November 8-9, November 8-9, Moving Forward Cancer Care by Practicing Individualized Medicine. Conrad San Juan Condado Plaza

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1 PRST STD US Postage PAID Permit No Meetings, Events and Conference Coordinators, Inc. P.O. Box RD ANNUAL PUERTO RICO FALL CANCER SYMPOSIUM Moving Forward Cancer Care by Practicing Individualized Medicine November 8-9, 2013 Conrad San Juan Condado Plaza 3RD ANNUAL PUERTO RICO FALL CANCER SYMPOSIUM CONFERENCE DIRECTORS Director, Auxilio Mutuo Cancer Center MD Anderson Cancer Center, Houston, Texas H. Lee Moffitt Cancer Center, Tampa, Florida Luis E. Raez, M.D., FACP, FCCP Director, Memorial Cancer Institute Clinical Associate Professor of Medicine Herbert Wertheim College of Medicine Florida International University Miami, Florida, FACP November 8-9, 2013 Conrad San Juan Condado Plaza Medical Director of Cancer Research Thoracic Oncology Program Lynn Cancer Institute Boca Raton, Florida Sponsored by: THE MEDICAL EDUCATOR CONSORTIUM

2 DISTINGUISHED FACULTY EDUCATIONAL COMMITTEE Ana Botero, M.D. Javier Pinilla-Ibarz, M.D. Luis E. Raez, M.D., FACP, FCCP Anastasia Ramos, RN, FACP DISTINGUISHED FACULTY Jose Lutzky, M.D. Co-Chief, Hematology & Oncology Director, Mount Sinai Melanoma Program Mount Sinai Medical Center Louise Morrell, M.D. Director, Lynn Cancer Institute Breast Cancer Care and Cancer Genetics Boca Raton, FL Jaffer A. Ajani, M.D. Professor of Medicine Department of Gastrointestinal, Medical Oncology The University of Texas/MD Anderson Cancer Center Houston, TX Alejandra Perez, M.D. Director, Breast Cancer Program Memorial Cancer Institute Memorial Health Care System Hollywood, FL Ana Botero, M.D. Department of Radiation Oncology Memorial Cancer Institute Memorial Health Care System Hollywood, FL Sixto Perez Garcia, M.D. Centro Integral de Oncologia Torre Hospital Metropolitano San Juan, PR Director, Auxilio Mutuo Cancer Center MD Anderson Cancer Center, Houston, Texas H. Lee Moffitt Cancer Center, Tampa, FL Jonathan L. Kaufman, M.D. Associate Professor Associate Vice Chair for Quality Department of Hematology and Medical Oncology Winship Cancer Institute of Emory University Atlanta, GA Javier Pinilla-Ibarz, M.D., Ph.D. Associate Member and Director of Immunotherapy Malignant Hematology Department H. Lee Moffitt Cancer Center & Research Institute Tampa, FL Luis E. Raez, M.D, FACP, FCCP Medical Director, Memorial Cancer Institute Clinical Associate Professor of Medicine Herbert Wertheim College of Medicine Florida International University Suresh Ramalingam, M.D. Associate Professor of Hematology-Oncology Chief of Medical Oncology Georgia Cancer Coalition Distinguished Scholar Emory University School of Medicine Winship Cancer Institute Atlanta, GA Caio Max S. Rocha Lima, M.D. Professor of Medicine Division of Hematology/Oncology Co-Leader Colorectal, Pancreatic, Liver and related Cancers Group Co-Director of the Phase I Unit Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine, FACP Medical Director of Cancer Research Thoracic Oncology Program Lynn Cancer Institute Boca Raton, FL Adalberto Torres-Hernandez, RN, BSN, OCN Vice-Presidente, Asociación de Enfermería Oncológica y Hematológica de Puerto Rico, Inc. (AEHOPRI) Centro Médico de Puerto Rico Servicio de Medicina Hiperbárica San Juan, PR Vicente Valero, M.D., FACP Ad-Interim Chairman and Professor, Breast Medical Oncology Department Clinical Director, The Morgan Welch Inflammatory Breast Cancer Research Program and Clinic The University of Texas/MD Anderson Cancer Center Houston, TX

3 3RD Annual Puerto Rico Fall Cancer Symposium CONFERENCE DESCRIPTION This is a two-day course designed for medical oncologists and hematologists, radiation oncologists, surgical oncologists, oncology nurses, and healthcare professionals in cancer care. General practitioners (internal medicine and family medicine) will have the benefit of a review of the standard of care and new developments in cancer therapy. Residents in training and fellows from these specialties are encouraged to attend. Topics in breast cancer, lung cancer, gastrointestinal (GI) malignancies, genito-urinary (GU) cancers, melanoma, brain tumors, head and neck cancers, and hematological malignancies including multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia and non-hodgkin s lymphoma will be presented. There will also be a special session devoted to the area of supportive care in oncology, with emphasis on bone metastasis and management of chemotherapy related side effects. The areas of focus for this conference will include the review of current standards of care in the treatment of these malignancies and new developments in these oncology and hematological areas. There will be a lot of emphasis on molecular diagnosis and individualization of cancer therapy base on molecular phenotypes. Presentations from latest national (ASCO 2013 or ASH 2012) and International (ESMO 2013) meetings will be reviewed and guidelines of cancer care will be emphasized. The participants in the meeting will have a chance not only to learn the most recent management in these clinical areas but also personal interaction with our panel of experts in the field during our question and answer sessions and breakout sessions. CONFERENCE OBJECTIVES Upon completion of this course attendees will be able to: Understand the latest advances in chemotherapy treatments in the areas of breast cancer, lung cancer, GI malignancies, GU cancers, melanoma, brain tumors, head and neck cancers, and hematological malignancies including multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia and non-hodgkin s lymphoma. Evaluate the current standards of care in the treatment of hematological malignancies as well as solid tumors. Apply molecular genetic analyses and results into the therapeutic decision making of these malignancies. Understand the novel mechanisms of action and clinical applications of novel targeted agents approved or in clinical development for the treatment of malignant diseases. Recognize complications from novel therapeutic agents or combined treatment regimens and how to apply the most appropriate supportive care and management in these instances. ACCREDITATION The Medical Educator Consortium is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CREDIT HOURS (CME) The Medical Educator Consortium, designates this live activity for a maximum of 12.5 hours AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. FACULTY DISCLOSURE STATEMENT The Medical Educator Consortium (MEC) adheres to the ACCME Standards for Commercial Support. All persons that will be in a position to control the content of the CME Activity are required to disclosure all relevant financial Relationships. Faculty disclosure forms outlining this information will be made available to all participants prior to educational Activity. MEC has also implemented a mechanism to identify and resolve all conflicts of interest prior to the education activity being delivered to learners. The source of all support from commercial interests will also be disclosed to learners prior to the beginning of the educational activity. NURSING CEU This course has been approved for 12 hours of nursing credits provided by JEEPR.

4 PROGRAM AGENDA 3RD ANNUAL PUERTO RICO FALL CANCER SYMPOSIUM FRIDAY, NOVEMBER 8TH, :00 pm -3:30 pm Registration Opens & Visit Exhibits 5:35 pm - 6:00 pm Coffee Break & Visit Exhibits 3:30 pm - 3:35 pm Welcome and Introduction 6:00 pm - 8:00 pm 3:35 pm - 6:20 pm MELANOMA, PROSTATE CANCER, HEAD & NECK AND THYROID CANCER SESSION Moderator: SUPPORTIVE CARE, STEROTATIC RADIOTHERAPY AND THROMBOSIS SESSION Moderator: Luis E. Raez, M.D. 6:00 pm - 6:30 pm 3:35 pm - 4:15 pm How to Choose the Best Treatment for Metastatic Melanoma Patients: Developments in Molecular Markers and Metastatic Therapy. Jose Lutzky, M.D. Management of Chemotherapy induced side-effects: Neutropenic fever, Nausea and Vomiting and Bony Skeletal-Related Events. Adalberto Torres-Hernandez, M.D. 6:30 pm - 7:00 pm Stereotactic Radiation Therapy and Current Applications in Oncology. Ana Botero, M.D. 7:00 pm - 7:30 pm Hypercoagulable State and Thrombosis in Oncology: What is New in the Management of Thrombosis and Anticoagulation? Sixto Perez, M.D. 4:15 pm - 4:55 pm Systemic Therapy for Metastatic Prostate Cancer: How to Stratify Therapeutic Options based on Mechanisms of Action and Targeted Population. 4:55 pm - 5:35 pm 2013 ASCO Update and State of the Art Therapy in Head & Neck and Thyroid Cancers. Luis E. Raez, M.D. SATURDAY, NOVEMBER 9TH, :30 am - 7:30 am Registration Opens & Visit Exhibits 10:30 am -10:45 am Coffee Break & Visit Exhibits 7:30 am - 8:15 am Breakfast Symposia (non-cme) 10:45 am - 12:20 pm 8:15 am - 10:00 am LUNG CANCER SESSION Moderator: Luis E. Raez, M.D. GASTROINTESTINAL TUMORS SESSION Moderator: 8:15 am - 08:55 am Biomarkers and Targeted Therapy in NSCLC in 2013: Where Personalized Medicine is Taking Us. 10:45 am - 11:25 am Neoadjuvant, Adjuvant and Novel Regimens for Advanced Colorectal Cancer. Jaffer Ajani, M.D 8:55 am - 09:35 am Consolidation and Maintenance Therapy in Locally Advanced and Metastatic NSCLC. Luis E. Raez, M.D. 11:25 am - 12:05 pm Updates in the Management of Biliary Tract and Pancreas Cancers. Caio Max Rocha-Lima, M.D. 9:35 am - 10:15 am Anti-angiogenesis Therapy and New Agents for NSCLC. Suresh Ramalingam, M.D. 10:15 am -10:30 am Round Table Discussion and Q&A. Luis E. Raez, M.D. Suresh Ramalingam, M.D. 12:05 pm - 12:20 pm Round Table Discussion and Q&A. Jaffer Ajani, M.D. Caio Max Rocha-Lima, M.D. 12:20 pm - 12:35 pm Coffee Break & Visit Exhibits 12:35 pm - 01:20 pm Lunch symposia (non-cme)

5 SATURDAY, NOVEMBER 9TH, 2013 Continued 1:30 pm - 03:45 pm 1:30 pm - 02:10 pm HEMATOLOGY MALIGNANCIES SESSION Moderator: Novel Advances in CLL and CML. Javier Pinilla-Ibarz, M.D. 4:40 pm - 05:20 pm Hormonal Therapy: Novel Combinations in the Clinical Settings of Breast Cancer. Alejandra Perez, M.D. 5:20 pm - 06:00 pm Novel Developments for Systemic Therapy in Breast Cancer Including Her-2 Blockage (non-hormonal therapies). Vicente Valero, M.D. 2:10 pm - 02:50 pm Targeted Therapy for B- and T-cell Non-Hodgkin s Lymphomas. 2:50 pm - 03:30 pm New Challenges in the Treatment of Multiple Myeloma. Jonathan Kaufman, M.D. 6:00 pm - 06:15 pm Round Table Discussion and Q&A. Javier Pinilla-Ibarz, M.D. Jonathan Kaufman, M.D. Round Table Discussion and Q&A. Vicente Valero, M.D. Louise Morrell, M.D. Alejandra Perez, M.D. 6:15 pm - 06:20 pm Adjourn & Closing Remarks. 3:30 pm - 03:45 pm 3:45 pm - 04:00 pm Coffee Break & Visit Exhibits 4:00 pm - 06:15 pm BREAST CANCER SESSION Moderator: Louise Morrell, M.D. 4:00 pm - 04:40 pm Genomics, Predictive Biomarkers and Genetic Evaluation of High-Risk Breast Cancer Patients: Practical Recommendations. Louise Morrell, M.D.

6 REGISTRATION Registration fee: HOTEL INFORMATION Conrad San Juan Condado Plaza 999 Ashford Avenue San Juan, Puerto Rico Telephone: $125 Physicians $75 Residents, Fellows, Nurses and Allied Health Professionals $200 Industry Professionals Registration fee includes all day admission to the Friday and Saturday scientific presentation. Refunds must be provided in writing prior to October 9, After October 9th, 2013, no Refunds will be provided. For more information contact: The Conrad San Juan Condado is located just a few minutes from Muñoz Marín International Airport (SJU), the Puerto Rico Convention Center, and historic Old San Juan. The hotel is on a small headland at the northwestern part of the Condado district, and just 5 minutes from the cobblestoned streets of historic Old San Juan. As the only city retreat overlooking both the Atlantic Ocean and Condado Lagoon, our exclusive San Juan hotel provides an enchanting setting. Visit Puerto Rico and discover the colonial history of the island together with its modern culture on a stroll to Old San Juan. Visit museums to learn about art, music, and Juan Ponce de Leon. Wander the cobblestone streets and admire restored colonial architecture or plan an excursion to El Yunque Rainforest, just 45 minutes away. CONFERENCE MANAGEMENT MECC (Meetings Events & Conference Coordinators, Inc.) 1550 S Dixie Highway, Suite 202 Coral Gables, FL Telephone: Fax: Or visit our website at The hotel is offering special rates during this conference of $ 145 single or double plus tax, European plan (no meals). The cut of date to make reservations is October 8th, 2013 after this date reservations are subject to hotel availability. Make your reservations by calling or and identify yourself as attending the PR Fall Cancer Symposium group code ACTH or using the link. REGISTER ONLINE AT REGISTRATION FORM 3RD Annual Puerto Rico Fall Cancer Symposium Register online at or FAX to 305/ Name Degree Address City State Zip Telephone ( ) Fax ( ) address Specialty Type of Practice: o Private o Academic o Hospital o Resident/Fellow Registration fee: $125 Physicians $75 Residents, Fellows, Nurses and Allied Health Professionals $200 Industry Professionals Enclosed is my check in the i/a/o of for registration of this course. I authorize MECC to charge my credit card i/a/o $ for registration of this course using the following credit card. Name on Card Exp. Date Card number Authorized signer If you require special assistance or have specific dietary requirements, please contact MECC, Inc. no later than October 8th, 2013 via at tvalls@meccinc.com.