Management of Hepatitis C Infection

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1 Management of Hepatitis C Infection A self-paced online course Register Online Now!

2 Course Description The Management of Hepatitis C Infection is the second course in the HIV ecurriculum Series which is a comprehensive ecurriculum designed to assist the medical care provider on a lifelong journey of learning. The curriculum delivers relevant, practical, and tailored education as a series of courses encompassing the entire spectrum of HCV Medicine. Management of Hepatitis C Infection is comprised of 10 modules that address essential Hepatitis C Infection knowledge. The important features of the Management of Hepatitis C Infection course are: Participants are required to perform a one-time simple registration process for the course. During this process, a log-in ID and a password are set up. Participants access the course through a password-protected portal using their established log-in ID and password. Participants are required to progress sequentially from the first module to the next, and not haphazardly from topic to topic. Participants are not expected to peruse the educational content online; the intent of the program is that the content is printed and reviewed at the participant s leisure. Once participants complete reviewing the module content, they are required to log in again and respond to post test questions before they can progress to the next module. At the completion of the entire course, CME credit and a certificate of attendance/completion is awarded from the Mayo School of Continuous Professional Development. Participation in this online course does not indicate or guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course. Intended Audience Hepatitis C Infection Medical Care Providers including Physicians, Physicians Assistants and Nurse Practitioners Credit College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. College of Medicine designates this educational activity for a maximum of 10 AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity.

3 Other Health Care Professionals A certificate of attendance will be provided to other health care professionals. Educational Grants At the time of this printing, a complete listing of commercial supporters (financial or in-kind) was not available. Appropriate acknowledgment will be given to all supporters at the time of the meeting. Registration To register, visit, There is no charge for the course. For additional information, contact: Mayo School of Continuous Professional Development Website: cme@mayo.edu Phone: or Fax: Faculty Program Director Co-Course Director Co-Course Director Zelalem Temesgen, MD Professor of Medicine Rochester, Minnesota Bashar A. Aqel, MD Roshani Desai, MD St. Louis School of Medicine W. Ray Kim, MD Maria-Carlotta Londoño, MD, PhD Centro de Investigacion Biomedica, Spain Amy C. Sherman, BA, MSIV George Washington University School of Medicine Thomas von Hahn, MD Hannover Medical School Germany Stacey A. Rizza, MD Associate Professor of Medicine Rochester, Minnesota Faculty Bruce R. Bacon, MD St. Louis School of Medicine Douglas T. Dieterich, MD Mt. Sinai School of Medicine Paul Yien Kwo, MD Indiana University Medical Center Valerie Martel-Laferrier, MD Mt. Sinai School of Medicine Kenneth E. Sherman, MD, PhD University of Cincinnati College of Medicine Hugo E. Vargas, MD Professor of Medicine Scottsdale, Arizona Michael Charlton, MD Xavier Forns, MD, PhD Centro de Investigacion Biomedica, Spain Keith Lindor, MD Arizona State University Hugo R. Rosen, MD University of Colorado Denver Rohit Talwani, MD University of Maryland Medical Center

4 Faculty Disclosure As a provider accredited by ACCME, College of Medicine, (Mayo School of Continuous Professional Development) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any offlabel and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentation. Learning Objectives Management of Hepatitis C Infection addresses essential general Hepatitis C knowledge. Upon conclusion of the course modules, the learner should be able to: Select the optimal treatment course for a patient with Hepatitis C virus infection Attend to special populations including HIV/HCV co-infected, post-liver transplant or cirrhotic patients Recognize the burden of Hepatitis C virus infection in special populations Review the anti-hepatitis C virus direct antiviral drug development pipeline

5 Management Of Hepatitis C Infection Module 1 Epidemiology Incidence Prevalence Transmission Module 2 Virology Structure Genome - Factors associated with progression of chronic Hepatitis C - Factors associated with spontaneous clearance - Patients with persistently normal serum aminotransferase levels - Immunocompromised patients Viral replication and life cycle Genotypes and quasispecies Module 3 Immunology Cell mediated immunity Humoral immunity Innate immunity Vaccine Module 4 Clinical Features Acute Chronic Hepatitis C Extrahepatic manifestations Module 5 Diagnosis Indirect assays Direct assays Selection of serologic and virologic tests Liver biopsy Noninvasive assessment of fibrosis Module 6 Treatment of Acute HCV Infection Spectrum of the clinical presentation and natural history of acute hepatitis C Correctly recognize and diagnose acute hepatitis C Timing, duration, and regimen of treatment for acute hepatitis C Module 7 Treatment of chronic HCV Eligibility (indications and contraindications Treatment goals and end-points Monitoring Nonresponders, relapses Module 8 Treatment of Chronic HCV Infection in the Setting of HIV Co-infection Recognize the importance of HCV infection in the HIV infected population Nuances of treatment in this patient population Review of the latest data with direct anti-hcv antivirals Module 9 Anti HCV Drugs Interferon Ribavirin Boceprevir Telaprevir Future drugs Module 10 HCV and Liver Transplantation Mono-infected HIV Co-infected

6 MAYO CLINIC 200 First Street SW Rochester, MN Management of Hepatitis C Infection A self-paced online course Register Online Now! If you already received a copy of this brochure, please give this brochure to an interested colleague Mayo Foundation for Medical Education and Research MC NON-PROFIT ORG. U.S. POSTAGE PAID MAYO CLINIC

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