HyPerforma Single-Use Bioreactor (S.U.B.) For optimal cell culture performance
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1 HyPerforma Single-Use Bioreactor (S.U.B.) For optimal cell culture performance
2 The Thermo Scientific HyPerforma Single-Use Bioreactor for mammalian cell culture We designed the Thermo Scientific HyPerforma Single-Use Bioreactor (S.U.B.) tank to provide enhanced functionality, ease of use, and efficiency while maintaining interoperability with any controller on the market today. 2
3 The original Functional and scalable Our Single-Use Bioreactor was the industry s first single-use stirred-tank bioreactor. The HyPerforma S.U.B. equipment and Thermo Scientific BioProcess Container (BPC) system are designed using traditional stainless steel bioreactor principles to helps ensure optimal cell culture performance. The complete line of HyPerforma S.U.B.s includes 50, 100, 250, 500, 1,000, and 2,000 L sizes with a 2:1 turndown ratio that ensures consistent scalability for final production. Tank design Refined and elegant The S.U.B. tank has been redesigned to provide increased functionality and is refined for cgmp requirements. The S.U.B. tank provides enhanced operator ergonomics, reduced footprint and improved cleaning capabilities that come from an open cart frame. Save precious lab space with a minimized vessel footprint Easier access to harvest lines with the open frame design Reduce hold-up volumes with the redesigned tank floor Simplified bag loading with a vertical access door (available on 500 and 1,000 L sizes; pneumatic hoist provided on 2,000 L S.U.B.) 3
4 Performance enhancements Efficient and proficient The water jacket and resistive heater design allows faster heat up and cool down times, reducing process cycle time. Optional precision load cells and standard sight volume indicators allow you to keep your processes running efficiently. Brushless DC motor includes encoder feedback for improved RPM accuracy and is GFCI-compatible Upgraded resistive heater provides 2.25 watts for faster heat up time Bottom heater on resistive and water-jacketed systems increase heat transfer surface area 3/8 dimple jacket improves flow rate through the water jacket for higher performance temperature control Optional precision load cells monitor mass/ volume accurately Graduated sight volume indicators accommodate visual volume references at a glance 4
5 Accessibility improvements Organized and ergonomic Effectively manage the process of setting up and maintaining the S.U.B. with these standard features. Dedicated adjustable tool holder keeps necessary tools available for convenience and ease Additional options available Cable management system provides greater organization for electrical cables, tubing, and line sets while making the unit easier to clean Line labels provide rapid identification of tubing lines Load cell lockout clamps maneuver the S.U.B. easily utilizing a tri-clamp device Universal filter bracket easily adjusts to various heights and positions on the vessel and facilitates single or dual filters in either 6 in. and/or 10 in. filter sizes. 5
6 The controller Adaptable and choice The HyPerforma S.U.B. offers a choice of control systems in either an open architecture or turnkey system. An open architecture system allows you to integrate with any control system of choice. Capital investment can be reduced by utilizing a control system already in use in your facility. A turnkey system is a ready-to-use, out-of-the-box system with a choice of a Finesse or Applikon dedicated controller. These systems work on PC, Delta V, Allen-Bradley, or Siemens software platforms. Applikon controller Finesse controller 6
7 The S.U.B. BioProcess Container Quality and performance Thermo Scientific BioProcess Containers (BPCs) will address your specific applications with either standard or customized configurations. They are also validated and interchangeable with your S.U.B. The standard designs are configured for a variety of applications, while the custom designs are for customer-specific applications. We will build what you need, while maintaining our quality and delivery times. Through our open architecture approach, we have qualified a variety of single-use sensors, tubing, and connectors for customer design flexibility. 7
8 Technical support: Knowledgeable and comprehensive A global field-based technical support team is available for local installation and technical support. A process development team is available for cell culture support, providing expertise on cell growth and troubleshooting. We can also provide you with additional support documentation upon request. All systems are supplied with: Comprehensive user s guide Equipment turnover package (ETP) Validation guide 8 8
9 Specifications S.U.B. hardware specifications 50 L 100 L 250 L 500 L 1,000 L 2,000 L Liquid working volume 50 L 100 L 250 L 500 L 1,000 L 2,000 L Minimum liquid working volume 25 L 50 L 125 L 250 L 500 L 1,000 L Total reactor volume (not working volume) Fluid geometry at working volume (height/diameter) ratio Overall reactor geometry (height/diameter) ratio Impeller (quantity x blade count) 65.5 L 120 L 316 L 660 L 1,320 L 2,575 L x 3 1 x 3 1 x 3 1 x 3 1 x 3 1 x 3 Mixing rate range RPM RPM RPM RPM RPM RPM S.U.B. hardware dimensions and weights Tank overall (including cable management tree: W x L x H) Resistive tank weight dry/wet (at full working volume) Jacketed tank weight dry/wet (at full working volume) 50 L 94.2 x 84.3 x cm (37.1 x 33.2 x 78.2 in.) kg (309.5 lbs) kg (419.8 lbs) kg (311.3 lbs) kg (421.5 lbs) 100 L 98.5 x 91.2 x cm (38.8 x 35.9 x 79.3 in.) kg (433 lbs) kg (653 lbs) kg (483 lbs) kg (703 lbs) 250 L x x cm (44.4 x x 84.4 in.) kg (516.5 lbs) kg (1,067.7 lbs) kg (548.7 lbs) kg (1,099.9 lbs) 500 L x x cm (49.3 x 47.8 x 98.9 in.) kg (724 lbs.) kg (1,826 lbs.) kg (799 lbs) kg (1,901 lbs) 1,000 L x x 284 cm (56.6 x 54.8 x in.) kg (1,300 lbs.) 1,589 kg (3,505 lbs.) kg (1,450 lbs) 1,637.5 kg (3,610 lbs) 2,000 L x x cm (70.5 x 67.5 x 140 in.) N/A kg (1,800 lbs) 2,812 kg (6,200 lbs) Add 29.2 cm (11.5 in.) to overall system width if cable management tree is added. Filter bracket extends 56.9 cm (22.4 in.) above top of motor, height to top of filter bracket given. Electrical box adds 35 cm (13.8 in.) to system width, dimension with electrical box given in table. All weights and dimensions are approximate measurements. Design request accruals will be presented. 9
10 Orders Place your order from the options below HyPerforma S.U.B. products Cat. No. Description Size SUB Resistive, DC motor, without load cell 50 L SUB Jacketed, DC motor, without load cell 50 L SUB Resistive, 120VAC, AC motor, without load cell 50 L SUB Jacketed, 120VAC, AC motor, without load cell 50 L SUB Resistive, 240VAC, AC motor, without load cell 50 L SUB Jacketed, 240VAC, AC motor, without load cell 50 L SUB Resistive, DC motor, without load cell 100 L SUB Jacketed, DC motor, without load cell 100 L SUB Resistive, 120VAC, AC motor, without load cell 100 L SUB Jacketed, 120VAC, AC motor, without load cell 100 L SUB Resistive, 240VAC, AC motor, without load cell 100 L SUB Jacketed, 240VAC, AC motor, without load cell 100 L SUB Resistive, DC motor, without load cell 250 L SUB Jacketed, DC motor, without load cell 250 L SUB Resistive, 120VAC, AC motor, without load cell 250 L SUB Jacketed, 120VAC, AC motor, without load cell 250 L SUB Resistive, 240VAC, AC motor, without load cell 250 L SUB Jacketed, 240VAC, AC motor, without load cell 250 L SUB Resistive, DC motor, without load cell 500 L SUB Jacketed, DC motor, without load cell 500 L SUB Resistive, 240VAC, AC motor, without load cell 500 L SUB Jacketed, 240VAC, AC motor, without load cell 500 L SUB Resistive, DC motor, without load cell 1,000 L SUB Jacketed, DC motor, without load cell 1,000 L SUB Resistive, 240VAC, AC motor, without load cell 1,000 L SUB Jacketed, 240VAC, AC motor, without load cell 1,000 L SUB Resistive, DC motor, without load cell 2,000 L SUB Jacketed, DC motor, without load cell 2,000 L 10
11 Orders Place your order from the options below Cable management system Cat. No. Description Size SV Cable Management System 50 L, 100 L SV Cable Management System 250 L SV Cable Management System 500 L SV Cable Management System 1,000 L Load cells Cat. No. Description Size SV Load cell with Sum card, without display 50 L SV Load cell with Sum card, without display 100 L, 250 L SV Load cell with Sum card, without display 500 L BioProcess Containers, S.U.B., CX5-14 Film Cat. No. Description Size SH BioProcess Container, S.U.B., CX5-14 Film 50 L SH BioProcess Container, S.U.B., CX5-14 Film 100 L SH BioProcess Container, S.U.B., CX5-14 Film 250 L SH BioProcess Container, S.U.B., CX5-14 Film 500 L SH BioProcess Container, S.U.B., CX5-14 Film 1,000 L SH BioProcess Container, S.U.B., with condenser, CX5-14 Film 2,000 L SH BioProcess Container, S.U.B., with condenser, CX5-14 Film 2,000 L BioProcess Containers, S.U.B., Aegis5-14 Film Cat. No. Description Size SH BioProcess Container, S.U.B., Aegis5-14 Film 50 L SH BioProcess Container, S.U.B., Aegis5-14 Film 100 L SH BioProcess Container, S.U.B., Aegis5-14 Film 250 L SH BioProcess Container, S.U.B., Aegis5-14 Film 500 L SH BioProcess Container, S.U.B., Aegis5-14 Film 1,000 L SH BioProcess Container, S.U.B., Aegis5-14 Film 2,000 L Accessories Cat. No. SH SH SH SV SV SV Description Bioreactor Probe Assembly (non-sterile) Sterile Sampling Manifold with luer-lock (individual) Sterile Sampling Manifold with luer-lock (10 count) Heavy Duty Tubing Clamp Heavy Duty Tubing Clamp (10 pack of SV ) S.U.B. Temperature/Sample Port 11
12 Integrated solutions for bioproduction Single-Use Mixers (S.U.M.s) A variety of options up to 5,000 L for both upstream and downstream applications Liquid- and dry-format media We offer both custom manufacturing and a full range of chemically defined performance media and supplement products BioProcess Containers (BPCs) A variety of configurations up to 2,000 L for liquid harvest, storage, and transportation Sera Our sera are the industry standards for consistent quality and reliability Single-Use Bioreactors (S.U.B.s) 50 2,000 L bioreactors capable of integrating with an existing control system Buffers and process liquids Custom and standard buffers and process liquids, including Gibco Water For Injection (WFI) quality water Integrity testing systems A true point-of-use integrity testing system to confirm the integrity of BPCs before use Find out more at thermofisher.com/sut Logan, Utah United States of America +(1) Millersburg, Pennsylvania United States of America +(1) Cramlington NE23 1WA United Kingdom +44 (0) Matamoros, Tamaulipas Mexico +011 (52) Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. Finesse is a trademark of Finesse Solutions, Inc. Applikon is a trademark of Applikon B.V. Corporation. Delta V is a trademark of Emerson Electric Co. Siemens is a trademark of Siemens Aktiengesellschaft. COL
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