WHO Guidelines on Diagnosis and Classification of Hyperglycaemia first Detected in Pregnancy

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1 WHO Guidelines on Diagnosis and Classification of Hyperglycaemia first Detected in Pregnancy Gojka Roglic Departmentof Management of NCDs, Disability, Violence and Injury Prevention

2 Update of the 1999 WHO classification and diagnosis Diagnostic criteria for hyperglycaemia in pregnancy recommended by WHO in 1999 were not evidence-based needed to be updated in the light of new data A panel of international experts convened at WHO to revise the Diagnosis and Classification of hyperglycemia in pregnancy

3 Update of the 1999 WHO classification and diagnosis WHO procedures for guidelines development: Systematic reviews for key questions GRADE methodology to assess quality of the evidence and determine the strength of the recommendation on the diagnostic cut-off values for GDM Where evidence was absent (diagnosis of diabetes in pregnancy) or GRADE was not deemed suitable (classification) recommendations were based on consensus.

4 Published in 2013 WHO/NMH/MND/

5 After examining the best available evidence, WHO made three recomendations Recomendation 1 Hyperglycaemia first detected at any time during pregnancy should be classified as either : Diabetes mellitus in pregnancy Gestational diabetes mellitus (GDM) Quality of evidence: not graded Strength of recommendation: not evaluated

6 After examining the best available evidence, WHO made three recomendations Recommendation 2 Diabetes in pregnancy should be diagnosed if one or more of the following criteria are met: fasting plasma glucose 7.0 mmol/l (126 mg/ dl) 2-hour plasma glucose 11.1 mmol/l (200 mg/dl) following a 75g oral glucose load random plasma glucose 11.1 mmol/l (200 mg/ dl) in the presence of diabetes symptoms. Quality of evidence: not graded Strength of recommendation: not evaluated

7 After examining the best available evidence, WHO made three recomendations Recommendation 3 GDM should be diagnosed at any time in pregnancy if one or more of the following criteria are met: - fasting plasma glucose mmol/l ( mg/dl) - 1-hour plasma glucose 10.0 mmol/l (180 mg/dl) following a 75g oral glucose load - 2-hour plasma glucose mmol/l ( mg/dl) following a 75g oral glucose load Quality of evidence: very low Strength of recommendation: weak

8 Important: Differentiation between pre-existing (albeit unknown) diabetes in pregnant women versus GDM Fasting glucose > 126 mg/dl OR 2-hour 75 g oral glucose challenge >200 mg OR Random glucose >200 mg with symptoms of diabetes This is Diabetes in Pregnancy (and not GDM) If undiagnosed and untreated, these women (who represent a small proportion of all pregnancies) could have maternal and perinatal complications.

9 Most frequent adverse pregnancy outcomes in hyperglycaemia Congenital anomalies/ miscarriage Perinatal /maternal mortality Neonatal macrosomia Future DM in offspring Hypertensive disorders of pregnancy Future DM in mother Type 1 DM n/a Type 2 DM n/a GDM?? +? + +

10 2013 WHO diagnostic criteria for GDM Diagnostic criteria for GDM are based on the risk of some adverse pregnancy outcomes However since there is a continuous risk of adverse outcomes with increasing glycaemia, any diagnostic thresholds will be arbitrary Maternal or perinatal MORTALITY were not part of the outcomes used to establish the new diagnostic criteria; these events are very rare and have not been associated with GDM in the HAPO study, which enrolled over 25,000 women in 11 different countries.

11 2013 WHO diagnostic criteria for GDM WHO endorsed the criteria proposed by the International Association for the Study of Diabetes in Pregnancy Group (IADPSG), based on the findings of the HAPO study Pregnancies with 1 or more of these values have an 1.75 fold higher risk for one or more of these outcomes: birth weight >90th percentile cord C-peptide >90th percentile neonatal percent body fat >90th percentile compared to women with mean values for fasting, 1-hour, and 2-hour OGTT plasma glucose values. There is no association with MORTALITY outcomes

12 2013 WHO diagnostic criteria for GDM WHO has not issued recommendations on screening for hyperglycaemia in pregnancy

13 What would be the impact of universal screening for GDM? Impact of gestational diabetes mellitus screening strategies on perinatal outcomes: a simulation study. Falavigna M, Prestes I, Schmidt MI, Duncan BB, Colagiuri S, Roglic G. Diabetes Res Clin Pract Mar;99(3):358-65

14 No screening for GDM versus universal screening using the WHO 2013/ IADPSG-criteria: simulated effect on outcomes (Falavigna, 2013) Assuming : GDM prevalence according to WHO/IADPSG: 15% (13% %) Incidence of Large for Gestational Age (LGA) Births: 9,5% (9% - 10%) Incidence of Pre-eclampsia: 4,8% (3% - 7%) Frequency of Caesarean Section: 19% (10% - 30%) Outcome Incidence reduction LGA Births 0.85% (0,56 1,32) Preeclampsia Caesarean delivery 0.39% (0,16 0,61) Not significant NNS* GRADE Quality Coments 117 (76 180) 257 ( ) Not significant Very low + Very low + Very low + Downgraded due to indirect evidence (-2) and inconsistency Downgraded due to indirect evidence (-2) and inconsistency (-1) Downgraded due to indirect evidence (-2), inconsistency (-1) and lack of blinding (-1) * NNS: Number Needed to Screen

15 Universal screening for GDM has a modest impact on pregnancy outcomes. Costs and resources should also be considered in local selection of a screening approach. Falavigna et al Diabetes Res Clin Pract Mar;99(3):