ANNUAL REPORT EDUCATIONAL ACTIVITIES 397 STAFF 399

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "ANNUAL REPORT EDUCATIONAL ACTIVITIES 397 STAFF 399"

Transcription

1

2 PREFACE ANNUAL REPORT MARIO NEGRI INSTITUTE, MILAN DEPARTMENTS Department of Oncology.. 7 Department of Environmental Health Sciences Department of Neuroscience.. 83 Department of Cardiovascular Research Department of Molecular Biochemistry and Pharmacology Department of Epidemiology Department of Public Health LABORATORIES AND CENTERS Laboratory of Regulatory Policies Centre of Computer Science Engineering. 281 The Catullo and Daniela Borgomainerio Center 285 Library ANNA MARIA ASTORI CENTER DEPARTMENTS Department of Molecular Medicine Department of Biomedical Engineering. 319 ALDO and CELE DACCO CENTER DEPARTMENT Department of Renal Medicine. 339 LABORATORIES AND CENTERS Rare Diseases Documentation and Research International Relations Office of rare Diseases The Transplant Research Center. 395 EDUCATIONAL ACTIVITIES 397 STAFF 399 All the staff of the Institute is listed on its website PUBLICATIONS A comprehensive list of the Institute s publications is available on the website Section Publications 1

3 Edited by Isabella Bordogna printed April

4 PREFACE In 2014 the Mario Negri Institute for Pharmacological Research celebrated 53 years since its foundation. The date marked the first year of the Institute as IRCCS. In fact the Ministerial Decree published in the Italian Gazzetta Ufficiale No, 34, p.17, on 9 February 2013 recognized the Institute as an IRCCS an institute for research and healthcare. That means it is considered part of the National Health Service, and comes under the heading Pharmacology and clinical research for neurological, rare and environmental diseases. The Institute has been doing preclinical and clinical research in these areas for many years. This good news, however, unfortunately accompanies a generally worrying financial situation, not only in Italy but many other countries too, especially in southern Europe. This economic crisis has certainly affected scientific research in Italy, and contrary to what should normally be done in times of difficulty the Government has completely abandoned the whole sector to itself. Despite these problems, the Mario Negri Institute has been hard at work, producing worthwhile experimental and clinical results. Many of the findings have already been published, and others are in press. More than 420 articles were accepted in international scientific journals in As usual, research is described here department by department, though sometimes for single laboratories. Details of the findings are given in the body of the report, and here we shall just make some general observations. In 2014 we had regrettably to watch the Italian Parliament display its disdain for science with laws in which that researchers opinions had been replaced by pseudo-arguments put forward by charlatans. Debate on the European Directive on animal experimentation is a typical example of this attitude. Huge efforts will be needed to ensure the public understands that no progress can ever be achieved toward curing human beings and animals too without using animals in research. We had many delays in the authorization for the use of animals in experimentation Another example is the Stamina episode, which involved public health structures prescribing and administering products whose content was kept secret, with no regard whatsoever for all the barriers normally in place to safeguard patients who volunteer for clinical trials. Here the Health care Commission did some serious selfcriticism as the experts opinions were completely ignored, and great confusion was caused among the public. This year, as in the past, the Institute has focused on its main basic areas of research: oncology, neurosciences, cardiovascular and renal diseases, organ transplantation, rare diseases, using quantitative morphology techniques, together with genomics, proteomics and metabolomics, cell biology, molecular biochemistry.. The approach is always the same to develop around the overall area a complex series of strategies ranging from basic research to pharmacokinetics, pharmacology, controlled clinical trials, epidemiological analysis and, where possible, the epidemiology of healthcare services. Several important trials have been completed. One, on lung tumors, showed that docetaxel, an old drug, was more active than erlotinib, a new one that is much more expensive. Another trial found that L-acetylcarnitine together with riluzol prolonged survival for patients with amyotrophic lateral sclerosis ALS a rare disease. We hope to be able to confirm this finding in a trial with a larger number of patients. Another rare disease, uremic hemolytic syndrome, can benefit substantially from treatment with eculizumab. Studies have started on about 500 people who have reached the age of 100, completing the study on about 2000 people aged over 80, investigated in the Monzino 80+ Study with the aim of identifying factors that protect against dementia. A clinical trial now in progress is designed to establish the efficacy and toxicity of several opioids oxicodone, fentanyl and buprenorphine compared with morphine in cancer patients. Research is continuing on environmental pollutants in water, soil and foodstuffs, particularly PCBs and dioxin; the same laboratories have developed a method for quantifying drugs of abuse and medicinal drugs in waste waters. Particularly, we obtained interesting results about the use of new drugs, among which Ketamine. Under the heading of diseases of old age, the REPOSI trial is giving important results on the prevalence of multiple simultaneous pathologies and the consequent polypharmacology multiple drugs. In the cardiovascular area a series of studies have examined drugs that provide neuroprotection after prolonged cardiac arrest. An important European study has been started, to describe the epidemiology of head trauma and examine the molecular and phenotypic markers involved in brain damage. New methods have been used for studying cerebral and peripheral amyloidosis, using the worm C. elegans. We found interesting analogies with the behaviour of mammals. Promising results have already been achieved with the use of nanoparticles to improve drug entry into tumors, and to pass the blood/brain barrier. Particularly interesting are some nanoparticles that convey paclitaxel towards the cancer cells. Under the heading of transplants, a new method has been developed that achieves complete maturation in vivo of functioning renal organs, generated from suspensions of single embryonal renal cells. This is an important step towards building a functioning kidney. The results are particularly interesting and encouraging, because of the possibility to have in the future a kidney that will not be rejected. Gene therapy is currently being developed to prevent chronic rejection of a transplanted solid organ. In a controlled clinical trial octreotide had beneficial effects on the progression of renal polycystic disease. Another study identified some predictors of the response to rituximab in patients with idiopathic membranous nephropathy. 3

5 An on-line register of the controlled clinical trials conducted at the Mario Negri Institute is available, where anyone can look to see how each trial is progressing. There is no space here to give even brief details of the large number of trials but information can be found in the text ( An essential part of research is training young scientists so that in the laboratory they not only have a chance to express their ideas, but can also earn a qualification.the Institute offers a professional course recognized by the Lombardy Region (964 students have earned diplomas to date) and, at a more advanced level, runs a Ph.D. degree course in collaboration with the UK Open University (more than 90 students have passed); there is also a research doctorate recognized by the Ministry of University and Research in Italy (15 diplomas have been awarded so far). Finally, an essential part of the Institute s work involves providing information at all levels. There is the Rare Diseases Information Center ( click on Centro Malattie Rare), and the Drug Information Center also easily reached on the Institute website ( ). The Institute works constantly to provide information for physicians, nurses and patients associations, and to the public, using all the media available. From 2000 to 2014, a total of 1611 articles for the lay public were published. The site has developed fast. A European project is in progress to inform the public on the details and advantages of controlled clinical trials. Research is moving through increasingly difficult times and researchers are struggling to make evergreater efforts. All possible assistance is needed from all possible sources - the government, public bodies, charities and private persons. Silvio Garattini Director 4

6 Mario Negri INSTITUTE FOR PHARMACOLOGICAL RESEARCH Milan ANNUAL REPORT 2014 departments and laboratories 5

7 6

8 DEPARTMENT OF ONCOLOGY STAFF Chief Maurizio D INCALCI, M.D. Oncological Studies Office and Documentation Scientific Documentalist Stefania FILIPPESCHI, Chemist Laboratory of Cancer Pharmacology Head Biophysics Unit Head Flow Citometry Unit Head Translational Genomic Unit Head Maurizio D INCALCI, M.D. Paolo UBEZIO, Phys.D. Eugenio ERBA, Biochem.D Sergio MARCHINI, Biol.Sci.D., Ph.D Cancer Clinical Pharmacology Unit Head Massimo ZUCCHETTI, Chem.Pharm.D. Preclinical Experimental Therapeutics Unit Head Roberta FRAPOLLI, Chem.Pharm.D. Laboratory of Molecular Pharmacology Head Molecular Genetics Unit Head DNA Repair Unit Head Massimo BROGGINI, Ph.D. Mirko MARABESE, Biol.Sci.D., Ph.D. Giovanna DAMIA, M.D. Laboratory of Biology and Treatment of Metastases Head Tumor Angiogenesis Unit Head Unit located in Bergamo Raffaella GIAVAZZI, Biol.Sci.D., Ph.D. Giulia TARABOLETTI, Biol.Sci.D. 7

9 Molecular Cancer Therapeutics Unit Head Maria Rosa BANI, Biol.Sci.D., Ph.D. Laboratory of Life Science Informatics Head Luca CLIVIO, Eng. Laboratory of Cancer Cachexia AIRC Start-Up Head Rosanna PICCIRILLO, Biotec. Med. D., Ph.D. Laboratory of Methodology of Biomedical Reseach Head Valter TORRI, M.D. Systematic reviews methodology and guidelines production Unit Head Michela CINQUINI, Stat. D. Computational Statistics Unit Head Luca Porcu Laboratory of Clinical Research Head Irene FLORIANI, Dr.Sci.Biol., Dr.Stat., Ph.D. Coordinating, Management and Monitoring Unit Head Davide POLI, Phys.D. Statistics Unit Head Eliana RULLI, Stat. D. Quality Assurance Unit Head Marlen Victoria LLERENA MESA, Pharm. D. Planning and Design Unit Head Gynecology Oncology Unit Head Lital Hannah HOLLANDER, Sc.Med, PG Cert Clin Res, MPH Roldano FOSSATI, M.D. Pain and Palliative care Research Unit Head Oscar CORLI, M.D. 8

10 CURRICULA VITAE Maurizio D'Incalci obtained his Medical Degree cum Laude from the University of Milan in After specializing in Pharmacology at the Mario Negri Institute of Milan in 1979 and in Oncology at the University of Genoa in 1981, he worked in the Laboratory of Molecular Pharmacology of the National Cancer Institute in Bethesda, MD, USA. Since 1986 he has been chief of the Laboratory of Cancer Chemotherapy at the Mario Negri Institute and since 1996 he has become chief of the Department of Oncology at the Mario Negri Institute. He has been President of the Pharmacology and Molecular Mechanisms Group of the European Organization for Research and Treatment of Cancer (EORTC). From 1994 to 1997 he was Chairman of the New Drug Development Coordinating Committee and from 1997 to 2000 he was chairman of the Research Division of the EORTC. He has been member of the Board of the EORTC from April 2000 to Since 1995 he is member of the Board of Directors of the Nerina and Mario Mattioli Onlus Foundation. From 1997 to 2012 he has been the Preclinical Coordinator of the Southern Europe New Drug Organization (SENDO) and from 2005 to 2012 he has been the Chairman of the New Agents Committee (NAC) of SENDO. From 2003 to 2013 he has been member of the Ethic Committee of the Centro di Riferimento Oncologico (CRO) of Aviano. From 2006 he is president of the Scientific Committee of the Mario Negri Gynecologic Oncology group (MaNGO). From 2007 he is member of the Scientific Committee of the Italian Association for Cancer Research (AIRC). From 2009 to 2013 he has been member of the Board of Directors of the Italian Cancer Society (SIC). From 2010 he is member of the Scientific Committee of the Buzzi Unicem Onlus Foundation for the research, diagnosis and cure of malignant mesothelioma. From November 2013 he is member of the Ethic Committee of the Fondazione del Piemonte per l Oncologia IRCCS of Candiolo. From 2014 he is member of the Board of Directors of the Controlled Release Society (CRS) Italy Chapter, as representant of the medical-biology area. From September 2014 he is member of the IFOM Ethics Committee for Biomedical Research. He is on the editorial board of many international cancer-related scientific journals and from September 2000 to December 2010 he has been Editor for Experimental Oncology of the European Journal of Cancer. Dr D'Incalci is author of more than 490 papers on cancer chemotherapy published in peer reviewed international journals, and of several chapters in books on cancer chemotherapy. Selected publications Parikh A., Lee C., Joseph P., Marchini S., Baccarini A., Kolev V., Romualdi C., Fruscio R., Shah H., Wang F., Mullokandov G., Fishman D., D Incalci M., Rahaman J., Kalir T., Redline R.W., Brown B.D., Narla G., Di Feo A. microrna-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition. Nature Communication, DOI: /ncomms3977. Fuso Nerini I, Morosi L, Zucchetti M, Ballerini A, Giavazzi R, D'Incalci M. Intratumor heterogeneity and its impact on drug distribution and sensitivity. Clin Pharmacol Ther., 96(2): (2014). Di Giandomenico S., Frapolli R., Bello E., Uboldi S., Licandro S.A., Brich S., Mauro V., Tamborini E., Pilotti S., Casali P., Grosso F., Sanfilippo R., Gronchi A., Mantovani R., Galmarini C., Fernandez Sousa-Faro J.M., D Incalci M. Mode of action of trabectedin in myxoid liposarcomas. Oncogene, 2013 e-pub. Germano G., Frapolli R., Belgiovine C., Anselmo A., Pesce S., Liguori M., Erba E., Uboldi S., Zucchetti M., Pasqualini F., Nebuloni M., Van Rooijen N., Mortarini R., Beltrame L., Marchini S., Fuso Nerini I., Sanfilippo R., Casali P.G., Pilotti S., Anichini A., Mantovani A., D Incalci M., Allavena P. Role of Macrophage targeting in the anti-tumor activity of Trabectedin. Cancer Cell, 23(2): (2013). Marchini S., Cavalieri D., Fruscio R., Calura E., Garavaglia D., Fuso Nerini I., Mangioni C., Cattoretti G., Clivio L., Beltrame L., Katsaros D., Scarampi L., Menato G., Perego P., Chiorino G., Buda A., Romualdi C., D Incalci M.Association between mir-200c and survival of stage I epithelial ovarian cancer patients. A retrospective study on two independent tumour tissue collections. The Lancet Oncology, 12(3): ( 2011). Frapolli R., Tamborini E., Virdis E., Bello E., Tarantino E., Marchini S., Grosso F., Sanfilippo R., Gronchi A., Tercero J.C., Peloso G., Casali P., Pilotti S., D Incalci M. Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacological features of human tumors. Clinical Cancer Res., 16(20): (2010). Massimo Broggini followed the faculty of Science of the University of Milan, got the specialization in Biochemistry at Mario Negri Institute, and the PhD degree at the Open University, London,UK. He worked in the laboratory of Molecular Pharmacology of the National Cancer Institute of Bethesda, Md, in From 1991 he is the head of the Molecular Pharmacology Unit of the Mario Negri Institute and from 1999 he his the head of the Laboratory of Molecular Pharmacology of the same Institute. His main fields of interest are the study of the mechanism of action of new anticancer agents, the search of altered proteins and genes in human cancer and the study of oncosuppressor genes. He is member of the "Pharmacology and Molecular Mechanisms Group" of the European Organisation for the Research and Treatment of Cancer (EORTC) and of the American Association for Cancer Research. He is in the Editorial board of the European Journal of Cancer, Frontiers in Cancer Genetics and American Journal for Cancer Research. He is author of more than 150 articles published in international journals. 9

11 Selected publications Polato F, Rusconi P, Zangrossi S, Morelli F, Boeri M, Musi A, Marchini S, Castiglioni V, Scanziani E, Torri V, Broggini M. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosupprossor. J Natl Cancer Inst Apr;106(4):dju053. Garassino MC, Martelli O, Broggini M, Farina G, Veronese S, Rulli E, Bianchi F, Bettini A, Longo F, Moscetti L, Tomirotti M, Marabese M, Ganzinelli M, Lauricella C, Labianca R, Floriani I, Giaccone G, Torri V, Scanni A, Marsoni S; TAILOR trialists.. Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial. Lancet Oncol Sep;14(10): Sabatino MA, Geroni C, Ganzinelli M, Ceruti R, Broggini M. Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin. Epigenetics Jun;8(6): Ricci F, Broggini M, Damia G. Revisiting ovarian cancer preclinical models: implications for a better management of the disease. Cancer Treat Rev Oct;39(6): Previdi S, Abbadessa G, Dalò F, France DS, Broggini M.Breast Cancer-Derived Bone Metastasis Can Be Effectively Reduced through Specific c-met Inhibitor Tivantinib (ARQ 197) and shrna c-met Knockdown. Mol Cancer Ther Jan;11(1): Mazzoletti M, Bortolin F, Brunelli L, Pastorelli R, Di Giandomenico S, Erba E, Ubezio P, Broggini M. Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlates. Cancer Res Jul 1;71(13): Luca Clivio has a Master degree in Informatics Engineering and a Post degree Master in Evidence Based Medicine and Methodology of Sanitary Research. Senior developer in the fields of Clinical Research distributed databases and Bioinformatics. he is the developer of an open source validated software for handling ecrf for Clinical Trials and Biobanks and has realized with that about 150 ecrf in various fields. Currently all of the Clinical Trials and Biobanks in the Department of Oncology at Mario Negri Institute make use of his software covering the data collection and validation. He has ben working on the implementation of High Performance Computer centres in collaboration with the University of Aberdeen, Maastricht and the INRIA in Rennes. He is currently responsible for the Cluster Room at the Mario Negri Institute in Milan. His collaborations range between the Department of Oncology, Cardiovascular, Neurosciences for managing Clinical Trials and Biobanks. Selected publications mirna landscape in Stage I Epithelial Ovarian Cancer defines the histotype specificities. Enrica Calura, Robert Fruscio, Lara Paracchini, Eliana Bignotti, Antonella Ravaggi, Paolo Martini, Gabriele SaleS, Luca Beltrame, Luca Clivio, Lorenzo Ceppi, Mariacristina Di Marino, Ilaria Fuso Nerini, Laura Zanotti, Duccio Cavalieri, Giorgio Cattoretti, Patrizia Perego, Rodolfo Milani, Dionyssios Katsaros, Germana Tognon, Enrico Sartori, Sergio Pecorelli, Costantino Mangioni, Maurizio D Incalci, Chiara Romualdi, Sergio Marchini. Clin Clin Cancer Res Aug 1;19(15): The zinc finger gene ZIC2 has features of an oncogene and its over- expression correlates strongly with the clinical course of epithelial ovarian cancer. Sergio Marchini, Elizabeth Poynor, Richard R Barakat, Luca Clivio, Michela Cinquini, Robert Fruscio, Luca Porcu, Cecilia Bussani, Maurizio D Incalci, Eugenio Erba, Michela Romano, Giorgio Cattoretti, Dionyssios Katsaros, Andrew Koff, Lucio Luzzatto. Clin Cancer Res Aug 15;18(16): Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer. Sergio Marchini, Robert Fruscio, Luca Clivio, Luca Beltrame, Luca Porcu, Ilaria Fuso Nerini, Duccio Cavalieri, Giovanna Chiorino, Giorgio Cattoretti, Costantino Mangioni, Rodolfo Milani, Valter Torri, Chiara Romualdi, Alberto Zambelli, Michela Romano, Mauro Signorelli, Silvana di Giandomenico, Maurizio D Incalci. Eur J Cancer Aug 13. Analysis of gene expression in early-stage ovarian cancer. Sergio Marchini, Pietro Mariani, Giovanna Chiorino, Eleonora Marrazzo, Riccardo Bonomi, Robert Fruscio, Luca Clivio, Annalisa Garbi, Valter Torri, Tiziana Dell Anna, Giovanni Apolone, Massimo Broggini, and Maurizio D Incalci. Clin. Cancer Res 2008;14(23) Irene Floriani got her degree in Biological Sciences at the University of Milan in 1988, her degree in Biostatistics and Experimental Statistics at the University of Milan-Bicocca in 2003 and her phd at Open University Research School of London in After ten-year experience in pharmaceutical industries, in 2002 she became Head of the Biometry and Data Management Unit of Laboratory of Clinical Research in Oncology and since 2006 she is Head of Laboratory of Clinical Research (until 2012 Laboratory of Clinical Trials). Since 1998 she is member of Ethics Committee of Fondazione IRCCS Carlo Besta Neurological Institute (from 2002 to 2013 as vice-president). From 1999 to 2006 she was member of Ethics Committee of Istituto Scientifico Eugenio Meda. From 2002 to 2013 she was member of Ethics Committee of Azienda Ospedaliera San Paolo of Milan. From 2004 to 2013 she was member of Ethics Committee of Azienda Ospedaliera Sant'Anna of Como (from 2010 to 2013 as Chairman). From 2010 to 2013 she was member of Ethics Committee of Azienda ospedaliera della Valtellina e Valchiavenna. Since 2011 he is on the editorial board of World Journal of Methodology. Since 2013 she is chairman of Ethics Committee of Lecco Como e Sondrio. Since 2014 she is Associate Editor of Endocrine. 10

12 Since 2011 he is on the editorial board of World Journal of Methodology and since 2014 of Endocrine. The main areas of interest include statistical and methodological aspects of clinical research, with focus on randomized clinical trials in oncology; systematic reviews of medical literature and methodological aspects of diagnostic test evaluation. She is author of approximately 100 papers published in peer reviewed international journals. Selected publications Gregorc V, Novello S, Lazzari C, Barni S, Aieta M, Mencoboni M, Grossi F, De Pas T, de Marinis F, Bearz A, Floriani I, Torri V, Bulotta A, Cattaneo A, Grigorieva J, Tsypin M, Roder J, Doglioni C, Levra MG, Petrelli F, Foti S, Viganò M, Bachi A, Roder H. Predictive value of a proteomic signature in patients with non-small-cell lung cancer treated with second-line erlotinib or chemotherapy (PROSE): a biomarker-stratified, randomised phase 3 trial. Lancet Oncol Jun;15(7): Bajetta E, Floriani I, Di Bartolomeo M, Labianca R, Falcone A, Di Costanzo F, Comella G, Amadori D, Pinto C, Carlomagno C, Nitti D, Daniele B, Mini E, Poli D, Santoro A, Mosconi S, Casaretti R, Boni C, Pinotti G, Bidoli P, Landi L, Rosati G, Ravaioli A, Cantore M, Di Fabio F, Aitini E, Marchet A; ITACA-S (Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach Trial) Study Group.Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer. Ann Oncol Jul;25(7): Rulli E, Biagioli E, Riva I, Gambirasio G, De Simone I, Floriani I, Quaranta L. Efficacy and Safety of Trabeculectomy vs Nonpenetrating Surgical Procedures: A Systematic Review and Meta-analysis. JAMA Ophthalmol Dec 1;131(12): D'Onofrio M, Biagioli E, Gerardi C, Canestrini S, Rulli E, Crosara S, De Robertis R, Floriani I. Diagnostic performance of contrast-enhanced ultrasound (CEUS) and contrast-enhanced endoscopic ultrasound (ECEUS) for the differentiation of pancreatic lesions: a systematic review and meta-analysis. Ultraschall Med Dec;35(6): Miglior S, Zeyen T, Hoffmann EM, Torri V, Rulli E, Floriani I, Poli D, Aliyeva S, Cunha-Vaz J, Pfeiffer N. Predictive value of heidelberg retina tomograph parameters for the development of glaucoma in the European glaucoma prevention study. Am J Ophthalmol Feb;159(2): e1. Raffaella Giavazzi obtained her Biological Sciences degree (1979) at the University of Milan and her PhD in Pharmacology at the Mario Negri Institute of Milan (1984), followed by a specialization in pharmacology (1994) at the University of Milan. From 1981 to 1983 she was a post-doc Fellow in the Cancer Metastasis and Treatment Laboratory, NCI-FCRDC, Frederick, MD, and from 1983 to 1985 Assistant Professor at the Department of Cell Biology of M.D. Anderson Hospital and Tumour Institute, University of Texas System Cancer Centre in Houston, TX. From 1986 to 1993 she was Head of the Cancer Metastasis Treatment Unit and since 1993 she has been the Head of the Laboratory of Biology and Treatment of Metastasis at Mario Negri Institute for Pharmacological Research. She was adjuvant Professor of Oncology at the Medical School of the University of Brescia ( ) and of the University of Pisa ( ) and in the Teaching Committee for the PhD course in Physiology-Pharmacology- Molecular and Cellular Toxicology at the University of Siena. Since 2012 she is member of the Board of Directors (CdA) at the University of Trento. She was consulting scientist for the NCI-Drug Therapeutics Program, USA ( ), and member of the Executive Committee at the Southern Europe New Drug Development Organization ( ). She was in the Board ( ) and President ( ) of the Italian Cancer Society, member of the Executive Committee of the European Association for Cancer Research ( ) and in the Board of the International Metastasis Research Society ( ). From 2008 she is member of the Pezcoller Foundation Scientific Committee. In 1996 she was Honorary Research Fellow and Visiting Professor, Division of Oncology, Richard Dimble Department of Cancer/ICRF, London, UK. In 2003 she received the Researcher Career Award Italian League Against Tumor and in 2012 she gave the Giorgio Prodi Lecture" at the Italian Cancer Society. She is on the Editorial Board of a number of international scientific journals. She has published approximately 200 articles on peer reviewed scientific journals and is coauthor of several chapters in books on cancer biology and therapy. She has been invited as speaker at numerous national and international congresses on cancer research. Selected publications Decio A., Taraboletti G., Patton V., Alzani R., Perego P., Fruscio R., Jürgensmeier J.M., Giavazzi R., Belotti D. Vascular Endothelial Growth Factor C promotes ovarian carcinoma progression through paracrine and autocrine mechanisms. The American Journal of Pathology 184(4): , Ricci R., *Bizzaro F., Cesca M., Guffanti F., Ganzinelli M., Decio A., Ghilardi C., Perego P., Fruscio R., Buda A., Milani R., Ostano P., Chiorino G., Bani M.R., Damia G., Giavazzi R. A platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer. Cancer Res. 74(23): , *Equal contribution, Corresponding Author. Rovida A, Castiglioni V, Decio A, Scarlato V, Scanziani E, Giavazzi R, Cesca M. Chemotherapy counteracts metastatic dissemination induced by antiangiogenic treatment in mice. Molecular Cancer Therapeutics (10): Moschetta M, Pretto F, Berndt A, Galler K, Richter P, Bassi A, Oliva P, Micotti E, Valbusa G, Schwager K, Kaspar M, Trachsel E, Kosmehl H, Bani MR, Neri D, Giavazzi R. Paclitaxel enhances the therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin positive metastatic human melanoma xenografts. Cancer Res : Oliva P, Decio A, Castiglioni V, Bassi A, Pesenti E, Cesca M, Scanziani E, Belotti D, Giavazzi R. Cisplatin plus paclitaxel and maintenance of bevacizumab on tumor progression, dissemination, and survival of ovarian carcinoma xenograft models. British Journal of Cancer : Borgia B., Rösli C., Fugmann T., Schliemann C., Cesca M., Neri D., Giavazzi R. A proteomic approach for the identification of vascular markers of liver metastasis. Cancer Research, 70(1):309-18,

13 Rosanna Piccirillo graduated summa cum laude in Medical Biotechnologies in 2001 with a thesis in Experimental Oncology at the Istituto Nazionale dei Tumori in Milan. In 2006, she obtained the international PhD in Molecular and Cellular Biology at the San Raffaele Scientific Institute in Milan, studying the intracellular sorting and transport of a protein implied in a human genetic disease (Ocular Albinism Type 1). In 2006, this original research work was awarded with the prestigious Premio Sapio Junior per la Ricerca Italiana ( In 2007, she worked as Visiting Assistant Researcher in the Department of Human Genetics at the University of California, Los Angeles (UCLA), where she acquired useful biochemical skills. From 2007 to 2012, she worked as Postdoctoral Research Fellow in the lab headed by Prof. Alfred L. Goldberg in the Cell Biology Department at Harvard Medical School in Boston, MA, where she expanded her knowledge about protein ubiquitination and degradation in neurodegenerative diseases as well as in muscle atrophy. Since March 2012, she is head of the laboratory Cancer Cachexia AIRC Start-Up in the Oncology Department at Mario Negri Research Institute. She is leading a research group aimed at dissecting the molecular mechanisms causing muscle wasting during cancer growth in the attempt to block this devastating condition. Selected Publications F. Pretto, C. Ghilardi, M. Moschetta, A. Bassi, A. Rovida, V. Scarlato, L. Talamini, F. Fiordaliso, C. Bisighini, G. Damia, M.R. Bani, R. Piccirillo, R. Giavazzi (2014) Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF- 1 activation in muscle. Oncotarget Nov 15. F. Demontis, R. Piccirillo, A.L. Goldberg, N. Perrimon (2013). Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech Nov;6(6): R. Piccirillo, F. Demontis, A.L. Goldberg, N. Perrimon (2013). Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn Feb;243(2): F. Demontis, R. Piccirillo, A. L. Goldberg and N. Perrimon (2013). The influence of skeletal muscle on systemic aging and lifespan. Aging Cell Dec;12(6): R. Piccirillo and A. L. Goldberg (2012). The p97/vcp ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins. EMBO J. 31(15): R. Piccirillo, I. Palmisano, G. Innamorati, P. Bagnato, D. Altimare, M.V. Schiaffino (2006). An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1. J Cell Sci. 119: Valter Torri got his Medical degree in 1985 and the specialization in medical Oncology in 1989 at the University of Milano. Education: 1985: MD Degree with full honors cum Laude, University of Milano; 1988 Post-Doctoral Degree in Pharmacological Research, Mario Negri Institute, Milano; 1989 Post-Doctoral Degree in Medical Oncology, University of Milano; Research Fellow at the Biometric Research Branch of Cancer Treatment Evaluation Program, NCI, Bethesda, MD (USA). Areas of Interest: Statistical aspects of clinical research methodology with focus on Controlled Clinical Trials in Oncology; Systematic Overview of the medical literature; Methodological aspects of diagnostic test evaluation. Present Position: Head of Laboratory of Methodology of Biomedical Research, Oncology Department, Mario Negri Institute, Milano. Chronology of Professional Appointments: : Clinical research Fellow in Internal Medicine at the University Hospital, University of Milan; : Research assistant at the Clinical Trial Unit of the Laboratory of Clinical Epidemiology, Mario Negri Institute for Pharmacological Research, Milano; : Research fellow at the Biometric Research Branch of Cancer Treatment Evaluation Program, NCI, Bethesda, MD (USA); 1994: Head of Biometric Unit of the Laboratory of Cancer Clinical Epidemiology, Oncology Department, Mario Negri Institute for Pharmacological Research, Milano, Italy; 1995 Vice Director of the Italian Cochrane Center; 2001: Head of Laboratory of Clinical Research In Oncology, Oncology Department, Mario Negri Institute, Milano. 2006: Head of Laboratory for the development of new pharmacological strategies, Oncology Department, Mario Negri Institute, Milano; 2011: Head of Laboratory of Methodology of Biomedical Research. Member of Consiglio Direttivo Nazionale dell Associazione Italiana di Oncologia Medica. Member of Independent data monitoring committee of International Randomised Clinical trials in NSCLC and ovarian carcinoma. Co-author of more than 200 papers published on peer reviewed journals and of 5 chapters of scientific books relative to clinical research methodology for therapeutic and diagnostic studies. Selected publications Taverna G, Tidu L, Grizzi F, Torri V, Mandressi A, Sardella P, La Torre G, Cocciolone G, Seveso M, Giusti G, Hurle R, Santoro A, Graziotti P. Olfactory System of Highly Trained Dogs Detects Prostate Cancer in Urine Samples. J Urol Sep 28. pii: S (14)04573-X. Gregorc V, Novello S, Lazzari C, Barni S, Aieta M, Mencoboni M, Grossi F, De Pas T, de Marinis F, Bearz A, Floriani I, Torri V, Bulotta A, Cattaneo A, Grigorieva J, Tsypin M, Roder J, Doglioni C, Levra MG, Petrelli F, Foti S, Viganò M, Bachi A, Roder H. Predictive value of a proteomic signature in patients with non-small-cell lung cancer treated with second-line erlotinib or chemotherapy (PROSE): a biomarkerstratified, randomised phase 3 trial. Lancet Oncol Jun;15(7): Polato F, Rusconi P, Zangrossi S, Morelli F, Boeri M, Musi A, Marchini S, Castiglioni V, Scanziani E, Torri V, Broggini M. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. J Natl Cancer Inst Apr;106(4):dju053 12

14 Cazzaniga ME, Torri V, Villa F, Giuntini N, Riva F, Zeppellini A, Cortinovis D, Bidoli P. Efficacy and Safety of the All-Oral Schedule of Metronomic Vinorelbine and Capecitabine in Locally Advanced or Metastatic Breast Cancer Patients: The Phase I-II VICTOR-1 Study. Int J Breast Cancer. 2014;2014: Bramati A, Girelli S, Torri V, Farina G, Galfrascoli E, Piva S, Moretti A, Dazzani MC, Sburlati P, La Verde NM. Efficacy of biological agents in metastatic triple-negative breast cancer. Cancer Treat Rev Jun;40(5): Maria Rosa Bani got her Biological Sciences degree at the University of Milan in 1998 attaining the Italian Government Qualification to practice as Biologist in She obtained the specialization in Pharmacological Research from the Department of Education of the Regional Government of Lombardia in 1991 and the specialization in Biomedical Research from the Department of Education of the Regional Government of Abruzzo in In 2005 she was awarded the degree of Doctor of Philosophy (PhD), Discipline of Life Sciences of the Open University Research School (UK). From 1991 to 1995 she was a Post Doctoral Fellow at the Cancer Research Division, Sunnybrook Health Science Centre, University of Toronto (Canada); from 2000 to 2001 she was Guest Scientist at the Advance Technology Centre, National Cancer Institute, National Institute of Health (USA). From 1996, she was a Fellow Research Scientist at the Mario Negri Institute for Pharmacological Research, Laboratory of Biology and Treatment of Metastasis and she became a staff research scientist in Since 2004 she was appointed Head of the Molecular Cancer Therapeutics Unit in the same laboratory. She has been the Scientific Manager of STROMA and ADAMANT, two Integrated Projects funded in the 6 th and 7 th Framework Programs of the European Commission. She is a member of the American Association for Cancer Research (AACR), the European Association for Cancer Research (EACR) and the Italian Cancer Society (SIC). Maria Rosa Bani research interests are in the field of cancer biology and preclinical therapeutics, with a focus on studying endothelial cell biology and understanding the role of endothelium in cancer progression for a translational opportunity. She is co-author of 38 peer reviewed publications, 2 book chapters and 72 abstracts of which 17 selected for oral presentations at international meetings. Selected publications Ricci F, Bizzaro F, Cesca M, Guffanti F, Ganzinelli M, Decio A, Ghilardi C, Perego P, Fruscio R, Buda A, Milani R, Ostano P, Chiorino G, Bani MR, Damia G, Giavazzi R. Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations. Cancer Research 74: , 2014 Borsotti P., Ghilardi C., Ostano P., Silini A., Dossi R., Pinessi D., Foglieni C., Scatolini M., Lacal P.M., Ferrari R., Moscatelli D., Sangalli F., D'Atri S., Giavazzi R., Bani M.R., Chiorino G., Taraboletti G. Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2. Pigment Cell Melanoma Res 28: 73-81, 2014 Moschetta M, Pretto F, Berndt A, Galler K, Richter P, Bassi A, Oliva P, Micotti E, Valbusa G, Schwager K, Kaspar M, Trachsel E, Kosmehl H, Bani MR, Neri D, Giavazzi R. Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts. Cancer Research 72: , 2012 Silini A, Ghilardi C, Figini S, Sangalli F, Fruscio R, Dahse R, Pedley RB, Giavazzi R, Bani M. Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor's proangiogenic microenvironment. Cellular and Molecular Life Sciences, 69: , 2012 Silini A., Ghilardi C., Ardinghi C., Bernasconi S., Carraro F., Naldini A., Bani M.R., Giavazzi R. Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype. Clinical Experimental Metastasis, 27 (1) : 43-53, 2010 Ghilardi C., Chiorino G., Dossi R., Nagy Z., Giavazzi R., Bani M.R. Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium. BMC Genomics, 30(9), 201, Michela Cinquini got her degree in Statistical Science in 2005 at the University of Milano-Bicocca and her specialization in Specialist in Pharmacological Research " at the Mario Negri Institute in She has been working at Mario Negri Institute since She is now head of the Systematic reviews methodology and guidelines production unit by the Laboratory of Methodology of Biomedical Research. In she worked as a Fellow at the Centre for Statistics in Medicine - Oxford, UK (Supervisor Doctor Altman DG). Since 2006 she has been teaching in several post-doctoral Masters in Clinical Research Methodology at Ferrara and Parma University and since 2010 in Systematic reviews at Milano University. Since 2008 she has been member of the Italian Cochrane Centre. Reasearch interest: Statistical and methodological aspects of Systematic reviews and Meta-analysis of intervention; Quality evaluation of evidence-based medicine and production of oncological guidelines using the GRADE approach. Selected publications Haspinger ER, Agustoni F, Torri V, Gelsomino F, Platania M, Zilembo N, Gallucci R, Garassino MC, Cinquini M. Is there evidence for different effects among EGFR-TKIs? Systematic review and meta-analysis of EGFR tyrosine kinase inhibitors (TKIs) versus chemotherapy as first-line treatment for patients harboring EGFR mutations. Crit Rev Oncol Hematol Nov 22. pii: S (14) doi: /j.critrevonc [Epub ahead of print] Review. PubMed PMID: Haspinger ER, Garassino MC, Torri V, Cinquini M, De Braud F, Gelsomino F. Do we really need another epidermal growth factor receptor tyrosine kinase inhibitori in first-line treatment for patients with non-small-cell lung cancer and EGFR mutations? J Clin Oncol Mar 10;32(8): doi: /JCO Epub 2014 Feb 3. PubMed PMID:

15 Marchini S, Poynor E, Barakat RR, Clivio L, Cinquini M, Fruscio R, Porcu L, Bussani C, D'Incalci M, Erba E, Romano M, Cattoretti G, Katsaros D, Koff A, Luzzatto L. The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer. Clin Cancer Res Aug 15;18(16): Epub 2012 Jun 25. PubMed PMID: Banzi R, Cinquini M, Liberati A, Moschetti I, Pecoraro V, Tagliabue L, Moja L.Speed of updating online evidence based point of care summaries: prospective cohort analysis. BMJ Sep 23;343:d5856 Galfrascoli E, Piva S, Cinquini M, Rossi A, La Verde N, Bramati A, Moretti A, Manazza A, Damia G, Torri V, Muserra G, Farina G, Garassino MC; ORION Collaborative Group. Risk/benefit profile of bevacizumab in metastatic colon cancer: a systematic review and metaanalysis. Dig Liver Dis Apr;43(4): Rossi A., Garassino MC., Cinquini M., Sburlati P., Borgonovo K., La Verde N., Farina G. and Torri V. Maintenance or consolidation therapy in Small Cell Lung Cancer (SCLC) with non chemotherapic agents: a systematic overview. Lung Cancer Nov;70(2): Marchini S, Mariani P, Chiorino G, Marrazzo E, Bonomi R, Fruscio R, Clivio L, Garbi A, Torri V, Cinquini M, Dell'Anna T, Apolone G, Broggini M, D'Incalci M. Analysis of gene expression in early-stage ovarian cancer. Clin Cancer Res Dec 1;14(23): Oscar Corli got his Medical degree in 1974 at the University of Milan and the specialization in Anesthesiology and Intensive Care in From June 1975 to January 1994 he was an Assistant Director of Anesthesiology Department at Vittore Buzzi Hospital (Milan). From February 1994 to January 2008 he was a Director of Palliative Care Unit at Istituti Clinici di Perfezionamento Hospital (Milan) and from 2008 up to now he was a director of C.E.R.P. and presently he the head of Palliative care Unit. Founding member of the S.I.C.P. (Italian Society of Palliative Care ), then national secretary from 1986 to 1994, then national president of SICP from 1994 to Founding member of the E.A.P.C. (European Association for Palliative Care) and a founding member of SIMPA (Italian School of Medicine and Palliative Care ). Teacher in Pain Therapy and Palliative Medicine at the University of Milan, Verona and University of Rome (Masters courses in palliative medicine). Member of the National Oncological Commission (Ministry of Health) in and member of C.U.F. (Ministry of Health), in the group "Pain Management " ( ). Member of the Commission for Palliative Care (Regione Lomabardia) in and member of the "Pain Management" - Department of Medicines and Pharmacovigilance (Ministerial Decree of ) and national coordinator of the same committee at the AIFA since January 2004, confirmed the coordination on 6 July 2005 until Member of the Commission "Pain therapy, palliative care and end of life" - Ministry of Health - in December Editor of Italian Observatory Palliative Care ( Selected publications Deandrea S, Corli O, Consonni D, Villani W, Greco MT, Apolone G. Prevalence of Breakthrough Cancer Pain: A Systematic Review and a Pooled Analysis of Published Literature. J Pain Symptom Manage 2014; 47: Corli O, Montanari M, Greco MT, Brunelli C, Kaasa S, Caraceni A, Apolone G. How to evaluate the effect of pain treatments in cancer patients: Results from a longitudinal outcomes and endpoint Italian cohort study. Eur J Pain. 2012; 17: Corli O, Montanari M, Deandrea S, Greco MT, Villani W, Apolone G. An exploratory analysis on the effectiveness of four strong opioids in patients with cancer pain. Pain Med Jul; 13(7): Knudsen AK, Brunelli C, Klepstad P, Aass N, Apolone G, Corli O, Montanari M, Caraceni A, Kaasa S. Which domains should be included in a cancer pain classification system? Analyses of longitudinal data. Pain Mar; 153(3): Greco MT, Corli O, Montanari M, Deandrea S, Zagonel V, Apolone G; Writing Protocol Committee; Cancer Pain Outcome Research Study Group (CPOR SG) Investigators. Epidemiology and pattern of care of breakthrough cancer pain in a longitudinal sample of cancer patients: results from the Cancer Pain Outcome Research Study Group. Clin J Pain Jan; 27(1): Apolone G, Corli O, Caraceni A, Negri E, Deandrea S, Montanari M, Greco MT; Cancer Pain Outcome Research Study Group (CPOR SG) Investigators. Pattern and quality of care of cancer pain management. Results from the Cancer Pain Outcome Research Study Group. Br J Cancer May 19; 100(10): Giovanna Damia obtained her Medical Degree cum Laude from the University of Milan in After specializing in Pharmacology at the Mario Negri Institute of Milan and in Oncology at the University of Milan, she worked as a postdoctoral fellow in the Laboratory of Experimental Immunology of the National Cancer Institute, Frederick, USA. She worked as a research fellow in the Laboratory of Cancer Chemotherapy at the Mario Negri Institute and since April 2003 she has become chief of the DNA Repair Unit at the Mario Negri Institute. From 1992 to1995 she has been consultant of the General Secretariat of the Progetto Finalizzato CNR "Applicazioni Cliniche della Ricerca Oncologica". Since September 2005 she is Deputy Editor for Experimental Oncology of the European Journal of Cancer. Her main fields of interest are: mechanism of action of anticancer drugs, cell cycle checkpoints and natural compounds. Selected publications Chilà R, Basana A, Lupi M, Guffanti F, Gaudio E, Rinaldi A, Cascione L, Restelli V, Tarantelli C, Bertoni F, Damia G, Carrassa L. Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma. Oncotarget Oct 25. [Epub ahead of print] PubMed PMID: Ricci F, Bizzaro F, Cesca M, Guffanti F, Ganzinelli M, Decio A, Ghilardi C, Perego P, Fruscio R, Buda A, Milani R, Ostano P, Chiorino G, Bani MR, Damia G, Giavazzi R. Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations. Cancer Res Dec 1;74(23): doi: / CAN Epub 2014 Oct 10. PubMed PMID: Damia G, Garattini S. The pharmacological point of view of resistance to therapy in tumors. Cancer Treat Rev Sep;40(8): doi: /j.ctrv Epub 2014 Jun 9. Review. PubMed PMID:

16 Ricci F, Broggini M, Damia G. Revisiting ovarian cancer preclinical models: Implications for a better management of the disease. Cancer Treat Rev Oct;39(6):561-8 Bello E, Taraboletti G, Colella G, Zucchetti M, Forestieri D, Licandro SA, Berndt A, Richter P, D'Incalci M, Cavalletti E, Giavazzi R, Camboni G, Damia G. The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triplenegative breast cancer xenografts. Mol Cancer Ther Feb;12(2): Eugenio Erba has obtained his Biological and Biochemistry Analysis Degree at the University of Urbino. He worked as a research fellow in the Laboratory of Cancer Chemotherapy at the Mario Negri Institute and since 1984 he is head of the Flow Cytometry Unit in the Department of Oncology at the Mario Negri Institute of Milan. He has worked as a visiting fellow in the Department of Istochemistry and Cytochemistry of the University of Leiden, The Netherlands in Since 1997 he is Teacher of Post-Graduate Studies in Cytometry at the University of Milan and Co-ordinator and Teacher of Post-Graduate Studies in Cytometry for the Italian Cytometry Group. He has been President of the Italian Cytometry Group from 1999 to Since 2001 he is member of the Executive Board of the Italian Cytometry Group. Scientific areas of interest: studies on the mechanism of action of different compounds with provided antitumoral activity evaluating the mechanism of cell death and cell cycle phase perturbations induced on different human cancer cell lines by using flow cytometry. Co-ordinator of working-group in a quality control study on flow cytometric DNA content analysis in human tumors. Selected publications Germano G., Frapolli R., Belgiovine C., Anselmo A., Pesce S., Liguori M., Erba E., Uboldi S., Zucchetti M., Pasqualini F., Nebuloni M., Van Rooijen N., Mortarini R., Beltrame L., Marchini S., Fuso Nerini I., Sanfilippo R., Casali P.G., Pilotti S., Anichini A., Mantovani A., D Incalci M., Allavena P. Role of Macrophage targeting in the anti-tumor activity of Trabectedin. Cancer Cell, 23(2): (2013). Urru S.A.M., Veglianese P., De Luigi A., Fumagalli E., Erba E., Gonella Diaza R., Carrà A., Davoli E., Borsello T., Forloni G., Pengo N., Monzani E., Cascio P., Cenci S., Sitia R., Salmona M. A new fluorogenic peptide determines proteasome activity in single cells. J.Med.Chem., 53: (2010). Germano G., Frapolli R., Simone M., Tavecchio M., Erba E., Pesce S., Pasqualini F., Grosso F., Sanfilippo R., Casali P., Gronchi A., Virdis E., Tarantino E., Pilotti S., Greco A., Nebuloni M., Galmarini C.M., Tercero J.C., Mantovani A., D Incalci M., Allavena P. Anti-tumor and antiinflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res., 70(6): (2010). C. Forni, M Minuzzo, E. Virdis, E. Tamburini, M. Simone, M. Tavecchio, E. Erba, F. Grosso, A. Gronchi, P.Aman, P. Casali, M. D Incalci, S. Pilotti, R. Mantovani. Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol. Ca. Ther. 8(2), , 2009 E. Marrazzo, S. Marchini, M. Tavecchio, T. Alberio, S. Previdi, E. Erba, V. Rotter, M. Broggini. The expression of the Np73 isoform of p73 leads to tetraploidy. Eur J Ca 45, , 2009 M.Tavecchio, M. Simone, E.Erba, I. Chiolo, G. Liberi, M. Foiani, M. D Incalci, G. Damia. Role of homologous recombination in trabectedininduced DNA damage. Eur. J. Ca 44: (2008) Roldano Fossati got his Medical Degree cum Laude from the University of Milan in 1980, his Post-Doctoral Degree in Endocrinology cum Laude from the University of Verona in 1983 and his Post-Doctoral Degree in Medical Statistics from the University of Milan in He has been consultant at the Mario Negri Institute since 1983 and, at present, he is head of the Gynecology and Oncology Unit of the Laboratory of Clinical Research. Areas of Interest: Statistical and methodologic aspects of clinical research with focus on Controlled Clinical Trials in Oncology; Systematic Overview of the medical literature. Selected publications Panici PB, Basile S, Salerno MG, Di Donato V, Marchetti C, Perniola G, Palagiano A, Perutelli A, Maneschi F, Lissoni AA, Signorelli M, Scambia G, Tateo S, Mangili G, Katsaros D, Campagnutta E, Donadello N, Greggi S, Melpignano M, Raspagliesi F, Cormio G, Grassi R, Franchi M, Giannarelli D, Fossati R, Torri V, Crocè C, Mangioni C. Secondary analyses from a randomized clinical trial: age as the key prognostic factor in endometrial carcinoma.. Am J Obstet Gynecol Dec 18. pii: S (13) doi: /j.ajog Dell' Anna T, Signorelli M, Benedetti-Panici P, Maggioni A, Fossati R, Fruscio R, Milani R, Bocciolone L, Buda A, Mangioni C, Scambia G, Angioli R, Campagnutta E, Grassi R, Landoni F. Systematic lymphadenectomy in ovarian cancer at second-look surgery: a randomised clinical trial. Br J Cancer Aug 21;107(5): Hogberg T, Signorelli M, de Oliveira CF, Fossati R, Lissoni AA, Sorbe B, Andersson H, Grenman S, Lundgren C, Rosenberg P, Boman K, Tholander B, Scambia G, Reed N, Cormio G, Tognon G, Clarke J, Sawicki T, Zola P, Kristensen G. Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer--results from two randomised studies. Eur J Cancer Sep;46(13): Epub 2010 Jul 7. Signorelli M, Lissoni AA, Cormio G, Katsaros D, Pellegrino A, Selvaggi L, Ghezzi F, Scambia G, Zola P, Grassi R, Milani R, Giannice R, Caspani G, Mangioni C, Floriani I, Rulli E, Fossati R. Modified Radical Hysterectomy Versus Extrafascial Hysterectomy in the Treatment of Stage I Endometrial Cancer: Results From the ILIADE Randomized Study. Ann Surg Oncol Oct 16 Andrea Alberto Lissoni, Nicoletta Colombo, Antonio Pellegrino, Gabriella Parma, Paolo Zola, Dionyssios Katsaros, Stefania Chiari, Alessandro Buda, Fabio Landoni, Michele Peiretti, Tiziana Dell Anna, Robert Fruscio, Mauro Signorelli, Roberto Grassi, Irene Floriani, Roldano Fossati, Valter Torri, Eliana Rulli. A phase II, randomized trial of neoadjuvant chemotherapy comparing a three-drug combination of paclitaxel, ifosfamide and cisplatin (TIP) versus paclitaxel and cisplatin (TP) followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the Snap-02 Italian Collaborative Study. Annals of Oncology, 20: ;2009 Fruscio R, Colombo N, Lissoni AA, Garbi A, Fossati R, Ieda' N, Torri V, Mangioni C.A phase II randomised clinical trial comparing cisplatin, paclitaxel and ifosfamide with cisplatin, paclitaxel and epirubicin in newly diagnosed advanced epithelial ovarian cancer: longterm survival analysis. Br J Cancer Feb 5; 15

17 Roberta Frapolli, got her degree in Pharmacological Chemistry (110/110 summa cum laude) at the University of Milan in In 2003, she specialised in Pharmacology at "Mario Negri" Institute for Pharmacological Research of Milan. From 2004 to 2005, she was researcher at Prassis, Institute for Research sigma-tau, and from 2005 to 2013 research scientist at the "Mario Negri" Institute for Pharmacological Research, Department of Oncology, Laboratory of Cancer Pharmacology. Since January 2013 she is head of the Preclinical Experimental Therapeutics Unit. Main research activities: preclinical antitumor activity studies; development of experimental models of soft tissue sarcomas and mesothelioma to evaluate new compounds and combinations. Pharmacokinetics studies in animal models. Selected publications Dossi R, Frapolli R, Di Giandomenico S, Paracchini L, Bozzi F, Brich S, Castiglioni V, Borsotti P, Belotti D, Uboldi S, Sanfilippo R, Erba E, Giavazzi R, Marchini S, Pilotti S, D'Incalci M, Taraboletti G. Antiangiogenic activity of trabectedin in myxoid liposarcoma: involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1. Int J Cancer Feb 1;136(3): Di Giandomenico S, Frapolli R, Bello E, Uboldi S, Licandro S A, Marchini S, Beltrame L, Brich S, Mauro V, Tamborini E, Pilotti S, Casali P, Grosso F, Sanfilippo R, Gronchi A, Mantovani R, Gatta R, Galmarini C M, Sousa-Faro J M F, D'Incalci M. Mode of action of trabectedin in myxoid liposarcomas. Oncogene 2013 E-pub D'Incalci M, Frapolli R, Germano G, Allavena P. New activities for the anti-tumor agent trabectedin: taking two birds with one stone. Oncotarget : Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, Erba E, Uboldi S, Zucchetti M, Pasqualini F, Nebuloni M, van Rooijen N, Mortarini R, Beltrame L, Marchini S, Fuso Nerini I, Sanfilippo R, Casali P G, Pilotti S, Galmarini C M, Anichini A, Mantovani A, D'Incalci M, Allavena P. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell : Germano G, Frapolli R, Simone M, Tavecchio M, Erba E, Pesce S, Pasqualini F, Grosso F, Sanfilippo R, Casali P, Gronchi A, Virdis E, Tarantino E, Pilotti S, Greco A, Nebuloni M, Galmarini C M, Tercero J C, Mantovani A, D'Incalci M, Allavena P. Antitumor and antiinflammatory effects of trabectedin on human mixoid liposarcoma cells. Cancer Res : Frapolli R, Tamborini E, Virdis E, Bello E, Tarantino E, Marchini S, Grosso F, Sanfilippo R, Gronchi A, Tercero J C, Peloso G, Casali P, Pilotti S, D'Incalci M. Novel models of myxoid liposarcoma xenografts mimicking the biological and pharmacologic features of human tumors. Clin Cancer Res : Lital Hollander holds a Bachelor s Degree in Medical Sciences from the School of the Medicine of the Hebrew University in Jerusalem, a post-graduate certificate in Clinical Research from the UniversitàStatale di Milano, and a Master s Degree in Public Health from the University of Liverpool. Since 1994 she has conducted research programs on HIV infection and reproductive health in people living with HIV in collaboration with Italian, European and US (CDC) Institutions. In parallel she has been involved in Health Promotion, Advocacy and Health Policy initiatives aiming to improve the involvement of people living with HIV in all areas concerning their health, rights and well being. She has collaborated with the Department of Oncology since As of 2013 she has become Head of Unit for Research Design and Planning. Her fields of interest include: 1. Research methodology and its application to the design of clinical research and experimental instruments 2. Exposure and outcome measures in oncology and their application in vulnerable populations 3. Use of evidence base in regulatory and health policy areas 4. Management and reform of complex adaptive systems with particular attention to academic and health organizations. Selected publications Semprini AE, Macaluso M, Hollander L, et al. Safe conception for HIV-discordant couples: insemination with processed semen from the HIVinfected partner. Am J ObstetGynecol 2013;208:402.e1-402.e9. Bujan L, Gilling-Smith C, Hollander L, et al. Lack of clinical and scientific evidence to justify the systematic use of ICSI in HIVserodiscordant couples wishing to conceive where the male partner is infected. FertilSteril Mar;91(3):e1-2 Semprini AE, Hollander L, Vucetich A, Gilling-Smith C. Infertility treatment for HIV-positive women. Women s Health 2008; 4(4): Sunderam S, Hollander L, Macaluso M et al., Safe Conception for HIV Discordant Couples through Sperm-Washing: Experience and Perceptions of Patients in Milan, Italy. Reproductive Health Matters 2008;16(31): Bujan L, Hollander L, Coudert M et al. Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected: results from the European CREAThE network. AIDS 2007; 21: Garassino MC, Hollander L, Torri V. Bevacizumab for Non-Small-Cell Lung Cancer. NEJM 2007; 356 (13): 1373 Marlen Victoria Llerena Mesa got her degree in Pharmaceutic Science at the University of Havana (Cuba) in In 2003 she got the Lead Auditor Certificate according to ISO standard at the Institute for Standardization Research, Havana, Cuba. In 2005 and 2006 she got the title of Master in Pharmacologic Science and in Clinical Trials, respetctively. Since Aprile 2012 she has been head of the Quality Assurance Unit. Main areas of interest are the control 16

18 and improvement of the quality assurance system, the approval of standard operative procedures (SOPs) and development of a documentation system meant to guarantee the traceability of all the activities in accord to the Norme of Good Clinical Practices (GCP) and legal directives. Selected publications Llerena Mesa M, Biagioli E. Importanza della assicurazione della qualità negli studi clinici. Medical Oncology Progress & Perspectives 2012 ; Update 41 : Álvarez S, Rodríguez O, Llerena M. Unidad de Calidad: desarrollo e importancia para el Centro Nacional Coordinador de Ensayos Clínicos. Revista Cubana de Farmacia 2010:44(Suplemento Especial 2). Llerena M, Rodríguez OM, Pérez B, Álvarez S. Necesidad de información sobre Gestión de Calidad: programa de entrenamiento. Revista Cubana de Farmacia 2004:38(Suplemento 1): Llerena M, Rodríguez OM, Pérez B, Álvarez S. Plegable, herramienta para comunicar información sobre Gestión de la Calidad. Revista Cubana de Farmacia 2004:38(Suplemento 1): Pérez B, Pérez A, Llerena M, Rodríguez OM, Álvarez S. Aseguramiento de la calidad en el sitio de ejecución de los ensayos clínicos coordinados por el CENCEC en el periodo Revista Cubana de Farmacia 2003: 37(Suplemento Especial). Pérez B, Pérez A, Llerena M. Manual de instrucciones al farmacéutico que participa en un ensayo clínico coordinado por el CENCEC. Revista Cubana de Farmacia 2003:37(Suplemento Especial). Mirko Marabese got his Biological Sciences degree at the University of Milan in 2001 attaining the Italian Government Qualification to practice as Biologist in He obtained the specialization in Pharmacological Research from the Mario Negri Institute for Pharmacological Research in In the same year he was awarded the degree of Doctor of Philosophy (PhD), Discipline of Life Sciences of the Open University Research School (UK). From 2001, he was a Fellow Research Scientist at the Mario Negri Institute for Pharmacological Research, Laboratory of Molecular Pharmacology and he became a staff research scientist in From 2003 to 2004 he was a Visiting Fellow at Apoptosis & Cancer Laboratory at Medical Research Council (MRC) Toxicology Unit of Leicester (UK).Since 2011 he was Head of the Molecular Genetics Unit in the Oncology Department at Mario Negri Institute for Pharmacological Research. The research activities of the Molecular Genetics Unit are focused on the characterization from a molecular point of view the tumors and to understand the role of the gene alterations in relationship with the therapy response. Thanks to the strog collaboration with clinician in orspitals, the recent activities are focused on non small cell lung cancer. In particular the aim of the research is to define a strategy to bypass the chemotherapy resistance of KRAS mutated tumors that account for 25% of all lung tumors. At the same time, the research team is also focused on the acquired resistance after chemotherapy of the small cell lung cancer. Selected publications Caiola E, Broggini M, Marabese M. Genetic markers for prediction of treatment outcomes in ovarian cancer. Pharmacogenomics J Oct;14(5): doi: /tpj Epub 2014 Jul 8. PubMed PMID: Brunelli L, Caiola E, Marabese M, Broggini M, Pastorelli R. Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget Jul 15;5(13): PubMed PMID: ; PubMed Central. Garassino MC, Martelli O, Broggini M, Farina G, Veronese S, Rulli E, Bianchi F, Bettini A, Longo F, Moscetti L, Tomirotti M, Marabese M, Ganzinelli M, Lauricella C, Labianca R, Floriani I, Giaccone G, Torri V, Scanni A, Marsoni S; TAILOR trialists.erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial.lancet Oncol Sep;14(10): Caiola E, Rulli E, Fruscio R, Buda A, Broggini M, Marabese M. KRas-LCS6 polymorphism does not impact on outcomes in ovarian cancer. Am J Cancer Res. 2012;2(3): Garassino MC, Marabese M, Rusconi P, Rulli E, Martelli O, Farina G, Scanni A, Broggini M. 10.Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer. Ann Oncol Jan;22(1): Caiola E, Porcu L, Fruscio R, Giuliani D, Milani R, Torri V, Broggini M, Marabese M. DNA-damage response gene polymorphisms and therapeutic outcomes in ovarian cancer. Pharmacogenomics J. Dec Sergio Marchini was graduated summa cum laude, in Biological Science, University of Milan in 1993.,attaining the Italian Government Qualification to practice as Biologist in He obtained the specialization in Pharmacological Research from the Department of Education of the Regional Government of Lombardia in 1997 and the in 2000 he was awarded in advanced studies in Pharmacology, University of Pavia, Italy. In 2003 he got the Ph. D. degree at the Open University, London UK. Professional Positions: 2001-up to now: permanent position as a researcher at the "Mario Negri" Institute for Pharmacological research. Since 2011 he was appointed Head of of Translational Genomic Unit, Laboratory of Cancer Chemotherapy. In 2001, he was visiting scientist at MGH, Boston, Ma, US and 1998 he was visiting scientist at the Birmingham University (U.K.), Department of Medical Genetic. Honour and Awards: 2001: First rank in the prize "ONLUS-AICC 2001" for young Italian scientists. 1995: First rank in the prize "MIGLIORI POSTER S.I.C." XIII Riunione Nazionale di Oncologia Sperimentale e Clinica (Verona, ottobre 1995). Research activities: translational research activities are mainly focused on ovarian cancer tumors as well as on mixoid liposarcomas. By exploiting -omic approaches on different cohort of tumor biopsies, the research activities of the Translational Genomic Unit are focused on defying and integrate the transcriptional (mirna, and gene expression) 17

19 and mutational landscape (target resequencing) of ovarian cancer and mixoid liposarcomas tumors to identify molecular determinant with prognostic and diagnostic value. Selected publications Wiring mirnas to pathways: a topological approach to integrate mirna and mrna expression profiles. Calura, Enrica; Martini, Paolo; Sales, Gabriele; Beltrame, Luca; Chiorino, Giovanna; D'Incalci, Maurizio; Marchini, Sergio; Romualdi, Chiara. NAR doi: /nar/gku354 First published online: May 6, 2014 microrna-181a plays a critical role in ovarian cancer progression through the regulation of epithelial-mesenchymal transition. Aditya Parikh, Christine Lee, Peronne Joseph, Sergio Marchini, Alessia Baccarini, Valentin Kolev, Chiara Romualdi, Robert Fruscio, Hardik, Shah, Feng Wang, Gavriel Mullokandov, David Fishman, Maurizio D Incalci, Jamal Rahaman, Tamara Kalir, Raymond W. Redline, Brian D. Brown, Goutham Narla, and Analisa DiFeo. Nature Communication, DOI: /ncomms3977. DRAGO (KIAA0247), a New DNA Damage-Responsive, p53-inducible Gene That Cooperates With p53 as Oncosuppressor. Polato F, Rusconi P, Zangrossi S, Morelli F, Boeri M, Musi A, Marchini S, Castiglioni V, Scanziani E, Torri V, Broggini M. J Natl Cancer Inst Mar 20. mirna landscape in Stage I Epithelial Ovarian Cancer defines the histotype specificities. Enrica Calura, Robert Fruscio, Lara Paracchini, Eliana Bignotti, Antonella Ravaggi, Paolo Martini, Gabriele SaleS, Luca Beltrame, Luca Clivio, Lorenzo Ceppi, Mariacristina Di Marino, Ilaria Fuso Nerini, Laura Zanotti, Duccio Cavalieri, Giorgio Cattoretti, Patrizia Perego, Rodolfo Milani, Dionyssios Katsaros, Germana Tognon, Enrico Sartori, Sergio Pecorelli, Costantino Mangioni, Maurizio D Incalci, Chiara Romualdi, Sergio Marchini. Clin Clin Cancer Res Aug 1;19(15): Role of Macrophage targeting in the anti-tumor activity of Trabectedin. Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, Erba E, Uboldi S, Zucchetti M, Pasqualini F, Nebuloni M, van Rooijen N, Mortarini R, Beltrame L, Marchini S, Fuso Nerini I, Sanfilippo R, Casali PG, Pilotti S, Galmarini CM, Anichini A, 9Mantovani A, D Incalci M, and P. Allavena. Cancer Cell 23, February 11, 2013 The zinc finger gene ZIC2 has features of an oncogene and its over- expression correlates strongly with the clinical course of epithelial ovarian cancer. Sergio Marchini, Elizabeth Poynor, Richard R Barakat, Luca Clivio, Michela Cinquini, Robert Fruscio, Luca Porcu, Cecilia Bussani, Maurizio D Incalci, Eugenio Erba, Michela Romano, Giorgio Cattoretti, Dionyssios Katsaros, Andrew Koff, Lucio Luzzatto. Clin Cancer Res Aug 15;18(16): Davide Poli got his master s degree in Physics at the University of Milan in 2007 and his specialization in Biochemical Research Technician" at the Mario Negri Institute for Pharmacological Research in Since November 2012 is a Head of Coordination, Management and Monitoring in the Laboratory of Clinical Research. His areas of interest are: design of ecrf in Clinical Trials, new electronic aspects of Clinical Research especially towards technologies of Web-based Electronic Data Capture, methodology, data management and local monitoring aspects in Clinical Research. Selected publications Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer. Bajetta E, Floriani I, Di Bartolomeo M, Labianca R, Falcone A, Di Costanzo F, Comella G, Amadori D, Pinto C, Carlomagno C, Nitti D, Daniele B, Mini E, Poli D, Santoro A, Mosconi S, Casaretti R, Boni C, Pinotti G, Bidoli P, Landi L, Rosati G, Ravaioli A, Cantore M, Di Fabio F, Aitini E, Marchet A; ITACA-S (Intergroup Trial of Adjuvant Chemotherapy in Adenocarcinoma of the Stomach Trial) Study Group. Ann Oncol Jul;25(7): Ocular Hypertension Treatment Study Group, European Glaucoma Prevention Study Group (EGPS), Poli D. The accuracy and clinical application of predictive models for primary open-angle glaucoma in ocular hypertensive individuals. Ophthalmology, Volume 115, Number 11 pp , November 2008 Porcu L, Poli D, Torri V, Rulli E, Cropalato di Tullio M, Cinquini M, Bajetta E, Labianca R, Di Costanzo F, Nitti D, Floriani I. Impact of recent legislative bills regarding clinical research on Italian ethics committee activity. Journal of Medical Ethics 2008, Volume 34, pp Gordon MO, Torri V. Miglior S, Beiser JA, Floriani I, Miller JP, Gao F, Adamsons I, Poli D, D'Agostino RB, Kass MA. A validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension. Ophthalmology, Volume 114, Number 1, pp , January 2007 Parmar MK, Ledermann JA, Colombo N, du Bois A, Delaloye JF, Kristensen GB, Wheeler S, Swart AM, Qian W, Torri V, Floriani I, Jayson G, Lamont A, Tropé C; ICON and AGO Collaborators, Poli D. Paclitaxel plus platinum-based chemotherapy versus conventional platinumbased chemotherapy in women with relapsed ovarian cancer: The ICON4/AGO-OVAR-2.2 Trial. Lancet 2003; 361: Luca Porcu obtained his degree as Biochemical Research Technician" from the Mario Negri Institute for Pharmacological Research in From 2001 to 2007 he has been employed as Coordinator and Data Manager of Clinical Trials in the Clinical Epidemiology Laboratory; from 2007 to 2009 he has been employed as Contract Research Associate in charge for the auditing of Clinical Trials; from 2007 up to now he is employed for data analysis, metaanalysis, development of predictive models in Oncology, statistical computing in Biomedical Research in the Laboratory of Methodology for Biomedical Research. His scientific focus is the methodology of Biomedical Research, in particular the probabilistic models implemented in the oncological setting (e.g.: probabilistic models fitting Survival-Post-Progression endpoint), the statistical methodology for rare tumors,.for preclinical and translational research Selected Publications Califano R, Karamouzis MV, Banerjee S, de Azambuja E, Guarneri V, Hutka M, Jordan K, Kamposioras K, Martinelli E, Corral J, Postel- Vinay S, Preusser M, Porcu L, Torri V Use of adjuvant chemotherapy (CT) and radiotherapy (RT) in incompletely resected (R1) early stage Non-Small Cell Lung Cancer (NSCLC): a European survey conducted by the European Society for Medical Oncology (ESMO) young oncologists committee. Lung Camcer Jul;85(1):

20 Rossi A, Torri V, Garassino MC, Porcu L, Galetta D. The impact of personalized medicine on survival: Comparisons of results in metastatic breast, colorectal and non-small-cell lung cancers Cancer Treat Rev Sep 25 Marchini S, Fruscio R, Clivio L, Beltrame L, Porcu L, Nerini IF, Cavalieri D, Chiorino G, Cattoretti G, Mangioni C, Milani R, Torri V, Romualdi C, Zambelli A, Romano M, Signorelli M, Giandomenico SD, D'Incalci M. Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer. Eur J Cancer Aug 13 Marchini S, Poynor E, Barakat R, Clivio L, Cinquini M, Fruscio R, Porcu L, Bussani C, D'Incalci M, Erba E, Romano M, Cattoretti G, Katsaros D, Koff A, Luzzatto L. The zinc finger gene ZIC2 has features of an oncogene and its over- expression correlates strongly with the clinical course of epithelial ovarian cancer. Clin Cancer Res Jun 25 Caiola E, Porcu L, Fruscio R, Giuliani D, Milani R, Torri V, Broggini M, Marabese M. DNA-damage response gene polymorphisms and therapeutic outcomes in ovarian cancer. Pharmacogenomics J Dec 13 Porcu L, Poli D, Torri V, Rulli E, Di Tullio MC, Cinquini M, Bajetta E, Labianca R, Di Costanzo F, Nitti D, Floriani I. Impact of recent legislative bills regarding clinical research on Italian ethics committee activity. J Med Ethics Oct;34(10): Eliana Rulli got her master s degree in Biostatistics and Experimental Statistic in 2007, her degree in Statistical Science in 2004 at the University of Milano-Bicocca and her specialization in Specialist in Pharmacological Research " at Mario Negri Institute in She has been working at institute Mario Negri since 2003, at this time she is in charge of Statistic unit at the Laboratory of Clinical Trials. She is member of the Ethics Committee of the association "La Nostra Famiglia" - IRCCS "E. Medea". Areas of interest: methodology and statistical aspects of clinical research, systematic reviews and quality assessment of medical literature Selected publications Diagnostic performance of Contrast-Enhanced Ultrasound (CEUS) and Contrast-Enhanced Endoscopic Ultrasound (ECEUS) for the differentiation of pancreatic lesions: A systematic review and meta-analysis D'Onofrio M, Biagioli E, Gerardi C, Canestrini S, Rulli E, Crosara S, De Robertis R, Floriani I Ultraschall Med 2014 ; 35 : Massi D, Brusa D, Merelli B, Ciano M, Audrito V, Serra S, Buonincontri R, Baroni G, Nassini R, Minocci D, Cattaneo L, Tamborini E, Carobbio A, Rulli E, Deaglio S, Mandalà M PD-L1 marks a subset of melanomas with a shorter overall survival and distinct genetic and morphological characteristics Ann Oncol 2014 ; 25 : Rulli E, Biagioli E, Riva I, Gambirasio G, De Simone I, Floriani I, Quaranta L. Efficacy and safety of trabeculectomy vs nonpenetrating surgical procedures: A systematic review and meta-analysis. JAMA Ophthalmol Dec 1;131(12): Garassino M C, Martelli O, Broggini M, Farina G, Veronese S, Rulli E, Bianchi F, Bettini A, Longo F, Moscetti L, Tomirotti M, Marabese M, Ganzinelli M, Lauricella C, Labianca R, Floriani I, Giaccone G, Torri V, Scanni A, Marsoni S, TAILOR trialists. Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial. Lancet Oncol 2013 ; 14 : Hoffmann EM, Miglior S, Zeyen T, Torri V, Rulli E, Aliyeva S, Floriani I, Cunha-Vaz J, Pfeiffer N.The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors. Acta Ophthalmol Dec;91(8):e Caiola E, Rulli E, Fruscio R, Buda A, Broggini M, Marabese M. KRas-LCS6 polymorphism does not impact on outcomes in ovarian cancer. Am J Cancer Res 2012 ; 2 : Giulia Taraboletti got her degree cum laude in Biological Sciences at the University of Pavia (Pavia, Italy) in 1983, and the specialization in Pharmacological Research at the Mario Negri Institute, Milano, Italy in From 1986 to 1988 she was a post-doctoral fellow at the Laboratory of Pathology, NCI, NIH, Bethesda, MD, and from research scientist at Mario Negri Institute in Bergamo, Italy. Since 1995 she is Head of the Unit of Tumor Angiogenesis, at Mario Negri Institute, in Bergamo. Research interests include tumor angiogenesis, endogenous inhibitors of angiogenesis (thrombospondin-1) and preclinical studies of antiangiogenic and vascular disrupting compounds, including tubulin-targeting agents. She is author of more than 80 articles published in peer reviewed international journals (h index 43). She is member of Metatasis Research Society (MRS, board of directors ), American Association for Cancer Research (AACR), European Association for Cancer Research (EACR), and the Italian Society of Oncology (SIC, board of directors ). She is on the editorial board of European Journal of Cancer, TheScientificWorldJournal, Current Cancer Therapy Reviews, and Physiological Reviews. Selected publications Borsotti P, Ghilardi C, Ostano P, Silini A, Dossi R, Pinessi D, Foglieni C, Scatolini M, Lacal PM, Ferrari R, Moscatelli D, Sangalli F, D Atri S, Giavazzi R, Bani MR, Chiorino G and Taraboletti G. Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2. Pigment Cell Melanoma Res, 28:73-81, 2015 Dossi R, Frapolli R, Di Giandomenico S, Paracchini L, Bozzi F, Brich S, Castiglioni V, Borsotti P, Belotti D, Uboldi S, Sanfilippo R, Erba E, Giavazzi R, Marchini S, Pilotti S, D Incalci M, and Taraboletti G. Antiangiogenic activity of trabectedin in myxoid liposarcoma: involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1. Int J Cancer 136: 721-9, 2015 Colombo G, Margosio B, Ragona L, Neves M, Bonifacio S, Annis DS, Stravalaci M, Tomaselli S, Giavazzi R, Rusnati M, Presta M, Zetta L, Mosher DF, Ribatti D, Gobbi M, Taraboletti G. Non-peptidic thrombospondin-1-mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds. J Biol Chem, 285: , Bonezzi K., Taraboletti G., Borsotti P., Bellina F., Rossi R., Giavazzi R. Vascular disrupting activity of tubulin-binding 1,5-diaryl-1Himidazoles. J Med Chem 52, ,

Laboratory of Cancer Pharmacology

Laboratory of Cancer Pharmacology D E P A R T M E N T O F O N C O L O G Y S T A F F Chief Maurizio D INCALCI, M.D. Oncological Studies Office and Documentation Scientific Documentalist Stefania FILIPPESCHI, Chemist Laboratory of Cancer

More information

Laboratory of Cancer Pharmacology

Laboratory of Cancer Pharmacology D E P A R T M E N T O F O N C O L O G Y S T A F F Chief Maurizio D INCALCI, M.D. Oncological Studies Office and Documentation Scientific Documentalist Stefania FILIPPESCHI, Chemist Laboratory of Cancer

More information

ANNUAL REPORT EDUCATIONAL ACTIVITIES 379 STAFF 383

ANNUAL REPORT EDUCATIONAL ACTIVITIES 379 STAFF 383 PREFACE ANNUAL REPORT MARIO NEGRI INSTITUTE, MILAN www.marionegri.it DEPARTMENTS Department of Oncology.. 7 Department of Environmental Health Sciences... 53 Department of Neuroscience.. 73 Department

More information

ANNUAL REPORT EDUCATION ACTIVITIES 359 STAFF 361

ANNUAL REPORT EDUCATION ACTIVITIES 359 STAFF 361 PREFACE ANNUAL REPORT MARIO NEGRI INSTITUTE, MILAN www.marionegri.it DEPARTMENTS Department of Oncology.. 7 Department of Environmental Health Sciences... 53 Department of Neuroscience.. 73 Department

More information

Curriculum Vitae. Education. Brief Chronology of Employment. Academic Positions held. Pier Paolo Di Fiore M.D. Ph.D.

Curriculum Vitae. Education. Brief Chronology of Employment. Academic Positions held. Pier Paolo Di Fiore M.D. Ph.D. Pier Paolo Di Fiore M.D. Ph.D. Curriculum Vitae Education 1981 - M.D., summa cum laude, University of Naples, 2nd Medical School, Naples, Italy 1984 - Board in Oncology, summa cum laude, University of

More information

E UROPEAN CURRICULUM VITAE FORMAT

E UROPEAN CURRICULUM VITAE FORMAT E UROPEAN CURRICULUM VITAE FORMAT PERSONAL INFORMATION Name Address VALENTINA GUARNERI University of Padova Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche Istituto Oncologico Veneto

More information

ANNUAL REPORT EDUCATION ACTIVITIES 339 STAFF 341

ANNUAL REPORT EDUCATION ACTIVITIES 339 STAFF 341 PREFACE ANNUAL REPORT MARIO NEGRI INSTITUTE, MILAN www.marionegri.it DEPARTMENTS Department of Oncology.. 7 Department of Environmental Health Sciences... 57 Department of Neuroscience.. 77 Department

More information

Targeted Therapy What the Surgeon Needs to Know

Targeted Therapy What the Surgeon Needs to Know Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures

More information

PERSONAL INFORMATION ALESSANDRO BUDA E U R O P E A N C U R R I C U L U M V I T A E. Name. Born date 28/07/1972

PERSONAL INFORMATION ALESSANDRO BUDA E U R O P E A N C U R R I C U L U M V I T A E. Name. Born date 28/07/1972 E U R O P E A N C U R R I C U L U M V I T A E PERSONAL INFORMATION Name ALESSANDRO BUDA country ITALY Born date 28/07/1972 JOB EXPERIENCES Date (from to) hospital 12/05 to date MD Gynecologist at the Division

More information

Ariela Benigni. Biol.Sci.D., Ph.D. Curriculum Vitae

Ariela Benigni. Biol.Sci.D., Ph.D. Curriculum Vitae Ariela Benigni Biol.Sci.D., Ph.D. Curriculum Vitae Personal Data Name: Date and place of birth: Citizenship: E-mail: Ariela Benigni December 16, 1955 - Bergamo, Italy Italian ariela.benigni@marionegri.it

More information

Curriculum Vitae - Sara Gandini

Curriculum Vitae - Sara Gandini Curriculum Vitae - Sara Gandini Academic information 2004 PHD IN CANCER STUDIES at the University of Birmingham (Public Health), UK. Thesis: Meta-Analysis in Cancer Epidemiology. 1995 MASTER OF SCIENCE

More information

Scientific Programme

Scientific Programme Scientific Programme Scientific Committee Hilary Calvert UCL Cancer Institute, London, UK Luca Gianni Ospedale San Raffaele IRCCS, Milan, Italy Ana Maria Gonzalez-Angulo Cristiana Sessa Istituto Oncologico

More information

Practical experience from a reviewer. What do I expect?

Practical experience from a reviewer. What do I expect? Practical experience from a reviewer What do I expect? Giovanni Apolone Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy DIA-ERIQA Workshop Paris, May 10 2004 Overview The speaker The context

More information

National Horizon Scanning Centre. Vandetanib (Zactima) for advanced or metastatic non-small cell lung cancer. December 2007

National Horizon Scanning Centre. Vandetanib (Zactima) for advanced or metastatic non-small cell lung cancer. December 2007 Vandetanib (Zactima) for advanced or metastatic non-small cell lung cancer December 2007 This technology summary is based on information available at the time of research and a limited literature search.

More information

Patronage requested A. ANICHINI (MILAN) M.P. COLOMBO (MILAN) V. BRONTE (VERONA) M. DEL VECCHIO (MILAN) M. DI NICOLA (MILAN) M.

Patronage requested A. ANICHINI (MILAN) M.P. COLOMBO (MILAN) V. BRONTE (VERONA) M. DEL VECCHIO (MILAN) M. DI NICOLA (MILAN) M. Patronage requested Faculty A. ANICHINI (MILAN) M.P. COLOMBO (MILAN) V. BRONTE (VERONA) M. DEL VECCHIO (MILAN) M. DI NICOLA (MILAN) M. FIGINI (MILAN) J. GALON (PARIS) G. KROEMER (PARIS) M. MAIO (SIENA)

More information

Avastin in breast cancer: Summary of clinical data

Avastin in breast cancer: Summary of clinical data Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading

More information

Curriculum Vitae of Luca Gianni

Curriculum Vitae of Luca Gianni Education: 1976: State University of Milan, Milan, Italy: Medical Doctor with honors 1981: State University of Milan, Milan, Italy: Board- Certified in Internal Medicine Brief Chronology of Activities

More information

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials)

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) 3 Integrated Trials Testing Targeted Therapy in Early Stage Lung Cancer Part of NCI s Precision Medicine Effort in

More information

Future Directions in Clinical Research. Karen Kelly, MD Associate Director for Clinical Research UC Davis Cancer Center

Future Directions in Clinical Research. Karen Kelly, MD Associate Director for Clinical Research UC Davis Cancer Center Future Directions in Clinical Research Karen Kelly, MD Associate Director for Clinical Research UC Davis Cancer Center Outline 1. Status of Cancer Treatment 2. Overview of Clinical Research at UCDCC 3.

More information

Data from an interim analysis from the pivotal Phase 3 trial of YONDELIS in soft tissue sarcoma, SAR-3007, will be presented in an oral presentation

Data from an interim analysis from the pivotal Phase 3 trial of YONDELIS in soft tissue sarcoma, SAR-3007, will be presented in an oral presentation PharmaMar announces new advances in oncology at ASCO 2015 for its compounds YONDELIS and PM1183 in small cell lung cancer, soft tissue sarcoma, and mesothelioma Compelling clinical activity of PM1183 in

More information

Lung Cancer: More than meets the eye

Lung Cancer: More than meets the eye Lung Cancer Education Program November 23, 2013 Lung Cancer: More than meets the eye Shantanu Banerji MD, FRCPC Presenter Disclosure Faculty: Shantanu Banerji Relationships with commercial interests: Grants/Research

More information

ANNUAL REPORT EDUCATION ACTIVITIES 336 STAFF 338

ANNUAL REPORT EDUCATION ACTIVITIES 336 STAFF 338 PREFACE ANNUAL REPORT MARIO NEGRI INSTITUTE, MILAN www.marionegri.it DEPARTMENTS Department of Oncology.. 7 Department of Environmental Health Sciences... 51 Department of Neuroscience.. 69 Department

More information

Avastin in breast cancer: Summary of clinical data

Avastin in breast cancer: Summary of clinical data Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading

More information

The following information is only meant for people who have been diagnosed with advanced non-small cell

The following information is only meant for people who have been diagnosed with advanced non-small cell Important information for people with advanced non-small cell lung cancer The following information is only meant for people who have been diagnosed with advanced non-small cell lung cancer (NSCLC). NSCLC

More information

E UROPEAN PERSONAL INFORMATION

E UROPEAN PERSONAL INFORMATION E UROPEAN CURRICULUM VITAE FORMAT PERSONAL INFORMATION Name Work Address ARTURO CHITI Humanitas University, Via A. Manzoni 113, 20089 Rozzano (MI), Italy Nuclear Medicine Department, Humanitas Research

More information

Date and place of birth 28th January 1958; Moretta (Cuneo) (Italy). Two children

Date and place of birth 28th January 1958; Moretta (Cuneo) (Italy). Two children ANNA SAPINO Date and place of birth 28th January 1958; Moretta (Cuneo) (Italy). Two children MEDICAL EDUCATION: Medical Degree, University of Turin (1982); Professional specialization in Pathological Anatomy

More information

GIORGIO VITTORIO SCAGLIOTTI, M.D. CURRICULUM VITAE

GIORGIO VITTORIO SCAGLIOTTI, M.D. CURRICULUM VITAE GIORGIO VITTORIO SCAGLIOTTI, M.D. CURRICULUM VITAE Personal Information Date of birth July 2, 1953 Place of birth Torino, Italy Office address Department of Oncology S. Luigi Gonzaga Hospital, Oncology

More information

Resumen Curricular de los Profesores. Jesse Boehm

Resumen Curricular de los Profesores. Jesse Boehm Resumen Curricular de los Profesores Jesse Boehm Jesse Boehm is the assistant director of the Cancer Program at the Broad Institute. In this role, he works closely with Cancer Program director Todd Golub

More information

Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma

Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma The Use of Kinase Inhibitors: Translational Lab Results Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma Sheelu Varghese, Ph.D. H. Richard Alexander, M.D.

More information

Mediterranean School of Oncology

Mediterranean School of Oncology Mediterranean School of Oncology Organized and supported by: CINBO Consorzio Interuniversitario Nazionale per la Bioncologia HIGHLIGHTS IN THE MANAGEMENT OF COLORECTAL CANCER, February 1-2, 2007 Domus

More information

Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review of Comparative Effectiveness and Cost-Effectiveness

Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review of Comparative Effectiveness and Cost-Effectiveness Department of Veterans Affairs Health Services Research & Development Service Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review of Comparative Effectiveness and Cost-Effectiveness

More information

Genomic Medicine The Future of Cancer Care. Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America

Genomic Medicine The Future of Cancer Care. Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America Genomic Medicine The Future of Cancer Care Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America Personalized Medicine Personalized health care is a broad term for interventions

More information

Pharmacogenomic Approaches. Luis Paz-Ares Hospital Universitario Virgen del Rocio Seville, Spain

Pharmacogenomic Approaches. Luis Paz-Ares Hospital Universitario Virgen del Rocio Seville, Spain Pharmacogenomic Approaches Luis Paz-Ares Hospital Universitario Virgen del Rocio Seville, Spain Pharmacogenetics & Pharmacogenomics Medicine tailored to the individual Genetic information, including the

More information

Houston Cancer Institute

Houston Cancer Institute Houston Cancer Institute A personal path to healing Memorial-West Houston Katy Northwest Houston Southeast Houston Sugar Land Convenience for Patients State of the Art Therapies and Diagnosis Real Support

More information

Is the third-line chemotherapy feasible for non-small cell lung cancer? A retrospective study

Is the third-line chemotherapy feasible for non-small cell lung cancer? A retrospective study Turkish Journal of Cancer Volume 34, No.1, 2004 19 Is the third-line chemotherapy feasible for non-small cell lung cancer? A retrospective study MUSTAFA ÖZDO AN, MUSTAFA SAMUR, HAKAN BOZCUK, ERKAN ÇOBAN,

More information

MOH Policy for dispensing NEOPLASTIC DISEASES DRUGS

MOH Policy for dispensing NEOPLASTIC DISEASES DRUGS MOH Policy for dispensing NEOPLASTIC DISEASES DRUGS All prescriptions for antineoplastic drugs must be accompanied by the MOH special form. All the attachments mentioned on this form shall be submitted

More information

What is New in Oncology. Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals

What is New in Oncology. Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals What is New in Oncology Michael J Messino, MD Cancer Care of WNC An affiliate of Mission hospitals Personalized Medicine Personalized Genomics Genomic Medicine Precision Medicine Definition Application

More information

Scientific Committee Hilary Calvert UCL Cancer Institute, London, United Kingdom

Scientific Committee Hilary Calvert UCL Cancer Institute, London, United Kingdom Scientific Committee Hilary Calvert UCL Cancer Institute, London, United Kingdom Luca Gianni Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy Ana Maria Gonzalez-Angulo M.D. Anderson Cancer

More information

Exelixis Showcases R&D Pipeline at JPMorgan Healthcare Conference

Exelixis Showcases R&D Pipeline at JPMorgan Healthcare Conference Exelixis Showcases R&D Pipeline at JPMorgan Healthcare Conference Two New Clinical Programs and Significant Expansion of Cancer Pipeline Planned for 2004 SOUTH SAN FRANCISCO, Calif., Jan. 13 /PRNewswire-FirstCall/

More information

NCCN Non-Small Cell Lung Cancer V.1.2011 Update Meeting 07/09/10

NCCN Non-Small Cell Lung Cancer V.1.2011 Update Meeting 07/09/10 Guideline Page and Request NSCL-3 Stage IA, margins positive delete the recommendation for chemoradiation. Stage IB, IIA, margins positive delete the recommendation for chemoradiation + Stage IIA, Stage

More information

Ovarian Cancer (Event Driven)

Ovarian Cancer (Event Driven) Brochure More information from http://www.researchandmarkets.com/reports/2367241/ Ovarian Cancer (Event Driven) Description: Owing to the lack of screening programs across the markets under study, ovarian

More information

Promises and challenges of developing new drugs in oncology

Promises and challenges of developing new drugs in oncology 3 rd International Michelangelo Conference Promises and challenges of developing new drugs in oncology Chairman: Luca Gianni, Milan I July 2-3, 2015 Venue: Museo della Scienza e della Tecnologia Via San

More information

1 page Overview. CONCURRENT 1D, 1E, 1F Biology & Pathogenesis Multi-Modality Immunology 1

1 page Overview. CONCURRENT 1D, 1E, 1F Biology & Pathogenesis Multi-Modality Immunology 1 1 page Overview 21 Oct Tuesday 1500 on REGISTRATION 1800 Welcome Reception & Cocktails at the Cape Town International Conference Centre (CTICC) 22 Oct Wednesday 0730 REGISTRATION 0830 OPENING 0900 PLENARY

More information

Nuevas tecnologías basadas en biomarcadores para oncología

Nuevas tecnologías basadas en biomarcadores para oncología Nuevas tecnologías basadas en biomarcadores para oncología Simposio ASEBIO 14 de marzo 2013, PCB Jose Jimeno, MD, PhD Co-Founder / Vice Chairman Pangaea Biotech SL Barcelona, Spain PANGAEA BIOTECH BUSINESS

More information

New strategies in anticancer therapy

New strategies in anticancer therapy 癌 症 診 療 指 引 簡 介 及 臨 床 應 用 New strategies in anticancer therapy 中 山 醫 學 大 學 附 設 醫 院 腫 瘤 內 科 蔡 明 宏 醫 師 2014/3/29 Anti-Cancer Therapy Surgical Treatment Radiotherapy Chemotherapy Target Therapy Supportive

More information

A Career in Pediatric Hematology-Oncology? Think About It...

A Career in Pediatric Hematology-Oncology? Think About It... A Career in Pediatric Hematology-Oncology? Think About It... What does a pediatric hematologist-oncologist do? What kind of training is necessary? Is there a future need for specialists in this area? T

More information

PROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S.

PROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. PROSPETTIVE FUTURE NEL TRATTAMENTO MEDICO DEL mrcc Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. Candiolo Future strategies in mrcc Improve therapeutic

More information

Guideline Development The American Society of Clinical Oncology

Guideline Development The American Society of Clinical Oncology Assessing Genomic Sequencing Information for Health Care Decision Making Decision Making Once Evidence is Assessed/Graded Evaluated Guideline Development The American Society of Clinical Oncology Gary

More information

Support Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine

Support Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine Support Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine January 27, 2009 Dear Professors (representative) of departments, Subject:

More information

Non Small Cell Lung Cancer: Scientific Discoveries and the Pursuit of Progress

Non Small Cell Lung Cancer: Scientific Discoveries and the Pursuit of Progress Non Small Cell Lung Cancer: Scientific Discoveries and the Pursuit of Progress Lung Cancer Accounts for 14% of All New Cancer Diagnoses in the United States 1 Lung cancer is the second most common malignancy

More information

REPORT ASCO 2002 ORLANDO : LUNG CANCER Johan F. Vansteenkiste, MD, PhD, Univ. Hospital and Leuven Lung Cancer Group

REPORT ASCO 2002 ORLANDO : LUNG CANCER Johan F. Vansteenkiste, MD, PhD, Univ. Hospital and Leuven Lung Cancer Group REPORT ASCO 2002 ORLANDO : LUNG CANCER Johan F. Vansteenkiste, MD, PhD, Univ. Hospital and Leuven Lung Cancer Group In the 2002 edition of the ASCO meeting, a total of 315 abstracts in the field of respiratory

More information

! " " # $$# %%& ' $(! % $ ) * +, + *

!   # $$# %%& ' $(! % $ ) * +, + * ! " " # $$# %%& ' $(! % $ ) * +, + * -,,! " # $ # " # # # % % & # # '! # % % # ( ) # * + % % % % # % ", # #! % # % - # %! % +,,, +,,! " # $ # " # # # % + '! '! % & # #! / # # & %,,,, *,,! % & / 0 1& #

More information

Emerging Drug List GEFITINIB

Emerging Drug List GEFITINIB Generic (Trade Name): Manufacturer: Gefitinib (Iressa ) formerly referred to as ZD1839 AstraZeneca NO. 52 JANUARY 2004 Indication: Current Regulatory Status: Description: Current Treatment: Cost: Evidence:

More information

Version 1 2015. Module guide. Preliminary document. International Master Program Cardiovascular Science University of Göttingen

Version 1 2015. Module guide. Preliminary document. International Master Program Cardiovascular Science University of Göttingen Version 1 2015 Module guide International Master Program Cardiovascular Science University of Göttingen Part 1 Theoretical modules Synopsis The Master program Cardiovascular Science contains four theoretical

More information

Promises and challenges of developing new drugs in oncology

Promises and challenges of developing new drugs in oncology 3 rd International Michelangelo Conference Promises and challenges of developing new drugs in oncology Chairman: Luca Gianni, Milan I July 2-3, 2015 Venue: Museo della Scienza e della Tecnologia Via San

More information

Developments in Biomarker Identification and Validation for Lung Cancer

Developments in Biomarker Identification and Validation for Lung Cancer Developments in Biomarker Identification and Validation for Lung Cancer Alexandre Passioukov, MD, PhD Alexandre.Passioukov@eortc.be Contents Introduction Lung cancer pathogenesis NSCLC treatment options

More information

Rilevanza dell innovazione tecnologica per la

Rilevanza dell innovazione tecnologica per la Rilevanza dell innovazione tecnologica per la ricerca traslazionale e la terapia in oncologia Ruggero De Maria Dipartimento di Ematologia Oncologia e Medicina Molecolare, Istituto Superiore di Sanità Translational

More information

Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle

Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle TITLE PROJET NOM HOPITAL Assessment of tumor angiogenesis using PET/CT with 18 F-Galacto- RGD. (PNC_29_001) Division of

More information

Cancer Treatments Subcommittee of PTAC Meeting held 2 March 2012. (minutes for web publishing)

Cancer Treatments Subcommittee of PTAC Meeting held 2 March 2012. (minutes for web publishing) Cancer Treatments Subcommittee of PTAC Meeting held 2 March 2012 (minutes for web publishing) Cancer Treatments Subcommittee minutes are published in accordance with the Terms of Reference for the Pharmacology

More information

Future Directions in Cancer Research What does is mean for medical physicists and AAPM?

Future Directions in Cancer Research What does is mean for medical physicists and AAPM? Future Directions in Cancer Research What does is mean for medical physicists and AAPM? John D. Hazle, Ph.D., FAAPM, FACR President-elect American Association of Physicists in Medicine Professor and Chairman

More information

Curriculum Vitae Massimo M. Santoro, PhD

Curriculum Vitae Massimo M. Santoro, PhD Curriculum Vitae Massimo M. Santoro, PhD Current position Full Professor, KU Leuven, Belgium Group Leader, VIB-Vesalius Research Center, Leuven, Belgium Education 1994 BS in Biology summa cum laude and

More information

Cellular, Molecular, and Biochemical Targets in Breast Cancer

Cellular, Molecular, and Biochemical Targets in Breast Cancer Cellular, Molecular, and Biochemical Targets in Breast Cancer Kristy Kummerow Ingrid Meszoely December 12, 2012 VUMC Resident Bonus Conference One size fits all surgical treatment of breast cancer Wilhelm

More information

*see next pages for the list of Committees and Boards Members

*see next pages for the list of Committees and Boards Members PAIN IN CANCER AN OUTCOME RESEARCH PROJECT EVALUATING THE EPIDEMIOLOGY AND THE EFFECTS OF DIFFERENT PHARMACOLOGICAL STRATEGIES TO TREAT PAIN IN CANCER PATIENTS The Protocol Writing Committee, on behalf

More information

Future Oncology: Technology, Products, Market and Service Opportunities

Future Oncology: Technology, Products, Market and Service Opportunities Brochure More information from http://www.researchandmarkets.com/reports/296370/ Future Oncology: Technology, Products, Market and Service Opportunities Description: Future Oncology is an analytical newsletter

More information

CURRICULUM VITAE Mariano Ferraresso, M.D., Ph.D.

CURRICULUM VITAE Mariano Ferraresso, M.D., Ph.D. CURRICULUM VITAE Mariano Ferraresso, M.D., Ph.D. Birthday and Place : Permanent Address : Nationality : Present Position : August 21 st, 1961. Piove di Sacco (Padova), Italy Via E. Caruso, 2-20133 Milano

More information

BNC105 PHASE II RENAL CANCER TRIAL RESULTS

BNC105 PHASE II RENAL CANCER TRIAL RESULTS ABN 53 075 582 740 ASX ANNOUNCEMENT 19 March 2014 BNC105 PHASE II RENAL CANCER TRIAL RESULTS Results show BNC105 utility in patients with advanced disease Identified biomarkers which correlate with patient

More information

The EGFR mutation and precision therapy for lung cancer

The EGFR mutation and precision therapy for lung cancer for lung cancer Outcomes in advanced lung cancer have seen meaningful improvement in the past decade thanks to new precision drug therapies. Because tumors usually develop resistance to the drugs, scientists

More information

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div.

National Pharmaceutical Pricing Authority 3 rd Floor, YMCA Cultural Centre 1 Jai Singh Road New Delhi 110001 File No. 23(01)2014/Div. Dated 21 st November 2014 NPPA Invites Comments of Pharmaceutical Industry & Trade, Consumer Organisations, Public Health Experts and other Stakeholders on the Recommendations of Tata Memorial Centre under

More information

CancerStemCell Markers in Lung Cancers: Proofsof. Reservations. Lourdes Cortes-Dericks, PhD University of Hamburg Hamburg, Germany

CancerStemCell Markers in Lung Cancers: Proofsof. Reservations. Lourdes Cortes-Dericks, PhD University of Hamburg Hamburg, Germany CancerStemCell Markers in Lung Cancers: Proofsof ConceptsandSome Reservations Lourdes Cortes-Dericks, PhD University of Hamburg Hamburg, Germany Lung cancer: highest death rate and poorest patient survival

More information

Everolimus plus exemestane for second-line endocrine treatment of oestrogen receptor positive metastatic breast cancer

Everolimus plus exemestane for second-line endocrine treatment of oestrogen receptor positive metastatic breast cancer LONDON CANCER NEWS DRUGS GROUP RAPID REVIEW Everolimus plus exemestane for second-line endocrine treatment of oestrogen receptor positive metastatic breast cancer Everolimus plus exemestane for second-line

More information

Come è cambiata la storia naturale della malattia

Come è cambiata la storia naturale della malattia Malattia Metastatica del Carcinoma del Grosso Intestino Tecniche e terapie Innovative Come è cambiata la storia naturale della malattia Antonio Frassoldati Oncologia Clinica - Ferrara 29 ottobre 2011 Colorectal

More information

Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development

Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development Sanjeeve Bala, MD, MPH Ovarian Cancer Endpoints Workshop FDA White Oak September 3, 2015 Overview Immune agents from

More information

San Antonio Breast Cancer Symposium

San Antonio Breast Cancer Symposium Tuesday, December 9, EDUCATION SESSIONS 2:00 p.m. 5:30 p.m. Management of metastatic HER2 positive disease: optimizing current therapies and an overview of new agents in development - Ballroom B Reconstruction

More information

Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022

Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022 Brochure More information from http://www.researchandmarkets.com/reports/2228475/ Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022 Description: Avastin (Renal Cell Carcinoma) Analysis and

More information

BNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED

BNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED ASX ANNOUNCEMENT 3 August 2011 ABN 53 075 582 740 BNC105 CANCER CLINICAL TRIALS REACH KEY MILESTONES CLINICAL PROGRAM TO BE EXPANDED Data from renal cancer trial supports progression of the trial: o Combination

More information

Lung Cancer Research: From Prevention to Cure!

Lung Cancer Research: From Prevention to Cure! Lung Cancer Research: From Prevention to Cure! Ravi Salgia, M.D, Ph.D Associate Professor of Medicine Director, Thoracic Oncology Research Program Department of Medicine Section of Hematology/Oncology

More information

Gastric Cancer. Brochure More information from http://www.researchandmarkets.com/reports/2228929/

Gastric Cancer. Brochure More information from http://www.researchandmarkets.com/reports/2228929/ Brochure More information from http://www.researchandmarkets.com/reports/2228929/ Gastric Cancer Description: Gastric cancer (GC) is one of the most common malignancies in terms of incidence and the second

More information

Protein kinase C alpha expression and resistance to neo-adjuvant gemcitabine-containing chemotherapy in non-small cell lung cancer

Protein kinase C alpha expression and resistance to neo-adjuvant gemcitabine-containing chemotherapy in non-small cell lung cancer Protein kinase C alpha expression and resistance to neo-adjuvant gemcitabine-containing chemotherapy in non-small cell lung cancer Dan Vogl Lay Abstract Early stage non-small cell lung cancer can be cured

More information

New Directions in Treatment of Ovarian Cancer. Amit M. Oza Princess Margaret Hospital University of Toronto

New Directions in Treatment of Ovarian Cancer. Amit M. Oza Princess Margaret Hospital University of Toronto New Directions in Treatment of Ovarian Cancer Amit M. Oza Princess Margaret Hospital University of Toronto Newly diagnosed: scenario Ist line Surgery chemotherapy Cure If can t cure can we turn into chronic

More information

Università degli Studi di Milano Bicocca Monza

Università degli Studi di Milano Bicocca Monza Università degli Studi di Milano Bicocca Monza Under the patronage of Associazione Italiana di Medicina Nucleare ed Imaging Molecolare A.I.R.O. Società Italiana di Radioterapia Oncologica Società Italiana

More information

Click to edit Master title style

Click to edit Master title style O ral Cancer - so much research, Click to edit Master title style so little progress-why? Click to edit Master text styles Second Level Christopher Squier Third Level Department of O ral Pathology Fourth

More information

Non-small cell lung cancer, advanced or metastatic, switch-therapy after gemcitabine/carboplatin

Non-small cell lung cancer, advanced or metastatic, switch-therapy after gemcitabine/carboplatin COMPENDIA TRANSPARENCY TRACKING FORM DRUG: Docetaxel INDICATION: Non-small cell lung cancer, advanced or metastatic, switch-therapy after gemcitabine/carboplatin COMPENDIA TRANSPARENCY REQUIREMENTS 1 Provide

More information

Fact Sheet: Molecular Imaging and Cancer

Fact Sheet: Molecular Imaging and Cancer Fact Sheet: Molecular Imaging and Cancer Cancer causes one in every four deaths in the United States, second only to heart disease. According to the American Cancer Society, an estimated 1.48 million new

More information

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer

Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer Effects of Herceptin on circulating tumor cells in HER2 positive early breast cancer J.-L. Zhang, Q. Yao, J.-H. Chen,Y. Wang, H. Wang, Q. Fan, R. Ling, J. Yi and L. Wang Xijing Hospital Vascular Endocrine

More information

Regulation of Protein Translation and c-jun expression by Prostate Tumor Overexpressed1 (PTOV1)

Regulation of Protein Translation and c-jun expression by Prostate Tumor Overexpressed1 (PTOV1) Regulation of Protein Translation and c-jun expression by Prostate Tumor Overexpressed1 (PTOV1) Verónica Cánovas, PhD Student Laboratory of Cell Signalling and Cancer Progression, Dra. Rosanna Paciucci

More information

Scientific Programme

Scientific Programme Scientific Programme Scientific Committee Hilary Calvert UCL Cancer Institute, London, UK Luca Gianni Ospedale San Raffaele IRCCS, Milan, Italy Ana Maria Gonzalez-Angulo The University of Texas, MD Anderson

More information

R508 A NEW NON-TOXIC DRUG TREATMENT THAT KILLS CANCER

R508 A NEW NON-TOXIC DRUG TREATMENT THAT KILLS CANCER WE NEED YOUR HELP TESTING R508 A NEW NON-TOXIC DRUG TREATMENT THAT KILLS CANCER WE NEED $25,000 FOR CURRENT TESTING OF THIS POWERFUL NEW CANCER TREATMENT TABLE OF CONTENTS WHAT YOU NEED TO KNOW ABOUT R508

More information

Evaluation of the role of gene polymorphisms in anticancer drug efficacy using in vitro models

Evaluation of the role of gene polymorphisms in anticancer drug efficacy using in vitro models Group members and Contact details Jacques Robert graduated in medicine from the University of Strasbourg in 1974 and received hi Research projects: The objectives of our group are: (1) to identify preclinical

More information

Griffith University - Case for Support. Mesothelioma Research Program

Griffith University - Case for Support. Mesothelioma Research Program Griffith University - Case for Support Mesothelioma Research Program Professor Lyn Griffiths Director, Dean, Research and Director, Genomics Research Centre (GHI) Established in 2007. Integrated health

More information

Past Recipients of the President s Leadership Award for Advancing Women Faculty

Past Recipients of the President s Leadership Award for Advancing Women Faculty Past Recipients of the President s Leadership Award for Advancing Women Faculty 1. 2016 Recipient Elizabeth A. Grimm, Ph.D. Waun Ki Hong Distinguished Chair in Translational Oncology Deputy Division Head

More information

Farmacologia degli inibitori TK e mtor

Farmacologia degli inibitori TK e mtor Farmacologia degli inibitori TK e mtor Romano Danesi Professore ordinario di Farmacologia UOC Farmacologia Universitaria Azienda Ospedaliero-Universitaria Pisana Dipartimento di Medicina Interna Università

More information

The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers.

The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers. The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers. Irene Catucci 1,2,12, Paolo Verderio 3,12, Sara Pizzamiglio 3,12, Siranoush Manoukian 4, Bernard Peissel 4, Daniela Zaffaroni

More information

Prognostic and Predictive Factors in Oncology. Mustafa Benekli, M.D.

Prognostic and Predictive Factors in Oncology. Mustafa Benekli, M.D. Prognostic and Predictive Factors in Oncology Mustafa Benekli, M.D. NCI Definitions ESMO Course -Essentials of Medical Oncology -Istanbul 2 Prognostic factor: NCI Definition A situation or condition, or

More information

10 th EADO Congress Vilnius, 7-10 May 2014. Ipilimumab update. Michele Maio

10 th EADO Congress Vilnius, 7-10 May 2014. Ipilimumab update. Michele Maio 10 th EADO Congress Vilnius, 7-10 May 2014 Ipilimumab update Michele Maio Medical Oncology and Immunotherapy, Department of Oncology University Hospital of Siena, Istituto Toscano Tumori SIENA, ITALY Evolving

More information

2 Year (2013 15) CLL/SLL Research Initiative CLL/SLL Collaborative Grant

2 Year (2013 15) CLL/SLL Research Initiative CLL/SLL Collaborative Grant 2 Year (2013 15) CLL/SLL Research Initiative CLL/SLL Collaborative Grant Guidelines & General Instructions for Application KEY DATES: Application Release Date: December 12, 2012 Application Deadline: February

More information

Pharmacogenomic markers in EGFR-targeted therapy of lung cancer

Pharmacogenomic markers in EGFR-targeted therapy of lung cancer Pharmacogenomic markers in EGFR-targeted therapy of lung cancer Rafal Dziadziuszko, MD, PhD University of Colorado Cancer Center, Aurora, CO, USA Medical University of Gdansk, Poland EMEA Workshop on Biomarkers,

More information

18.5 Percent Overall Response Rate Observed in Pembrolizumab-Treated Patients with this Aggressive Form of Breast Cancer

18.5 Percent Overall Response Rate Observed in Pembrolizumab-Treated Patients with this Aggressive Form of Breast Cancer News Release Media Contacts: Annick Robinson Investor Contacts: Joseph Romanelli (514) 837-2550 (908) 740-1986 Stephanie Lyttle NATIONAL Public Relations (514) 843-2365 Justin Holko (908) 740-1879 Merck

More information

Resolving Cancer Heterogeneity:

Resolving Cancer Heterogeneity: INTERNATIONAL SYMPOSIUM ON: Resolving Cancer Heterogeneity: The way to personalised medicine Palazzo della Gran Guardia Verona (Italy), June 30 th July 2 nd, 2016 PROGRAM Organized by: ARC-Net Centre for

More information

OVARIAN CANCER 101 7/16/14 FAST FACTS

OVARIAN CANCER 101 7/16/14 FAST FACTS OVARIAN CANCER 101 Victoria L Chiou, MD Women s Malignancies Branch National Cancer Institute, National Institutes of Health July 11, 2014 FAST FACTS Approximately 22,000 women will be diagnosed with ovarian

More information

San Antonio Breast Cancer Symposium

San Antonio Breast Cancer Symposium Tuesday, December 8, EDUCATION SESSIONS 12:35 p.m. Careers in Translational Research Geoffrey Shapiro, MD, PhD Director, Early Drug Development Center Clinical Director, Center for DNA Damage and Repair

More information