20% Backgr. frequency frequency enrichment. Unclassified E+00

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1 Group A 20% 80% enrichment +/- P-value Unclassified E+00 Group B 10% 2 58% muscle contraction actomyosin structure organization enrichment +/- P-value Muscle contraction (GO: ) 15 5 > E-02 Muscle system process (GO: ) 22 6 > E-02 Myofibril assembly (GO: ) 40 7 > E-02 Striated muscle cell development(go: ) 54 8 > E-02 Muscle cell development (GO: ) 54 8 > E-02 Actomyosin structure organization (GO: ) 66 9 > E-02 Unclassified E+00

2 Group C 1 25% female meiotic division mitotic cell cycle 57% enrichment +/- P-value Spindle assembly involved in female meiosis (GO: ) 15 6 > E-02 Female meiotic division(go: ) E-02 Meiotic cell cycle (GO: ) E-02 Cell cycle (GO: ) E-04 Cell cycle process (GO: ) E-03 Unclassified E+00

3 Group D negative regulation of histone modification female meiotic division 1% 19% 8% 1% 4% 3% 1% 1% 1% 5% DNA conformation change DNA replication chromosome segregation reciprocal meiotic recombination chromosome condensation 2 10% 3% DNA-templated transcription, initiation negative regulation of gene expression, epigenetic centrosome cycle organelle fission cellular response to DNA damage stimulus mitotic cell cycle negative regulation of metabolic process regulation of gene expression primary metabolic process translation Negative regulation of histone modification 5 18 > E-15 Negative regulation of chromatin modification > E-11 Nucleosome assembly > E-26 Female meiosis chromosome segregation > E-11 Chromatin assembly > E-25 Negative regulation of chromosome organization > E-09 Protein-DNA complex assembly > E-28 Regulation of histone modification > E-07 Nucleosome organization > E-22 DNA packaging E-29 Protein-DNA complex subunit organization E-23 DNA conformation change E-28

4 DNA conformation change E-28 Cell cycle DNA replication E-03 Meiotic chromosome segregation E-11 Female meiotic division E-11 DNA-dependent DNA replication E-07 Nuclear chromosome segregation E-19 Reciprocal meiotic recombination E-02 Chromosome condensation E-04 Reciprocal DNA recombination E-02 DNA replication E-09 Chromosome segregation E-17 DNA-templated transcription, initiation E-07 Mitotic sister chromatid segregation E-06 Sister chromatid segregation E-06 Chromatin assembly or disassembly E-12 Negative regulation of gene expression, epigenetic E-03 Chromatin silencing E-03 Regulation of chromatin organization E-04 Regulation of chromatin modification E-03 Negative regulation of organelle organization E-04 Negative regulation of protein modification process E-04 Centrosome duplication E-04 Regulation of chromosome organization E-05 Centrosome cycle E-05 DNA recombination E-02 Meiosis I E-03 DNA metabolic process E-14 Microtubule organizing center organization E-06 Cellular macromolecular complex assembly E-12 Meiotic nuclear division E-08 Meiotic cell cycle process E-08 Meiotic cell cycle E-08 Centrosome organization E-05 RNA biosynthetic process E-07 Nuclear division E-15 Nucleic acid-templated transcription E-06 Transcription, DNA-templated E-06 Chromosome organization E-21 Protein complex assembly E-11 Negative regulation of cellular component organization E-04 Protein complex biogenesis E-11 Organelle fission E-15 Gene silencing E-02 DNA repair E-03 Chromatin organization E-11 Macromolecular complex assembly E-12 Mitotic nuclear division E-04 Nucleobase-containing compound biosynthetic process E-07

5 Regulation of mitotic cell cycle E-04 Cell cycle process E-16 Cell cycle E-16 Nucleic acid metabolic process E-20 Regulation of cell cycle process E-03 Regulation of cell cycle E-05 Heterocycle biosynthetic process E-05 Aromatic compound biosynthetic process E-05 Negative regulation of nucleobase-containing compound metabolic process E-03 Regulation of organelle organization E-03 Mitotic cell cycle E-07 Negative regulation of RNA biosynthetic process E-02 Negative regulation of transcription, DNA-templated E-02 Negative regulation of nucleic acid-templated transcription E-02 Microtubule cytoskeleton organization E-04 Negative regulation of gene expression E-04 Mitotic cell cycle process E-06 Negative regulation of macromolecule biosynthetic process E-03 Negative regulation of cellular macromolecule biosynthetic process E-03 Cellular response to DNA damage stimulus E-02 Negative regulation of cellular biosynthetic process E-03 Negative regulation of biosynthetic process E-03 Protein complex subunit organization E-07 Negative regulation of RNA metabolic process E-02 Organic cyclic compound biosynthetic process E-04 Negative regulation of nitrogen compound metabolic process E-03 Nucleobase-containing compound metabolic process E-14 RNA metabolic process E-07 Negative regulation of macromolecule metabolic process E-05 Positive regulation of macromolecule biosynthetic process E-02 Regulation of cellular macromolecule biosynthetic process E-09 Regulation of macromolecule biosynthetic process E-09 Macromolecular complex subunit organization E-08 Heterocycle metabolic process E-13 Negative regulation of metabolic process E-04 Cellular aromatic compound metabolic process E-12 Regulation of biosynthetic process E-09 Regulation of cellular biosynthetic process E-09 Regulation of RNA biosynthetic process E-07 Regulation of transcription, DNA-templated E-07 Regulation of nucleic acid-templated transcription E-07 Cellular component assembly E-06

6 Regulation of cellular protein metabolic process E-02 Organic cyclic compound metabolic process E-11 Regulation of gene expression E-08 Regulation of nucleobase-containing compound metabolic process E-07 Regulation of protein metabolic process E-02 Negative regulation of cellular metabolic process E-02 Regulation of nitrogen compound metabolic process E-07 Positive regulation of macromolecule metabolic process E-02 Single-organism organelle organization E-07 Cellular component biogenesis E-05 Regulation of cellular component organization E-03 Regulation of RNA metabolic process E-05 Regulation of macromolecule metabolic process E-09 Macromolecule biosynthetic process E-03 Cellular macromolecule biosynthetic process E-03 Organelle organization E-10 Regulation of primary metabolic process E-07 Regulation of cellular metabolic process E-07 Negative regulation of biological process E-04 Cellular nitrogen compound metabolic process E-06 Regulation of metabolic process E-06 Negative regulation of cellular process E-03 Cellular component organization E-10 Positive regulation of biological process E-03 Positive regulation of cellular process E-02 Nervous system development E-05 Cellular component organization or biogenesis E-09 Organic substance biosynthetic process E-02 Regulation of cellular process E-11 Neurogenesis E-03 Cellular macromolecule metabolic process E-07 Regulation of biological process E-11 Nitrogen compound metabolic process E-04 Biological regulation E-11 System development E-05 Multicellular organismal development E-05 Cell differentiation E-03 Single-organism cellular process E-14 Cellular developmental process E-03 Anatomical structure development E-04 Cellular process E-16 Developmental process E-04 Single-organism developmental process E-04 Cellular metabolic process E-04 Macromolecule metabolic process E-03 Single-organism process E-11 Primary metabolic process E-03 Single-multicellular organism process E-02

7 Organic substance metabolic process E-02 Unclassified E+00 Translation E-03 Amide biosynthetic process E-03 Peptide biosynthetic process E-03

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