Expertise You Can Trust

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1 Expertise You Can Trust

2 For the Diagnostics, Life Sciences, and Pharma Biotech Industry We are ready for the challenges you face. Products with proven quality Custom specifications that are vital to your business A partner that can navigate the regulatory landscape A partner you can rely on Partnering with Roche Custom Biotech means: GMP production backmix reactor for final stage crystallization: Head of production biosubstances Georg Tafertshofer and Martin Albrecht discussing final process parameters Control panel of an automated large scale downstream production plant Experienced experts Exceptional portfolio Customized production Proven quality Regulatory expertise

3 High Quality Products Quality and regulatory We stand by the quality of our reagents and raw materials and use them in our own kits and products. Roche is ISO 9001 certified and operates in compliance with GMP, FDA and USDA regulations. Our commitment to stringent quality standards guarantees a robust supply chain and high lot-to-lot consistency. Flexibility We meet your requirements and specifications with highquality production, scalable pack sizes, and logistic flexibility. Supply chain security We offer high level order management with dedicated service personnel assigned to ensure excellent customer service from order inquiry to delivery. Our skilled and customer-focused logistics staff work directly with you to ensure continuous supply. GMP production of datp, sodium salt solution Product portfolio and customization Access the current Roche Custom Biotech catalog covering over 1000 products at custombiotech.roche.com Pharmaceutical Biotech Diagnostics Life Science Manufacturer Industry Manufacturer Industry Fermentation Roche Custom Biotech fosters strong relations with Roche Diagnostics and Pharmaceuticals, harnessing their expertise to best serve you.

4 Customized Solutions We understand the importance of your business. A customer focused team dedicated to meet all your needs is ready to serve you. The highly trained Key Account Manager is your key interface between your company and Roche Custom Biotech, accessing products and providing expertise to bring you the best. The Logistics Specialist maintains and monitors your secure supply. The Technical Specialist provides product technical support. The Global Marketing team provides project management and product management. Feasibility Stage 1 Starting Point for New Product Development Customer Contact Sampling Feasibility Stage 2 Starting Point for Lab-Scale Performance Evaluation by Customer Evaluation and Process Feasibility Development of Lab-Scale Process Optimization Confirmation Price Indication From raw material to the fully customized solution from catalog to custom packaging from an idea to the final product from inquiry to delivery, we leverage Roche know-how to bring you the best possible in service and product quality. Lab-Scale Sampling Process Development and Up-Scale Evaluation and Approval by Customer Development of Process Production on Final Scale and Validation Downstream Processing Chemical and Biochemical Synthesis Kit Production Routine Manufacturing Process Routine Production at Roche Custom Biotech

5 The Roche Custom Biotech Team Your Gateway to the Worldwide Roche Network Roche Custom Biotech local headquarters Indianapolis Laval Mannheim Singapore Tokyo Roche Custom Biotech global headquarter Penzberg Tuscon Branchburg Mannheim Rotkreuz Penzberg Roche production facilities Building on over 30 years of industry experience, Roche Custom Biotech uses the powerful multidisciplinary skills found in Roche facilities across the world. Our research and production complex in Penzberg, Germany, has become one of the largest biotechnology centers in Europe, and is the centerpiece of a constantly growing international corporate presence that provides solutions to over 500 major customers and partners.

6 Published by Roche Diagnostics GmbH Roche Applied Science Werk Penzberg Penzberg Germany 2010 Roche Diagnostics GmbH All rights reserved Your Roche Custom Biotech Customer Service Customers in Europe, Middle East, Africa, and Latin America: Roche Diagnostics Deutschland GmbH Sandhofer Straße Mannheim, Germany Phone Fax Customers in the United States: Roche Diagnostics Corporation Roche Applied Science 9115 Hague Road P.O. Box Indianapolis, IN , USA Phone , ext (toll-free) Fax Customers in Canada: Roche Diagnostics 201, Boulevard Armand-Frappier HV 4A2 Laval, Québec, Canada Phone Fax Customers in Japan: Roche Diagnostics K.K. Roche Custom Biotech Applied Science 6-1, Shiba 2-chome Minato-ku, Tokyo , Japan Phone Fax Customers in Asia Pacific: Roche Diagnostics Asia Pacific Pte. Ltd. Regional Sales and Market Development 298 Tiong Bahru Road # 16-01/06 Central Plaza Singapore, Phone Fax custombiotech.roche.com

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