Encephalitis Related research January 2014

Size: px
Start display at page:

Download "Encephalitis Related research January 2014"

Transcription

1 Study title Lead Institution and lead investigator Abstract or further info on study Funder Funding awarded Start date (or date of award) Proposed end date ES Coapplicant status 1 Informal study of Encephalitis Angela VINCENT Suhkvir Wright and Yael Hacohen, Oxford; Ming Lim, London 2 Faciobrachial dystonic seizures a prodrome to LGI1-antibody encephalitis 3 Faciobrachial dystonic seizures: an immunotherapy responsive syndrome whose treatment may prevent encephalitis 4 Audit of children/adolescents following encephalitis seen for neuropsychological assessment 5 Understanding and Improving the Outcome of Encephalitis Oxford, Prof A Vincent London, Mike Johnson and Oxford, Sarosh Irani Paediatric Neuropsychology Service, Nottingham University Hospitals NHS Trust Dr Arleta Starza-Smith, Dr and Dr Emily Talbot in collaboration with Dr Rachel Kneen & Dr Vicky Gray at Alder Hey in Liverpool Prof. Tom Solomon, Brain Infections Group, University of Liverpool Presence of antibodies to neuronal antigens in sera from children with autoimmune encephalitis. Retrospective study on children from five UK centres (Hacohen et al 2012). Two other pediatric cohort studies in progress Preliminary results published : Irani et al Ann Neurol May;69(5): A prospective study to understand whether immunotherapy for Faciobrachial dystonic seizures prevents encephalitis Looking to audit children/adolescents who had encephalitis and been seen for neuropsychological assessment across two centres Study the clinical predictors of Encephalitis, and of poor outcome Better understand those outcomes in terms of cognitive function, quality of life, and cost Develop the means of intervening to Wellcome Trust NIHR Oxford Biomedical NIHR Oxford Biomedical NIHR Oxford Biomedical Within NHS Trusts WT clinical training fellowship to Suhkvir Wright Oxford Biomedical training fellowship to Yael Hacohen NIHR fellowship to Sarosh Irani April 1 st 2012 March 31 st /2007 indefinite On going indefinite n/a 2013 End 2013 NIHR 2 million

2 improve the outcome 6 Understanding the role of Inflammation in Encephalitis 7 Enhanced diagnostic and management strategies to improve the identification and outcome of individuals with encephalitis 8 Cognitive dysfunction in autoimmune limbic encephalitis and its implications for the neuroscience of remote memory. Dr Benedict Michael, Brain Infections Group, University of Liverpool Dr Julia Granerod/HPA University of Oxford; Dr. Christopher Butler and Dr Thomas Miller In humans, which of these protein molecules causes the inflammation in HSV encephalitis and are they more closely related to a poor outcome than the amount of virus? Aims 1. To devise a standard diagnostic algorithm for the laboratory investigation of encephalitis across the UK; 2. To establish how improved access to intrathecal and autoantibody testing will contribute to better management of cases; 3. To ensure consistent high-level molecular diagnostics are available across the England; 4. To establish a communications strategy for general physicians, general practitioners (GPs) and the general public to raise awareness of encephalitis and contribute to rapid referral; 5. To establish a bio-bank for further work on the aetiology of encephalitis cases; 6. To define the role of scans in early management of encephalitis cases; 7. To define and quantify sequelae postencephalitis. Limbic encephalitis (LE) is a disease in which amnesia and seizures arise from inflammation of the medial temporal lobes (MTL), a region critical for memory. Many cases of LE are due to autoimmune disease where antibodies against proteins in the cell membrane of neurons, NIHR 456, DoH 413,840 January 2013 The Encephalitis Society Patrick Berthould Charitable Trust 2 years with total of 150,000 January /1/ /1/2015

3 9 Intravenous Immunoglobulin in the management of Encephalopathy University of Oxford and Professor Andrew J Pollard especially the voltage-gated potassium channel complex (VGKC-LE). Patients with VGKC-LE usually improve with treatment, but some develop lasting problems with their memory, probably as a result of permanent brain damage. Very little is known about the cause of patients memory difficulties or how they can be prevented. VGKC-LE was first described in Oxford, and there is a large number of people in the region who have been treated for it. We will perform memory testing and detailed brain scans in these people, and in a group of newly-diagnosed patients, in order to understand how VGKC-LE causes memory impairment and improve the management of this condition. VGKC-LE also offers unique opportunities for understanding how the brain processes memories. Many scientists think that, although the MTL is important for memory, it is not involved in remembering events that occurred long ago ( remote memory ). However, our preliminary work suggests that patients with VGKC-LE, who have damage to the MTL, are unable to remember events even from their childhood. We now need to check this finding in a large number of patients using detailed tests of remote memory and state-of-the-art brain scanning. If true, it will have important implications for our understanding of how memories are laid. To determine whether early treatment with intravenous immunoglobulin (IVIG) additional to standard care for children presenting with symptoms and signs of acute encephalitis EME 2,360,932 1/9/ /8/2016

4 improves outcome when compared to standard care alone. 10 Neuropsychological Outcome of Encephalitis in Children - a better understanding to develop improved services Rachel Kneen Arleta Starza Smith Ava Easton Dr Marta García- Fiñana Michael Kopelman Tom Solomon We will study the neuropsychological outcome of encephalitis in children & adolescents (<18 years). We will do this by studying children and adolescents enrolled in a previous Health Protection Agency (HPA) study of encephalitis (funded by Department of Health) and those enrolled in the NIHR programme grant. The research is led by Alder Hey Children s NHS Foundation Trust in partnership with the Liverpool Brain Infections Group, the Encephalitis Society, the HPA and other experts in this area.?? 11 Mechanism and Efficacy of Corticosteroids in Herpes simplex virus Encephalitis in Adults Tom Solomon Test the primary hypothesis that treatment with the corticosteroid dexamthasone, rather than placebo, is associated with a reduction in the swelling of the temporal lobe measured by magnetic resonance imaging at 2 weeks, without an associated in detectable virus in the CSF. The aims are: 1. is to set up a randomised placebo controlled trial of dexamethasone versus placebo in adults with HSV encephalitis 2. to perform MRI scanning at admission, and 2 weeks later, to allow examination of the effect of dexamethasone on brain swelling in the temporal lobe 3. to see whether dexamethasone treatment affects the proportion of EME 1,154,637??

5 patients who have HSV still detectable in the routine CSF examination which is performed at 2 weeks into treatment. 12 Acute encephalitis in children- Which outcomes are important Prof Tom Solomon and Dr Rachel Kneen (supervisors), Dr Jennifer Lemon (research fellow) We will also address these additional questions: 1. How do MRI scans at 6 months compare for patients treated with or without corticosteroids 2. What is the effect of corticosteroid treatment on host response patterns in the CSF and blood for patients with HSV encephalitis 3. How do clinical outcomes at 2 weeks and at 6 months compare for patients treated with or without corticosteroids. A need has been identified by researchers to standardise which outcomes are measured in clinical trials. The Core Outcomes Measurement in Effectiveness Trials (COMET) initiative suggests that this can be achieved by developing a Core Outcome Set (COS) which should be developed with stakeholder groups. A COS is a list of the minimum that should be measured and reported in all clinical trials of a specific condition. Encephalitis is a complex disease with a wide variety of different outcomes and can have a huge impact on the lives of patients and their families. There is currently no COS for paediatric encephalitis and this research aims to undertake the first steps towards development of this list by 1) Assessing what outcomes have been measured previously in clinical trials involving patients with acute Institute of Infection and Global health. The qualitative study is a sub study of the UK ChiMES study n/a Aug 2013 Dec 2014

6 13 Examining host response in viral encephalitis: towards developing novel immunomodulatory therapies Jeoffrey Segura encephalitis by means of a systematic review 2) Exploring via interviews with parents which outcomes matter most to children with encephalitis and their families, how perspectives on any problems experienced have changed over time and future expectations. To study the mechanisms of host damage in viral encephalitis we have a range of models, including a blood brain barrier model, cardiomyocyte model and neuronal cell model. These allow us to examine the effect of viral infection and of serum and cerebrospinal fluid from infected patients on host tissues, and to interrogate the host response through collaboration with Prof Neil Hall of Liverpool s Centre for Genomic Research. In this project we will thus determine the effects of the relevant host markers, and importantly explore the role of putative treatment to reverse these effects. In recent years antibodies against IL-6, IL-1Ra, and G-CSF have become available in clinical practise. This PhD project will determine which of these compounds might be suitable as development as treatment for viral encephalitis, as well as identifying possible new therapeutic targets. The Encephalitis Society/Kirkby Foundation/Univ ersity of Liverpool PhD Fellowship 17,859 per year for three years July

Brains on Fire Autoimmune causes of psychosis. Dr Belinda Lennox Department of Psychiatry, University of Oxford Belinda.lennox@psych.ox.ac.

Brains on Fire Autoimmune causes of psychosis. Dr Belinda Lennox Department of Psychiatry, University of Oxford Belinda.lennox@psych.ox.ac. Brains on Fire Autoimmune causes of psychosis Dr Belinda Lennox Department of Psychiatry, University of Oxford Belinda.lennox@psych.ox.ac.uk RCPsych Brighton 16 th October 2014 Overview The new disorders

More information

By Dr Sarosh R Irani, Dr Camilla Buckley and Prof Angela Vincent

By Dr Sarosh R Irani, Dr Camilla Buckley and Prof Angela Vincent Limbic Encephalitis By Dr Sarosh R Irani, Dr Camilla Buckley and Prof Angela Vincent This factsheet aims to provide people affected by Encephalitis, their families, friends and carers with a better undertstanding

More information

Herpes Simplex Encephalitis (HSE)

Herpes Simplex Encephalitis (HSE) Herpes Simplex Encephalitis (HSE) Dr Graham Cleator, Head, Division of Virology, Clinical Sciences Building, Manchester Royal Infirmary. Revised by Dr Nick Davies, St Mary s Hospital, London Herpes simplex

More information

This is the written version of our Hot Topic video presentation available at: MayoMedicalLaboratories.com/hot-topics

This is the written version of our Hot Topic video presentation available at: MayoMedicalLaboratories.com/hot-topics This is the written version of our Hot Topic video presentation available at: MayoMedicalLaboratories.com/hot-topics Welcome to Mayo Medical Laboratories Hot Topics. These presentations provide short discussion

More information

Immune-mediated epilepsy: Which Patients Should Be Tested? December 04, 2012

Immune-mediated epilepsy: Which Patients Should Be Tested? December 04, 2012 : Which Patients Should Be Tested? December 04, 2012 Christian G. Bien, Epilepsy Center Bethel, Germany American Epilepsy Society Annual Meeting Disclosure Service on scientific advisory boards of UCB,

More information

Acute Disseminated Encephalomyelitis (ADEM)

Acute Disseminated Encephalomyelitis (ADEM) Acute Disseminated Encephalomyelitis (ADEM) By Professor Clive Hawkins, Professor of Clinical Neurology, Consultant Neurologist, University Hospital of North Staffordshire and reviewed by Dr Sarosh Irani,

More information

Autoantibodies associated with diseases of the CNS: new developments and future challenges. Angela Vincent and the Neurosciences Group

Autoantibodies associated with diseases of the CNS: new developments and future challenges. Angela Vincent and the Neurosciences Group Autoantibodies associated with diseases of the CNS: new developments and future challenges Angela Vincent and the Neurosciences Group Nuffield Department of Clinical Neurosciences, Oxford AV and the Oxford

More information

After-effects of viral meningitis in adults

After-effects of viral meningitis in adults After-effects of viral meningitis in adults Dr Fiona McGill NIHR Doctoral Research Fellow Liverpool Brain Infections Group, Liverpool Specialist Registrar Infectious Diseases/Medical Microbiology Meningitis

More information

UK Strategy for Rare Diseases. NHS England Statement of Intent

UK Strategy for Rare Diseases. NHS England Statement of Intent UK Strategy for Rare Diseases NHS England Statement of Intent 1 NHS England INFORMATION READER BOX Directorate Medical Operations Patients and Information Nursing Policy Commissioning Development Finance

More information

Alzheimer s disease. Data driven drug development from target identification to proof of concept

Alzheimer s disease. Data driven drug development from target identification to proof of concept Alzheimer s disease Data driven drug development from target identification to proof of concept Collaboration for translational research in dementia Alzheimer s Research UK Drug Development Alliance Dementias

More information

SSPE: a Chronic Encephalitis as a Result of Measles

SSPE: a Chronic Encephalitis as a Result of Measles SSPE: a Chronic Encephalitis as a Result of Measles By Dr Pam Tomlin, Paediatric Neurologist and reviewed by Dr. Rachel Kneen, Consultant Paediatric Neurologist, Alder Hey Children s Hospital This factsheet

More information

L E A D I N G C N S A N T I B O D Y T E S T I N G S E R V I C E S

L E A D I N G C N S A N T I B O D Y T E S T I N G S E R V I C E S L E A D I N G C N S A N T I B O D Y T E S T I N G S E R V I C E S Paraneoplastic Autoimmune Neurological Disorder Testing Services New Tests Now Available. Why Athena Diagnostics? Faster, More Relevant

More information

Molecular Imaging and Prostate Cancer

Molecular Imaging and Prostate Cancer Molecular Imaging and Prostate Cancer Prostate cancer is the second leading cause of cancer death in American men, behind only lung cancer. Based on rates from 2004 2006, the National Cancer Institute

More information

VIRAL MENINGITIS AND ENCEPHALITIS

VIRAL MENINGITIS AND ENCEPHALITIS VIRAL MENINGITIS AND ENCEPHALITIS Pediatric RPAC Educational Day 19 April 2000 Bonita Biegalke, PhD Department of Biomedical Sciences Ohio University College of Osteopathic Medicine Athens, Ohio 45701

More information

Delivering for people with dementia

Delivering for people with dementia alzheimers.org.uk Delivering for people with dementia Quality research in dementia impact report 2007 08 September 2008 Publications 2007 2008 Scientists disseminate their research results by publishing

More information

Neonatal Herpes Simplex Infection

Neonatal Herpes Simplex Infection August 2011 Neonatal Herpes Simplex Infection Revision Dates Case Definition Reporting Requirements Remainder of the Guideline (i.e., Etiology to References sections inclusive) August 2011 August 2011

More information

Melanoma Central Nervous System Metastases

Melanoma Central Nervous System Metastases Melanoma Central Nervous System Metastases Current Approaches, Challenges and Opportunities In December, 2015, the Melanoma Research Foundation convened a major scientific meeting to address the issue

More information

Beyond the Pediatric Vaccine Schedule

Beyond the Pediatric Vaccine Schedule Beyond the Pediatric Vaccine Schedule Carolyn D. Deal, Ph.D. Chief, Sexually Transmitted Diseases Branch NIAID, NIH, DHHS Outline Current vaccine schedules for adolescents and adults Building adolescent

More information

Dementia current themes

Dementia current themes Dementia current themes Dr Daniel Harwood Consultant Psychiatrist and London Strategic Clinical Network Clinical Director for Dementia This talk What is dementia? The dementia care pathway if you or a

More information

Hashimoto's Encephalopathy

Hashimoto's Encephalopathy Hashimoto's Encephalopathy by Adult Down Syndrome Clinic on Tuesday, June 29, 2010 Hashimoto s Encephalopathy Brian Chicoine, MD Adult Down Syndrome Center What is Hashimoto s Encephalopathy? Hashimoto

More information

Local Clinical Trials

Local Clinical Trials Local Clinical Trials The Alzheimer s Association, Connecticut Chapter does not officially endorse any specific research study. The following information regarding clinical trials is provided as a service

More information

Defeating dementia through research

Defeating dementia through research Defeating dementia through research Foreword 700,000 people in the UK have dementia and one million people will develop the condition in the next 10 years. 1 Dementia is caused by diseases of the brain

More information

Alzheimer s Disease: A Priority of the Innovative Medicines Initiative. Elisabetta Vaudano PhD DVM

Alzheimer s Disease: A Priority of the Innovative Medicines Initiative. Elisabetta Vaudano PhD DVM Alzheimer s Disease: A Priority of the Innovative Medicines Initiative Elisabetta Vaudano PhD DVM Alzheimer s Disease Facts & Challenges Alzheimer s Disease in Europe The world's population is ageing.

More information

This vision does not represent government policy but provides useful insight into how brain & CNS cancer services might develop over the next 5 years

This vision does not represent government policy but provides useful insight into how brain & CNS cancer services might develop over the next 5 years Brain & CNS cancers 2015 Annex B Epidemiology 1. The incidence of brain & CNS tumours in England was reported to be just under 4,000 in 2007. 1 This is expected to increase further with an aging population

More information

Imaging Markers of Brain Network Dysfunction in Multiple Sclerosis

Imaging Markers of Brain Network Dysfunction in Multiple Sclerosis Faculty of Medicine & Health Sciences School of Medicine Radiological Sciences Research Group The University of Nottinham University Park Nottingham NG7 2RD t: +44 (0)115 823 0018 f: +44 (0)115 823 0004

More information

Genes & Scans: the role of Biomarkers in Dementia Diagnosis

Genes & Scans: the role of Biomarkers in Dementia Diagnosis Genes & Scans: the role of Biomarkers in Dementia Diagnosis G-Y. Robin Hsiung, MD MHSc FRCPC FACP Division of Neurology University of British Columbia, Vancouver, Canada What is a Biomarker? Biomarkers

More information

Standards of proficiency. Biomedical scientists

Standards of proficiency. Biomedical scientists Standards of proficiency Biomedical scientists Contents Foreword 1 Introduction 3 Standards of proficiency 7 Foreword We are pleased to present the Health and Care Professions Council s standards of proficiency

More information

Academic Clinical Fellowship in Infectious Diseases and Microbiology

Academic Clinical Fellowship in Infectious Diseases and Microbiology Academic Clinical Fellowship in Infectious Diseases and Microbiology Description of ACF Programme: Infectious Diseases and Medical Microbiology Title: Infectious Diseases and Medical Microbiology Duration:

More information

COMPASS. Antisense Therapeutic Approach for SMA The Ins and Outs of Antisense Drugs D R U G D I S C O V E R Y FALL 2013

COMPASS. Antisense Therapeutic Approach for SMA The Ins and Outs of Antisense Drugs D R U G D I S C O V E R Y FALL 2013 D R U G D I S C O V E R Y FALL 2013 COMPASS A Publication Dedicated To Research Updates Antisense Therapeutic Approach for SMA The Ins and Outs of Antisense Drugs ABC s of antisense drugs Antisense drugs

More information

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available.

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available. Thymus Cancer Introduction Thymus cancer is a rare cancer. It starts in the small organ that lies in the upper chest under the breastbone. The thymus makes white blood cells that protect the body against

More information

Outline. Personal profile & research interests. Rheumatology research in Ireland. Current standing. Future plans

Outline. Personal profile & research interests. Rheumatology research in Ireland. Current standing. Future plans Outline Personal profile & research interests Rheumatology research in Ireland Current standing Future plans Personal profile 1983 MB Queens University 1990-3 ARUK Clinical Research Fellowship 1990-93

More information

100,000 Genomes Project. Participant Information Sheet. For families of patients with rare genetic diseases. About the 100,000 Genomes Project

100,000 Genomes Project. Participant Information Sheet. For families of patients with rare genetic diseases. About the 100,000 Genomes Project 100,000 Genomes Project Insert hospital logo here Participant Information Sheet This sheet summarises the project and key points that you need to consider regarding your potential participation in this

More information

MG Research Update. Jeffrey T. Guptill MD, MA, MHS Assistant Professor of Neurology Duke University Medical Center

MG Research Update. Jeffrey T. Guptill MD, MA, MHS Assistant Professor of Neurology Duke University Medical Center MG Research Update Jeffrey T. Guptill MD, MA, MHS Assistant Professor of Neurology Duke University Medical Center Overview Clinical trial update Highlights from 2015 Scientific Session A few other items

More information

Alzheimers, Parkinson s... or is it NPH?

Alzheimers, Parkinson s... or is it NPH? Alzheimers, Parkinson s... or is it NPH? NPH The little-known I had never heard of NPH. But am I glad I know about it now. Bob Fowler, NPH survivor who now leads an active life. neurological disorder that

More information

100,000 Genomes Project West Midlands NHS Genomic Medicine Centre

100,000 Genomes Project West Midlands NHS Genomic Medicine Centre england 100,000 Genomes Project West Midlands NHS Genomic Medicine Centre not you want to take part. If you don t want to take part in this Project, you don t have to. You don t have to give a 1. INTRODUCTION

More information

Changes in the Brain

Changes in the Brain Alzheimer s Disease Alzheimer s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks. In most

More information

Acute polyradiculoneuropathy and Dengue Fever infection

Acute polyradiculoneuropathy and Dengue Fever infection Acute polyradiculoneuropathy and Dengue Fever infection Journée scientifique de l IPNC 21 Novembre 2013 Dr Olivier SIMON Neurologue CHT Gaston Bourret Nouméa Nouvelle Calédonie Plan 1- Introduction Neurological

More information

ß-interferon and. ABN Guidelines for 2007 Treatment of Multiple Sclerosis with. Glatiramer Acetate

ß-interferon and. ABN Guidelines for 2007 Treatment of Multiple Sclerosis with. Glatiramer Acetate ABN Guidelines for 2007 Treatment of Multiple Sclerosis with ß-interferon and Glatiramer Acetate Published by the Association of British Neurologists Ormond House, 27 Boswell Street, London WC1N 3JZ Contents

More information

Cancer Screening Uptake Among Patients with Type 2 Diabetes

Cancer Screening Uptake Among Patients with Type 2 Diabetes Background Cancer Screening Uptake Among Patients with Type 2 Diabetes Matthew Carr, Iain Buchan, Evan Kontopantelis, Tim Doran and Andrew Renehan (PI) National Awareness and Early Detection Initiative

More information

Improving quality, protecting patients

Improving quality, protecting patients Improving quality, protecting patients Standards of proficiency for Healthcare Science Practitioners 31 July 2014 Version 1.0 Review date: 31 July 2015 Foreword I am pleased to present the Academy for

More information

Diagnosing dementia and the caregiver role Kristin Kahle Wrobleski, Ph.D., HSPP

Diagnosing dementia and the caregiver role Kristin Kahle Wrobleski, Ph.D., HSPP Internal Use Only:Differential Diagnosis.64518.Apr2015. Diagnosing dementia and the caregiver role Kristin Kahle Wrobleski, Ph.D., HSPP National Alliance for Caregiving March 21 st, 2016 Washington, D.C.

More information

Nerve fibre bundles in the newborn brain captured by Magnetic Resonance Imaging

Nerve fibre bundles in the newborn brain captured by Magnetic Resonance Imaging Nerve fibre bundles in the newborn brain captured by Magnetic Resonance Imaging Contents Aim 2 Academic Staff 4 Funding 6 Research 8 Beyond the Laboratory 12 Neonatal Intensive Care Aim Our goal is to

More information

Ventricular Lavage for premature babies with brain haemorrhage

Ventricular Lavage for premature babies with brain haemorrhage Ventricular Lavage for premature babies with brain haemorrhage Exceptional healthcare, personally delivered Welcome to North Bristol NHS Trust At North Bristol NHS Trust we provide hospital and community

More information

TCHP Behavioral Health Psychological/Neuropsychological Testing Child/Adolescent Guidelines

TCHP Behavioral Health Psychological/Neuropsychological Testing Child/Adolescent Guidelines TCHP Behavioral Health Psychological/Neuropsychological Testing Child/Adolescent Guidelines Psychological testing involves the culturally and linguistically competent administration and interpretation

More information

Clinical Trials of Disease Modifying Treatments

Clinical Trials of Disease Modifying Treatments MS CENTER CLINICAL RESEARCH The UCSF MS Center is an internationally recognized leader in multiple sclerosis clinical research. We conduct clinical trials involving the use of experimental treatments,

More information

Integration of advanced care planning and end of life care into the management patients with chronic liver disease

Integration of advanced care planning and end of life care into the management patients with chronic liver disease Title: Integration of advanced care planning and end of life care into the management patients with chronic liver disease Investigator details: 1. Dr Benjamin Hudson Specialist trainee in gastroenterology

More information

The impact of clinical trials in treating inflammatory skin disease. Dr Andrew Pink Consultant Dermatologist, GSTT Honorary Clinical Lecturer, KCL

The impact of clinical trials in treating inflammatory skin disease. Dr Andrew Pink Consultant Dermatologist, GSTT Honorary Clinical Lecturer, KCL The impact of clinical trials in treating inflammatory skin disease Dr Andrew Pink Consultant Dermatologist, GSTT Honorary Clinical Lecturer, KCL St. John s Institute of Dermatology World class centre

More information

Getting involved in dementia research

Getting involved in dementia research Getting involved in dementia research Introduction This booklet aims to tell you more about what dementia research involves and how you can take part. Please contact us if you would like a version in a

More information

NIHR Research Design Service London Dr Peter Lovell Deputy Director

NIHR Research Design Service London Dr Peter Lovell Deputy Director NIHR Research Design Service London Dr Peter Lovell Deputy Director Research Design Service (RDS) A national network of support services; Supporting those who are putting together REGIONAL RDS North East

More information

NEUROIMMUNOLOGY MODULE SCHEDULE & OUTLINE 2010

NEUROIMMUNOLOGY MODULE SCHEDULE & OUTLINE 2010 NEUROIMMUNOLOGY MODULE SCHEDULE & OUTLINE 2010 Course Organisers: Dr, Dr Jana Haase Module Co-ordinator: Dr Jana Haase Credits: 5 Date & Time Session & Topic Co-ordinator 18 th March 1. Neuroimmunology:

More information

RELAPSE MANAGEMENT. Pauline Shaw MS Nurse Specialist 25 th June 2010

RELAPSE MANAGEMENT. Pauline Shaw MS Nurse Specialist 25 th June 2010 RELAPSE MANAGEMENT Pauline Shaw MS Nurse Specialist 25 th June 2010 AIMS OF SESSION Relapsing/Remitting MS Definition of relapse/relapse rate Relapse Management NICE Guidelines Regional Clinical Guidelines

More information

UNDER REVIEW. UK Standards for Microbiology Investigations. Serological Diagnosis of Syphilis

UNDER REVIEW. UK Standards for Microbiology Investigations. Serological Diagnosis of Syphilis UK Standards for Microbiology Investigations Serological Diagnosis of Syphilis Issued by the Standards Unit, Microbiology Services, PHE Virology V 44 Issue no: 1.3 Issue date: 14.04.14 Page: 1 of 12 Crown

More information

Diagnosis of Alzheimer s Disease

Diagnosis of Alzheimer s Disease Diagnosis of Alzheimer s Disease At the age of 58, Matthew Blair began to have difficulty reading, speaking, and performing daily tasks at work. His wife, Isabel, was convinced that he had Alzheimer s.

More information

Manualisation and feasibility of audiologistdelivered counselling for tinnitus

Manualisation and feasibility of audiologistdelivered counselling for tinnitus Manualisation and feasibility of audiologistdelivered counselling for tinnitus Derek Hoare, Senior Research Fellow NIHR Nottingham Hearing Biomedical Research Unit 28/06/2014 Measuring tinnitus Connectivity

More information

Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease.

Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease. Steps to getting a diagnosis: Finding out if it s Alzheimer s Disease. Memory loss and changes in mood and behavior are some signs that you or a family member may have Alzheimer s disease. If you have

More information

RISK FACTORS AND MARKERS FOR SEVERE ACUTE PANCREATITIS, GEORGIOS PAPACHRISTOU, MD 1

RISK FACTORS AND MARKERS FOR SEVERE ACUTE PANCREATITIS, GEORGIOS PAPACHRISTOU, MD 1 GEORGIOS PAPACHRISTOU, MD 1 My talk will focus on risk factors and markers for severe acute pancreatitis. Acute pancreatitis is a major problem in the US and around the world, the incidence of acute pancreatitis

More information

Big Data for Population Health

Big Data for Population Health Big Data for Population Health Prof Martin Landray Nuffield Department of Population Health Deputy Director, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery University of Oxford

More information

Summary of the risk management plan (RMP) for Blincyto (blinatumomab)

Summary of the risk management plan (RMP) for Blincyto (blinatumomab) EMA/642231/2015 Summary of the risk management plan (RMP) for Blincyto (blinatumomab) This is a summary of the risk management plan (RMP) for Blincyto, which details the measures to be taken in order to

More information

Research strategy and capacity development in population health science: an MRC and personal view

Research strategy and capacity development in population health science: an MRC and personal view Research strategy and capacity development in population health science: an MRC and personal view Professor Anne Johnson, UCL Former Chair, MRC Population Health Sciences Strategy Group Foci of MRC and

More information

SCHEDULE 2 THE SERVICES

SCHEDULE 2 THE SERVICES SCHEDULE 2 THE SERVICES A. Service Specifications Service Specification No. Service A07/S(HSS)a Atypical haemolytic uraemic syndrome (ahus) (all ages) Commissioner Lead Provider Lead Period Date of Review

More information

Work Package 8: Experimental medicine theme 2: Innate and adaptive immunity. B. Paul Morgan

Work Package 8: Experimental medicine theme 2: Innate and adaptive immunity. B. Paul Morgan Work Package 8: Experimental medicine theme 2: Innate and adaptive immunity. B. Paul Morgan morganbp@cardiff.ac.uk Innate and adaptive immunity. Aims and structures: This WP will develop innate and adaptive

More information

Medical Policy for Benefit Coverage

Medical Policy for Benefit Coverage Medical Policy for Benefit Coverage Policy: Neuropsychological Testing Last Review Date: 12/9/16 Policy Number: 028 Effective Date: 01/01/2015 General Information/Background Neuropsychological testing

More information

Paediatric Rheumatology

Paediatric Rheumatology Overview of the Department The Liverpool Clinical Academic Department of Paediatric Rheumatology is based at Alder Hey Children s NHS Foundation Trust and in the Institute of Child Health, University of

More information

2.1 Who first described NMO?

2.1 Who first described NMO? History & Discovery 54 2 History & Discovery 2.1 Who first described NMO? 2.2 What is the difference between NMO and Multiple Sclerosis? 2.3 How common is NMO? 2.4 Who is affected by NMO? 2.1 Who first

More information

CSF albumin and immunoglobulin analyses in childhood neurologic disorders

CSF albumin and immunoglobulin analyses in childhood neurologic disorders CSF albumin and immunoglobulin analyses in childhood neurologic disorders Yael Hacohen, MRCPCH Rahul Singh, MRCPCH Vhari Forsyth, MRCPCH Michael Absoud, MRCPCH, PhD Ming Lim, MRCPCH, PhD Correspondence

More information

New Onset Seizure Clinic

New Onset Seizure Clinic New Onset Seizure Clinic Timely Care from the Region s Experts The New Onset Seizure Clinic at UH Rainbow Babies & Children s Hospital provides expert diagnostic services, referrals, treatment and follow-up

More information

Dementia research: progress and challenges

Dementia research: progress and challenges Dementia research: progress and challenges University of Birmingham College of Medicine: Challenging Dementia September 6 th 2013 Dr Simon Ridley, Head of Research, Alzheimer s Research UK Alzheimer s

More information

Why use cerebrospinal fluid biomarkers for AD dementia diagnosis?

Why use cerebrospinal fluid biomarkers for AD dementia diagnosis? Biomarkers of AD 1. Holtzman. CSF Biomarkers for Alzheimer's Disease: current utility and potential future use. Neurobiol Aging (2011) 32:S4 S9 2. Hardy and Selkoe. The Amyloid Hypothesis of Alzheimer's

More information

Global Investment in HIV CURE Research and Development 2014

Global Investment in HIV CURE Research and Development 2014 July 2015 Global Investment in HIV CURE Research and Development 2014 Building the global investment and infrastructure to accelerate research towards a cure for HIV Towards an HIV Cure Antiretroviral

More information

Imaging atherosclerotic plaque inflammation in rheumatoid arthritis: methodology and initial findings in a single centre cohort study

Imaging atherosclerotic plaque inflammation in rheumatoid arthritis: methodology and initial findings in a single centre cohort study Imaging atherosclerotic plaque inflammation in rheumatoid arthritis: methodology and initial findings in a single centre cohort study Dr. Sarah Skeoch Clinical Research Fellow Centre for Musculoskeletal

More information

Roche Specimen Repositories - Frequently Asked Questions

Roche Specimen Repositories - Frequently Asked Questions Roche Specimen Repositories - Frequently Asked Questions 1. What is a Specimen Repository? A specimen repository, also known as a biobank, collects, stores, processes and distributes (according to appropriate

More information

A PARTICIPANT S GUIDE TO DRUG RESEARCH IN RETT SYNDROME

A PARTICIPANT S GUIDE TO DRUG RESEARCH IN RETT SYNDROME GUIDE TO DRUG RESEARCH IN RETT SYNDROME A PARTICIPANT S GUIDE TO DRUG RESEARCH IN RETT SYNDROME W PURPOSE OF THIS GUIDE ith the Rettsyndrome.org supporting multiple clinical trials that are aimed at changing

More information

Types of HIV test. Antigen - Any substance (such as an immunogen or a hapten) foreign to the body that stimulates an immune system response.

Types of HIV test. Antigen - Any substance (such as an immunogen or a hapten) foreign to the body that stimulates an immune system response. Types of HIV test There are two basic categories of HIV test 4 th generation and 3 rd generation. Each individual test differs as to what it tests (whether antibodies and/or p24 antigens), how it tests

More information

Unmet Needs for Parkinson s Disease Therapeutics

Unmet Needs for Parkinson s Disease Therapeutics Unmet Needs for Parkinson s Disease Therapeutics Coalition Against Major Diseases & FDA Workshop October 20, 2014 Caroline M Tanner MD, PhD Director, Parkinson's Disease Research Education and Clinical

More information

Diabetes: the future includes psychiatry! Khalida Ismail 78 th UWI/BAMP CME 14th November 2015

Diabetes: the future includes psychiatry! Khalida Ismail 78 th UWI/BAMP CME 14th November 2015 Diabetes: the future includes psychiatry! Khalida Ismail 78 th UWI/BAMP CME 14th November 2015 Depression-diabetes link depression type 2 diabetes 2 Overview Epidemiology of depression in type 2 diabetes

More information

ALGORITHM FOR SUSPECTED ACUTE VIRAL HEPATITIS

ALGORITHM FOR SUSPECTED ACUTE VIRAL HEPATITIS SEROLOGICAL TESTING FOR SUSPECTED VIRAL HEPATITIS Summary of the Clinical Practice Guideline January 2006 ALGORITHM FOR SUSPECTED ACUTE VIRAL HEPATITIS These recommendations are systematically developed

More information

CYTOKINE RELEASE SYNDROME

CYTOKINE RELEASE SYNDROME CYTOKINE RELEASE SYNDROME Jenny Lee MSN, ACNP-BC, CNS Nurse Practitioner Department of Hematology and Hematopoietic Cell Transplantation How the Experts Treat Hematologic Malignancies Las Vegas, NV Click

More information

Neuronal antibodies in pediatric epilepsy

Neuronal antibodies in pediatric epilepsy Neuronal antibodies in pediatric epilepsy Wright, Sukhvir; Geerts, Ada T; Jol-van der Zijde, Cornelia Maria; Jacobson, Leslie; Lang, Bethan; Waters, Patrick; van Tol, Maarten J D; Stroink, Hans; Neuteboom,

More information

The 2004 ACEP Seizure Clinical Policy: What About Pediatric Seizure and Status Epilepticus Patients?

The 2004 ACEP Seizure Clinical Policy: What About Pediatric Seizure and Status Epilepticus Patients? The 2004 ACEP Seizure Clinical Policy: What About Pediatric Seizure and Status Epilepticus Patients? Clinical Professor of Emergency Medicine George Washington University Washington, DC Director, Academic

More information

Academic Clinical Fellowship in Neurology

Academic Clinical Fellowship in Neurology Academic Clinical Fellowship in Neurology Description of ACF Programme: Title: Neurology Duration: 3 years Lead NHS Hospital/Trust and contact details: University Hospitals Southampton Trust Department

More information

Standards of proficiency. Operating department practitioners

Standards of proficiency. Operating department practitioners Standards of proficiency Operating department practitioners Contents Foreword 1 Introduction 3 Standards of proficiency 7 Foreword We are pleased to present the Health and Care Professions Council s standards

More information

Electrohypersensitivity and multiple chemical sensitivity: two clinicbiological. disorder?

Electrohypersensitivity and multiple chemical sensitivity: two clinicbiological. disorder? 5 th Paris Appeal Congress, 18th of May, 2015 Royal Academy of Medicine, Belgium IDIOPATHIC ENVIRONMENTAL INTOLERANCE: WHAT ROLE FOR ELECTROMAGNETIC FIELDS AND CHEMICALS? Electrohypersensitivity and multiple

More information

Clinical Trials Update

Clinical Trials Update Clinical Trials Update Joseph Muenzer, M.D., Ph.D. Professor of Pediatrics and Genetics Division of Genetics and Metabolism Department of Pediatrics University of North Carolina at Chapel Hill Chapel Hill,

More information

patient AND PUBLIC INVOLVEMENT A resource for researchers

patient AND PUBLIC INVOLVEMENT A resource for researchers patient AND PUBLIC INVOLVEMENT A resource for researchers Contents What is Patient and Public Involvement (PPI)? Methods of involvement PPI in clinical research PPI in basic research How Parkinson s UK

More information

The Parkinson s predicament

The Parkinson s predicament 4 The Parkinson s predicament The side effects of treating this devastating disease can be almost as awful as the illness itself. One Binghamton researcher hopes to change that. 5 Christopher Bishop 6

More information

Kirsty Mc Loughlin 05/11/15

Kirsty Mc Loughlin 05/11/15 Kirsty Mc Loughlin 05/11/15 Multiple Sclerosis MS is a chronic disease of the central nervous system. Progressive deterioration of various functions of CNS. MS refers to the scars(plaques/lesions) which

More information

LUPUS. and Blood Disorders LUPUSUK 2015

LUPUS. and Blood Disorders LUPUSUK 2015 8 LUPUS and Blood Disorders LUPUSUK 2015 LUPUS and Blood Disorders Systemic lupus erythematosus (SLE or lupus) has many clinical and laboratory manifestations. This factsheet relates to those manifestations

More information

My mysterious lost month of madness I was a happy 24-year-old suddenly stricken by paranoia & seizures. Was I going crazy? By SUSANNAH CAHALAN

My mysterious lost month of madness I was a happy 24-year-old suddenly stricken by paranoia & seizures. Was I going crazy? By SUSANNAH CAHALAN Autoimmune Diseases Josep Dalmau, MD, PhD University of Pennsylvania 2005 LE or diffuse encephalitis, treatment responsive 2001 LE, infrequently related to cancer, treatment responsive 1968 to 2000: Most

More information

Research Design Service London

Research Design Service London Research Design Service London Enabling Better Research Peter Lovell Programme Manager 27 th October 2011 Overview of presentation An introduction to the NIHR Research Design Service (RDS) Outline of the

More information

100,000 Genomes Project

100,000 Genomes Project 100,000 Genomes Project INSERT GMC LOGO Participant Information Sheet This information sheet describes the Project and key points that you need to consider when deciding whether or not you want to take

More information

Nottingham Trent University Course Specification

Nottingham Trent University Course Specification Nottingham Trent University Course Specification Basic Course Information 1. Awarding Institution: Nottingham Trent University 2. School/Campus: Science and Technology/Clifton 3. Final Award, Course Title

More information

SCHIZOPHRENIA. ELECTRON MICROSCOPE STUDIES

SCHIZOPHRENIA. ELECTRON MICROSCOPE STUDIES SCHIZOPHRENIA. ELECTRON MICROSCOPE STUDIES V INTERNATIONAL SYMPOSIUM PHARMACOTHERAPEUTIC AND BIOLOGICAL ASPECTS OF MENTAL DISEASES. JUNE 14-18, 2004. HAVANA, CUBA Latino American College of Neuropsychopharmacology

More information

BRAIN THE BEHAVIORAL RESEARCH AND IMAGING NEWSLETTER

BRAIN THE BEHAVIORAL RESEARCH AND IMAGING NEWSLETTER THE BRAIN THE BEHAVIORAL RESEARCH AND IMAGING NEWSLETTER FEATURED IN THIS ISSUE: UPCOMING EVENTS Learn about the new acting workshop being offered to past participants of our studies. PUBLICATIONS & AWARDS

More information

Article from: Long-Term Care News. December 2007 Issue No. 20

Article from: Long-Term Care News. December 2007 Issue No. 20 Article from: Long-Term Care News December 2007 Issue No. 20 Alzheimer s Disease Yesterday, Today and Tomorrow: Progress and Challenges by Maria C. Carrillo Alzheimer s Disease Yesterday The year 2006

More information

Behavioral Health Psychological/Neuropsychological Testing Guidelines

Behavioral Health Psychological/Neuropsychological Testing Guidelines Behavioral Health Psychological/Neuropsychological Testing Guidelines Psychological testing (procedural code 96101) and Neuropsychological Testing (procedural code 96118) involve the culturally and linguistically

More information

100,000 Genomes Project West Midlands NHS Genomic Medicine Centre

100,000 Genomes Project West Midlands NHS Genomic Medicine Centre england 100,000 Genomes Project West Midlands NHS Genomic Medicine Centre not you want to take part. If you don t want to take part in this Project, you don t have to. You don t have to give a 1. INTRODUCTION

More information

FURTHER EXPERIENCE WITH SUBCUTANEOUS IMMUNOGLOBULIN THERAPY IN CHILDREN WITH PRIMARY IMMUNE DEFICIENCIES

FURTHER EXPERIENCE WITH SUBCUTANEOUS IMMUNOGLOBULIN THERAPY IN CHILDREN WITH PRIMARY IMMUNE DEFICIENCIES FURTHER EXPERIENCE WITH SUBCUTANEOUS IMMUNOGLOBULIN THERAPY IN CHILDREN WITH PRIMARY IMMUNE DEFICIENCIES Dr Alison Jones Great Ormond Street Hospital for Children NHS Trust London WC1N 3JH United Kingdom

More information

Mapping the UK Precision Medicine Landscape

Mapping the UK Precision Medicine Landscape Mapping the UK Precision Medicine Landscape What is precision medicine? Precision medicine refines our understanding of disease prediction and risk, onset and progression in patients, informing better

More information

Viral meningitis, the facts

Viral meningitis, the facts Viral meningitis, the facts This fact sheet provides information about viral meningitis and answers some frequently asked questions. This can be read in addition to our Meningitis can affect anyone leaflet,

More information

VI.A. UNDERSTANDING YOUR LAB RESULTS

VI.A. UNDERSTANDING YOUR LAB RESULTS VI.A. UNDERSTANDING YOUR LAB RESULTS When physicians want to know how a patient is doing clinically they often ask what are the numbers? These numbers are lab results, usually from tests done on blood.

More information