PROSPERO International prospective register of systematic reviews
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1 PROSPERO International prospective register of systematic reviews Incidence of incisional hernia in the specimen extraction site for laparoscopic colorectal surgery Lawrence Lee, Maria Abou-Khalil, Liane Feldman, Sender Liberman Citation Lawrence Lee, Maria Abou-Khalil, Liane Feldman, Sender Liberman. Incidence of incisional hernia in the specimen extraction site for laparoscopic colorectal surgery. PROSPERO 2016:CRD Available from Review question(s) To determine the incidence of incisional hernia in the specimen extraction site in laparoscopic colorectal surgery, specifically comparing midline and off midline incisions To determine the incidence of incisional hernia in the specimen extraction site in laparoscopic colorectal surgery, specifically comparing midline and off midline incisions Searches MEDLINE, EMBASE, HealthStar, PubMed, Web of Science, Scopus, Cochrane Library, CINAHL, and the Database of Abstracts of Reviews of Effects (DARE) 1991 to present English or French language Reference lists of key records will be searched Experts in the field will be contacted if they know of any other relevant studies Searches MEDLINE, EMBASE, HealthStar, PubMed, Web of Science, Scopus, Cochrane Library, CINAHL, and the Database of Abstracts of Reviews of Effects (DARE) 1991 to present English or French language Reference lists of key records will be searched Experts in the field will be contacted if they know of any other relevant studies Types of study to be included Comparative studies RCTs Types of study to be included Comparative studies RCTs Condition or domain being studied Page: 1 / 5
2 Laparoscopic colorectal surgery Condition or domain being studied Laparoscopic colorectal surgery Participants/ population Patients undergoing laparoscopic colorectal surgery for benign or malignant conditions Participants/ population Patients undergoing laparoscopic colorectal surgery for benign or malignant conditions Intervention(s), exposure(s) Inclusion criteria Midline: peri- or trans-umbilical incisions for specimen extraction Off-midline: transverse (muscle-splitting/sparing and cutting) or Pfannenstiel Laparoscopic colon or rectal surgery Hand-assisted laparoscopic colon or rectal surgery Exclusion Stoma-site extraction SILS NOTES Case-series with no comparator group Open colon or rectal surgery Intervention(s), exposure(s) Inclusion criteria Midline: peri- or trans-umbilical incisions for specimen extraction Off-midline: transverse (muscle-splitting/sparing and cutting) or Pfannenstiel Laparoscopic colon or rectal surgery Hand-assisted laparoscopic colon or rectal surgery Exclusion Stoma-site extraction SILS NOTES Case-series with no comparator group Open colon or rectal surgery Page: 2 / 5
3 Comparator(s)/ control Control: Midline specimen extraction Comparator: off-midline specimen extraction Comparator(s)/ control Control: Midline specimen extraction Comparator: off-midline specimen extraction Outcome(s) Primary outcomes Incisional hernia in the specimen extraction site Incisional hernia in the specimen extraction site Follow-up of at least 1 (ideally 3) years Follow-up of at least 1 (ideally 3) years Secondary outcomes Surgical site infections Surgical site infections Risk of bias (quality) assessment MINORS instrument for comparative studies Cochrane Collaboration risk of bias tool for RCTs Risk of bias (quality) assessment MINORS instrument for comparative studies Cochrane Collaboration risk of bias tool for RCTs Strategy for data synthesis Dichotomous outcomes (including the main outcome) from individual studies will be combined to compute pooled odds ratios (OR) with 95% confidence intervals (CI). Continuous variables will be combined to calculated weighted mean differences (WMD) with 95% CI. It was decided a priori to use a random-effects model to calculate pooled effect estimates as it was anticipated that the studies included for meta-analysis would include a heterogeneous patient populations and surgical procedures (i.e. studies would include a subject population with mixed indications for surgery such as colorectal malignancy, inflammatory bowel disease, and other benign conditions, as well as report results for both colon and rectal procedures). Heterogeneity will be assessed using the I-squared statistic. Strategy for data synthesis Dichotomous outcomes (including the main outcome) from individual studies will be combined to compute pooled odds ratios (OR) with 95% confidence intervals (CI). Continuous variables will be combined to calculated weighted mean differences (WMD) with 95% CI. It was decided a priori to use a random-effects model to calculate pooled effect estimates as it was anticipated that the studies included for meta-analysis would include a heterogeneous patient populations and surgical procedures (i.e. studies would include a subject population with mixed indications for surgery such as colorectal malignancy, inflammatory bowel disease, and other benign conditions, as well as report results for both colon and rectal procedures). Heterogeneity will be assessed using the I-squared statistic. Analysis of subgroups or subsets We will analyze the different off-midline incisions (i.e. transverse and pfannenstiel) as different subgroups, as well as studies that have longer FU (>3 years) Page: 3 / 5
4 Analysis of subgroups or subsets We will analyze the different off-midline incisions (i.e. transverse and pfannenstiel) as different subgroups, as well as studies that have longer FU (>3 years) Contact details for further information Dr Lee Dr Lee 1650 Cedar Ave E Cedar Ave E Organisational affiliation of the review McGill University Health Centre McGill University Health Centre Review team Dr Lawrence Lee, McGill University Health Centre Dr Maria Abou-Khalil, McGill University Health Centre Dr Liane Feldman, McGill University Health Centre Dr Sender Liberman, McGill University Health Centre Anticipated or actual start date 16 August 2016 Anticipated or actual start date 16 August 2016 Anticipated completion date 01 December 2016 Anticipated completion date 01 December 2016 Funding sources/sponsors None Funding sources/sponsors None Conflicts of interest None known Language English, Finnish Language English, Finnish Page: 4 / 5
5 Powered by TCPDF ( Country Canada Country Canada Subject index terms status Subject indexing assigned by CRD Subject index terms Colorectal Surgery; Digestive System Surgical Procedures; Humans; Incidence; Incisional Hernia; Laparoscopy Stage of review Ongoing Stage of review Ongoing Date of registration in PROSPERO 29 August 2016 Date of publication of this revision 29 August 2016 Stage of review at time of this submission Started Completed Preliminary searches Yes No Piloting of the study selection process Yes No Formal screening of search results against eligibility criteria No No Data extraction No No Risk of bias (quality) assessment No No Data analysis No No PROSPERO International prospective register of systematic reviews The information in this record has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Page: 5 / 5
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