TB Skin Test Practicum Catalina Navarro, RN, BSN April 8, 2015

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1 TB Skin Test Practicum Catalina Navarro, RN, BSN April 8, 2015 TB Skin Test Practicum April 8, 2015 El Paso, TX EXCELLENCE EXPERTISE INNOVATION Catalina Navarro, RN, BSN has the following disclosures to make: No conflict of interests No relevant financial relationships with any commercial companies pertaining to this educational activity 1

2 TB Skin Test Practicum Catalina Navarro, RN, BSN April 8, 2015 TB Skin Test Practicum April 8, 2015 El Paso, TX How is TB Spread? TB is spread through the air from person to person TB bacteria are passed through the air when a person with TB disease coughs, laughs, sings or sneezes.. 2

3 How TB Is Transmitted From One Person to Another Core Curriculum on Tuberculosis (2000) Infectiousness of person with TB Susceptibility of contact Duration of exposure Concentration of droplet nuclei in air (Environment) What is the Probability that TB Will Be Transmitted?!Majority of contacts do not become infected! 3

4 What is the difference between Active TB disease vs. TB infection? Has TB bacteria in his/her body that are alive but inactive Does not feel sick and is NOT CONTAGIOUS May become sick if the bacteria become active in his/her body Should consider treatment for LTBI to prevent active TB disease Latent TB Infection (LTBI) 4

5 Active TB Disease Has active TB bacteria in his/her body Feels sick and experiences symptoms such as coughing, fever, and weight loss May spread TB bacteria to others Needs treatment to cure active TB disease Potential Sites of TB Disease 5

6 Mantoux Tuberculin Skin Test Purpose: Targeted Skin Testing Strategy for controlling and preventing TB Identifies and treats persons with TB disease Identifies and screens contacts to TB cases Screens populations at HIGH risk for LTBI (latent) and TB disease (active) Find persons who would benefit from Treatment Screening of LOW risk persons should be replaced by targeted testing. 6

7 Population at High Risk for LTBI Recent Contacts Immigrants from TB endemic countries Health care workers Persons with compromised immune systems Patients in renal dialysis units Persons using TNF alpha blockers HIGH Risk for LTBI Substance abusers (especially IVDU) Homeless Persons with inadequate health care Persons who live in institutional settings (shelters, nursing homes, correctional facilities) Migrant workers 7

8 Medical Risk Factors for Progression to Active TB HIV infection Diabetes mellitus Malignancy Chronic renal failure Transplant patients Malnutrition Immunosuppressive therapy History of gastrectomy or jejunoileal bypass Cer Testing Methods for LTBI Mantoux Tuberculin Skin Test Interferon Gamma Release Assays (IGRAs) QuantiFERON TB Gold in tube (QFT) T Spot TB Test 8

9 the decision to test is a decision to treat What do we DOCUMENT when reading the TST? Record date and time of reading and name of person reading TST Record in millimeters (mm) No reaction should be written as 00 mm 9

10 Tuberculin Skin Test interpretation >5 mm is considered positive in Close contacts of infectious TB cases HIV infected persons Fibrotic changes on CXR consistent with prior TB Patients with organ transplants and/or those receiving immunosuppressed treatments Tuberculin Skin Test Interpretation >10 mm is considered positive in Immigrants from high prevalence countries VDU, known to be HIV neg. Residents/employees of high risk congregate settings Mycobacteriology lab personnel Children < 4 years of age/ children exposed to adults at high risk Persons with medical conditions that place them at high risk of progression to TB disease 10

11 Tuberculin Skin Test Interpretation > 15mm is considered positive in; - persons with no risk factors (If there is not risk. Why did you test?) Targeted skin testing programs should only be conducted among high-risk groups What Do We Do with a Negative TST Result? Provide Documentation of result No further evaluation necessary 11

12 What Do We Do with a Positive TST Result? Evaluate Further Rule Out TB Disease CXR TB Symptom Screen/ Assessment MD Evaluation Sputum Collection If disease is ruled out, consider for LTBI treatment If patient not willing or able to take treatment, educate on TB signs and symptoms FAQ After TB has been transmitted, how long does it take for the body s immune system to be able to react to tuberculin? A hours B days C. 2-8 weeks D. 6 months or more 12

13 FAQ What do we do if client returns after 72 hours? If TST is positive measure and record induration in millmeters If TST is read as negative, repeat TST at this time FAQ Can Infants Be Tested? YES - Infants may not react to a TST before 6 months of age, but should be tested if there is risk of exposure 13

14 FAQ Can a person with a previous positive TST be retested? YES Retesting is not necessary if the previous result was documented Repeated skin tests do not sensitize or make persons allergic to tuberculin FAQ How soon may I repeat a TST? May be repeated right away if initial placement was incorrect If the patient fails to return within 72 hours of placement, a repeat TST is necessary as soon as possible 14

15 FAQ Can pregnant women be tested? YES No risk to mother or fetus. Pregnancy is often a good time to screen and test women who are at risk of TB FAQ Can HCW s read their own TST? NO HCW s should NEVER be allowed to read their own TST Experience has shown that HCW s do not measure their own TST results reliably 15

16 FAQ Do Vaccinations interfere with TST results? Yes, may cause false (-) reactions For persons scheduled to receive TST and live virus vaccines, the testing should be done either on the same day as vaccination or at least 1 month after vaccination to minimize potential of false (-) References Targeted Tuberculin Testing and Treatment of LTBI; MMWR June 9, 2000/Vol.49/No. RR 6 Guidelines for the Diagnosis of LTBI in the 21 st Century; NJ Medical School Global Tuberculosis Institute,2 nd edition June,2002 Controlling TB in the US; MMWR November 4,2005/Vol.54/No.RR 12 Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis; MMWR December 16, 2005/Vol. 54/ No. RR 15 16

17 Practicum Break into Groups Placing TST on each other Reading TST mannequins Hispanic Asian White Black Case scenarios 17

18 Hispanic 1. 6 MM MM MM MM MM Asian 1. 7 MM MM MM MM MM White 1. 6 MM MM MM MM MM Black MM MM 3. 7 MM MM MM 18

Guidelines for TB Blood Testing. Minnesota Department of Health TB Prevention and Control Program June 2011

Guidelines for TB Blood Testing Minnesota Department of Health TB Prevention and Control Program June 2011 Outline Interferon-Gamma Release Assays aka TB blood tests 1. What are they? 2. What are the current