re great
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