Bioanalysis Solutions
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1 Bioanalysis Solutions Mass Spectrometry for Clinical Research, Drug Testing, Routine and Forensic Toxicology Innovation with Integrity Mass Spectrometry
2 Improvement in precision and accuracy, specificity and sensitivity Bruker utilizes decades of expertise to provide a range of innovative mass spectrometry and separation solutions for clinical research and forensic analysis. Capable of analyzing thousands of drugs (legal and illegal) and their metabolites from any biological matrix, Bruker mass spectrometers offer improvements in precision and accuracy, specificity and sensitivity. In addition to platforms for drug analysis, Bruker has pioneered the application of MALDI-TOF Mass Spectrometry for the clinical laboratory. Bruker systems can greatly enhance the capabilities of clinicians to analyze infectious diseases or help determine the underlying mechanisms of cancer and its effects on patients. These high value systems represent some of the most high value, robust, and easy to use instruments on the market for bioanalysis. Bruker s Bioanalysis Solutions are renowned for: Excellent value Market leading instrument performance Innovative and easy to implement software Superior product reliability Outstanding expert service and support
3 Analytical Solutions Designed for your Clinical Research Application Whether you are operating in clinical research in a highly regulated toxicology laboratory, Bruker provides product and service packages designed to meet your needs. Microbiology Microorganism Identification Sub Species Typing Functional Resistance Testing Toxicology and Drug Testing Routine and Forensic Toxicology Drugs of Abuse Screening Doping Control Therapeutic Drug Monitoring Compliance Testing Vitamins Biomarkers MALDI Imaging molecular histology Tissue Imaging A Comprehensive Product Portfolio for Bioanalysis The Bruker product portfolio for Bioanalysis contains a variety of Mass Spectrometry and separation platforms designed to provide the analytical power and reliability needed to operate in a commercial or quality control laboratory. These solutions include: The FLEX Series TM of MALDI-TOF Mass Spectrometers Powerful, flexible systems with a range of capabilities that can be optimized for the clinical environment. The amazon TM Series of Ion Traps Fast, sensitive, reliable and easy to use solution for routine applications. The microtof TM Series of TOF and qtof Mass Spectrometers Outstanding, UHPLC compatible accurate mass systems for a variety of applications. 300 MS Series of Quadrupole GC Mass Spectrometers High performance, broad mass range GCMS systems for quantitative and qualitative studies. 400 Series Gas Chromatography System Compact, customizable systems with robust performance.
4 Microbial Identification Identification and characterization of microorganisms is a key step in clinical microbiology, hospitals hygiene and microbiological research. Bruker has pioneered the application of MALDI Mass Spectrometry to the challenge of microbial identification. Using the characteristic patterns of highly abundant proteins of the respective microorganisms, and the ability of Bruker systems to analyze those patterns, Bruker has created the ground breaking MALDI Biotyper for microbial identification. MALDI Biotyper The MALDI Biotyper combines the well proven, and easy to use, benchtop microflex TM MALDI Mass Spectrometer with a comprehensive database and data analysis software to provide a turn key solution for identification of a variety of microorganisms. Capable of identification down to the genus, species, and even strain level, the MALDI Biotyper produces results comparable to molecular methods but at a fraction of the time and cost of traditional biochemical methods. This robust and reproducible method applies the latest in technological advances resulting in reduced operating costs and improved turn-around time for critical isolates. With hundreds of peer reviewed publications the MALDI Biotyper is rapidly replacing existing biochemical and phenotypic methods for identification. The commercially available library has been built in collaboration with leading centers in the fields of clinical, veterinary, environmental and food microbiology. Thus, even fastidious microorganisms like anaerobic and non-fermenting bacteria as well as multicellular fungi can be identified with one approach. Moreover, a dedicated simple and straightforward sample preparation procedure allows the analysis of microorganisms directly from positive blood cultures in less than 30 minutes. Already in broad use around the world in many clinical and research laboratories, the MALDI Biotyper takes clinical microbiology to an entirely new level of performance. CE-IVD Workflow A fully validated workflow according to the European Union IVD Directive 98/79/EC is also available and utilizes most of the same strains contained within the combined database. Sample Preparation Reference Library Data Acquisition Data Analysis
5 Toxicology Routine Toxicology Routine toxicology screening of samples for drugs of abuse and other xenobiotics is a rapidly growing area with the desire to use a range of different biological matrices. Bruker s amazon speed Toxtyper system offers sensitivity and specificity and combines method flexibility with incredible speed. The Toxtyper software package with the simplified user interface, allows even non-expert users to easily run almost any sample. Full software control makes method development a pleasure. Instrument stability allows for multiple runs (hundreds of samples) without user intervention. With the amazon s Zero Delay alternating, ion polarity switching, there is no longer a need to extract your sample several times. You can analyse for acidic, neutral and basic compounds in one short UHPLC run. All this, and you can complete your Screening and confirmation on one system, with one extraction. Additionally, as many drugs and their metabolites are readily volatilized, Gas Chromatography and GC/MS have historically been significant tools for separation, identification, and measurement of a large number of drugs or intrinsic metabolites of interest for analysts and clinicians. Powerful and easy to use, Bruker GC and GC/MS are important analytical tools in bioanalysis. Bruker GC and GC/MS systems excel at delivering sensitive, accurate, and reliable results in a wide variety of routine and specialized assay methods. Especially optimized to meet the demands of a bioanalytical laboratory, these high value systems are among the best values in bioanalysis. Forensic Toxicology Forensic toxicology presents a set of challenges to the laboratory today. With hundreds, if not thousands of compounds available for illicit and nefarious use, it is almost impossible to know what to look for in every sample. The application of Bruker Time of Flight (TOF) Mass Spectrometry gives real advantages over historic techniques. As all data is acquired for every sample, this data can be retrospectively reviewed for components that were not considered at the time of analysis. The use of accurate mass MS and accurate mass MS/MS, True Isotopic Pattern (TIP) fitting, combined with SmartFormula software, make this technology a most powerful way to identify and measure both known and unknown sample components.
6 Target Screening With over 1000 well known and widely used pharmaceuticals and recreational drugs, and several potential different sample matrices to measure, performing analyses routinely and efficiently has become a significant challenge. Working in conjunction with a number of Toxicology and Drug Screening laboratories, Bruker has developed a powerful, fast, and easy to use system for drug metabolite analysis. Combining the analytical power of Bruker s microtof Q-II with comprehensive SmartFormula compound analysis software, Bruker has created the Target Screening system. This system is fully UHPLC compatible, and is capable of providing the sensitivity and dynamic range capabilities to analyze toxicology samples. The Target Screening system can deliver very accurate molecular identification and allows for the detection of both known and unknown compounds with a single system. The Target Screening system also delivers unique capabilities for both immediate and retrospective data analysis that are impossible with traditional analysis methods. Quantitative Analysis by Targeted Screening System Intens. x Cocaine Methamphetamine Examples of quantitative analysis for blood extracts, duplicate analysis, 5 to 200 ng/ml. 1.5 BPC Time [min] Simultaneous detection of 42 compounds in serum at 100 ng/ml.
7 MALDI Imaging molecular histology One of the innovative and exciting uses of Mass Spectrometry has been its application to in situ Tissue Imaging. This allows the untargeted, label-free molecular imaging compounds such as proteins, peptides, lipids, drugs and endogenous metabolites. MALDI images of rat cerebellum A B MALDI imaging is used in applications such as molecular analysis of tumor tissue, the analysis of drugs and metabolites in pharmaceutical development, but also in other areas such as microbial interactions, neurobiology and plants. The overlay of MALDI images with virtual microscopic slides turns MALDI imaging into a true molecular histology technique without the need for molecular labels or probes Da Da Da Da Da Distribution of lipids in rat cerebellum at a pixel size of 10µm. The mass signal of shows individual Purkinje cells. Bruker has revolutionized the sample preparation for MALDI imaging with the development of the ImagePrep system. This system allows the unattended and reproducible application of the MALDI matrix by a simple push-button operation. The intuitive fleximaging software allows the simple data measurement and evaluation as well as the integration of virtual microscopy for a detailed analysis of the molecular images in a histological context. Screenshot of fleximaging software. A microscopic image of a pancreatic tumor is overlaid with the distribution of a selected mass signal (in green). Learn more: Bruker Application-Note FTMS-47+MT-113.
8 Bruker Daltonics is continually improving its products and reserves the right to change specifications without notice. BDAL , For research use only. Not for use in diagnostic procedures. Bruker Daltonik GmbH Bremen Germany Phone +49 (0) Fax +49 (0) Bruker Daltonics Inc. Billerica, MA USA Fremont, CA USA Phone +1 (978) Phone +1 (510) Fax +1 (978) Fax +1 (510)
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