Tuesday, March 17, Wednesday, March 18, 2015

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1 KEY: PRE CONFERENCE SYMPOSIUM Sponsored Symposium Symposium Plenary Lecture Other Event *Pre-registration is required for the Informal Networking with Professor Lunch Session Tuesday, March 17, 2015 Hermes 08:00-15:00 14:30-17:00 PRE CONFERENCE SYMPOSIA - Neuropathology Workshop (Registration Required) PRE CONFERENCE SYMPOSIA - Imaging Satellite (Registration Required) (9:00-15:00) Wednesday, March 18, :30-10:30 ADVANCED CHARACTERIZATION OF EARLY DISEASE STAGE APP PROCESSING, ABETA AND SECRETASES PROFILING DLB, PD and FTD METABOLISM 1 10:30-11:00 Posters and Coffee 11:00 13:00 NEURODEGENERATIVE DISEASES CAN STANDARDIZATION IMPROVE THE PREDICATIVE VALUE OF ANIMAL MODELS? (PODIUM DISCUSSION) ALPHA-SYNUCLEIN:PATHOLOGICAL MECHANISMS LipiDiDiet - NUTRITIONAL INTERVENTION IN PRODROMAL AD CSF AND IMAGING BIOMARKERS OF AD 13:00 14:00 Lunch, Posters & Informal Networking with Professors* 14:00 16:00 PROPAGATION OF TAU-PATHOLOGY INFLAMMATION 1 UPDATE ON TREATMENT OF PD MITOCHONDRIA 16:00 16:30 Posters and Coffee STRESS AND TELOMERE MAINTENANCE MECHANISMS IN HUMAN LIFE TRAJECTORIES Elizabeth H. Blackburn, USA 16:30 18:00 THE CONCEPT OF SUBCONSCIOUSNESS IN ALZHEIMER AND PARKINSON DISEASES Yves Agid, France THE PRION MODEL AS A GUIDE DIAGNOSIS AND THERAPY OF TAUOPATHIES Marc Diamond, USA 18:00-18:15 Short 18:15 19:15 Opening Ceremony 19:15 Welcome Reception in the Exhibition Area

2 Thursday, March 19, 2015 Hermes HOW DO WE TREAT ALZHEIMER'S DISEASE A DECADE BEFORE DEMENTIA? Reisa Sperling, USA PROTEIN FOLDING, MISFOLDING AND DEGRADATION GENETICS 1 AMYLOID PRODUCTION AND ABETA TOXICITY TRANSLATIONAL STRATEGIES 1: ABETA TARGETS Exhibition, Posters, Lunch & Informal Networking with Professors* NEURONAL NETWORKSAND SYNAPTIC FUNCTION EPIGENETICS AND GENETIC MECHANISMS TAUOPATHIES 1 DISEASE MECHANISMS TRANSLATIONAL STRATEGIES 2: NUTRITION, TAU TARGETS 17:15-19:15 SEEDING, SPREADING, AND PRION-LIKE MECHANISMS TRANSLATIONAL STRATEGIES 3: CHOLINERGIC TARGETS, STEM CELLS AND GROWTH FACTORS ANIMAL MODELS - NEW WAYS TO GO? BIOMARKERS 2: PD AND LBD

3 Friday, March 20, 2013 OPTICAL DECONSTRUCTION OF FULLY-ASSEMBLED BIOLOGICAL SYSTEMS Karl Deisseroth, USA AMYLOID-REDUCING THERAPIES IN ALZHEIMER S DISEASE BIOMARKERS AND MRI 1 POTENTIAL NOVEL BIOMARKERS Exhibition, Posters, Lunch & Informal Networking with Professors ER STRESS, SIGMA-1 RECEPTORS AND GPCRS AS THERAPEUTIC TARGETS IN CNS DISEASES APP BIOLOGY 1 PET 1: TAU IMAGING BIOMARKERS 3 17:15-19:15 PRESENILIN BIOLOGY TRANSLATIONAL STRATEGIES 4: Gsk3BETA, TAU TARGETS (2) PET 2: AMYLOID AND RECEPTORS APOE: MECHANISMS AND APOE-BASED TREATMENT STRATEGIES 19:15-19: :15 Conference Educational Lecture: Art and Life - A Spiritual Journey (A lecture about Marc Chagall's way to represent a symbolic and an ethereal vision of the world)

4 Saturday, March 21, 2015 NEUROPROTECTIVE APPROACHES IN PARKINSON S DISEASE EXPLORED IN ALPHA-SYNUCLEIN OVEREXPRESSION MODELS Anders Björklund, Sweden MECHANISMS AND THERAPEUTIC STATEGIES IN ALS/FTD SPECTRUM DISEASES MRI 2 PROTEIN MODIFICATION AND DEGRADATION Exhibition, Posters, Lunch & Informal Networking with Professors DEMENTIA WITH LEWY BODIES: UPDATES FROM PRE-CLINICAL AND CLINICAL STUDIES, PART I TAU BIOLOGY AND DISEASE MECHANISMS 1 TDP 43, C9ORF72 AND TTR FUNCTIONS OF ETA SECRETASE AND BACE1 17:15-19:15 TAU IMMUNOTHERAPY PINK1, LRRK AND PARKIN VASCULAR ASPECTS OF NEURODEGENERATION SYNUCLEIONOPATHIES AND PRION DISEASES 19:15-20:15 20:15 ADPD Network Event

5 Sunday, March 22, 2015 ALZHEIMER S DISEASE: FROM PRECLINICAL STATES TO DEMENTIA Bruno Dubois, France MICROGLIA AND INNATE IMMUNITY UPDATE ON DLB:CLINICAL AND PRE- CLINICAL STUDIES (PART 2) RETROMERS IN AD AND PD TAU BIOLOGY AND DISEASE MECHANISMS 2 Coffee 11:45-13:45 CLINICAL TRIALS PODIUM DISCUSSION Is there a way to increase the chance of success in Phase 3? OTHER TREATMENT STRATEGIES TAU BIOLOGY AND DISEASE MECHANISMS 3 INFLAMMATION 2 13:45 14:15 Closing Ceremony