Life Sciences Outlook. Raleigh-Durham 2015

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1 Life Sciences Outlook Raleigh- 2015

2 Raleigh- The Raleigh- life sciences cluster is familiarly called the Research Triangle Region, due to the geographic nexus of the area s three leading research institutions: Duke University, North Carolina State and the University of North Carolina at Chapel Hill. The rich talent pool, stable socioeconomic structure, proximity to universities and high quality of life has attracted major players to the area. The Triangle s universities and research facilities continue to invest in expanding life sciences research. Orange County 85 South 40 RPT/RDU North Downtown Glenwood / Creedmoor 6 Forks Falls of Neuse Route 1 Major lab supply: Clusters of established lab stock with long-time industry presence Emerging lab supply: Areas with limited lab stock today that are poised for growth Cary West Downtown Raleigh Raleigh 440 East Raleigh Life Sciences manufacturing supply: Clusters of manufacturing space devoted to pharmaceutical, biological or medical device & instrument manufacturing is the new hub of the Life Sciences sector in the Triangle. Two high-profile projects, The Chesterfield and ID, are redeveloping the area to stimulate further growth. Duke University and Duke Medicine are the current anchor lab tenants in this submarket. RTP/ RDU is home to nearly 75.0 percent of the region s lab space. Agro-biotech firms have displayed strong growth in the past few years. This submarket is home to four of the top five ag-tech companies, including Syngenta, Bayer CropScience, BASF and Monsanto. The area is seeing little new lab supply under construction, along with increased demand for lab space, tightening the market. The majority of the lab spaces in this submarket is owner-occupied and includes manufacturing space devoted to pharmaceutical, biological or medical device & instrument manufacturing. West Raleigh West Raleigh s life sciences sector is clustered around the NC State University s Centennial Campus. The Campus is a core research-oriented microregion, and the lab product is a mix of biotechnology and biomedical research, nanotechnology and advanced materials, environmental health, smart systems and information technology. JLL Raleigh- Life Science Outlook

3 Economic scorecard Workforce Total life sciences % life sciences to private employment Year-overyear growth Employment 31, % 17.9% Establishments % 4.9% Funding Total life sciences % to total U.S. VC funding $295.0M 20.8% NIH funding $537.4M 2.4% Cluster score: 66.4 As the local economy and funding environment has improved, multiple small and early stage companies were established in the past few years. The vibrant local urban environment has led to strong in-migration of younger generations of the workforce. Strong ties between the educational and private institutions helped to recruit, train and retain talent locally. Innovation Total life sciences % to all patent classes Patents % Universities in the Triangle have pursued ways to spark interdisciplinary collaborations with the private sector, creating new public and private sector jobs. Institutions like North Carolina State University s Bio-manufacturing Training and Education Center provide training opportunities to develop skilled professionals, attracting firms looking for a well-trained workforce. Life sciences employment composition 38.0% 7.0% Life sciences employment 31, % 6.0% 24.0% 20.0% non-lab using lab using Pharma & medicine manufacturing Electromedical instrument manufacturing Medical equipment & supplies manufacturing Testing laboratories Research & development Medical & diagnostic laboratories Life sciences patents by classification 68.0% 1.5% Life sciences patents % Medical equipment & instruments Pharmaceuticals & biotechnology Crop science Funding to support Research and Development in the market is a combination of pubic and private sources. The local universities have helped researchers and entrepreneurs build worldclass companies in the Triangle. As one of the hottest markets for Biotech research, potential investors will find this an attractive market in which to invest. JLL Raleigh- Life Science Outlook

4 Raleigh- New mixed-use development provides opportunities for biotech firms, known for drawing technology and startups, is bringing new high profile redevelopment projects that aim at attracting life sciences and biotechnology companies. The Chesterfield, a 284,000-square-foot historic building in, is being renovated to a mixed-use office and lab facility. This seven-story former tobacco factory is expected to complete its renovations by early Innovation District, a 15-acre project located west of Downtown, will function as a research hub and collaborate closely with Duke University. More than 115,000 square feet renovations of laboratory space at Main Street and Carmichael Buildings are planned. Growth, driven by increased investment, means new developments are needed, known for its manufacturing and large headquarter campuses, continues to experience steady growth. Leasing activity is prominent among small and mid-tier area tenants, while mature corporations are right-sizing based on their competitive landscape. The investment and owner-user sales activity were on track with previous years. Argos Therapeutics purchased their nearly 100,000-square-foot headquarters and manufacturing facility that is currently under construction for $7.6 million from the developer, The Keith Corp. Locally, funding by investors is largely focused on the smaller drug and medical device developers. Viamet, Sprout and Vascular are some of the pharmaceutical firms that recently received funding. The larger corporations continued to consolidate their positions with mergers and acquisitions. No new speculative lab developments have broken ground so far, though there is a reasonable need for new lab facilities in the market. Facilities scorecard Supply Rentable lab stock (% of total stock) Direct vacancy (Change year-over-year) QUINTILES 5927 S Miami Blvd 31,643 s.f. Expansion in Imperial Center Business Park 701 W Main Street (The Chesterfield) 284,000 s.f. available Class A *under renovation Raleigh- Major lab 9.92 m.s.f. 20.6% 16.5% (1.8) ppts # of large blocks over 100,000 s.f. 23 Under construction (s.f.) Demand # of requirements Total s.f. requirements Pricing Average asking rent (NNN) (Change year-over-year) Activity key: Leasing Sales 0 m.s.f m.s.f. $18.98 p.s.f. (3.4)% Syngenta Biotechnology 629 Davis Drive 94,915 s.f. Renewal ARGOS THERAPEUTICS 1733 TW Alexander Drive Class A 97,500 s.f. *investing $57 million in a new bio manufacturing plant Under construction Large blocks of space JLL Raleigh- Life Science Outlook

5 For more information, please contact: Mehtab Randhawa Research Manager Raleigh +1 (919) About JLL JLL (NYSE: JLL) is a professional services and investment management firm offering specialized real estate services to clients seeking increased value by owning, occupying and investing in real estate. With annual fee revenue of $4.0 billion and gross revenue of $4.5 billion, JLL has more than 200 corporate offices, operates in 75 countries and has a global workforce of approximately 53,000. On behalf of its clients, the firm provides management and real estate outsourcing services for a property portfolio of 3.0 billion square feet, or million square meters, and completed $99.0 billion in sales, acquisitions and finance transactions in Its investment management business, LaSalle Investment Management, has $50.0 billion of real estate assets under management. JLL is the brand name, and a registered trademark, of Jones Lang LaSalle Incorporated. For further information, visit About JLL Research JLL s research team delivers intelligence, analysis and insight through market-leading reports and services that illuminate today s commercial real estate dynamics and identify tomorrow s challenges and opportunities. Our more than 400 global research professionals track and analyze economic and property trends and forecast future conditions in over 60 countries, producing unrivalled local and global perspectives. Our research and expertise, fueled by real-time information and innovative thinking around the world, creates a competitive advantage for our clients and drives successful strategies and optimal real estate decisions. This publication is the sole property of Jones Lang LaSalle IP, Inc. and must not be copied, reproduced or transmitted in any form or by any means, either in whole or in part, without prior written consent of Jones Lang LaSalle IP, Inc. COPYRIGHT JONES LANG LASALLE IP, INC. 2015

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