Sun Protection. Boosting Performance with Multi-Functional Technology
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1 Sun Protection Boosting Performance with Multi-Functional Technology
2 How to Achieve Maximum SPF in Sun Care Formulations? Good Spreadability Incorporation of Film-Formers Complete Solubilization of Crystalline Sunfilters Boosting the Dielectric Constant Inolex has several products to address these performance issues.
3 Solubility & Spreadability LexFeel 7 Ultra-dry, fast spreading emollient ensures even coverage Less greasy than typical sunscreen emollients Solubilizes more sunscreen than C12-15 alkyl benzoate LexSolv A Super-solubilizer to prevent recrystallization of UVA filters Safe, effective, globally approved
4 LexFeel 7 Ultra-dry initial feel with a velvety after feel Fast spreading Spreading Diameter, cm LexFeel 7 C12-15 Alkyl Benzoate Phenyl Trimethicone Dimethicone, 10 cst Minutes Solubilizes better than C12-15 alkyl benzoate LexFeel 7 C12-15 alkyl benzoate Oxybenzone 17.9% 15.5% Avobenzone 13.4% 13.4%
5 LexSolv A Outperforms current market leaders for UVA filter solubilization. Uvinul A Plus* Tinosorb S Avobenzone LexSolv A 15% 17% 20% dicaprylyl carbonate 10% 9% 13% c12-15 alkyl benzoate 6% 14% 15% * INCI: diethylamino hydroxybenzoyl hexyl benzoate INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine INCI: butyl methoxydibenzoylmethane
6 Benefits of Film Formers Creating an even film of UV protection For products to be efficient/effective they must evenly coat the rough topography of the skin. Creating a thicker film (increased path length for photons) Simply by doubling the film thickness you get up to 100X the protection against UV rays! Increasing Water/Wear Resistance
7 Film Forming Lexorez 100 Water resistant film-former Lexorez 200 Water resistant film-former LexFilm Sun Water-proofing agent and solubilizer for UV actives LexFilm Spray High adhesion, soluble in hydro-alcoholic systems
8 Lexorez 100 & Key Features Leading polyester polymers used in sunscreens to provide waterproofing and water resistance. They are 100% active liquid and are dispersible in organic UV absorbers and emollients. They can also be used in color cosmetics with SPF (lipsticks, mascara, foundations) to provided transfer resistance. Use level ~ 3% Patented Inolex technology
9 Lexorez 100 Very Water Resistant SPF Person FDA Methodology Ingredients %w/w A Deionized Water Q.S. Xanthan Gum (Keltrol) Glycerin 96% 1.50 Butylene Glycol 1.00 Tetrasodium EDTA 0.10 Caprylyl Glycol (Lexgard O) B Octinoxate (Uvinul MC 80) Oxybenzone (Uvinul M40) Octisalate (Dermoblock OS) Avobenzone (Eusolex 9020) Homosalate (Neo Heliopan HMS) Glyceryl Stearate and PEG-100 Stearate (Lexemul 561) Neopentyl Glycol Diheptanoate (LexFeel 7) Adipic Acid/Diglycol Crosspolymer (Lexorez 100) C Hydroxyethylacrylate/Sodium Acryloyldimethyltaurate Copolymer and Squalane and Polysorbate 60 (Simulgel NS) D Silica (MSS-500) Total
10 LexFilm Sun Pourable Fluid Easy to work with and easy for manufacturing Contributes Less Formulation Cost Only 3-5% total excipient needed Superior Solubilization LexFilm Sun has better solvency power than traditional formulation strategy of Finsolv plus Ganex: LexFilm Sun Ganex & Finsolv TN (60/40) Oxybenzone 18.75% 11% Avobenzone 13.25% 9.5% Good Dielectric Properties
11 LexFilm Sun Test Formulation Very Water Resistant SPF 30 Five persons using FDA methodology; four 20 minute immersions Retention of 97% Mean SPF before immersion: 32.2 (range: 32-34) Mean SPF after immersion: 31.3 (range of 30-32) Ingredients %w/w A Deionized Water Q.S. Xanthan Gum (Keltrol CG) Glycerin 96% 5.00 Butylene Gly col 1.00 Tetrasodium EDTA 0.10 Dipotassium Glycyrrhizate ( Ritamectant K2) Caprylyl Glycol (Lexgard 1 O) 1.00 Sorbic Acid 0.20 B Octinoxate ( Uvinul MC 80) Oxybenzone ( Uvinul M40) Octisalate ( Jeescreen OS) Avobenzone ( Eusolex 9020) Octocrylene ( Uvinul N 539 T) Alpha Bisabolol Glyceryl Stearate and PEG Stearate (Lexemul 561) # Polyester - 7 (and) Neopentyl Glycol Diheptanoate (LexFilm Sun) Hydroxyethylacrylate /Sodium Acryloy ldimethyltaurate Copolymer and C Squalane and Polysorbate 60 ( Simulgel NS) D Silica (MSS- 500) E Citric acid, 25% aq. solution Q.S. Total
12 LexFilm Spray Patented technology designed for popular hydro-alcoholic spray systems Easy to work with and easy for manufacturing Formulation attributes: 2-4% for up to 100% SPF retention Contributes less formulation costs than other hydro-alcoholic compatible polymers Excellent solubilizer High dielectric constant to aid photostability
13 SPF 30 Water Resistant Spray Five person in-vivo, very water proof methodology LexFilm Spray: 100% retention of SPF SDA 40-B anhydrous LexFilm Spray 4.00 Propylene Glycol Dibenzoate 0.00 Oxybenzone 5.00 Octisalate 5.00 Octinoxate 7.50 Homosalate Avobenzone 2.00 Diethylhexyl Naphthalate
14 Maximize UV Filter Efficiency and Photostability by Boosting Dielectric Constant Organic UV absorbers convert the sun s radiation into electronic excitation energy. Excitation energy has several possible outlets: Destructive e.g., isomerization, bimolecular reactions Non-Destructive e.g., heat, fluorescence, energy transfer Materials with a high dielectric constant tend to promote nondestructive pathways and lead to: More photostable formulas Increased SPF values
15 Dielectric Constants of Common Materials Benzophenone Octocrylene LexFilm Spray Lexgard O 8.02 LexSolv A 7.50 Lexorez Ethylhexyl salicylate 6.20 Diethylhexyl malate 5.78 Butyloctyl salicylate 5.35 Lexorez LexFilm Sun 4.90 Diethylhexyl 2,6-naphthalate 4.34 Diethylhexyl adipate 4.21 LexFeel Caprylic/Capric triglycerides 3.83 C12-15 alkyl benzoates (Finsolv TN) 3.78 Isopropyl myristate 3.24 Ethylhexyl stearate (palmitate) 3.05(3.06) Octyldodecyl neopentanoate 3.04 Mineral oil (& other hydrocarbons)
16 Lexgard O Lexgard O is The most effective non-preservative preservative on the market Broad formulation compatibility (solubility, ph) Provides humectancy and great skin-feel Effective from % Self-preserving systems are possible with Lexgard O at 1%
17 Lexgard O Boost your SPF In-vitro test formula with organic UV-absorbers and increasing levels of Lexgard O Avg. SPF Values % Lexgard O
18 Summary LexFeel 7 Ultra-dry fast spreading emollient LexSolv A Optimized UVA solubilization Lexorez 100 / 200 Water resistant film-former LexFilm Sun Water-proofing agent and solubilizer for UV actives LexFilm Spray High adhesion, soluble in hydro-alcoholic systems Lexgard O Multi-functional preservation enhancement
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