The Sisene Biotechnology Experience
|
|
- Moris Floyd
- 7 years ago
- Views:
Transcription
1 The Sisene Biotechnology Experience Jean Marsac, MD PhD CEO, Sisene Pépinière Paris Santé Cochin, Paris, France Olivier Rixe, MD, PhD Director, Experimental Therapeutics Program GRU Cancer Center, Augusta, GA
2 Disclosure Jean Marsac : none Olivier Rixe : consultant, stockholder, Sisene Oncology 2
3 Sisene Company Profile 2007 Creation of SISENE, a Biotechnology Company developing new patented drugs in cancer and ophthalmology. Founded in 2007 by Jean Plouët, MD, PhD Pioneer of angiogenesis research in France. Co-discoverer of Vascular Endothelial Growth Factor (VEGF). Exclusive license of two patents (CNRS, INSERM, IVS) : Novel anti-angiogenic agent and its use, in particular in cancer treatment NOV and NOV C-ter, in preclinical development. Mutated Netrin-4, fragments thereof and their use as medicines. Two products with innovative non VEGF-dependent mechanisms of action : NOV C-ter : solid tumors, inflammatory and neovascular eye diseases. Netrin-4 : neovascular eye diseases. From Proof of concept to Clinical Phase employees, including 5 full-time researchers. 3
4 Sisene Corporate Pipeline Objectives Development of innovative anti-angiogenic products for cancer and eye diseases treatment Mode of Action Targeting cancer cells and microenvironment Inhibiting neovascularization Products NOV/NOV C-ter Netrin-4 Clinical Targets Fast-track in Glioblastoma Other cancers Eye diseases 4
5 Accelerated development. Sisene Corporate Strategy SISENE focuses on Target Product profiles: Oncology therapeutics: Glioblastoma Ophthalmology therapeutics: Angiogenic (AMD), inflammatory lesions of the eye (Uveitis) Fast track registration: First entering the clinic with a glioma cancer indication. Strategic alliance with a big Pharma. 5
6 Sisene Private and Public Partnerships Private Industry Academic Research Teaching Hospitals 6
7 Private and Public Partnerships Private Industry: THEA Lab. (Leading independent Ophthalmic Group in Europe). Academic Research: Teaching Hospitals : Georgia Health Sciences University (GHSU), National Cancer Institute (NCI), University of Cincinnati (UC), INSERM, Paris V and Paris VI Universities. Cohortes of patients, Phase I clinical units, Complementary clinical research : Predictive markers, Dose-responses studies, Safety-efficacy margin in patients, Medico-economic assessment. 7
8 Innovation Financial Tools and Support JEI : Young innovative company status Incubator : Lodge new start-ups companies OSEO : Public financial innovation support CIR : Research Tax Credit Various Research Grants : French (national ANR, regional Critt) USA (research alliance GHSU) University Hospitals : Specific clinical research budget for clinical trials (proof of concept) Eligible : SME, < 8 years old, independant, R&D expenses > 15% deductible charges Eligible : after scientific evaluation Refund : in case of commercial success Eligible : after scientific evaluation Principles : 35% - 50% of R&D expenses Refund : balance after commercial success Eligible : after scientific evaluation Principles : 40% - 35% - 30% of R&D costs No refund (subvention) Eligible : after scientific evaluation No refund (subvention) Eligible : after scientific evaluation No refund (subvention) 8
9 EVENTS Sisene Biotech Early Development Financing FINANCING YEARS : Minister of Research Incubator Paris Biotech Industrial partner (THEA) 2007/ Creation Innovation Awards & Support Seed Money K US / NIH Grants CRADA Three year financing plan Creation Sisene Onco Inc. US - GHSU US dev. financing Innovation support (OSEO) Industrial partner (THEA) Research Tax Credit (CIR) K Grants : ANR / Critt / Cifre US Res. Agreement CRITICAL PATH Preclinical Development IND Possible financing gap! IND? 9
10 Sisene Biotechnology perspectives Implement a partnership through GHSU Georgia University. Speed-up the registration process through an investigator IND. Focus on fast track procedure on Glioblastoma. Consolidate a strategic alliance with a big pharma : To work on additional developments in Oncology. To optimize the time to market and the first commercial revenues. 10
11 Nov C-Ter NOV/CCN3 is a founder member of a multimodular secreted proteins family: CCN (CYR61, CTGF, NOV): N IGFBP VWC Hinge TSP-1 CT C NOV NOV C-ter consists of a truncated NOV containing the thrombospondin (TSP-1) and C-terminal (CT) domains: TSP-1 CT C NOV C-ter 11
12 Nov C-Ter Physiology NOV C-ter is detected in human biological fluids (serum, cerebrospinal fluid ). NOV NOV C-ter is physiologically detected in many tissues (brain, heart, kidney, adrenal cortex ). Pathology NOV C-ter Human serum (protein) NOV C-ter mediates NOV anti-tumor activities in several models such as: Anti-proliferative activity Human Glioblastoma (Bleau et al. 2007). Pro-apoptotic activity Human Adrenocortical Cancer (Doghman et al. 2007). Thibout et al
13 Inhibition (%) Inhibition (%) Milestone #1: NCI - Mechanism of Action (1) Endothelial cells proliferation and migration: Proliferation 0,5 µm 5 µm Migration Tube formation assay (tested in Human, Porcine and Macaque endothelial cells) in vitro: ,5 µm 5 µm - FBS 1% FBS 1% FBS NOV C-ter 1μg/ml 1% FBS NOV C-ter 5μg/ml 1% FBS NOV C-ter 10μg/ml 1% FBS NOV C-ter 80μg/ml PAE cells, 4 hours treatment 13
14 Milestone #2 : UCCI - Anti-tumor effect (GBM) Confirm the efficacy of NOV C-ter (125µg/injection) Evaluate the efficacy of a lower dose (12.5µg/injection) Human Xenograft Model (X12) Sham PBS NOV C-ter 125µg Day 9 Sham: stereotaxic surgery without tumor cells injection. No toxic effect of NOV C-ter has been observed. 14
15 Milestone #3 : GRU Cancer Center Incorporation of Sisene Oncology in the US (Augusta, GA) GRA Grant Ongoing experiments Zebrafish nodel Validation on other in vivo models Toxicology studies Additional mechanistic studies (in vitro) 15
16 HUVEC Proliferaiton inhibition (%) Milestone #4 : NCI - Mechanism of Action (2) NOV C-ter Dose: 5µM A new class of agent VEGF bfgf Adrenomedullin (AM) Apelin-13 Apelin N- terminal fragment 16
17 Mechanism of Action (3) A new class of agent NOV C-ter an original mode of action in endothelial cells: NOV C-ter inhibits Adrenomedullin- and Apelin-induced endothelial cells proliferation. VEGF and AM-induced MAP Kinase and Akt phosphorylation are inhibited by NOV C-ter. P-AKT P-p44/42 Total AKT Total p44/42 NOV-CT 100ug/ml AM 10nM NOV-CT 100ug/ml VEGFA 10ng/ml NOV-CT 100ug/ml AM 10nM VEGFA 10ng/ml Ctl NOV-CT 100ug/ml AM 10nM NOV-CT 100ug/ml VEGFA 10ng/ml NOV-CT 100ug/ml AM 10nM VEGFA 10ng/ml Ctl 17
18 Thank you! 18
Peptide and Sustained Release Technology to Treat Ocular Diseases and Cancer
Peptide and Sustained Release Technology to Treat Ocular Diseases and Cancer Jordan Green, PhD, Co-Founder and CEO Wendy Perrow, MBA, Senior Business Advisor February 11, 2015 www.asclepix.com Advantages
More informationTargeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma
The Use of Kinase Inhibitors: Translational Lab Results Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma Sheelu Varghese, Ph.D. H. Richard Alexander, M.D.
More informationAchieving Regulatory Success: Areas of focus for biotechnology companies. Michael J. Schlosser, PhD, DABT April 21, 2013
Achieving Regulatory Success: Areas of focus for biotechnology companies Michael J. Schlosser, PhD, DABT April 21, 2013 Regulatory Success Outline Regulatory Initiatives Regulatory Science Pre-Regulatory
More informationHow To Treat Mesothelioma With A Tumor Stem Cell Inhibitor
FAK INHIBITOR DEFACTINIB (VS-6063) TARGETS MESOTHELIOMA CANCER STEM CELLS Rationale for maintenance therapy after conventional therapy Jonathan Pachter, Ph.D. Vice President of Research, Verastem, Inc.
More informationTHE CANCER STEM CELL INHIBITORS VS-6063 AND VS-5584 EXHIBIT SYNERGISTIC ANTICANCER ACTIVITY IN PRECLINICAL MODELS OF MESOTHELIOMA
THE CANCER STEM CELL INHIBITORS VS-6063 AND VS-5584 EXHIBIT SYNERGISTIC ANTICANCER ACTIVITY IN PRECLINICAL MODELS OF MESOTHELIOMA Mitchell Keegan, Ph.D. Vice President of Development, Verastem, Inc. 1
More informationEudendron: an Innovative Biotech Start-up
Eudendron: an Innovative Biotech Start-up Mauro Angiolini & Fabio Zuccotto I Venti dell Innovazione, Ville Ponti - Varese, 20 Marzo 2013 Bioindustry Park S. Fumero (Ivrea) - Italy Eudendron: a Quick Description
More informationNew Advances in Cancer Treatments. March 2015
New Advances in Cancer Treatments March 2015 Safe Harbour Statement This presentation document contains certain forward-looking statements and information (collectively, forward-looking statements ) within
More informationThe Commercialization of Technology Concepts into Medical Products
The Commercialization of Technology Concepts into Medical Products Kevin J. Scanlon, Ph.D. New Zealand 2006 International BioScience Overview Pharmaceutical Industry Biotechnology Startups Investment Community
More informationNuevas tecnologías basadas en biomarcadores para oncología
Nuevas tecnologías basadas en biomarcadores para oncología Simposio ASEBIO 14 de marzo 2013, PCB Jose Jimeno, MD, PhD Co-Founder / Vice Chairman Pangaea Biotech SL Barcelona, Spain PANGAEA BIOTECH BUSINESS
More informationPh.D. in Molecular Medicine
Ph.D. in Molecular Medicine and Translational Research College of Medicine 1. Introduction: The College of Medicine, while consolidating on its undergraduate innovative educational programs, decided to
More informationExelixis Showcases R&D Pipeline at JPMorgan Healthcare Conference
Exelixis Showcases R&D Pipeline at JPMorgan Healthcare Conference Two New Clinical Programs and Significant Expansion of Cancer Pipeline Planned for 2004 SOUTH SAN FRANCISCO, Calif., Jan. 13 /PRNewswire-FirstCall/
More informationCellectar Biosciences
Cellectar Biosciences NASDAQ: CLRB October 2015 1 Safe Harbor Statement This slide presentation contains forward-looking statements. Such statements are valid only as of today, and we disclaim any obligation
More informationEVT Execute & EVT Innovate World-class drug discovery
EVT Execute & EVT Innovate World-class drug discovery Evotec AG, First Quarter Report 2015, 12 May 2015 Forward-looking statements Information set forth in this presentation contains forward-looking statements,
More informationCellectar Biosciences
Cellectar Biosciences NASDAQ: CLRB September 2015 1 Safe Harbor Statement This slide presentation contains forward-looking statements. Such statements are valid only as of today, and we disclaim any obligation
More informationFDA approves Lucentis (ranibizumab injection) for treatment of diabetic macular edema
Media Release Basel, 13 August 2012 FDA approves Lucentis (ranibizumab injection) for treatment of diabetic macular edema First major treatment advance in more than 25 years for sight-threatening condition
More informationManagement Discussion and Analysis of the Financial Condition and Results of Operations
Management Discussion and Analysis of the Financial Condition and Results of Operations Fiscal 2014 First Quarter for the three months ended July 31, 2013 Table of Contents Overview 1 Forward looking Statements
More informationICH Topic S 1 A The Need for Carcinogenicity Studies of Pharmaceuticals. Step 5
European Medicines Agency July 1996 CPMP/ICH/140/95 ICH Topic S 1 A The Need for Carcinogenicity Studies of Pharmaceuticals Step 5 NOTE FOR GUIDANCE ON THE NEED FOR CARCINOGENICITY STUDIES OF PHARMACEUTICALS
More informationCLINICAL TRIALS SHOULD YOU PARTICIPATE? by Gwen L. Nichols, MD
CLINICAL TRIALS SHOULD YOU PARTICIPATE? by Gwen L. Nichols, MD Gwen L. Nichols, M.D., is currently the Oncology Site Head of the Roche Translational Clinical Research Center at Hoffman- LaRoche. In this
More informationPROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S.
PROSPETTIVE FUTURE NEL TRATTAMENTO MEDICO DEL mrcc Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. Candiolo Future strategies in mrcc Improve therapeutic
More informationA Letter from MabVax Therapeutics President and Chief Executive Officer
A Letter from MabVax Therapeutics President and Chief Executive Officer Dear Fellow Stockholder: You have invested in MabVax Therapeutics because you share our passion for finding new therapies for the
More informationCareer Opportunities within the French Alliance for Life and Health Sciences
1 Career Opportunities within the French Alliance for Life and Health Sciences Mireille Guyader, PhD Director, Inserm-USA Office INSERM KEY FIGURES (Year 2013) Budget: 970 M (~ $1.2 Billion) Human resources:
More informationGroundbreaking Collaborative Clinical Trial Launched
Groundbreaking Collaborative Clinical Trial Launched For immediate release Media Contacts: June 16, 2014 Richard Folkers Alison Hendrie 9:00 a.m., EDT Foundation for the NIH Rubenstein Communications (301)
More informationINTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE S1A. Current Step 4 version
INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE ICH HARMONISED TRIPARTITE GUIDELINE GUIDELINE ON THE NEED FOR CARCINOGENICITY STUDIES
More informationHP8 herbal formula selectively inhibits prostate cancer cell line proliferation by inducing G2/M cell cycle arrest.
HP8 herbal formula selectively inhibits prostate cancer cell line proliferation by inducing G2/M cell cycle arrest. Flowers A, Banbury L, Leach D and Waterman P. Centre for Phytochemistry and Pharmacology,
More informationHigh Grade Gliomas: Update in Treatment and Care Ryan T. Merrell, M.D. Clinical Assistant Professor of Neurology NorthShore University HealthSystem
High Grade Gliomas: Update in Treatment and Care Ryan T. Merrell, M.D. Clinical Assistant Professor of Neurology NorthShore University HealthSystem rmerrell@northshore.org Objectives Provide updates on
More informationContact Information Korea Health Industry Development Institute
AGM-130, a novel CDK inhibitor with a marked anti-tumor activity and reduced toxicity, targeting the triple negative breast cancer(tnbc) and tamoxifen-resistant estrogen receptor (ER) positive breast cancer
More informationDevelopment of the Anti- Parasitic Drug Mebendazole for High Grade Glioma Therapy
Development of the Anti- Parasitic Drug Mebendazole for High Grade Glioma Therapy Seminar for Neuro-Oncology Updates Meeting, Nashville, TN September 16, 2011 Gregory J. Riggins M.D., Ph.D. E-mail- griggin1@jhmi.edu
More informationTranslational research infrastructure in Neurosciences 15.06.2011/Bruxelles
ITMO Neurosciences, sciences cognitives, neurologie, psychiatrie Translational research infrastructure in Neurosciences 15.06.2011/Bruxelles ITMO Technologie pour la santé 1 NEUROSCIENCE MEDICAL CHALLENGES
More informationTITLE: Treatment of Prostate Cancer with a DBP-MAF-Vitamin D Complex to Target Angiogenesis and Tumorigenesis
AD AWARD NUMBER: W81XWH-04-1-0010 TITLE: Treatment of Prostate Cancer with a DBP-MAF-Vitamin D Complex to Target Angiogenesis and Tumorigenesis PRINCIPAL INVESTIGATOR: Michael W. Fannon, Ph.D. CONTRACTING
More informationThe Clinical Trials Process an educated patient s guide
The Clinical Trials Process an educated patient s guide Gwen L. Nichols, MD Site Head, Oncology Roche TCRC, Translational and Clinical Research Center New York DISCLAIMER I am an employee of Hoffmann-
More informationA career on the science park
A career on the science park Onno van de Stolpe December 2014 Copyright 2014 Galapagos NV 1987 MOGEN Agricultural biotech pioneer Design of transgenic plants with improved traits Close link with Prof Schilperoort
More informationBiotech Short Profile
The Company X is leading the development of next generation biological therapies and production systems. The Company is in two pivotal Phase III clinical studies in colorectal cancer for a unique anticancer
More informationSpinning out in the UK personal experiences and perspectives
Professor Neil A. Williams Head of Department of Cellular and Molecular Medicine Founder, Director of Science, KWS BioTest Ltd Founder, Aegis (Hunter-Fleming) Pharmaceuticals Ltd Spinning out in the UK
More informationMOLOGEN AG German Equity Forum 2015
German Equity Forum 2015 Dr. Mariola Söhngen Chief Executive Officer Frankfurt am Main 24 November 2015 We are Pioneers in the Field of Immunotherapies Biotechnology company with focus on immunotherapies
More informationAffitech A/S reports financial result for the first six months of 2012
Release no. 23/2012 Affitech A/S reports financial result for the first six months of 2012 Clinical trials sites initiated in Russia in late June 2012 by Affitech s collaboration partner IBC Generium for
More informationSMALL BUSINESS INNOVATION RESEARCH (SBIR) SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) GRANT APPLICATIONS
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES PHS 2015-2 OMNIBUS SOLICITATION OF THE NATIONAL INSTITUTES OF HEALTH, CENTERS FOR DISEASE CONTROL AND PREVENTION, FOOD AND DRUG ADMINISTRATION, AND ADMINISTRATION
More informationCompany Presentation June 2011 Biotest AG 0
Company Presentation June 2011 0 Disclaimer This document contains forward-looking statements on overall economic development as well as on the business, earnings, financial and asset situation of and
More informationCurriculum Vitae. Prof. Dr. Bernhard Kutscher, Ph.D. Personal Details. Education
Curriculum Vitae Prof. Dr. Bernhard Kutscher, Ph.D. Personal Details Private Address: Date, Place of Birth: Marital Status: Nationality: Languages: Stresemannstraße 9, 93477 Maintal, Germany, Tel. +49
More informationMedical Therapies Limited EGM Presentation
Medical Therapies Limited EGM Presentation Maria Halasz Chief Executive Officer 5 May 2009 1 Agenda 1. Company information 2. Recent developments 3. Business strategy 4. Key value inflection points for
More informationa Phase 2 prostate cancer clinical trial is ongoing. Table 2: Squalamine vs Standard-of-care literature
PRODUCT FACT SHEET Spring 2007 MISSION STATEMENT Genaera Corporation is a biopharmaceutical company with a focus on metabolic and respiratory diseases. The compounds in the Genaera pipeline address signal
More informationAvastin in breast cancer: Summary of clinical data
Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading
More informationReissuance of RFA-CA-08-504 Adult Brain Tumor Consortium
Reissuance of RFA-CA-08-504 Adult Brain Tumor Consortium Bhupinder S Mann, MBBS GU, HN and Adult Brain Cancers Therapeutics Clinical Investigations Branch CTEP DCTD NCI William C Timmer, PhD ABTC Program
More informationBioWorld s PARTNER in FOCUS: Covance AN ADVERTISING SERVICE FROM BIOWORLD
BioWorld s PARTNER in FOCUS: Covance AN ADVERTISING SERVICE FROM BIOWORLD PARTNERING Trend Allows Smart CROs TO Provide Gamut of Services TO Any Size COMPANy Five years ago, contract research organizations
More informationCOMMITTEE FOR PROPRIETARY MEDICINAL PRODUCTS (CPMP) NOTE FOR GUIDANCE ON THE PRE-CLINICAL EVALUATION OF ANTICANCER MEDICINAL PRODUCTS
The European Agency for the Evaluation of Medicinal Products Human Medicines Evaluation Unit London, 23 July 1998 COMMITTEE FOR PROPRIETARY MEDICINAL PRODUCTS (CPMP) NOTE FOR GUIDANCE ON THE PRE-CLINICAL
More informationBIOMEDICAL ENGINEERING NEURO-ONCOLOGY
BIOMEDICAL ENGINEERING NEURO-ONCOLOGY SCAFFOLDING 10 MICRONS THIN NEUROSURGERY DEPLOYMENT THROUGH CATHETERS BRAIN EXVADERS A NOVEL BIOENGINEERING SOLUTION AIMED AT PEDIATRIC BRAIN TUMORS COULD SOMEDAY
More informationTERM SHEET EXAMPLE. 1 P age
1 P age TERM SHEET EXAMPLE BIOTECHCO Overview & Business Strategy BIOTECHCO (the licensor), located in North Dakota, has a proprietary technology called ZIP that can generate fully human antibodies with
More informationCall 2014: High throughput screening of therapeutic molecules and rare diseases
Call 2014: High throughput screening of therapeutic molecules and rare diseases The second call High throughput screening of therapeutic molecules and rare diseases launched by the French Foundation for
More informationMOLOGEN AG. Q1 Results 2015 Conference Call Dr. Matthias Schroff Chief Executive Officer. Berlin, 12 May 2015
Q1 Results 2015 Conference Call Dr. Matthias Schroff Chief Executive Officer Berlin, 12 May 2015 V1-6 Disclaimer Certain statements in this presentation contain formulations or terms referring to the future
More informationNewsletter. WntResearch AB, Medeon Science Park, Per Albin Hanssons väg 41, 205 12 Malmö, Sweden. Primary Objective:
Newsletter This resume of the results from the phase 1 study with Foxy-5 is based on clinical and laboratory data from the study, and these data have now been locked into the database. The full report
More informationInflammatory Cytokine-induced Expression of Vasohibin-1 by Rheumatoid Synovial Fibroblasts
9 6 6 958 Inflammatory Cytokine-induced Expression of Vasohibin- by Rheumatoid Synovial Fibroblasts a b c a a a a d e a* a a b c d e 5 6 6 9 5 56 67 7 ʼ ʼ ʼ ʼ ʼ ʼ ʼ ʼ 5 6 6 ʼ 5 75 989 6 69 8 95 56 56896
More informationDiabetes & blindness. due to DME BLINDNESS IN EUROPE
Diabetes & blindness due to DME BLINDNESS IN EUROPE Blindness is a life-changing disability which puts a heavy strain on the daily lives of sufferers, their families, and society at large. Today, 284 million
More informationSystematic Drug Repurposing: Some Successes, Caveats, and Directions
Systematic Drug Repurposing: Some Successes, Caveats, and Directions Christopher P. Austin, M.D. Director, Division of Preclinical Innovation National Center for Advancing Translational Sciences National
More informationDaiichi Sankyo to Acquire Ambit Biosciences
For Immediate Release Company name: DAIICHI SANKYO COMPANY, LIMITED Representative: Joji Nakayama, Representative Director, President and CEO (Code no.: 4568, First Section, Tokyo Stock Exchange) Please
More informationOverview of Phase 1 Oncology Trials of Biologic Therapeutics
Overview of Phase 1 Oncology Trials of Biologic Therapeutics Susan Jerian, MD ONCORD, Inc. February 28, 2008 February 28, 2008 Phase 1 1 Assumptions and Ground Rules The goal is regulatory approval of
More informationMATHEMATICAL MODELS OF TUMOR GROWTH INHIBITION IN XENOGRAFT MICE AFTER ADMINISTRATION OF ANTICANCER AGENTS GIVEN IN COMBINATION
MATHEMATICAL MODELS OF TUMOR GROWTH INHIBITION IN XENOGRAFT MICE AFTER ADMINISTRATION OF ANTICANCER AGENTS GIVEN IN COMBINATION Nadia Terranova UNIVERSITÀ DI PAVIA New model development: course of action
More informationAdocia reports positive results from phase IIa clinical study of ultra-fast acting BioChaperone Lispro
PRESS RELEASE Adocia reports positive results from phase IIa clinical study of ultra-fast acting BioChaperone Lispro BioChaperone Lispro is significantly faster than Humalog in type I diabetic patients;
More informationAcucela Inc. IR Meeting
Acucela Inc. IR Meeting Tokyo May 20, 2015 Acucela is a clinical-stage biotechnology company that specializes in discovering and developing novel therapeutics to treat and slow the progression of sight-threatening
More informationStem Cells Market Trends based on Primary Industry Analysis
GENReports: Market & Tech Analysis Stem Cells Market Trends based on Primary Industry Analysis > Enal Razvi, Ph.D. Biotechnology Analyst, Managing Director SELECTBIO US enal@selectbio.us > Gary Oosta,
More informationVascular Tissue Challenge Official Rules
Vascular Tissue Challenge Official Rules June 13, 2016 SECTION 1: Executive Summary 2 SECTION 2: Definitions & Assumptions 3 SECTION 3: Evaluation Criteria 3 SECTION 4: Safety & Care 5 SECTION 5: Registration
More informationBNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED
ASX ANNOUNCEMENT 3 August 2011 ABN 53 075 582 740 BNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED Data from renal cancer trial supports progression of the trial: o Combination
More informationKey Results of 2008 Leem Nanomedecine Study
Key Results of 2008 Leem Nanomedecine Study Nanobio Dialogue Session Annick Schwebig,, M.D., General Manager, Actelion Pharmaceuticals France Vice-President of Leem Biotech Committee EuroBio,, Paris, October
More informationexactly. The need for efficiency in developing effective new therapeutics has never been greater.
exactly. The need for efficiency in developing effective new therapeutics has never been greater. As demands on the global healthcare system increase and treating disease becomes more complex, the research,
More information1) Aug 2005 In Vitro Chromosomal Aberration Study Cytotoxicity (File: TS39) Conclusion No cytotoxicity can be detected at concentrations up to 100%.
Endotoxicity and Cytotoxicity Studies 1) Aug 2005 In Vitro Chromosomal Aberration Study Cytotoxicity (File: TS39) Chinese Hamster Ovary (CHO) cells were grown in monolayer with and without metabolic activation.
More informationMALIGNANT PLEURAL FLUIDS AID MESOTHELIOMA CELL GROWTH AND PROPAGATION
MALIGNANT PLEURAL FLUIDS AID MESOTHELIOMA CELL GROWTH AND PROPAGATION HUI MIN CHEAH PhD Candidate School of Medicine and Pharmacology University of Western Australia Lung Institute of Western Australia
More informationAvastin in breast cancer: Summary of clinical data
Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading
More informationThe Cell Therapy Catapult
The Cell Therapy Catapult Keith Thompson CEO January 29 2013 info@ct.catapult.org.uk Catapult is a Technology Strategy Board programme The Launch of Catapults Hauser 2 Hauser Report Creating new manufacturing
More informationLeukemia Drug Pathway Analyzer
Brochure More information from http://www.researchandmarkets.com/reports/2673689/ Leukemia Drug Pathway Analyzer Description: Extra value: One year of free online updates included with this product There
More informationJ D R F R E Q U E S T S E X P R E S S I O N S O F I N T E R E S T F O R : C O M B I N AT I O N T H E R AP I E S I N T Y P E 1 D I A B E T E S
J D R F R E Q U E S T S E X P R E S S I O N S O F I N T E R E S T F O R : C O M B I N AT I O N T H E R AP I E S I N T Y P E 1 D I A B E T E S PURPOSE JDRF, the world s leading non-profit organization with
More informationwww.iproteos.com Corporate Presentation November, 2013
www.iproteos.com Corporate Presentation November, 2013 The company Iproteos is an early-stage drug development company founded in 2011: Spin-Out from Institute for Research in Biomedicine (IRB Barcelona)
More informationKempen & Co 4 th Healthcare/Life Sciences Conference. Brussels March 29, 2011
Kempen & Co 4 th Healthcare/Life Sciences Conference Brussels March 29, 2011 Safe Harbour This presentation includes forward-looking statements. Actual results could differ materially from those included
More informationBayer Invests Heavily in R&D and is committed to innovation Sustained Innovation Output from all Subgroups
Open Innovation@BayerHealthCare Dr. Daniel Forler External Innovation Therapeutics Global Drug Discovery, Bayer HealthCare ASTP-Proton Conference Page 1 Bayer Invests Heavily in R&D and is committed to
More informationAriela Benigni. Biol.Sci.D., Ph.D. Curriculum Vitae
Ariela Benigni Biol.Sci.D., Ph.D. Curriculum Vitae Personal Data Name: Date and place of birth: Citizenship: E-mail: Ariela Benigni December 16, 1955 - Bergamo, Italy Italian ariela.benigni@marionegri.it
More informationDr.ssa Maria Luisa Nolli CEO
IL RUOLO DELLE PICCOLE E MEDIE INDUSTRIE NELLA PROMOZIONE DELLA MEDICINA TRASLAZIONALE Quality and Innovation Dr.ssa Maria Luisa Nolli CEO INTRODUCTION ARETA INTERNATIONAL 12 years of experience in contract
More informationFuture Directions in Clinical Research. Karen Kelly, MD Associate Director for Clinical Research UC Davis Cancer Center
Future Directions in Clinical Research Karen Kelly, MD Associate Director for Clinical Research UC Davis Cancer Center Outline 1. Status of Cancer Treatment 2. Overview of Clinical Research at UCDCC 3.
More informationGene Silencing Oligos (GSOs) Third Generation Antisense
Gene Silencing Oligos (GSOs) Third Generation Antisense Walter R. Strapps, Ph.D. Executive Director, RNA Therapeutics Idera Pharmaceuticals Cambridge, MA NASDAQ: IDRA www.iderapharma.com Idera is a leader
More informationImmunovaccine Inc. (TSX-V: IMV)
May 2014 Immunovaccine Inc. (TSX-V: IMV) Targeted T cell Activation Immunotherapies FORWARD-LOOKING STATEMENTS This document contains forward-looking information pursuant to applicable securities law.
More informationINSERM/ A. Bernheim. Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance
A. Bernheim Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance OVER-MyR is funded by the European Commission within its FP7 specific
More informationOncoxx Biotech. Saverio Alberti. Anti-Trop-2 monoclonal antibodies for cancer therapy and target diagnosis
Oncoxx Biotech Saverio Alberti Anti-Trop-2 monoclonal antibodies for cancer therapy and target diagnosis INTRODUCTION Oncoxx Biotech S.r.l. is a Cancer Biotech Company as partnership between Chieti University
More informationPX Therapeutics : the partner for early stage biotherapeutics development Biotuesday, May 5 2009
PX Therapeutics : the partner for early stage biotherapeutics development Biotuesday, May 5 2009 Christelle Dagoneau, PhD Business Development Director Company Profile Protein expert incorporated in 2000
More informationCrossing the drug development divide
6 Crossing the drug development divide 35 Crossing the drug development divide Few basic scientists have the expertise to make a drug-like compound, test it in animals and begin the initial steps toward
More informationUK- India Science Bridge: BioPharm 2020
DST INDIA - RESEARCH COUNCILS UK UK- India Science Bridge: BioPharm 2020 Entrepreneurial Opportunities for Indian and UK Scientists in the Pharmaceutical and Biotechnology Industries UK-India Impact Symposium
More informationCorporate Overview. Dr Robert Scoffin CEO. http;//www.re-pharm.com/ STAND NUMBER: 27 rob@re-pharm.com
Corporate Overview Dr Robert Scoffin CEO http;//www.re-pharm.com/ STAND NUMBER: 27 rob@re-pharm.com Re-Pharm Summary > Focus on commercially valuable early stage assets. > Repositioned compounds > Using
More informationInitial results of treatment with Linear Shockwave Therapy (LSWT) by Renova in patients with Erectile Dysfunction A pilot clinical study
Initial results of treatment with Linear Shockwave Therapy (LSWT) by Renova in patients with Erectile Dysfunction A pilot clinical study Investigators Dr. Ahmed Hind, MD Consultant to Pr.Catanzaro Milano
More informationProduct Development Services for Global Registration of Drugs & Biologics. 16-17 th April 2014. Contact: kevin.breesch@toxikon.be
Product Development Services for Global Registration of Drugs & Biologics 16-17 th April 2014 Contact: kevin.breesch@toxikon.be CONTENT OF PRESENTATION» History» Company Profile» Current Services» Proof-of-Concept:
More informationCompany Update. March 2011
Company Update March 2011 Safe Harbour This presentation includes forward-looking statements. Actual results could differ materially from those included in the forward-looking statements due to various
More informationWelcome to the Launch of Biocon s Breakthrough Innovation. For Psoriasis. Treatment
Welcome to the Launch of Biocon s Breakthrough Innovation For Psoriasis Treatment PRESS MEET Bangalore, August 10, 2013 Autoimmune Diseases are on the Rise Globally Autoimmune Disease Segment includes
More informationMedical Device Solutions. Battelle. Applied Research Device Development Clinical Research Sustaining Engineering
Medical Device Solutions Battelle Applied Research Device Development Clinical Research Sustaining Engineering 0 2 Overview Applied Research Device Development Clinical Research Sustaining Engineering
More informationEVT Execute & EVT Innovate Leading drug discovery
EVT Execute & EVT Innovate Leading drug discovery Evotec AG, Nine-month 2015 Interim Report, 10 November 2015 Forward-looking statements Information set forth in this presentation contains forward-looking
More informationJoin our scientific talent community
Join our scientific talent community There has never been a better time to be a part of Janssen Research & Development. We are at the forefront of healthcare leading, evolving and transforming it into
More informationBN201: a paradigm-shift (neuroprotection) in the treatment of neurodegenerative diseases
Programa Cooperación Farma-Biotech 9º encuentro (4 de julio de 2013) BN201: a paradigm-shift (neuroprotection) in the treatment of neurodegenerative diseases Barcelona, 4 de julio de 2013 Programa Cooperación
More informationH. Richard Alexander, Jr., M.D. Department of Surgery and The Greenebaum Cancer Center University of Maryland School of Medicine Baltimore, Md
Major Advances in Cancer Prevention, Diagnosis and Treatment~ Why Mesothelioma Leads the Way H. Richard Alexander, Jr., M.D. Department of Surgery and The Greenebaum Cancer Center University of Maryland
More informationGlycArt Biotechnology AG From Inception to trade sale and what happened after...
GlycArt Biotechnology AG From Inception to trade sale and what happened after... Dr. Joël Jean-Mairet From the Idea to Spin-off from the Swiss Federal Institute of Technology 1996 At the midst his PhD
More informationLocalised Cancer Treatment. PCI Biotech. Amphinex a new product for localised cancer treatment
Localised Cancer Treatment PCI Biotech Amphinex a new product for localised cancer treatment Disclaimer This document (the Presentation ) has been produced by PCI Biotech Holding ASA (the Company ). The
More informationAcademic Drug Discovery in the Center for Integrative Chemical Biology and Drug Discovery
Academic Drug Discovery in the Center for Integrative Chemical Biology and Drug Discovery www.pharmacy.unc.edu/cicbdd Stephen V. Frye, Ph.D. University of North Carolina Chapel Hill Outline Why Academic
More informationApplications of comprehensive clinical genomic analysis in solid tumors: obstacles and opportunities
Applications of comprehensive clinical genomic analysis in solid tumors: obstacles and opportunities Vincent A. Miller, M.D. Foundation Medicine, Inc. AACR Annual Meeting 2012 Current Concepts session
More informationPCI Biotech Holding ASA - Second Quarter Report 2008
PCI Biotech Holding ASA - Second Quarter Report 2008 Highlights Demerger and Initial Public Offering at Oslo Axess in June Raised NOK 60 million Per Walday, PhD hired as new CEO Board has been strengthened
More informationThe Trials and Tribulations of the CRM: the DFO Experience
The Trials and Tribulations of the CRM: the DFO Experience Yuko Y. Palesch, PhD Professor and Director, Division of Biostatistics and Epidemiology Department of Medicine. Medical University of South Carolina
More informationFINDING PROTEINS THAT HIT THE MARK PROVEN TRACK-RECORD OF PROTEOMICS EXPERTISE
FINDING PROTEINS THAT HIT THE MARK PROVEN TRACK-RECORD OF PROTEOMICS EXPERTISE Bioanalytical Services Fit-for-Purpose Assays Biomarker Discovery and Development Proven track-record of proteomics expertise
More informationThe Myelin Repair Foundation: Accelerating New Treatments for Multiple Sclerosis and All Diseases. Scott Johnson CEO, President and Founder
The Myelin Repair Foundation: Accelerating New Treatments for Multiple Sclerosis and All Diseases Scott Johnson CEO, President and Founder Introduction Broken system of medical research No fault, system
More information