2 nd PhD course. Measurement, modelling and control in biochemical engineering

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1 2 nd PhD course Measurement, modelling and control in biochemical engineering July 1 4, 2013 Technical University of Denmark (DTU), Lyngby, Denmark Following the success of the first edition of the course, the main purpose of this second edition is to provide an introduction to measurement, monitoring, modelling and conrol (M3C) applied to biochemical engineering processes. Scope and form: Three days of teaching and computer exercises, followed by a one day excursion to Novo Nordisk production facilities. Course material and computer codes are supplemented with an additional set of reading material. Lectures by an international team of experts: Jochen Büchs (RWTH Aachen, Germany) Jarka Glassey (University of Newcastle upon Tyne, UK) Reiner Luttmann (University of Applied Sciences, Hamburg, Germany) Yuhong Zhou (University College London, UK) Volker Hass (University of Applied Sciences, Bremen, Germany) Frans van den Berg (University of Copenhagen, Denmark) Krist V. Gernaey (Technical University of Denmark, Lyngby, Denmark) Course credits: 2.5 ECTS Course fee and registration: The course fee includes relevant course materials, lunches and coffee breaks. PhD student: 300 Euros Industrial participants: 600 Euros Participants are expected to cover own expenses related to the travelling and accommodation, as well as to bring a laptop, preferably with Matlab installed. Course registration: Complete the registration form and send it to gnie@kt.dtu.dk. Course fee is to be paid by bank transfer, and should be paid 2 weeks before the start of the course at the latest. Payment is to be made to: Technical University of Denmark IBAN: DK Swift Code: DABADKKK The following reference should be included with the payment: I 1 + Name of participant If you need an invoice, please contact us. For additional information: Gitte Nielsen. gnie@kt.dtu.dk

2 Course program: Day 1 9:00 10:30 10:30 10:45 10:45 12:00 12:00 13:00 13:00 14:30 14:30 14:45 14:45 15:45 Introduction to biochemical engineering Processes Process development principles (J. Büchs, Krist V. Gernaey) Data collection in bioprocessing (1): Operating principles of advanced online sensors (Reiner Luttmann) Lunch break Data collection in bioprocessing (2): Getting most out of your sensors: data pre processing, PCA, PLS (Frans van den Berg) Design of Experiments (DoE) (Frans van den Berg) Day 2 8:30 10:15 10:15 10:45 10:45 12:00 12:00 13:00 13:00 14:00 14:00 14:15 14:15 15:45 Mechanistic models of biochemical engineering processes (1): Model implementation, parameter estimation, differential sensitivity analysis (Krist V. Gernaey) Mechanistic models of biochemical engineering processes (2): Case study / hands on: Parameter estimation and differential sensitivity analysis (Krist V. Gernaey) Lunch break Basic principles of PAT and QbD (Jarka Glassey, Krist V. Gernaey) Case study 1: Development of fully automated optimized Integrated Bioprocesses + automated DOE (Reiner Luttmann) Day 3 8:30 10:15 10:15 10:45 10:45 12:00 12:00 13:00 13:00 14:30 14:30 14:45 14:45 15:45 Bioprocess control (Volker Hass, Krist V. Gernaey, Reiner Luttmann) Case study 2: PAT methodology in cell culture development (Jarka Glassey) Lunch break Case study 3: Modelling and simulation of down stream processing operations (Yuhong Zhou) 15:45 16:30 19:00 Dinner Uncertainty and global sensitivity analysis in a PAT context (Krist V. Gernaey) Course evaluation, questions and answers 15:45 16:15 16:15 18:00 19:00 Dinner Advanced topic: Small scale reactors for biochemical engineering process development and PAT (Jochen Büchs) 15:45 16:15 16:15 18:00 19:00 Dinner Bioprocess data interpretation: Reducing lead times using multivariate data analysis methods; Rapid deviation detection; Software sensors (Jarka Glassey) Day 4 8:00 9:30 9:30 14:30 14:30 16:00 Transport by bus from DTU to Novo Nordisk Visit Novo Nordisk Transport by bus from Novo Nordisk to DTU

3 PhD course Measurement, modelling and control in biochemical engineering REGISTRATION FORM: July 1 4, 2013 Technical University of Denmark (DTU), Lyngby, Denmark First name: Family name: Organisation: Department: Address: Postal code: City: Country: Telephone: I will participate in the visit to Novo Nordisk on July 4 th (yes/no): Signature: Date: Course registration: Complete the registration form and send it to gnie@kt.dtu.dk. Course fee is to be paid by bank transfer, and should be paid 2 weeks before the start of the course at the latest. Payment is to be made to: Technical University of Denmark IBAN: DK Swift Code: DABADKKK The following reference should be included with the payment: I 1 + Name of participant If you need an invoice, please contact us! For additional information: Gitte Nielsen. gnie@kt.dtu.dk

4 M3C PhD course Technical University of Denmark Campus Lyngby DTU Lyngby

5 Public transportation to Technical University of Denmark (DTU) There are several easy ways of getting to DTU, but we have picked out the easiest way, please use rejseplanen.dk. DTU is a big Campus therefore the busses stops at several places at Campus. Make sure to get of the right place by asking the Busdriver to announce in the speakerphone, when you have to get of. By public transport - from Copenhagen Airport to DTU By Taxi - approx. 25 min. and up to 45 min. in rush hours. costs around DKK 420 on weekdays and DKK 540 in the weekends. By Metro, train and bus approx 50 min. - Take Metro M2 towards Vanløse St (Metro) Get off the metro at Nørreport st. (Metro) Get on at Nørerport st bus nr. 173E towards Søhuset, Forskerparken Get off at DTU/Rævehøjvej Walk (approx. 1,0 km, approz. 13 min.) Arrive at Kemitorvet 210, 2800 Lyngby Tickets for the Metro are available at the Metro station and at the DSB ticket sales counter in Terminal 3. Please note that the ticket machines do only accept coins and Cards such as VISA, and MasterCard. You will need to buy 6 zones price around 9,6 euro (72 DKR) By public transport - from Central Station Copenhagen (København H) By S-Train and bus approx 40 min. Take S-train towards Hillerød St. Get off the S-train at Lyngby st. Walk (approx. 6 min.) Take Bus 180E towards Lyngby St. (bus) Get of Handelsskolen Kbh Nord (buiness school copenhagen North) Walk (approx. 300 m, approx. 5 min) Arrive at Kemitorvet 210, 2800 Lyngby You are able to buy ticket in the bus - only cash, you wil need to buy 5 zones Prices around 8 euro 60 Dkr. But you are also able to buy vouchers, which is cheaper. You can buy these at the train station.

6 Classroom Kemitorvet 210, room 008 How to find classroom

7 A) First Hotel Vesterbrogade Copenhagen Tel: (45) Vesterbro/ B) Andersen Hotel Helgolandsgade Copenhagen V Tel. : (+45) info@andersen-hotel.dk C) Grand Hotel Vesterbrogade Copenhagen V Tel. (+45) grandhotel@arp-hansen.dk D) Scandic Eremitage (close to DTU) Klampenborgvej Lyngby Tel: (+45) eremitage@scandichotels.com Eremitage/

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