Does a higher rate of reported transfusion reactions mean a hospital is safer?
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1 Does a higher rate of reported transfusion reactions mean a hospital is safer? Johanna (Jo) Wiersum-Osselton TRIP Hemovigilance and biovigilance office
2 Outline Hemovigilance reporting in The Netherlands Study: does a higher rate of reported transfusion reactions mean that a hospital is safer? Achieving safety improvement: SHOT France Within-hospital learning? What are the ingredients for avoiding errors? How can we bring about improvement?
3 Reports per year Reports per 1000 units distributed After ten years Total reports Serious reports (grade 2,3,4) Reports per 1000 units Still counting, no apparent improvement: no reduction in numbers of reports Is there a parameter which could indicate safety of blood transfusion?
4 Reports 70 Variation in rate of reports per 1000 units Serious TR (excl alloantibodies and mild NHFR) Units transfused
5
6 TR per 1000 units in Consistency from year to year Consistency from year to year: Linear regression of rate in 2010 with 2009, and blood use level: R 2 = 0.55 (p<0.001) TR per 1000 units in 2009 TR = transfusion reactions: definite, probable or possible, excluding new allo-antibodies and mild febrile reactions
7 % of hospitals Analysis of data TR reporting rate (reports per 1000 units) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% > to 3.7 <1.8 Hospital annual blood use (total units) TR = transfusion reactions: definite, probable or possible, excluding new allo-antibodies and mild febrile reactions
8 % of hospitals 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% Are hospitals with more TR reports safer? Incorrect blood component transfused a possible proxy for unsafe transfusion OR 2.5 ( ) OR 4.2 ( ) adjusted odds ratios Vox Sanguinis < to 3.7 >3.7 Rate of transfusion reaction reporting No IBCT 1 or more Conclusion: the data do not support that hospitals with a higher rate of transfusion reaction reports are safer
9 Hospital factors associated with higher likelihood of IBCT report Presence of transfusion safety officer 1-4 years adjusted OR 2.8, 95% CI vs no TSO All years adjusted OR 2.2, 95% CI vs no TSO Hospital also reported near miss or other incident Near miss adjusted OR 14.2, 95% CI Other incident OR 15.0, 95% CI Hospital also reported alloantibody formation or mild non-hemolytic febrile reactions (<2 o C) Conclusion: Consistent with better surveillance and more complete reporting; it cannot be excluded that hospitals with higher rates of transfusion reactions may have more incorrect transfusions to report.
10 Serious reactions and incidents (adverse events) Other reactions and incidents Reporting/ consultation Recalls and lookbacks TRIP Foundation A reporting system is not in itself a measure to reduce errors and transfusion reactions TRIP report; annual overview Board/ HV Advisory Board EU reporting Ministry of Health Sanquin Possibly product-related Hospital/ Treating physician TRIP office Healthcare Inspector ate
11 Reports per 1000 units transfused Consistency of reporting rate n=97 hospitals TR rate Reporting level in 2006 Level 1 <1.8 TR/1000 u Level TR/1000 u Level 3 >3.7 TR/1000 u TR = transfusion reactions: definite, probable or possible, excluding new allo-antibodies and mild febrile reactions
12 Data from SHOT All other IBCT cases ABO incompatible red cell transfusions
13 ABO incompatibility (France) Reduction of ABO incompatible RBC transfusions France RBC Plasma Platelets Contrôle ultime of ABO compatibility at bedside (since 1985); ministerial circular in 2003 stressed importance of identification of patient/unit
14 Incident reports to TRIP Incidents Hospitals with reports (ever) Incorrect blood component transfused ABO-risk* ABO incompatible RBC transfusion Near miss Other incident # *TRIP assessment: risk to which the patient was exposed # includes unnecessary transfusions and (SHOT term) right blood right patient
15 Yes and no
16 Transfusion safety Primary prevention Only transfuse if necessary Blood component Bloed transfusion laboratory: component selection Adhere to protocols, don t allow yourself to be distracted Patient safety culture Secondary prevention Premedication (?) Component selection Speed of transfusion etc. Tertiary prevention Monitor patient Respond appropriately Training Professionals Management
17 No. of TRALI (incl. possible TRALI) Transfuson-related acute lung injury (TRALI): male-only plasma FFP (and other bc) no FFP Before after Prior to change P.A.R (95% CI ) TRANSFUSION 2011;51:
18 No. of TRALI International consensus definition: possible TRALI = ALI within 6h of Tf, in presence of other risk factors: Direct Lung Injury aspiration, pneumonia, toxic inhalation, lung contusion, near drowning Indirect Lung Injury severe sepsis, shock, multiple trauma, burn injury, acute pancreatitis, cardiopulmonary bypass, drug overdose FFP (and other bc) no FFP 5 0 Before After After excluding cases of possible TRALI P.A.R ( ) TRANSFUSION 2011;51:
19 Hemovigilance data and bacterial contamination Use of hemovigilance data to evaluate the effectiveness of diversion and bacterial detection (Québec) Robillard P et al, Transfusion 2011; 51: In NL: bacterial screening, diversion pouch and improved skin preparation introduced in 2001 After introduction of diversion the number of positive screening cultures [of platelet concentrates] decreased significantly from 0.85% to 0.37%. De Korte D et al, Transfusion Med and Hemotherapy 2011; 38:
20 M. Ruesch, IHS Amsterdam >Implementation of pathogen reduction
21 M. Ruesch et al, IHS Brussels 2013 Transfusion reactions Switzerland: transfusion reactions associated with platelets cpcs 2011 & 2012 PI-PCs PCs TRIP 2011 Units transfused 66,000 62, distributed All definite / probable reports Definite/ probable grade 3 reports Septic transfusion reactions (n) Reports Rate per 1000 Reports Rate per 1000 Rate per N=4 N=0 N=1 PC=platelet concentrate cpc=conventional platelet concentrate PI-PC=Intercept Pathogen-Inactivated platelet concentrates
22 Units distributed in NL 700 Optimal blood use Major role of blood transfusion committee and transfusion safety officer RBC plasma Platelets
23 Quality indicators for blood transfusion practice Indicator 5 Indication setting for RBC transfusion: percentage of transfusions with pre-transfusion Hb level 6 mmol/l ( 9.6 g/dl) Revised national transfusion guideline Please also visit Poster no 2-22
24 78% of hospitals voluntarily provided data: transfusion committee 96% TSO appointed 85%
25 Number of reports Recommendation 2004: Kell negative or Kell compatible 2011: Rhesus c negative or compatible New alloantibody formation in women aged <45 years Year of transfusion
26 Where next Limitations of HV data Lack of info about uncomplicated transfusions! Problems of underreporting, incomplete information Keep up good data collection (improve efficiency if possible) Results accessible for policymakers and professionals Apply lessons learned: Implement measure Evaluate Tweak Act Plan Do Check
27 Vigilance In Progress IHN initiative representatives of HV systems with data Data comparisons Shared research projects Evaluating measures Donor and recipient HV Kick-off meeting Friday 7th March If you are interested in participating or in receiving information: or
28 Acknowledgements TRIP colleagues Hospital HV officers and TSOs in The Netherlands Colleagues from IHN member systems
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