Ovarian cancer surgery technique of omentectomy
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1 Ovarian cancer surgery technique of omentectomy intraperitoneal omentum omentum adherent to anterior abdominal wall dissect off anterior abdominal wall
2 Ovarian cancer surgery technique of omentectomy liver mobilize hepatic flexure and carve omentum off liver
3 Ovarian cancer surgery technique of omentectomy gastrohepatic ligament hepatic flexure cut line of toldt and gastrohepatic ligament
4 Ovarian cancer surgery technique of omentectomy gastrocolic ligament posterior surface transverse mesocolon transverse colon incise gastrocolic ligament to open lesser sac
5 Ovarian cancer surgery technique of omentectomy omentum lesser sac transverse mesocolon the proper plane is avascular
6 Ovarian cancer surgery technique of omentectomy lesser sac transverse colon omentum attached to stomach only
7 Ovarian cancer surgery technique of omentectomy stomach resect gastroepiploic arch with omentum
8 Risk of Developing Ovarian Cancer 30 yo G2P2, nurse on the oncology unit. I want to be tested for ovarian cancer. 42 yo G1P1 My mother has been diagnosed with ovarian cancer. What is my risk?
9 OVARIAN CANCER LIFETIME RISK # of First-degree Relatives Lifetime Risk (%) with Ovarian Cancer Definite Hereditary Syndrome 40.0
10 Screening for Non-hereditary Ovarian Cancer Transvaginal sonography CA-125 level Pelvic Exam Insufficient evidence to support routine use. Clinical Investigation Growth Factors (LPA, EGF, MMP) Proteomics spectroscopy patterns
11 OVARIAN CANCER ULTRASOUND SCREENING AUTHORS NUMBER WOMEN SURG. # CANCERS # STAGE I OVARIAN Campbell ,479 (18-78) DePriest 3, (33-90) Bourne 1, (17-79) Karlan (35-80) Muto, (20-60) TOTAL 11, (5 Invasive) SENS. % OV CA (5 Ov Ca) 5 (3 LMP) (1 granulosa) (6 Ov Ca) (3 LMP) (LMP) PPV % OV CA
12 NIH CONSENSUS CONFERENCE OVARIAN CANCER: SCREENING, TREATMENT, AND FOLLOW-UP THERE IS NO EVIDENCE AVAILABLE YET THAT THE CURRENT SCREENING MODALITIES OF CA-125, AND TRANSVAGINAL ULTRASONOGRAPHY CAN BE EFFECTIVELY USED FOR WIDESPREAD SCREENING TO REDUCE MORTALITY FROM OVARIAN CANCER NOR THAT THEIR USE WILL RESULT IN DECREASED RATHER THAN INCREASED MORBIDITY AND MORTALITY. JAMA, 1995, 273:
13 Risk of Developing Ovarian Cancer 30 yo G2P2, nurse on the oncology unit. I want to be tested for ovarian cancer. 42 yo G1P1 My mother has been diagnosed with ovarian cancer. What is my risk?
14 Non-surgical Risk Reduction
15 RISK OF OVARIAN CANCER ORAL CONTRACEPTIVE EFFECT REVIEW OF CANCER AND STEROID HORMONE STUDY (CASH) SURVEILLANCE, EDIPEMIOLOGY & END RESULTS STUDY (SEER) META ANALYSIS ESTIMATES PER 100,000 OC USERS COMPARED TO NEVER USERS COMPARED USERS VS NONUSERS STRATIFIED FOR AGE, PARITY, DURATION OF USE 5 YEARS OF USE BY NULLIP = PAROUS NONUSER 10 YEARS OF USE WITH POS. FAMILY HX = or < RISK OF NEG. FAMILY HX NONUSER GROSS & SCHLESSELMAN, Obstet Gynecol, 1994
16 RISK OF OVARIAN CANCER EFFECT OF ORAL CONTRACEPTIVES YEARS OF OC 0 YEARS OF OC 1 YEARS OF OC 5 YEARS OF OC 10 POS. FAMILY HX AGE AGE AGE NEG. FAMILY HX AGE AGE AGE GROSS AND SCHLESSELMAN, Obstet Gynecol, 1994
17 Pelvic Mass Likelihood of Ovarian Cancer? 74 yo, G6P6 with hip fracture. Ovarian mass found during MRI of left hip. 40 yo, G2P1Ab1 with complaints of pelvic pain. Sono shows 7 cm solid and cystic mass. CA-125 = 96 units. 54 yo Go with early satiety and bloating. CT scan shows a 12 cm complex mass and probable ascites.
18 Pelvic Mass Evaluation and Therapy Symptomatic Yes / No? Sonographic Characteristics CA-125 level Optimal Surgical Candidate Yes / No?
19 Pelvic Mass Diagnostic Factors Mass Size Diagnostic Tests Symptoms Pt. Age Exam History
20 OVARIAN MASS EVALUATION TVS SCORING SYSTEM WALL SMOOTH OR - SOLID OR PAPILLARITIES STRUCTURE IRREG < 3mm NONAPPLICABLE >or= 3mm SHADOWING YES NO - - SEPTA NONE OR THIN THICK <3mm >or= 3mm - - ECHOGENICITY SONOLUCENT OR - - MIXED OR HIGH LOW ECHO LERNER et al, AM J OBSTET GYN, 1994
21 OVARIAN CARCINOMA SCREENING SONOGRAPHY PROLATE ELLIPSOID FORMULA W x H x L x.523 NORMAL VOLUME = 8 CUBIC CM. OR < MORPHOLOGY CONSIDERED ALSO UNIFORMITY COMPLEXITY CYSTIC NATURE SEPTAE VAN NAGELL, CANCER, 1991
22 OVARIAN CARCINOMA SONOGRAPHIC SCREENING 1,300 ASYMPTOMATIC, POST- MENOPAUSAL WOMEN 33/1300 (2.5%) OVARIAN MASSES 27/33 EXPLORATORY LAPAROTOMY 3/27 CARCINOMA 1 METASTATIC COLON CA. 2 STAGE I OVARIAN CA. VAN NAGELL, CANCER, 1991
23 Simple cyst
24 Multiseptated ovary
25 Complex mass
26 PELVIC MASS SONO ACCURACY 312 PATIENTS SURGERY FOR PELVIC MASS PREOPERATIVE SONOGRAPHY HERRMAN, OBSTET GYNEC, 1987
27 SONO CRITERIA BENIGN vs MALIGNANT SIZE UNI vs MULTILOCULAR THIN OR THICK SEPTAE COMPLEX (SOLID & CYSTIC) HERRMAN, 1987
28 PELVIC MASS SONO ACCURACY HISTOLOGY BENIGN MALIGNANT NORMAL PELVIS 7 0 BENIGN BORDERLINE 1 3 CANCER 6 38 HERRMAN, 1987
29 PELVIC MASS SONO ACCURACY SENSITIVITY 83% SPECIFICITY 92% PREDICTIVE POWER POSITIVE 73% NEGATIVE 96% HERRMAN, OBSTET GYNEC, 1987
30 CA-125 EXPRESSED BY DERIVATIVE OF COELOMIC EPITHELIUM GLYCOPROTEIN > 200 KD SHED INTO SERUM IDENTIFIED BY RIA USING OC-125
31 CANCER CA-125 LEVELS % > 35 U/ML OVARIAN 83 PANCREATIC 59 LUNG 32 BREAST 12 COLORECTAL 23 MISC GI 27 MISC NON-GI 25
32 CA-125 LEVELS POPULATION STUDIED % > 35 U/ML NORMAL, HEALTHY 1 BENIGN COND. 6 PREGNANCY, EARLY 16 PID 10 LEIOMYOMAS 4 CIRRHOSIS 70 PERICARDITIS 70 ENDOMETRIOSIS 54
33 PELVIC MASS LOW RISK PREMENOPAUSAL MASS <8 CM IN DIAMETER NORMAL CA-125 UNILATERAL LESION REASSURING SONOGRAPHY UNILOCULAR NON-COMPLEX (CYSTIC ONLY) NO ASCITES
34 PELVIC MASS HIGH RISK POSTMENOPAUSAL PATIENT MASS > 8 CM. IN DIAMETER ELEVATED CA-125 BILATERAL MASSES SYMPTOMATIC NONREASSURING SONOGRAPHY MULTILOCULATED COMPLEX (SOLID & CYSTIC) ASCITES
35 Ovarian Carcinoma Postmenopausal Pelvic mass CA-125 >95 U/ML High Risk 85-96% Positive Predictive Value for carcinoma. Einhorn et al, Obstet Gynecol,1992;80:14-18 Zurawski et al.int J Cancer, 1988;42: Malkasian et al,
36 Ovarian Cancer UKSM,W IV 9% Not Spec 13% I 21% III 48% II 9% 2005, 772 Pt.
37 Ovarian Cancer % Alive, NED Stage I Stage II Stage III Stage IV Not Spec. 6 UKSM,W, 2005, 772 Pt.
38 OVARIAN STROMAL TUMORS PATHOLOGY GRANULOSA-STROMAL TUMORS GRANULOSA CELL TUMORS ADULT TYPE JUVENILE TYPE THECOMA-FIBROMA GROUP THECOMA FIBROMA FIBROSARCOMA SCLEROSING STROMAL TUMOR
39 OVARIAN STROMAL TUMORS PATHOLOGY SERTOLI-LEYDIG CELL TUMORS (ANDROBLASTOMA) SERTOLI CELL TUMORS LEYDIG CELL TUMOR (HILUS CELL TUMOR) SERTOLI-LEYDIG TUMOR (WELL, MODERATE, POORLY DIFFERENTIATED)
40 OVARIAN STROMAL TUMORS PATHOLOGY GRANULOSA-STROMAL TUMORS GRANULOSA CELL TUMORS ADULT TYPE JUVENILE TYPE THECOMA-FIBROMA GROUP THECOMA FIBROMA FIBROSARCOMA SCLEROSING STROMAL TUMOR SERTOLI-LEYDIG CELL TUMORS (ANDROBLASTOMA) SERTOLI CELL TUMORS
41 STROMAL TUMORS CHARACTERISTICS THECOMA-FIBROMA TUMORS PERI AND POSTMENOPAUSAL WOMEN MENSTRUAL IRREGULARITY OR POSTMENOPAUSAL BLEEDING MAY PRODUCE ESTROGEN UNILATERAL, SOLID ASYMPTOMATIC MASS
42 STROMAL TUMORS CHARACTERISTICS SERTOLI-LEYDIG CELL TUMORS THIRD AND FOURTH DECADE OF LIFE MAY BE SOLID OR CYSTIC VIRILIZATION IS COMMON OLIGOMENORRHEA/AMENORRHEA BREAST ATROPHY HIRSUTISM CLITOROMEGALY RARELY BILATERAL (<1%)
43 Ovarian Cancer UKSM,W # of Pt. 0 Stage I Stage II Stage III Stage IV Not Spec. 2005, 698 Pt.
44 OVARIAN CARCINOMA POPULATION RISK LIFE TIME RISK WITH NO AFFECTED RELATIVES: 1/70 LIFE TIME RISK WITH 1 FIRST-DEGREE RELATIVE: 5% LIFE TIME RISK WITH 2 FIRST-DEGREE RELATIVES: 7% HEREDITARY OVARIAN CANCER SYNDROME: 40-50%
45 OVARIAN CARCINOMA GENETIC RISK LYNCH SYNDROME II OVARIAN CARCINOMA IN HEREDITARY NONPOLYPOSIS COLORECTAL CANCER HEREDITARY BREAST-OVARIAN CANCER SITE SPECIFIC OVARIAN CANCER FAMILIES
46 PELVIC MASS PRE-OP REQUIREMENTS PRE-OP BOWEL PREP MIDLINE INCISION AVAILABILITY OF ACCURATE FROZEN SECTION EVAL. CAPABILITY TO PERFORM FULL STAGING ABILITY TO PERFORM APPROPRIATE AND AGGRESSIVE CYTOREDUCTIVE SURGERY ABILITY TO PRESERVE FERTILITY IN APPROPRIATE PATIENTS
47 OVARIAN CANCER STAGING (FIGO-SURGICAL) STAGE I GROWTH LIMITED TO OVARIES Ia LIMITED TO ONE OVARY, NO TUMOR ON EXTERNAL SURFACE, CAPSULE INTACT. Ib LIMITE D TO BOTH OVARIES, NO TUMOR ON EXTERNAL SURFACE, CAPSULE INTACT. Ic TUMOR ON SURFACE OF OVARY(IES), OR CAPSULE RUPTURED, OR WITH ASCITES/PERITONEAL WASHINGS WITH (+) CYTOLOGY.
48 OVARIAN CANCER STAGING (FIGO-SURGICAL) STAGE II PELVIC EXTENSION IIa TO UTERUS AND/OR TUBES IIb EXTENSION TO OTHER PELVIC ORGANS IIc EITHER IIa OR IIb WITH TUMOR ON SURFACE OR RUPTURED CAPSULE, OR (+) CYTOLOGY
49 STAGE III IIIa IIIb IIIc OVARIAN CANCER STAGING (FIGO-SURGICAL) GROSSLY LIMITED TO PELVIS, WITH NEG. NODES BUT MICROSCOPIC DISEASE IN UPPER ABDOMEN ABDOMINAL IMPLANTS <2 CM. NODES NEG IMPLANTS > 2 CM., +/OR POS. RETROPERITONEAL OR INGUINAL NODES
50 OVARIAN CANCER STAGING (FIGO-SURGICAL) STAGE IV DISTANT METASTASES +/OR PLEURAL EFFUSIONS (+) +/OR PARENCHYMAL LIVER METS.
51 OVARIAN CARCINOMA CURRENT INVESTIGATION Doublet/Triplet Therapy Taxol/Carboplatin (+) Doxil or Topotecan or Gemzar Intraperitoneal Therapy?? Consolidation Therapy Gene Therapy Immune Therapy Targeted Therapy
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