COVERAGE MANAGEMENT PROGRAMS

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1 COVERAGE MANAGEMENT PROGRAMS The purpose of coverage management programs is to help improve the quality of care by encouraging the right patient and provider behaviors to avoid compromised care and unnecessary costs. Beginning January 1, 2010, Express Scripts will be your prescription benefits provider. How coverage management works Certain medications may require approval through a coverage review before they will be covered. This review uses plan rules based on FDA-approved prescribing and safety information, clinical guidelines, and uses that are considered reasonable, safe, and effective. There are three different coverage management programs under your plan: Prior Authorization, Qualification by History (Step Therapy), and Quantity Management. During a coverage review, Express Scripts contacts your doctor for more information before the medication will be covered under your plan. If you know in advance that your prescription requires a coverage review, ask your doctor to call the coverage review team before you go to the pharmacy. This call will initiate a review, which typically takes one to two business days. Once the review is complete, Express Scripts will send a letter to notify you and your doctor of its decision. If the review is approved, the letter will tell you the length of your coverage approval. If coverage is denied, the letter will include the reason for coverage denial and instructions on how to submit an appeal. The coverage review process To save you time and help avoid any confusion, we d like to highlight the coverage review process, both at a retail pharmacy and through mail order. At a retail pharmacy in your plan s network: You take the prescription to your local pharmacist, who submits the information to Express Scripts. If a coverage review is necessary, Express Scripts automatically notifies the pharmacist, who in turn tells you that the prescription needs to be reviewed or requires prior authorization. As an enrolled member, you, the pharmacist, or your doctor may start the review process by calling directly the Express Scripts managed care department toll-free at (800) , 8:00 a.m. to 9:00 p.m., eastern time, Monday through Friday. Express Scripts contacts your doctor requesting more information than what is on the prescription. After receiving the necessary information, Express Scripts notifies you and the doctor (usually within 1 to 2 business days) confirming whether or not coverage has been approved. If coverage is approved, you simply pay your normal coinsurance for the medication. If coverage is not approved, you will be responsible for the full cost of the medication or, if appropriate, you can talk to your doctor about alternatives that may be covered. (You have the right to appeal the decision. Information about the appeal process will be included in the letter that you receive.) Special note: If your plan has a limit on the amount of medication covered, your pharmacist can fill your prescription up to the amount allowed. If the prescription exceeds the amount covered by your plan, Express Scripts will alert the pharmacist whether a coverage review is available to obtain an additional amount.

2 continued Through the Express Scripts Pharmacy, your mail-order service: You mail the prescription to Express Scripts. If a coverage review is necessary to obtain coverage for the medication, Express Scripts contacts your doctor, requesting more information than what is on the prescription. After receiving the necessary information, Express Scripts notifies you and the doctor (usually within 1-2 business days), confirming whether or not coverage has been approved. If coverage is approved, you receive your medication and simply pay your normal coinsurance for the medication. If coverage is not approved, the prescription is returned to you. (You have the right to appeal the decision. Information about the appeal process will be included in the letter that you receive.) Special note: If your plan has a limit on the amount of medication, then Express Scripts will only dispense the amount allowed. Express Scripts will send you a statement that explains the limit and tells you whether a coverage review is available to obtain an additional amount. Below is a list of each coverage management program with the corresponding partial list of medications. To find out more about coverage reviews, prior authorization, and coverage on your medications, please call the LM HealthWorks Plan at (877) Member Services will assist with drug coverage and any questions you may have before connecting the caller (your pharmacist, doctor or yourself) to the managed care department to initiate the case. Prior Authorization Some medications require that you obtain approval through a coverage review before the medication can be covered under your plan. The coverage review process will allow the benefit manager to obtain information not available on your original prescription to determine whether a given medication qualifies for coverage under your plan. Medications are periodically added to these programs when new FDA-approved drugs become available. If you are getting the prescription filled through a retail pharmacy, your pharmacist will be notified that the drug cannot be filled without prior approval and that your physician must call to get approval for the prescription. Actinic keratoses (Solaraze ) Allergy (Grastek, Oralair, Ragwitek ) Androgens & Anabolic Steroids (Anroderm, AndroGel, Axiron, Fortesta, Striant, Testim, First Testostrone, Injectable Testosterone) (Preferred Step Therapy also applies) Alpha 1 Proteinase Inhibitors (Aralast, Glassia, Prolastin, Zemaira ) (Preferred Step Therapy also applies) Antinarcoleptics (Nuvigil, Provigil ) Antiviral Agents (Incivek, Olysio, Sovaldi, Victrelis )(Preferred Step Therapy and Quantity Management also apply Antiviral Agents (Copegus, Rebetol, Ribasphere ) Bile Acids (Chenodal ) Blood disorders- phenylketonuira agents (Kuvan ) Blood disorders- thrombocytopenia (NPlate, Promacta ) Cholesterol Lowering Agents (Lovaza, Vescepa )

3 Chronic obstructive pulmonary disease (Daliresp ) Cosmetics - Botulinum (Botox, Dysport, Mybloc, Xeomin ) Cryopyrin-Associated Periodic Syndrome Agents (Arcalyst, Ilaris ) (Preferred Step Therapy also applies) Dermatologicals - Topical Tretinoins/Tazorac (Atralin, Avita, Fabicor,Retin A, Tretin X, Tazorac, Veltin, Ziana ) Erythroid Stimulants (Aranesp. Epogen, Procrit ) (Preferred Step Therapy also applies) Eye Conditions (Restasis) Growth Hormones (Egrifta, Genotropin, Humatrope, Increlex, Norditropin Novo Nordisk, Nutropin, Nutropin AQ, Omnitrope, Saizen, Serostim, Tev-Tropin, Zorbtive ) (Preferred Step Therapy also applies) Growth Hormone receptor antagonist (Somavert ) Hyaluronic Acid Derivatives (Euflexxa, Gel-One, Hyalgan, Orthovisc, Supartz, Synvisc, Synvisc- One ) Immune Globulins (Bivigam, Carimune, Gammagard, Gammaked, Gammunex, Hizentra, Octagam, Privigen, Vivaglobin ) Interferons (Pegasys, PegIntron ) Korlym Leuprolide long acting (Eligard, Lupron ) Lipodystrophy (Myalept ) Macular Degeneration Agents (Eylea, Lucentis, Macugen ) Melatonin receptor agonist (Hetlioz ) Misc. (Samsca ) Misc. Enzymes (Krystexxa ) Misc.Hormones (Acthar Gel ) Misc. Hormone (Makena ) Multiple Sclerosis Agents (Ampyra, Avonex, Betaseron, Copaxone, Extavia, Rebif, Tysabri ) (Preferred Step Therapy and Quantity Management also apply) Myeloid Stimulants (Granix, Neulasta, Neupogen ) Neurological Agents (Xenazine ) Osteoporosis (Boniva, Forteo, Prolia, Reclast ) Psoriasis Therapy (Otezla,Stelara ) Pulmonary Agents Asthma (Xolair ) Pulmonary Agents - Hereditary Angioedema (Berinert, Cinryze, Firazyr, Kalbitor ) (Quantity Management also applies) Pulmonary Arterial Hypertension (Adcira, Adempas,Flolan, Letairis, Opsumit, Orenitram, Remodulin, Revatio, Tracleer, Tyvaso, Veletri, Ventavis ) (Preferred Step Therapy and Quantity Management also apply Neuropathic ulcer Agents (Regranex ) Rheumatoid arthritis therapy Agents (Actema, Cimzia, Enbrel, Humira, Kineret, Orencia, Remicaide, Rituxan, Simponi ) (Preferred Step Therapy and Quantity Management also apply) RSV Agents (Synagis )

4 Topical Anesthetic (Lidoderm ) Ulcerative Colitis and Crohn s (Entyvio ) Weight Loss Drugs (Adipex, Belviq,Bontril, Didrex, Qsymia, Sanorex, Suprenza, Tenuate, Xenical, Step Therapy Some medications may require to first try one or more specified drugs to treat a particular condition before the plan will cover another (usually more expensive) drug that your doctor may have prescribed. In these cases, a coverage review will be required if certain criteria cannot be determined from past history. Step therapy is intended to reduce costs to you and your plan by encouraging use of medications that are less expensive but can still treat your condition effectively. If you know in advance that your prescription requires a coverage review, ask your doctor to call the coverage management team before you go to the pharmacy. To see which medications are affected by step therapy, please visit or call Express Scripts Member Services. Angiotensin II Receptor Blockers (Atacand/Atacand HCT, Avalide, Avapro, Cozaar, Diovan /Diovan HCT, Edarbi, Edarbyclor, Hyzaar, Micardis/Micardis HCT, Teveten/ Teveten HCT, Twynsta ) Benign Prostatic Hyperplasia (Avodart, Proscar, Jalyn ) Bisphosphonates (Actonel, Atelvia, Binosto, Boniva, Fosamax D ) COX2 Inhibitors (Celebrex ) Fenofibrates (Antara, Fenoglide, Fibricor, Lipofen, Lofibra, Tricor, Triglide, Triliprix Infertility (Bravelle, Follistim AQ, Gonal ) Inhaled Corticosteroids (Flovent ) Nasal Steroids (Beconase AQ, Dymista, Flonase, Nasacort, Omnaris, Rhinocort Aqua, Veramyst, Zetona ) Non Steroidal Anti Inflamatory Drugs (Arthrotec, Cambia, Duexis, Flector, Mobic, Pennsaid, Ponstel, Voltaren, Lodine, Motrin, Naprosyn, Naprelan, Vimovo, Voltaren/Gel, Zipsor etc.) Overactive bladder (Detrol/LA, Sanctura/XR, Vesicare, Enablex, Oxytrol, Ditropan/XL, Toviaz, Genique ) Prostate Cancer Analogs (Frimagon, Lupron Depot, Trelstar/Depot ) Proton Pump Inhibitors (Aciphex, Dexilant Prevacid, Prilosec, Prevpac, Protonix, Zegerid ) Sedative Hypnotics (Ambien/CR, Edluar, Intermezzo, Lunesta, Rozerem, Silenor, Sonata, Zolpimist ) Tetracyclines- oral (Adoxa, Doryx, Dynacyn, Monodox, Ocudox, Oracea, Oraxyl, Periostat, Solodyn, Sumycin, Vibramycin ) Topical Acne Agents (brand topical benzyl peroxide agents, topical antibiotics, topical cleansers, kits, ect) Topical Corticosteroids (Aclovate, Clobex, Elocon, Kenolog, Locoid, Luxiq, Olux, Dermatopp/AF, Ultavate, ect) Topical Immunomodulators (Elidel, Protopic )

5 Quantity Management To ensure safe and effective drug therapy, certain covered medications may have quantity restrictions. These quantity restrictions are based on manufacturer and/or clinically approved guidelines and are subject to periodic review and change. Some examples include antimigraine drugs, rheumatoid arthritis and osteoarthritis drugs, impotence drugs, sedative hypnotics, and pain management drugs. Allergies (Non sedating antihistamines, Nasal Steroids) Anaphylaxis Anti- influenza Antiemetic Agents Antifungal Antiviral Agents Asthma Blood Cell Deficiency Bone Conditions Contraceptives Chronic obstructive pulmonary disease Diabetic Agents - Byetta/Symlin/Victoza Endocrine Disorders Erectile Dysfunction Agents Eye Conditions (Restasis) Fertility Agents Hepatitis C High Blood Cholesterol High Blood Pressure Hormone Supplementation Hypnotic Agents Migraine Therapy Narcotic Analgesics/Pain Overactive bladder Pulmonary Agents - Cystic Fibrosis Wound Care \ NOTE: The information outlined above is accurate as of 1/1/2015; however, it is subject to change. Please call Member Services at (877) if you have any questions or for further verification.

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