ERC Advanced Grants 2013 Results Life Sciences - List of Principal Investigators Host Institution as indicated by the PI at time of application

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1 Last First Institution name PENNINGER Josef Martin Institute of Molecular Biotechnology Institut für Molekulare Biotechnologie GmbH AT HAPLOID ZECHNER Rudolf University of Graz Universität Graz AT LipoCheX BOECKXSTAENS INZÉ SCHOOFS TAVERNIER VANRHAEGHEN HIO Guy Eduard Elisabeth Dirk, Gustaaf Liliane Jan Pierre Christoph Georg Fritz Catholic University of Leuven Flanders Institute for Biotechnology (VIB) Catholic University of Leuven Flanders Institute for Biotechnology (VIB) Free University of Brussels (ULB) Katholieke Universiteit Leuven Vlaams Instituut voor Biotechnologie Katholieke Universiteit Leuven Vlaams Instituut voor Biotechnologie Université Libre de Bruxelles Cholstim AMAIZE PEPTILEARNI NG CYRE GENVOCORT EX University of Basel Universität Basel CH FICModFun DOTTO Gian-Paolo University of Lausanne Université de Lausanne CH ECAP DUTZLER Raimund University of Zurich Universität Zürich CH AnoBest GÖNCZY Pierre Swiss Federal Institute of Technology Lausanne (EPFL) Ecole Polytechnique Fédérale de Lausanne CH CENFOR GONZALEZ-GAITAN Marcos University of Geneva Université de Genève CH Morphogen HUBLL LEMAITRE MARTIN Jeffrey Alan Bruno Roland Michael Gunnar Swiss Federal Institute of Technology Lausanne (EPFL) Swiss Federal Institute of Technology Lausanne (EPFL) Ecole Polytechnique Fédérale de Lausanne Ecole Polytechnique Fédérale de Lausanne CH CH Cytrix DrosoSpiro University of Zurich Universität Zürich CH HLA-DR15 in MS Yeast genetics in mammalian cells to identify fundamental mechanisms of physiology and pathophysiology The Role of Lipolysis in the Pathogenesis of Cancer-associated Cachexia Cholinergic modulation of immune homeostasis: new opportunities for treatment Atlas of leaf growth regulatory networks in MAIZE The Role of Neuropeptides in Learning and Memory. Cytokine Receptor Signaling Revisited: Implementing novel concepts for cytokinebased therapies Genetic links between development and evolution of the human cortex FIC-Mediated Post-Translational Modification at the Pathogen- Interface: Elucidating Structure, Function and Role in Infection Genetic/epigenetic basis of ethnic differences in cancer predisposition Structure function and pharmacology of calcium-activated chloride channels: Anoctamines and Bestrophins Dissecting the mechanisms governing centriole formation Morphogenetic growth control by time derivatives of signaling Engineering Cytokines for Super-Affinity Binding to Matrix in Regenerative Medicine The Drosophila-Spiroplasma interaction as a model to dissect the molecular mechanisms underlying insect endosymbiosis Functional Role of the HLA-DR15 Haplotype in Multiple Sclerosis 2013 European Research Council 03/10/2013 Page 1 of 9

2 Last First Institution name VAN R GOOT Francoise Gisou Swiss Federal Institute of Technology Lausanne (EPFL) Ecole Polytechnique Fédérale de Lausanne CH PalmERa VOLTERRA Andrea University of Lausanne Université de Lausanne CH astromnesis ADAMS Ralf Heinrich Max Planck Society COUPLAND George Max Planck Society DUBILIER Nicole Max Planck Society ESCHENHAGEN GOETZ GROSS Thomas Hans Magdalena Cornelius University Hospital Hamburg Helmholtz-German Research Centre for Environmental Health European Molecular Biology Laboratory JENTSCH Stefan Max Planck Society Universitätsklinikum Hamburg-Eppendorf Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt European Molecular Biology Laboratory AngioBone HyLife BathyBiome IndivuHeart ChroNeuroRepair COREFEAR SUMOGROUP Roles of Palmitoylation networks in ER architecture and functions The language of astrocytes: multilevel analysis to understand astrocyte communication and its role in memoryrelated brain operations and in cognitive behavior Angiogenic growth, specialization, ageing and regeneration of bone vessels Exploiting hybrids between annual and perennial plant species to identify genes conferring agronomically important traits The Symbiome of Bathymodiolus Mussels from Hydrothermal Vents: From the Genome to the Environment Individualized early risk assessment for heart diseases Chromatin states in neurogenesis from understanding chromatin loops to eliciting neurogenesis for repair Functional wiring of the core neural network of innate fear Principles of Protein Group Modification by the SUMO Pathway MARX Andreas University of Konstanz Universität Konstanz EvoEPIGEN Evolved Replication Systems for Epigenetics * * University Hospital Bonn Universitätsklinikum Bonn MULTIGEVOS MÜLLER Christoph European Molecular Biology Laboratory PARNISKE Martin University of Munich European Molecular Biology Laboratory Ludwig-Maximilians- Universität München POL1PIC EvolvingNodules The other side of optogenetics: multicolored genetically encoded hybrid voltage sensors (GEVOS) for ultrafast membrane potential measurements in cortical microcircuits Dynamic architecture of the RNA polymerase I transcription initiation machinery Molecular inventions underlying the evolution of the nitrogen-fixing root nodule symbiosis 2013 European Research Council 03/10/2013 Page 2 of 9

3 Last First Institution name RAMMENSEE Hans-Georg University of Tübingen REHLING Peter University Medical Center Goettingen WEIGEL Detlef Max Planck Society WILLNOW Thomas E. Max Delbrück Center for Molecular Medicine Eberhard Karls Universität Tübingen Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin Max-Delbrück-Centrum für Molekulare Medizin MUTAEDITING MITRAC IMMUNEMESIS BeyOND Mutation-driven immunoediting of human cancer? Mitochondrial translational regulation coupled to respiratory chain assembly and protein import The Plant Immune System: Epistasis and Fitness-Tradeoffs Metabolic Basis Of Neurodegenerative Disease JÄÄTTELÄ Marja Helena The Danish Cancer Society Kræftens Bekæmpelse DK LYSOSOME Lysosomes as targets for cancer therapy JENSEN Torben Heick Aarhus University Aarhus Universitet DK EURECA Eukaryotic Regulated RNA Catabolism KOLLIAS ALARCON George Balbino Biomedical s Research Center Alexander Fleming Spanish National Research Council (CSIC) Biomedical s Research Center Alexander Fleming Agencia Estatal Consejo Superior de Investigaciones Científicas EL ES MCs-inTEST NOVARIPP ARTAL Pablo University of Murcia Universidad de Murcia ES SEECAT BATLLE Eduard Institute for Research in Biomedicine Institut de Recerca Biomèdica/Instituto de Investigación Biomédica (IRB) ES editcrc * * University of Navarra Universidad de Navarra ES PREDIMED II KAILA Kai Kalervo University of Helsinki Helsingin yliopisto FI PressBirth * * University of Helsinki Helsingin yliopisto FI Near-infrared probes AMIGORENA Sebastian Curie Institute Institut Curie DCBIOX Mesenchymal Cells of the Lamina Propria in Intestinal Epithelial and Immunological Homeostasis. Novel properties of antigen receptors and instruments to modulate lymphoid function in physiological and pathological conditions Seeing through cataracts with advanced photonics A genome editing-based approach to study the stem cell hierarchy of human colorectal cancers Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease: the PREDIMED-II Study Arginine vasopressin and ion transporters in the modulation of brain excitability during birth and birth asphyxia seizures Near-infrared fluorescent probes based on bacterial phytochromes for in vivo imaging Phagosome functions and antigen cross presentation in primary dendritic cells European Research Council 03/10/2013 Page 3 of 9

4 Last First Institution name LLAICHE Yohanns Curie Institute Institut Curie TiMORPH NDAHMANE CERF SPOUSE NSUSSAN CHARPAK CHOQUET Abdelhafid Nadine Christine Serge Daniel French National Institute for Agricultural Research (INRA) National Institute of Health and Medical Research (Inserm) National Institute of Health and Medical Research (Inserm) National Center for Scientific Research (CNRS) Institut National de la Recherche Agronomique Institut National de la Santé et de la Recherche Médicale Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique (CNRS) SEXYPART IMMUNOBIOTA Imaging-inthe- Magnet FORTERRE Patrick Paris-Sud University Université Paris-Sud EVOMOBIL GENSCHIK Pascal National Center for Scientific Research (CNRS) Centre National de la Recherche Scientifique (CNRS) ADOS PHAGORISC GOUD Bruno Curie Institute Institut Curie MYODYN KREMER PROCHIANTZ Antoine Alain French National Institute for Agricultural Research (INRA) National Institute of Health and Medical Research (Inserm) Institut National de la Recherche Agronomique Institut National de la Santé et de la Recherche Médicale TREEPEACE HOMEOSIGN REY Félix A. Pasteur Institute Institut Pasteur Celcelfus Morphogenesis of proliferative epithelial tissue Unraveling sex determination and parthenocarpy mechanisms to improve crops -microbiota interactions across the gut immune system: lessons from early onset inflammatory bowel diseases and from gnotobiotic mice Bridging the gap between cellular imaging and fmri BOLD imaging AMPA Receptor Dynamic Organization and Synaptic transmission in health and disease Co-evolution of viruses, plasmids and cells in Archaea: pattern and process Connecting RNA and protein degradation machineries Myosins and the dynamics of intracellular membranes From Holocene to Anthropocene: the pace of microevolution in trees HOMEOSIGN : Homeoprotein signaling during development and in the adult Cell-Cell fusion in fertilization and developmental biology: a structural biology approach SANSONETTI Philippe Pasteur Institute Institut Pasteur CRYPT Decrypting signals in the crypt. TANTER Mickael TORA Laszlo CERBM Pierre-Gilles de Gennes Research Foundation Fondation Pierre-Gilles de Gennes pour la Recherche Centre Européen de Recherche en Biologie et en Médecine FUSIMAGINE BIRTOACTION A new neuroimaging modality: from bench to bedside From birth to action: regulation of gene expression through transcription complex biogenesis 2013 European Research Council 03/10/2013 Page 4 of 9

5 Last First Institution name BARKAI Naama RMAN Judith Tel Aviv University Tel Aviv University IL RAPLODAPT FAINZILR IEDMAN JUNG NELKEN BIFFO Michael Nir Steffen Israel Stefano The Hebrew University of Jerusalem The Hebrew University of Jerusalem University of Piedmont Amedeo Avogadro The Hebrew University of Jerusalem The Hebrew University of Jerusalem Università degli Studi del Piemonte Orientale Amedeo Avogadro IL PNet Principles of biomolecular networks IL IL IL IL IT NEUROGROWTH ChromatinSys MONOTOMACRO RATLAND TRANSLATE BROCCOLI Vania Hospital San Raffaele Ospedale San Raffaele IT ReproPARK CAMPALLI-FIUME Gabriella University of Bologna Università di Bologna IT GRANDI Guido University of Trent GROHMANN Ursula University of Perugia PELICCI DZIERZAK JETTEN SPITS Pier Giuseppe Elaine Michael Hergen European Institute of Oncology Erasmus Medical Center Rotterdam Radboud University Nijmegen Academic Medical Centre, Amsterdam Università degli Studi di Trento Università degli Studi di Perugia Istituto Europeo di Oncologia Srl Erasmus Universitair Medisch Centrum Rotterdam Radboud Universiteit Nijmegen Academisch Medisch Centrum Bij de Universiteit Van Amsterdam IT IT IT ONCOLYTIC- HERPES OMVac DIDO InMec NOVOHSC Eco-MoM AsthmaVir Ploidy change as a rapid mechanism of adaptation Axonuclear Communication in Neuronal Growth Control Systematic Approach to Dissect the Interplay between Chromatin and Transcription Studying in vivo differentiation of monocytes into intestinal macrophages and their impact on gut homeostasis Understanding Auditory Information Processing in Naturalistic Environments Noncoding and Translational Modulation of Gene Expression and Epigenetic Changes New experimental therapeutic approaches for Parkinson s disease by direct DA neuronal reprogramming ONCOLYTIC HERPESVIRUSES RETARGETED TO CANCER- SPECIFIC RECEPTORS Outer Membrane Vesicles (OMVs) from Vaccinobacter : A Synthetic Biology approach for effective vaccines against infectious diseases and cancer Innovative drugs targeting IDO molecular dynamics in autoimmunity and neoplasia Inside mechanisms sustaining cancer stem cells Blood regeneration: de novo development of human hematopoietic stem cells Ecology of anaerobic methane oxidizing microbes The roles of innate lymphoid cells and rhinovirus in asthma exacerbations 2013 European Research Council 03/10/2013 Page 5 of 9

6 Last First Institution name STUNNENRG VAN KOOYK VERMEULEN VERSTEEG VISSER Hendrik Gerard Yvette van Willem Rogier Marcel Erik MOSER Edvard I. Radboud University Nijmegen VU University Medical Centre Erasmus Medical Center Rotterdam Academic Medical Centre, Amsterdam Royal Netherlands Academy of Arts and s Norwegian University of and Technology Trondheim Radboud Universiteit Nijmegen Vrije Universiteit - Medisch Centrum Erasmus Universitair Medisch Centrum Rotterdam Academisch Medisch Centrum Bij de Universiteit Van Amsterdam Koninklijke Nederlandse Akademie van Wetenschappen - KNAW Norges teknisknaturvitenskapelige universitet Trondheim SysStemCell GlycoTreat ERC-ID RealLifeCancer E-Response RGGREN Per-Olof Karolinska Institute Karolinska Institutet SE BetaImage IBANEZ Carlos Karolinska Institute Karolinska Institutet SE p75ntr BAKER Andrew University of Glasgow University of Glasgow UK VASCMIR BALASUBRAMANIAN Shankar University of Cambridge University of Cambridge UK RNAQUAD BAULCOM David University of Cambridge University of Cambridge UK TRI BRADLEY Mark University of Edinburgh University of Edinburgh UK ADREEM BROCKDORFF Neil University of Oxford University of Oxford UK PRIME CHITTKA Lars Queen Mary and Westfield College, University of London Queen Mary and Westfield College, University of London Regulatory transcriptional networks orchestrating mouse pluripotent embryonic stem cells Novel vaccine generation for the treatment of cancer. A glyco-nanomedial approach instructing T cells Excision Repair and chromatin interaction dynamics Challenging the gaps in global cancer concepts by a real life tumor: human childhood neuroblastoma Evolutionary responses to a warming world: physiological genomics of seasonal timing NO GRIDCO Cortical maps for space UK SpaceRadarPollin ator COLLINGRIDGE Graham Leon University of Bristol University of Bristol UK HippoKAR An in vivo imaging approach to understand pancreatic beta-cell signal-transduction Understanding death-receptor signaling and physiology in the nervous system: A roadmap for the development of new treatments to neurodegenerative diseases and neurotrauma Vascular remodelling and mirna therapeutics The chemical biology of RNA G- quadruplexes Transgressive Inheritance in plant Breeding and Evolution Adding Another Dimension Arrays of 3D Bio-Responsive Materials Polycomb repressor interactions in relation to the mammalian epigenome. Space use by bees radar tracking of spatial movement patterns of key pollinators Understanding the roles of kainate receptors in the hipocampus 2013 European Research Council 03/10/2013 Page 6 of 9

7 Last First Institution name COOPER Jonathan University of Glasgow University of Glasgow UK Bio-Phononics AN Caroline John Innes Centre John Innes Centre UK MEXTIM EATON Philip King's College London King's College London UK CARDIOREDOX EELES ASER Rosalind Anne Christophe Institute of Cancer Research - Royal Cancer Hospital Imperial College of, Technology and Medicine Institute of Cancer Research - Royal Cancer Hospital Imperial College of, Technology and Medicine UK UK BARCO EHIVE ASER Peter The Babraham Institute The Babraham Institute UK VOCHROMO HUNTER Christopher University of Sheffield University of Sheffield UK SYNTHPHOTO JIGGINS Christopher University of Cambridge University of Cambridge UK SpeciationGenetic s NAISMITH James University of St Andrews University of St Andrews UK NCB-TNT O'DONNELL Valerie Cardiff University Cardiff University UK LIPIDArray POWRIE Fiona M University of Oxford University of Oxford UK INCA PROUDFOOT Nicholas Jarvis University of Oxford University of Oxford UK polyloop SELBY Peter John University of Leeds University of Leeds UK ONCOVIRVAX TATE Christopher Medical Research Council Medical Research Council UK EMPSI TOMLINSON Ian Phlip Mark University of Oxford University of Oxford UK EVOCAN Advanced Microfluidics & Diagnostics using Acoustic Holograms Bio-Phononics Measurement of temperature exposure and integration over time Redox sensing and signalling in cardiovascular health and disease The use of genetic profiling to guide prostate cancer targeted screening and cancer care Bridging the Evolution and Epidemiology of HIV in Europe Chromosome structure and genome organization in early mammalian development Powering cells with light: the synthetic biology of photosynthesis The genomic architecture of speciation in tropical butterflies New chemical biology for tailoring novel therapeutics Development and application of global lipidomic arrays to inflammatory vascular disease. Genetic and environmental factors that control inflammation-driven colon cancer Policing mammalian transcriptomes: regulation of long ncrna synthesis by transcriptional termination, gene loops and R-loops. Novel cancer vaccines with virus based cdna libraries and monitoring for resistant tumour cell populations in prostate cancer Receptors, Channels and Transporters: Development and Application of Novel Technologies for Structure Determination Why do cancers occur where they do? A genetic and evolutionary approach European Research Council 03/10/2013 Page 7 of 9

8 Last First Institution name TOWERS Gregory John University College London University College London UK HIVInnate WALDMANN Herman University of Oxford University of Oxford UK PARIS WOOLFSON Derek Neil University of Bristol University of Bristol UK AL Characterisation and Manipulation of Primate Lentiviral Interactions with Innate Immunity Physician aided reconstitution of the immune system Alpha-helical Barrels: Exploring, Understanding and Exploiting a New Class of Protein Structure 2013 European Research Council 03/10/2013 Page 8 of 9

9 Physical sciences and Engineering (PE) Life s (LS) Social s and Humanities (SH) PE1 Mathematics Molecular and Structural Biology and Biochemistry SH1 Individuals, institutions and markets PE2 Fundamental constituents of matter Genetics, Genomics, Bioinformatics and Systems Biology SH2 Institutions, values, beliefs and behaviour PE3 Condensed matter physics Cellular and Developmental Biology SH3 Environment, space and population PE4 Physical and analytical chemical sciences Physiology, Pathophysiology and Endocrinology SH4 The Human Mind and its complexity PE5 Synthetic chemistry and materials Neurosciences and neural disorders SH5 Cultures and cultural production PE6 Computer science and informatics Immunity and infection SH6 The study of the human past PE7 Systems and communication engineering PE8 Products and processes engineering PE9 Universe sciences PE10 Earth system science Diagnostic tools, therapies and public health Evolutionary, population and environmental biology Applied life sciences and biotechnology EU Member States AT Austria Belgium BG Bulgaria CY Cyprus CZ Czech Republic Germany DK Denmark EE Estonia EL Greece ES Spain FI Finland France HR Croatia HU Hungary IE Ireland IT Italy LT Lithuania LU Luxembourg LV Latvia MT Malta Netherlands PL Poland PT Portugal RO Romania SE Sweden SI Slovenia SK Slovakia UK United Kingdom FP7 Associated Countries AL Albania BA Bosnia and Herzegovina CH Switzerland IL Israel IS Iceland FO Faroe Islands LI Liechtenstein MD Moldova ME Montenegro MK FYR of Macedonia NO Norway RS Serbia TR Turkey 2013 European Research Council 03/10/2013 Page 9 of 9