PROFESSIONAL TRAINING Epidemiology and Biostatistics, Boston University School of Public Health 2003

Transcription

1 C HUNYAN H E, S C D CURRICULUM VITAE Department of Public Health, Indiana University School of Medicine, Indianapolis, IN Phone: (317) ; Fax: (317) ; chunhe@iupui.edu EDUCATION Sc.D. Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 2009 Advisor: Professor David J. Hunter M.S. Molecular Biology, Shanghai Institute of Biochemistry & Cell Biology 1998 Chinese Academy of Science, Shanghai, China B.S. Biology and Computer Science, East China Normal University, 1995 Shanghai, China PROFESSIONAL TRAINING Epidemiology and Biostatistics, Boston University School of Public Health 2003 ACADEMIC APPIONMENTS AND RESEARCH EXPERIENCE Indiana University School of Medicine Indianapolis, IN 2009-present Assistant Professor, Department of Public Health Cancer Epidemiology Molecular and Genetic Epidemiology Genetic determinants of reproductive traits and diseases Harvard School of Public Health Boston, MA Research Assistant and Teaching Fellow, Department of Epidemiology Implemented epidemiological study on genetic susceptibility of breast cancer and skin cancer Assessed gene-gene and gene-environmental interactions on cancer risk Conducted genome-wide association study of age at menarche and age at natural menopause Identified genetic determinants of plasma hormone levels in hormone metabolism and IGF pathways National Institute of Child Health & Human Development (NICHD) Rockville, MD 2008 NIH Summer Internship, Division of Epidemiology, Statistics & Prevention Research (DESPR) Analyzed age at menarche and the risk of type 2 diabetes in two large prospective cohort studies Dana-Farber Cancer Institute Boston, MA Lab Lead Research Technician, Department of Medical Oncology Investigated cellular and molecular bases for the observed clinical heterogeneity of curable vs. fatal Large B-cell lymphoma (DLBCL). Studied the biological functions of two novel genes, BAL and BBAP, which are over-expressed in the high-risk DLBCL Washington University in St. Louis St. Louis, MO Research Assistant, Department of Chemistry Determined the role of individual amino acids in electron transfer of the photosynthetic reaction center of Rhodobacter sphaeroides by site-directed mutants in both L and M genes. PROFESSIONAL MEMBERSHIPS Member, American Association for Cancer Research Member, American Society of Human Genetics Member, International Genetic Epidemiology Society Member, Indiana Public Health Association Member, Indiana University Melvin and Bren Simon Cancer Center Member, CHARGE consortia on Reproductive Aging and Sex Hormones 1

2 HONORS AND AWARDS The Volunteer Leadership Award Scholarship, in honor of Drs. Joan L. and 2009 Julius H. Jacobson II, Harvard School of Public Health NIH Student Intramural Research Training Award (IRTA) Fellowship 2008 Graduate Student Scholarship for top students in Department of Epidemiology, Harvard School of Public Health Community Scholarship Awards, Boston University School of Public Health 2003 Graduate Student Fellowship, Chinese Academy of Sciences Outstanding Graduating Students in Shanghai Award, Shanghai 1995 Dean s Honor List, East China Normal University TEACHING EXPERIENCE Teaching Assistant Harvard School of Public Health: Introduction to Epidemiology (Fall 2006); Analysis of Case-Control and Cohort Studies (Spring 2007); Introductory Statistics for Medical Research (Summer 2007) Course Instructor/Lecturer Indiana University School of Medicine: Molecular and Genetic Epidemiology (Fall 2010 & 2011); Design and Analysis of Genetic Associations (Spring 2012); Doctoral Research Seminar in Epidemiology (Summer 2011); Chronic Disease Epidemiology (Spring 2010 & 2011, guest lecturer) Mentoring & Advising MPH students: Amy Brandt (2009), Megan Crister (2009), Joel Hartsell (2009), Tammie Nelson ( 2009), Julie Wirthwein (2009), Nida Habeeb (2009), Julie Beryer (2010), Ashley Bozell (2010), Abigail Fry (2010) Autumnlynn Glass (2010), Stephanie Moles (2010), Jason Pike (2010), Nicole Stein (2010), Betsy Barnett (2010), Charles Clark (2011), Jennifer Kirschstein (2012), Lauren Savitskas (2011), Staci Walters (2011), Kwassi Amevor (2012), Jayleen Gunn (2011), Ayana Birhanu (2011) PhD students: Kathy McCorkle (2010); Daojun Mo (2011) Post-doctoral fellows: Xiangbing Wu, PhD, 2010; Erin Wagner, PhD, 2011 INVITED SEMINARS AND PRESENTATIONS 1. International Symposium on Genetics of Age at Menopause Symposium, London, UK, May Dept of Medical and Molecular Genetics, Indiana University School of Medicine, May Center for Computation Biology and Bioinformatics, Indiana University School of Medicine, Sep Dept of OB/GYN Grand Rounds, Indiana University School of Medicine, Mar rd Annual World Cancer Congress: Epidemiology, Genetics and Prevention, Shanghai, Apr Endocrine research conference, Section of Pediatric Endocrinology and Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Feb Health Geographics Symposium, Center for Health Geographics, Indiana University, Feb GRANT ACTIVITIES Active Grants Title Molecular and Genetic Epidemiology of Cancer Goal Conduct pilot and independent molecular and genetic epidemiological studies of breast cancer and other reproductive cancers and generate preliminary data for grant proposals to NIH and other extramural funding agencies Agency Start-up Fund, Melvin and Bren Simon Cancer Center, Indiana University School of Medicine Amount $450,000 Period 07/01/ /31/2012 Title Goal Integrating genome-wide association and gene expression for identification of novel breast cancer susceptibility genes Conduct pilot epidemiological studies of breast cancer and generate feasibility and preliminary data for NIH proposal. The ultimate goal is to link genome-wide association study (GWAS) data to gene- 2

3 3 CURRICULUM VITAE expression profiling data for a better understanding of the underlying biological mechanisms Agency Project Development Team Award, The Indiana Clinical & Translational Sciences Institute (CTSI) Amount $20,000 Period 02/01/ /31/2011 Title Goal Genetic Variants, microrna Expression and Breast Cancer The goal of this application is to evaluate the polymorphisms in the mirna-related genes and tissue mirna expression in relation to breast cancer risk. Agency The V Foundation for Cancer Research & the Kay Yow Cancer Fund Amount $100,000 Period 04/01/ /31/2013 Title Goal GWAS and Data Analysis Grant for Breast Cancer The grant provides support for GWAS genotyping and data analysis for 600 samples of breast cancer cases and controls. The long-term goal is to combine genome-wide genotyping data with mrna sequencing data to allow mapping of genetic variants that influence quantitative levels of gene expression. Agency Expression Analysis and Illumina co-sponsored Amount $410,000 Period 04/01/ /30/2012 Grant Applications DOD Idea Award BC102780P1 (Chunyan He, Co-Principle Investigator) Title: Protein methylesterification: A novel regulator of genomic instability in breast cancer cells The goal of this application is to determine the correlations between common genetic variants in the C6orf211 gene region and (methytransferase) enzyme activity and methylation status of PCNA protein in breast cancer cases and controls. DOD Concept Award BC (Chunyan He, Principle Investigator) Title: Genetic Variation of Stemness Genes and the Risk of Breast Cancer The goal of this application is to examine the association of genetic variants of the five most important stemness genes and breast cancer risk in a case-control study. William T. Grant Scholars Program (Chunyan He, Principle Investigator) Title: Puberty timing-related genetic influences on somatic growth and blood pressure development in children and young adults The goal of this application is to determine the associations between puberty timing-associated genetic variants and the changes in physical growth (weight, height, and fat distribution) and blood pressure starting in childhood and continuing into adolescence in black and white children. Damon Runyon-Rachleff Innovation Award, Damon Runyon Cancer Research Foundation (Chunyan He, Principle Investigator) Title: Genetic effects on tissue-specific telomere length and breast cancer risk The goal of this application is to evaluate the relation of telomere length to the risk of breast cancer, by assessing telomere lengths in paired peripheral blood and breast tissue samples as well as the association with breast cancer for genetic variations in known telomere length-maintenance genes. JOURNAL REVIEWER 1. American Journal of Human Genetics 2. PLoS ONE 3. BMC Cancer 4. British Journal of Dermatology 5. Human Genetics

4 6. Clinical Endocrinology 7. Reproductive Biology and Endocrinology EDITORIAL BOARD Frontiers in Applied Genetic Epidemiology, Review Editor PLoS ONE, Academic Editor PEER REVIEWED PUBLICATIONS 1. Kirmaier C, He C, and Holten D. Manipulating the direction of electron transfer in the bacterial reaction center by swapping Phe for Tyr near BChl(M) (L181) and Tyr for Phe near BChl(L)(M208). Biochemistry 2001; 40(40): Kirmaier C, Cua A, He C, Holten D, and Bocian DF. Probing M-Branch Electron Transfer and Cofactor Environment in the Bacterial Photosynthetic Reaction Center by Addition of a Hydrogen Bond to the M-side Bacteriopheophytin. J Phys Chem. B 2002; 106: Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, and Shipp MA. The BAL-binding Protein BBAP and Related Deltex Family Members Exhibit Ubiquitin-Protein Isopeptide Ligase Activity. J Biol Chem. 2003; 278: Aguiar RC, Takeyama K, He C, Kreinbrink K, Shipp MA. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(adp-ribose) polymerase activity. J Biol Chem. 2005; 280(40): Gajdos ZK, Butler JL, Henderson KD, He C, Supelak P, Euyud M et al., Association studies of common variants in ten hypogonadotropic hypogonadism genes with age at menarche. J Clin Endocrinol Metab. 2008; 93(11): He C*, Tamimi RM, Hankinson SE, Hunter DJ, Han J. A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. Breast Cancer Res Treat. 2009; 113(3): (*corresponding author) 7. He C*, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock S, Ridker PM, Hunter DJ, Chasman DI. Genome-wide association studies identify novel loci associated with age at menarche and age at natural menopause. Nat Genet. 2009, 41(6): (*corresponding author) 8. He C*, Zhang C, Hunter DJ, Hankinson SE, Louis GMB, Hediger ML, Hu FB. Age at menarche and risk of type 2 diabetes: results from two large prospective cohorts. Am J Epidemiol. 2010; 171(3): (*corresponding author) 9. He C*, Nan H, Qureshi AA, Han J. Genetic Variants in P53BP1 gene and risk of skin cancer. J Investigative Dermatol. 2010; 130, (*corresponding author) 10. He C*, Qureshi AA, Han J. Polymorphisms in genes involved in oxidative stress and their interactions with lifestyle factors on skin cancer risk. J Dermatol Sci. 2010, 60(1): (*corresponding author) 11. He C*, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. A large-scale candidate-gene association study of age at menarche and age at natural menopause. Hum Genet. 2010; 128(5): (*corresponding author) 12. Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, Gudbjartsson DF, Esko T, Feenstra B, Hottenga JJ, Koller DL, Kutalik Z, Lin P, Mangino M, Marongiu M, McArdle PF, Smith AV, Stolk L, van Wingerden SW, Zhao JH, Albrecht E, Corre T, Ingelsson E, Hayward C, Magnusson PKE, Smith EN, 4

5 Ulivi S, Warrington NM, Zgaga L, Alavere H, Amin N, Aspelund T, Bandinelli S, Barroso I, Berenson GS, Bergmann S, Blackburn H, Boerwinkle E, Buring JE, Busonero F, Campbell H, Chanock SJ, Chen W, Cornelis MC, Couper D, Coviello AD, d Adamo P, de Faire U, de Geus EJC, Deloukas P, Döring A, Smith GD, Easton DF, Eiriksdottir G, Emilsson V, Eriksson J, Ferrucci L, Folsom AR, Foroud T, Garcia M, Gasparini P, Geller F, Gieger C, The GIANT Consortium, Gudnason V, Hall P, Hankinson SE., Ferreli L, Heath AC, Hernandez DG, Hofman A, Hu FB, Illig T, Järvelin MR, Johnson AD, Karasik D, Khaw KT, Kiel DP, Kilpeläinen TO, Kolcic I, Kraft P, Launer LJ, Laven JSE, Li S, Liu J, Levy D, Martin NG, McArdle WL, Melbye M, Mooser V, Murray JC, Murray SS, Nalls MA, Navarro P, Nelis M, Ness AR, Northstone K, Oostra BA30, Peacock M, Palmer LJ, Palotie A, Paré G, Parker AN, Pedersen NL, Peltonen L, Pennell CE, Pharoah P, Polasek O, Plump AS, Pouta A, Porcu E, Rafnar T, Rice JP, Ring SM, Rivadeneira F, Rudan I, Sala C, Salomaa V, Sanna S, Schlessinger D, Schork NJ, Scuteri A, Segrè AV, Shuldiner AR, Soranzo N, Sovio U, Srinivasan SR, Strachan DP, Tammesoo M, Tikkanen E, Toniolo D, Tsui K, Tryggvadottir L, Tyrer J, Uda M, van Dam RM, van Meurs JBJ, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Weedon MN, Wichmann HE, Willemsen G, Wilson JF, Wright AF, Young L, Zhai G, Zhuang WV, Bierut LJ, Boomsma DI, Boyd HA, Crisponi L, Demerath EW, van Duijn CM, Econs MJ, Harris TB, Hunter DJ, Loos RJF, Metspalu A, Montgomery GW, Ridker PM, Spector TD, Streeten EA, Stefansson K, Thorsteinsdottir U, Uitterlinden AG, Widen E, Murabito JM, Ong KK, Murray Al. (ReproGen Consortium) Thirty novel loci for age at menarche identified by a meta-analysis of genome wide association studies. Nat Genet. 2010; 42(12): MANUSCRIPTS SUBMITTED/IN PREPARATION: 1. Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne E, Ernst F, Esko T, Franceschini N, Gudbjartsson DF, Hottenga J, Kraft PL, McArdle PF, Porcu E, Smith AV, So Youn S, van Wingerden S, Zhai G, Zhuang WV, Bandinelli S, Ferrucci L, Folsom AR, Janssens A JW, McKnight B, Soranzo N, Albrecht E, Alizadeh BZ, Asplund T, Barac-Lauc L, Beckmann JS, Boban M, Boerwinkle E, Broekmans FJ, Burri A, Campbell H, Chanock SJ, Chen C, Cornelis C, Corre T, Coviello AD, d'adamo P, Davis G, de Faire U, de Geus EJC, de Keyzer JJ, Deary IJ, Dedoussis GVZ, Deloukas P, Ebrahim S, Eiriksdottir G, Eriksson JG, Fauser BCJM, Ferreli L, Garcia ME, Gasparini P, Gieger C, Glazer N, Grobbee DE, Hall P, Haller T, Hankinson SE, Hass M, Hayward C, Heath AC, Hofman A, Ingelsson E, Karasik D, Kardia SLR, Kiel DP, Kolcic I, Kutalik Z, Lahti J, Lai S, Laven JSE, Lawlor DA, Liu J, Lopez LM, Magnusson PKE, Marongiu M, Martin NG, Martinovic-Klaric I, Masciullo C, Medland SE, Melzer D, Mooser V, Navarro P, Newman AB, Nyholt DR, Onland-Moret C, Palotie A, Paré G, Parker A, Pedersen NL, Peeters PHM, Pistis G, Polasek O, Pop VJM, Räikkönen K, Rehnberg E, Rudan I, Sala C, Salumets A, Scuteri A, Singleton A, Smith JA, Snieder H, Stacey SN, Starr JM, Stathopoulou MG, Steegers EA, Stirrups K, Stolk R, Styrkarsdottir U, Sun YV, Tammesoo M, Tenesa A, Thorand B, Toniolo D, Tryggvadottir L, Tsui K, Turner ST, Ulivi S, Van Dam RM, van der Schouw YT, van Gils CC, Visscher PM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HErich, Widen E, Willemsen G, Wilson JF, Wolffenbuttel BHR, Wright A, Yerges-Armstrong LM, Zemunik T, Zgaga L, Zillikens CMC, Zygmunt M, the LifeLines cohort study, Arnold A, Boomsma DI, Buring J, Crisponi C, Demerath EW, Gudnason V, Harris TB, Hu FB, Hunter DJ, Launer LJ, Metspalu A, Montgomery GW, Oostra B, Ridker P, Sanna S, Schlessinger D, Spector TD, Stefansson K, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL. (ReproGen Consortium) Meta-analysis of genome-wide association studies of age at menopause: novel loci highlight DNA repair and immune pathways. Nat Genet (Under review). 2. He C*, Chasman DI, Dreyfus J, Hwang SJ, Ruiter R, Sanna S, Buring JE, Fernández-Rhodes L, Franceschini N, Hankinson SE, Hofman A, Lunetta KL, Palmieri G, Porcu E, Rivadeneira F, Rose LM, Splansky GL, Stolk L, Uitterlinden AG, Chanock SJ, Crisponi L, Demerath EW, Murabito JM, Ridker PM, Stricker BHCh, Hunter DJ. Reproductive aging associated common genetic variants and the risk of breast cancer. (*corresponding author) ( Submitted) 5

6 3. Perry JRB, Haring R, Koster A, Lagou V, Lyytikäinen LP, Mangino M, Petersen AK, Stolk L, Vaidya D, Vandenput L, Aalto V, Wellons MF, He C, Onland-Moret C, Ohlsson C, Lunetta K, on behalf of the CHARGE+ Sex Hormone Consortium. A genome-wide association study meta-analysis reveals multiple loci implicated in sex hormone regulation. (In development) ABSTRACTS 1. Aguiar RC, Takeyama K, He C, Mitra J, Klein U, Dalla-Favera R, Wilkinson K, and Shipp MA. The DLBCL Risk-related BAL-1 Protein Function as a Repressor of Transcription. Abstract accepted for presentation at the 44 th ASH meeting in December Takeyama K, Aguiar RC, He C, Kutok JL, Aster JC, and Shipp MA. BBAP and Deltex1, 2, and 3: A Novel Family of RING Finger Proteins with Ubiquitin E3 Ligase Activity. Abstract accepted for presentation at the 44 th American Society of Hematology (ASH) meeting in December He C, Hu FB, Louis GMB, Hediger, ML, Zhang C. Age at menarche and the risk of type 2 diabetes: results form a large prospective cohort study. NIH Summer Research Program Poster Day, August 7 th 2008 at NIH campus. 4. He C, Zhang C, Hunter DJ, Hankinson SE, Louis GMB, Hediger ML, Hu FB.Age at menarche and risk of type 2 diabetes: results form two large prospective cohorts. Abstract accepted for presentation at the 42 nd Annual Society for Epidemiologic Research (SER) Meeting and the 22 nd Annual Society for Pediatric and Perinatal Epidemiologic Research (SPER) Meeting in June He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock S, Ridker PM, Chasman DI, Hunter DJ. Breast cancer risk prediction: Incorporating common genetic variants identified from genome-wide association studies. Abstract accepted for oral presentation at the 3 rd Annual World Cancer Congress: Epidemiology, Genetics and Prevention, Shanghai in April He C, Nan H, Qureshi AA, Han J. Genetic Variants in P53BP1 gene and risk of skin cancer. Abstract accepted for presentation at the 101 st American Association for Cancer Research (AACR) Annual Meeting in April He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. A large-scale candidate-gene association study of age at menarche and age at natural menopause. Abstract accepted for presentation at the 60 th American Society for Human Genetics (ASHG) Annual Meeting in November He C, Chasman DI, Ruiter R, Dreyfus J, Porcu E, Hwang SJ, Hankinson SE, Buring JE, Stolk L, Franceschini N, Sanna S, Lunetta KL, Ridker PM, Stricker B, Demerath EW, Crisponi L, Murabito JM, Hunter DJ. Age at menarche and natural menopause associated SNPs and breast cancer risk. Abstract accepted for presentation at the CHARGE Investigator Meeting in February He C, Chasman DI, Ruiter R, Dreyfus J, Porcu E, Hwang SJ, Hankinson SE, Buring JE, Stolk L, Franceschini N, Sanna S, Lunetta KL, Ridker PM, Stricker B, Demerath EW, Crisponi L, Murabito JM, Hunter DJ. Genetic variants associated with reproductive aging and the risk of breast cancer. Abstract accepted for presentation at the 102 nd American Association for Cancer Research (AACR) Annual Meeting in April Perry JRB, Haring R, Koster A, Lagou V, Lyytikäinen LP, Mangino M, Petersen AK, Stolk L, Vaidya D, Vandenput L, Aalto V, Wellons MF, He C, Onland-Moret C, Ohlsson C, Lunetta K, on behalf of the CHARGE+ Sex Hormone Consortium. A genome-wide association study meta-analysis reveals multiple loci implicated in sex hormone regulation. Abstract accepted for presentation at the 61 th American Society for Human Genetics (ASHG) Annual Meeting in October