NBHSW Medical Carepathway-Investigation for Cytomegalovirus Infection*

Transcription

1 Child with SNHL Test maternal CMV lgg Negative ccmv Excluded Positive Under 3/52 Over 3/52 but Under 1 yr Over 1 yr Urine CMV PCR Urine CMV PCR Child CMV lgg Negative ccmv Excluded CMV PCR 2xCMV PCR 2x CMV PCR CMV PCR Positive Positive Negative Negative Positive Dried Blood Spot Card CMV PCR** CMV PCR Positive CMV PCR Negative Congenital c CMV Congenital CMV Congenital CMV Congenital CMV unlikely CMV Excluded highly unlikely

2 *This pathway is for the investigation of ccmv infection in immunocompetent children. ** Written permission from parents is required to authorise release of Dried Blood Spot Card for CMV PCR. Enquiries should be directed to the appropriate Regional Newborn Screening Laboratory. This pathway has been developed with Consultant Virologists Dr Nicky Price and Dr Rachel Jones, Public Health Wales and Dr Jennifer Evans Consultant Paediatrician Cardiff and Vale University Health Board. Acknowledgement: Dr Simone Walter: Flowchart for investigating CMV as a cause of sensorineural hearing impairment. Reference: Evidence based management guidelines for the detection and treatment of congenital CMV. S. Kadambari, E.J. Williams, S. Luck, P.D. Grifiths, M. Sharland. Early Human Development 87 (2011)

3 REGIONAL LAB CONTACT DETAILS Area Address Telephone Number BRISTOL SouthMead Hospital - covers Plymouth Cornwall, whole south west Bristol Newborn Screening Laboratory Pathology Sciences Laboratory Southmead Hospital Bristol BS10 5NB NBS lab Cambridge Newborn Screening Laboratory Box 247 Addenbrookes Hospital Hills Road Cambridge CB2 2QQ NBS lab Ext Great Ormond Street, London Newborn Screening Laboratory Newborn Screening Laboratory Chemical Pathology Great Ormond Street Hospital for Children NHS Trust London WC1N 3JH NBS lab switchboard then Ext 8383 Leeds Biochemical Genetics St James University Hospital Leeds Yorkshire LS9 7TF NBS Lab

4 Liverpool Alder Hey Children s Hospital Eaton Road Liverpool L12 2AP Manchester Paediatric Biochemistry Royal Manchester Children's Hospital Office; 4th Floor Paediatric Pathology Oxford Road Manchester M13 9WL NBS lab (they have answerphone and will call back) Fax no Newcastle Paediatric Metabolic Section Department of Clinical Biochemistry Newcastle upon Tyne Hospitals NHS Foundation Trust Royal Victoria Infirmary Queen Victoria Road Newcastle upon Tyne Tyne & Wear NE1 4LP NBS lab Oxford John Radcliffe Hospital Headington Oxford OX3 9DU NBS lab

5 PORTSMOUTH covers Salisbury Head of Blood Sciences Michael Darmady Laboratory Queen Alexandra Hospital Cosham Portsmouth Hants. PO6 3LY NBS Lab phone switch board and then ext SOUTH EAST THAMES, LONDON St Thomas' Hospital/Guys Hospital covers east Thames South East Thames Regional Newborn Screening Laboratory, Biochemical Science Service, 4th Floor North Wing, St THomas' Hospital, London SE1 7EH NBS lab South Yorkshire/Trent region Sheffield They cover Barnsley, Lincoln, Derbyshire, Doncaster, Grimsby, Scunthorpe, Leicester, North and South Lincolnshire, Nottingham, Basitlaw, Sheffield, Northampton, Kettering, Goole. West Midlands Regional Newborn ScreeningServiceSheffield Children s HospitalWestern BankSheffieldS10 2TJ Mr Paul Griffiths Clinical Chemistry Birmingham Children s Hospital Steelhouse Lane Birmingham B4 6NH NBS lab NBS lab

6 Northern Ireland Dept of Clinical Biochemistry Kelvin Building Royal Victoria Hospital Grosvenor Road Belfast NBS lab ext 3064 Scotland Newborn Screening Laboratory West of Scotland Genetic Services Laboratory Medicine Southern General Hospital 1345 Govan RD Glasgow G51 4TF Wales St Hillier Lab - London SW Thames covers Surrey Newborn Bloodspot Screening Laboratory Medical Biochemistry Department University Hospital Of Wales Heath Park Cardiff CF14 4XW Fax No Linda Mahony Dublin Childrens Hospital