Centre for Process Innovation

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2 Centre for Process Innovation Frank Millar Operations Director 2016 Centre for Process Innovation Limited. All Rights Reserved.

3 Who are CPI? CPI is a UK technology innovation centre and the Process Industry element of the Government s High Value Manufacturing Catapult. OPENING 2017 National Printable Electronics Centre National Industrial Biotechnology Facility National Biologics Manufacturing Centre National Formulation Centre We use applied knowledge in science and engineering combined with state of the art facilities to enable our clients to develop, prove, prototype and scale-up the next generation of products and processes.

4 Technology Readiness Levels (TRL) Technology Readiness Level 4-7 (Valley of Death) CPI helps companies succeed where many otherwise fail System prototype demonstration in an operational environment System prototype demonstration in an operational environment System model or prototype demonstration in a relevant environment Component validation in relevant environment Component validation in laboratory environment

5 CPI Industrial Biotechnology and Biorefining Services State of the Art Landscaping Engineering Assessment Scale-up and Scale-down Technology Selection Techno Economic Evaluation Process Modelling Demonstration Process Efficiency

6 National Industrial Biotechnology Facility Demonstrator Facility Pilot Facility 10,000 litre fermentation facilities Process Development Shake flasks to 10 litre fermenters Downstream processing equipment Analytical Capabilities litre fermentation facilities Pilot scale solvent extraction facilities Flexible plug and play downstream capabilities for: Solid / liquid separation Fractionation and extraction Clarification, purification and concentration Upstream processing capabilities for solids, slurries, aggregates and liquids Pilot scale distillation Demonstration of process and product Inline analytical technologies Downstream processing capabilities for: Solid / liquid separation Fractionation and extraction Clarification and concentration

7 C1 Gas Laboratory Process development at 1-10 litre scales Use of C1 gases and hydrogen feedstocks Traditional carbohydrate growth substrates

8 Anaerobic Digestion Development Centre Development Lab Lab scale projects Dedicated Gas Chromatography Analysis Suite of analytical equipment capability Pilot & Demonstrator Facility Pre-treatment Feedstock preparation vessels Shredder / Macerator Digestion Vertical CSTR digesters up to 1500l Horizontal digester 4000l Post Digestion Storage Screw press Scroll decanter Membrane gas holder Wednesday, 10 February 2016

9 How do you access CPI? Collaborative Research & Development IB Catalyst H2020 Innovate UK Private Partnerships Prepared Contract Terms Sample production Know How Wednesday, 10 February 2016

10 Planned Facilities D Loop Continuous Gas Reactor Wednesday, 10 February 2016

11 Calysta Gas Fermentation Pilot ; Product: Microbial Protein Work stream 1: Engineering Feasibility Study Work stream 2: Pilot Plant design, Build & Commissioning Work stream 3: Technical Transfer of process & Pilot Plant operation Work stream 4: Research &Development studies D-LOOP Gas Lab/NIBF2 + =

12 Terra Verdae Working with CPI Terra Verdae developed a unique and sustainable industrial production platform for the conversion of waste-derived "green" methanol into biodegradable plastic, and other biobased products. The company s focus was on the biodegradable plastic polyhydroxybutyrate (PHB) and development of PHB derivatives, (co)polymers, and composites for the rapidly emerging biomaterials market. Wednesday, 10 February 2016

13 Summary of CPI Reduce risk before investing large sums of money on new facilities by demonstrating and refining novel technologies Proof of concept and process scale-up showing that new concepts are feasible before approaching potential investors, stakeholders or funding programmes Decrease the time to market for a novel product or process by accessing proven demonstration assets and key expertise

14 Thank you... For more information, please visit

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