Nuclear Medicine & PET Research. F Production. Radiochemie.nl Cursus 18 F chemie

Size: px
Start display at page:

Download "Nuclear Medicine & PET Research. F Production. Radiochemie.nl Cursus 18 F chemie"

Transcription

1 18 F Production 1

2 Outline Cyclotron technique 18 F targetry : Fluoride and Fluorine production 2

3 Main PET Isotopes 11 C : 20 min, b + ( 970 KeV ), 14 N(p,a) 11 C 13 N : 10 min, b + ( 1190 KeV ), 16 O(p,a) 13 N 15 O : 2 min, b + ( 1720 KeV ), 14 N(d,n) 15 O 18 F : 110 min, b + ( 635 KeV ), 18 O(p,n) 18 F 3

4 Cyclotron production volt between D s 300 circles, 600 accelerations of volt = 18 MeV 4

5 Cyclotron 5

6 6

7 IBA 18/9 18 F : 2,3 ml H 2 18 O in nuobium 11 C : 60 ml N 2 + 0,5% O 2 in aluminium 13 N : 2,3 ml H 2 O in nuobium 15 O : 60 ml N 2 in aluminium 7

8 18 F Fluoride production Nuclear reaction 18 O(p,n) 18 F, obtained as Fluoride in water Proton energy from 10 MeV Side reaction 16 O(p,a) 13 N, obtained as nitrates in water Side products no nuclear side reactions 8

9 18 F Fluoride production Nuclear reaction 9

10 18 F Fluoride targetry target foil fill / empty protons Target H 2 18 O target body cooling Important chracteristics for target body material: Heat capacity coefficient (limiting factor for high beam currents: high pressure in target) Radionuclidic side products Chemical purity of [ 18 F]Fluoride from target 10

11 18 F Fluoride target body material Silver Advantage: Disadvantage: - high heat capacity (max ± 40 µa) - no long lived radio isotopes - Silver particles 11

12 18 F Fluoride target body material Titanium Advantage: Disadvantage: - clean 18 F solution - low heat capacity (max ± 30 µa) - 48 V as side product 12

13 Dose rate (msv/h) Activation of Titanium Accumulation of 48 V Production number 13

14 18 F Fluoride target body material Niobium Advantage: - clean 18 F solution - no long lived radio isotopes - high heat capacity (max ± 40 µa) Disadvantage: -? 14

15 Dose rate (Sv/hr) Nuobium activation F Time (hours) 15

16 Pressure (bar) Pressure in different materials Ag Ti Nb Beam intensity (µa) 16

17 Results different target materials Summary of the results after 120 minutes irradiation Target chamber material Ag Ti Nb Energy (MeV) Beam intensity (µa) Thick target yield sat) Radioactivity EOB (Ci)

18 Results at other centers 18

19 Fluoride target 19

20 Fluoride target 20

21 Fluoride target 21

22 Different materials Ti Ag 22

23 18 F Fluoride targetry beam Target volume ± 2.4 ml Target filling ± 2.4 ml max 40 ma 23

24 18 F Fluoride targetry beam Target volume ± 4.5 ml Target filling ± 3.3 ml ma XXXL : 150 ma? 24

25 18 F and [ 18 F]FDG yields uur 40 ma Start synthesis (End of synthesis 166 GBq [ 18 F]Fluoride 130 GBq [ 18 F]FDG) 3 uur 70 ma Start synthesis (End of synthesis 315 GBq [ 18 F]Fluoride 240 GBq [ 18 F]FDG) 25

26 18 F Fluorine production Nuclear reaction 20 Ne(d,a) 18 F or 18 O(p,n) 18 F deuterons from 7 MeV protons from 10 MeV Side reaction - Side products - 26

27 18 F Fluorine targets Target material : Nickel or Monel 1 st irradiation : 18 F fluorine deposit on target wall Empty target, fill with Neon % F 2 Irradiate Electrophilic fluorination, or via intermediate 27

28 18 F Fluorine target Groningen Installed in 1992 Design: Robert Dahl Nickel / 153 ml 30 psi 1% F 2 / 100 psi Neon Yield in 1992: 5 GBq / 50 µa / 1 hour 28

29 18 F Fluorine specific radioactivity Addition of F 2 is essential, but decreases specific radioactivity Typically : less then 1 GBq/µmol Gives problems for receptor studies, however for F-DOPA no problem 29

30 Production results 30

31 Production results Groningen Radionuclide production: Target SCX nickel plated / 150 ml Havar frontfoil (25 um) SCX nickel plated / 150 ml Havar frontfoil (25 um) Targetgas 0,44 % F2 in Neon / 75 psi 0,44 % F2 in Neon / 75 psi Beamcurrent 15 ua 25 ua Irradiation time minutes 120 minutes Preparation for the production 1x conditioning target and lines 1x 3 µah irradiation to waste 1 x conditioning target and lines 1 x 3 µah irradiation to waste Yield [ 18 F]F MBq/μAh at EOB GBq at BOS MBq/μAh at EOB GBq at BOS Specific activity 4.4 ± 1.0 GBq/mmol 10.7 ± 3.0 GBq/mmol 31

32 [ 18 F]F 2 via (p,n) on [ 18 O]O 2 Load target with 20 bars [ 18 O]O 2 Irradiate with 18MeV protons 18 F radicals deposit on target chamber wall Blow [ 18 O]O 2 away (can be trapped in liq N 2 ) Load target with Neon + 0.3% F 2 Irradiate with 18MeV protons again 18 F radicals exchane with F 2 to form [ 18 F]F 2 in Neon Advantage: nuclear reaction much more efficient Higher yield of 18 F (40-50 GBq) Higher specific activity 32

33 Further reading Radiopharmaceuticals for Positron Emission Tomography Ed G. Stöcklin and W.W. Pike Kluwer Academic publishers, Dordrecht, 1993, isbn Nuclear Science series: Fluorine-18 Labeling of Radiopharmaceuticals M.R. Kilbourn National Academy Press, Washington, 1990 Handbook of Radiopharmaceuticals : Radiochemistry and applications Ed MJ Welch, CS Redvanly Wiley, Sussex, 2003, isbn

Bert Windhorst Radiopharmaceutical scientist VU University Medical Center Amsterdam

Bert Windhorst Radiopharmaceutical scientist VU University Medical Center Amsterdam 18 F Production Bert Windhorst Radiopharmaceutical scientist VU University Medical Center Amsterdam 1 Outline Cyclotron technique 18 F targetry : Fluoride and Fluorine production 2 Main PET Isotopes 11

More information

CYCLONE 18 MOVING AHEAD DELIVERING MORE

CYCLONE 18 MOVING AHEAD DELIVERING MORE CYCLONE MOVING AHEAD DELIVERING MORE www.iba-radiopharmasolutions.com MAXIMIZING YOUR POTENTIAL TO STAY AHEAD OF TIME Based on 7 years of expertise, IBA has always developed innovative features for the

More information

A running centre for radioisotope production: present and future perspectives

A running centre for radioisotope production: present and future perspectives M. Marengo A running centre for radioisotope production: present and future perspectives Medical Physics Department University Hospital S.Orsola Malpighi, Bologna mario.marengo@aosp.bo.it mario.marengo@aosp.bo.it

More information

Production and Decay of Radioisotopes

Production and Decay of Radioisotopes Production and Decay of Radioisotopes A resource for NSW HSC Chemistry and Physics Teachers and Students November 2011 Production and Decay of Radioisotopes This document covers a number of outcomes from

More information

University of Birmingham MC40 Cyclotron. David Parker University of Birmingham

University of Birmingham MC40 Cyclotron. David Parker University of Birmingham University of Birmingham MC40 Cyclotron David Parker University of Birmingham History Uses Problems History of accelerators at Birmingham 60 Nuffield cyclotron (1948-1999) 10MeV p, 40MeV History of accelerators

More information

Bert Windhorst Radiopharmaceutical scientist VU University Medical Center Amsterdam

Bert Windhorst Radiopharmaceutical scientist VU University Medical Center Amsterdam 18 F practical aspects Bert Windhorst Radiopharmaceutical scientist VU University Medical Center Amsterdam 1 Outline Enriched water 18 F Fluoride and Fluorine work up Automation 2 Enriched water H 2 18

More information

The Structure of the Atom

The Structure of the Atom The Structure of the Atom Section 4.1 Early Ideas About Matter In your textbook, read about the philosophers, John Dalton, and defining the atom. For each statement below, write true or false. 1. Ancient

More information

Name Class Date ELECTRONS AND THE STRUCTURE OF ATOMS

Name Class Date ELECTRONS AND THE STRUCTURE OF ATOMS Atomic Structure ELECTRONS AND THE STRUCTURE OF ATOMS 4.1 Defining the Atom Essential Understanding Atoms are the fundamental building blocks of matter. Lesson Summary Early Models of the Atom The scientific

More information

RIA: A new Opportunity for Medical Isotope Research and Production

RIA: A new Opportunity for Medical Isotope Research and Production RIA: A new Opportunity for Medical Isotope Research and Production Jose R. Alonso Fanqing Guo Lawrence Berkeley` National Laboratory J. Alonso 1 Outline Accelerator-based medical isotope production today

More information

M. Marengo. Medical Physics Department University Hospital S.Orsola Malpighi, Bologna

M. Marengo. Medical Physics Department University Hospital S.Orsola Malpighi, Bologna M. Marengo Medical Physics Department University Hospital S.Orsola Malpighi, Bologna mario.marengo@aosp.bo.it Summary PET radiopharmaceuticals production Cyclotron site planning and shielding Cyclotron

More information

Name: KEY Block: Date: Unit 2 Test Review

Name: KEY Block: Date: Unit 2 Test Review Name: KEY Block: Date: Unit 2 Test Review Matter and Atomic Structure Complete the following problems to help prepare you for you Unit 2 Test. You more than likely will want to answer these questions on

More information

Turnkey Solutions for Radiation Protection in PET Laboratories R A D I A T I O N P R O T E C T I O N

Turnkey Solutions for Radiation Protection in PET Laboratories R A D I A T I O N P R O T E C T I O N Turnkey Solutions for Radiation Protection in PET Laboratories R A D I A T I O N P R O T E C T I O N Berthold Technologies has more than 60 years experience in manufacturing radiation protection measuring

More information

Production, quality control and initial imaging studies of [ 82m Rb]RbCl for PET studies

Production, quality control and initial imaging studies of [ 82m Rb]RbCl for PET studies NUKLEONIKA 2006;51(4):209 215 ORIGINAL PAPER Production, quality control and initial imaging studies of [ 82m Rb]RbCl for PET studies Pejman Rowshanfarzad, Amir Reza Jalilian, Mohsen Kiyomarsi, Mahsheed

More information

Medical Physics and Radioactivity

Medical Physics and Radioactivity Medical Physics and Radioactivity Radioactivity Unstable nucleus Electromagnetic wave particle Atoms which emit electromagnetic radiation or a particle by the spontaneous transformation of their nucleus

More information

HIGH CURRENT OPERATION OF THE ACSI TR30 CYCLOTRON

HIGH CURRENT OPERATION OF THE ACSI TR30 CYCLOTRON HIGH CURRENT OPERATION OF THE ACSI TR30 CYCLOTRON 18 th International Conference on Cyclotrons and their Applications, Sicily, 2007 Vasile Sabaiduc, Project Manager, RF Senior Engineer Advanced Cyclotron

More information

Abbreviations: NH 3, N-13 ammonia Normal Biodistribution

Abbreviations: NH 3, N-13 ammonia Normal Biodistribution Radiopharmaceutical Name Radiopharmaceutical Image Normal 13 NH3 Stress / Rest 13 NH 3, 13 N-ammonia, [ 13 N]NH 3 Abbreviations: NH 3, N-13 ammonia Normal Biodistribution Radiopharmaceutical Structure

More information

DEMONSTRATION ACCELERATOR DRIVEN COMPLEX FOR EFFECTIVE INCINERATION OF 99 Tc AND 129 I

DEMONSTRATION ACCELERATOR DRIVEN COMPLEX FOR EFFECTIVE INCINERATION OF 99 Tc AND 129 I DEMONSTRATION ACCELERATOR DRIVEN COMPLEX FOR EFFECTIVE INCINERATION OF 99 Tc AND 129 I A.S. Gerasimov, G.V. Kiselev, L.A. Myrtsymova State Scientific Centre of the Russian Federation Institute of Theoretical

More information

Main properties of atoms and nucleus

Main properties of atoms and nucleus Main properties of atoms and nucleus. Atom Structure.... Structure of Nuclei... 3. Definition of Isotopes... 4. Energy Characteristics of Nuclei... 5. Laws of Radioactive Nuclei Transformation... 3. Atom

More information

Cancer Therapy with Particle Beams

Cancer Therapy with Particle Beams Cancer Therapy with Particle Beams The potential to use high energy particle beams to treat many types of cancer has been known even before their creation. The availability of these treatments has been

More information

RADIOISOTOPES in MEDICINE:

RADIOISOTOPES in MEDICINE: RADIOISOTOPES in MEDICINE: Requirements - Production - Application and future prospectives 4 Isotopes for future Nuclear Medicine Gerd-Jürgen BEYER Prof.Dr.rer.nat.habil.(i.R.) Geneva, Switzerland THIRD

More information

Name Date Class ATOMIC STRUCTURE

Name Date Class ATOMIC STRUCTURE Name Date Class 4 ATOMIC STRUCTURE SECTION 4.1 DEFINING THE ATOM (pages 101 103) This section describes early atomic theories of matter and provides ways to understand the tiny size of individual atoms.

More information

We Need to Expand Medical Isotope Production!

We Need to Expand Medical Isotope Production! INTERVIEW: DR. GUY TURQUET DE BEAUREGARD We Need to Expand Medical Isotope Production! Dr. Turquet de Beauregard, a nuclear physicist with 15 years experience in nuclear medicine, is the vice president

More information

Cyclotron Centre in Poland and 2D thermoluminescence dosimetry

Cyclotron Centre in Poland and 2D thermoluminescence dosimetry Cyclotron Centre in Poland and 2D thermoluminescence dosimetry Jan Gajewski Institute of Nuclear Physics, Kraków, Poland Department of Radiation Dosimetry Nuclear Physics Institute Academy of Science of

More information

EXPERIMENTAL CONDITIONS FOR CROSS SECTION MEASUREMENTS FOR ANALYTICAL PURPOSES. L. Csedreki 1. Abstract. I. Introduction

EXPERIMENTAL CONDITIONS FOR CROSS SECTION MEASUREMENTS FOR ANALYTICAL PURPOSES. L. Csedreki 1. Abstract. I. Introduction ACTA PHYSICA DEBRECINA XLVI, 25 (2012) EXPERIMENTAL CONDITIONS FOR CROSS SECTION MEASUREMENTS FOR ANALYTICAL PURPOSES L. Csedreki 1 1 Institute of Nuclear Research of the Hungarian Academy of Sciences,

More information

ANTEP 2015 Needs from China (NNSA)

ANTEP 2015 Needs from China (NNSA) ANTEP 2015 Needs from China (NNSA) 1 Content of training/education that Decommissioning plan and technologies 2 Background of above need 1. Design life of Qinshan NPP is 30 years, and it has been put into

More information

For convenience, we may consider an atom in two parts: the nucleus and the electrons.

For convenience, we may consider an atom in two parts: the nucleus and the electrons. Atomic structure A. Introduction: In 1808, an English scientist called John Dalton proposed an atomic theory based on experimental findings. (1) Elements are made of extremely small particles called atoms.

More information

PHYA5/1. General Certificate of Education Advanced Level Examination June 2011. Unit 5 Nuclear and Thermal Physics Section A

PHYA5/1. General Certificate of Education Advanced Level Examination June 2011. Unit 5 Nuclear and Thermal Physics Section A Centre Number Surname Candidate Number For Examinerʼs Use Other Names Candidate Signature Examinerʼs Initials General Certificate of Education Advanced Level Examination June 2011 Question 1 2 Mark Physics

More information

Nuclear medicine. Answering your questions

Nuclear medicine. Answering your questions Nuclear medicine Answering your questions ANSTO s OPAL research reactor in Sydney What is nuclear medicine? This is a branch of medicine that uses radiation from radioactive tracers to provide information

More information

Worked solutions to student book questions Chapter 2 A particle view of matter

Worked solutions to student book questions Chapter 2 A particle view of matter Q1. Dalton and Thomson each proposed a model of an atom. a What experimental evidence did Thomson have that was not available to Dalton? b As a result of this experimental evidence, how did Thomson s model

More information

Objectives 404 CHAPTER 9 RADIATION

Objectives 404 CHAPTER 9 RADIATION Objectives Explain the difference between isotopes of the same element. Describe the force that holds nucleons together. Explain the relationship between mass and energy according to Einstein s theory

More information

REVIEW NUCLEAR CHEMISTRY 3/31/16 NAME: PD 3

REVIEW NUCLEAR CHEMISTRY 3/31/16 NAME: PD 3 3/31/16 NAME: PD 3 1. Given the equation representing a nuclear reaction in which X represents a nuclide: Which nuclide is represented by X? 2. Which nuclear emission has the greatest mass and the least

More information

Medical Applications of radiation physics. Riccardo Faccini Universita di Roma La Sapienza

Medical Applications of radiation physics. Riccardo Faccini Universita di Roma La Sapienza Medical Applications of radiation physics Riccardo Faccini Universita di Roma La Sapienza Outlook Introduction to radiation which one? how does it interact with matter? how is it generated? Diagnostics

More information

Seminar 7. Medical application of radioisotopes - radiotherapy

Seminar 7. Medical application of radioisotopes - radiotherapy Seminar 7 Medical application of radioisotopes - radiotherapy Radioisotopes in medical diagnosis. Gamma camera. Radionuclide imaging (PET, SPECT). Radiotherapy. Sources of radiation. Treatment planning.

More information

Quality Assurance Testing of AtomLab Dose Calibrators

Quality Assurance Testing of AtomLab Dose Calibrators (Manufacturer s* Instructions) Introduction The following procedures are the manufacturer s instructions for qualifying AtomLab 100, 100+, 200, 300, 400, and 500 dose calibrators in accordance with NRC

More information

Simulation of Proton Therapy Treatment Verification via PET imaging of Induced Positron-Emitters

Simulation of Proton Therapy Treatment Verification via PET imaging of Induced Positron-Emitters C-A/AP/#122 November 23 Simulation of Proton Therapy Treatment Verification via PET imaging of Induced Positron-Emitters J. Beebe-Wang, P. Vaska, F.A. Dilmanian, S.G. Peggs and D.J. Schlyer "This paper

More information

PET and PET/CT in Clinical Trials

PET and PET/CT in Clinical Trials PET and PET/CT in Clinical Trials Nathan C. Hall, M.D., Ph.D. The Ohio State University Medical Center CALGB Imaging Core Lab CALGB Imaging Committee Outline Introduction to PET Positron Emitter Physics

More information

Radiation Sciences Nuclear Medicine Technology Program Hot Lab Log Book (Material)

Radiation Sciences Nuclear Medicine Technology Program Hot Lab Log Book (Material) Radiation Sciences Nuclear Medicine Technology Program Hot Lab Log Book (Material) Table of Content Receiving a Radioactive Package Constancy Test Daily Survey Weekly Wipes Accuracy Test Linearity Geometric

More information

MATERIALS LICENSE. In accordance with the letter dated January 15, 2009,

MATERIALS LICENSE. In accordance with the letter dated January 15, 2009, NRC FORM 374 U.S. NUCLEAR REGULATORY COMMISSION PAGE 1 OF 5 PAGES Pursuant to the Atomic Energy Act of 1954, as amended, the Energy Reorganization Act of 1974 (Public Law 93-438), and Title 10, Code of

More information

RADIOACTIVE ISOTOPES

RADIOACTIVE ISOTOPES Radioactive Isotopes, their Application in Biomedical Research MODULE 30 RADIOACTIVE ISOTOPES 30.1 INTRODUCTION In the previous chapter we have seen about radioactivity and its types. In this topic we

More information

Atomic and Nuclear Physics Laboratory (Physics 4780)

Atomic and Nuclear Physics Laboratory (Physics 4780) Gamma Ray Spectroscopy Week of September 27, 2010 Atomic and Nuclear Physics Laboratory (Physics 4780) The University of Toledo Instructor: Randy Ellingson Gamma Ray Production: Co 60 60 60 27Co28Ni *

More information

Loma Linda University and Siemens PETNET Solutions, Inc.

Loma Linda University and Siemens PETNET Solutions, Inc. Loma Linda University and Siemens PETNET Solutions, Inc. announce operational state-of-theart PET production and research facility to advance molecular imaging FOR IMMEDIATE RELEASE CONTACT: Susan Onuma

More information

1. Structure and Properties of the Atom

1. Structure and Properties of the Atom SACE Stage 1 Chemistry - The Essentials 1. Structure and Properties of the Atom 1.1 Atoms: A simple definition of the atom is that it is the smallest particle that contains the properties of that element.

More information

Production of X-rays. Radiation Safety Training for Analytical X-Ray Devices Module 9

Production of X-rays. Radiation Safety Training for Analytical X-Ray Devices Module 9 Module 9 This module presents information on what X-rays are and how they are produced. Introduction Module 9, Page 2 X-rays are a type of electromagnetic radiation. Other types of electromagnetic radiation

More information

Modification of Pd-H 2 and Pd-D 2 thin films processed by He-Ne laser

Modification of Pd-H 2 and Pd-D 2 thin films processed by He-Ne laser Modification of Pd-H 2 and Pd-D 2 thin films processed by He-Ne laser V.Nassisi #, G.Caretto #, A. Lorusso #, D.Manno %, L.Famà %, G.Buccolieri %, A.Buccolieri %, U.Mastromatteo* # Laboratory of Applied

More information

Take notes while watching the following video tutorials to prepare for the Atomic Structure and Nuclear Chemistry Activity.

Take notes while watching the following video tutorials to prepare for the Atomic Structure and Nuclear Chemistry Activity. Take notes while watching the following video tutorials to prepare for the Atomic Structure and Nuclear Chemistry Activity. Atomic Structure Introduction dabe page 1 Atoms & Elements Part 0: Atomic Structure

More information

"Activation and Decay of Radioactive Nuclides"

Activation and Decay of Radioactive Nuclides TECHNICAL UNIVERSITY DRESDEN Institute of Power Engineering Training Reactor Reactor Training Course Experiment "Activation and Decay of Radioactive Nuclides" Instruction for Experiment Activation and

More information

SOURCES OF RADIOACTIVITY

SOURCES OF RADIOACTIVITY Section 10: FISSION POWER This section briefly describes the basic principles underlying the development of the fission power reactor, some examples of commercial reactors in use today and issues about

More information

IAEA-TECDOC-1605. A Guide to Clinical PET in Oncology: Improving Clinical Management of Cancer Patients

IAEA-TECDOC-1605. A Guide to Clinical PET in Oncology: Improving Clinical Management of Cancer Patients IAEA-TECDOC-1605 A Guide to Clinical PET in Oncology: Improving Clinical Management of Cancer Patients October 2008 IAEA-TECDOC-1605 A Guide to Clinical PET in Oncology: Improving Clinical Management of

More information

CHEM 103 Spring 2006 Final Exam 5 June 2006

CHEM 103 Spring 2006 Final Exam 5 June 2006 Name CHEM 103 Spring 2006 Final Exam 5 June 2006 Multiple Choice (5 points each) Write the letter of the choice that best completes the statement or answers the question in the blank provided 1. An aqueous

More information

radioactivity: a spontaneous (naturally-occurring) emission of particles or radiation from the nuclei of atoms

radioactivity: a spontaneous (naturally-occurring) emission of particles or radiation from the nuclei of atoms CHAPTER 20: Atomic Structure Nuclear Chemistry radioactivity: a spontaneous (naturally-occurring) emission of particles or radiation from the nuclei of atoms Historical Background Roentgen (1895) discovery

More information

Information Useful When Developing/Updating Shipping Papers and Radioactive Material Transportation Procedures

Information Useful When Developing/Updating Shipping Papers and Radioactive Material Transportation Procedures SHIPPING PAPERS Information Useful When Developing/Updating Shipping Papers and Radioactive Material Transportation Procedures Certain entries are required on shipping papers, bills of lading, declarations

More information

Chemistry 1000 Lecture 2: Nuclear reactions and radiation. Marc R. Roussel

Chemistry 1000 Lecture 2: Nuclear reactions and radiation. Marc R. Roussel Chemistry 1000 Lecture 2: Nuclear reactions and radiation Marc R. Roussel Nuclear reactions Ordinary chemical reactions do not involve the nuclei, so we can balance these reactions by making sure that

More information

Positron Emission Tomography (PET) Detector Development for Plant Biology

Positron Emission Tomography (PET) Detector Development for Plant Biology Positron Emission Tomography (PET) Detector Development for Plant Biology Objectives Develop limited angle PET tomography for application in plant biology research Apply the technology to studying dynamics

More information

Chemistry 106 Fall 2011 Final Exam. JDS Draft with correct answers noted.

Chemistry 106 Fall 2011 Final Exam. JDS Draft with correct answers noted. Chemistry 106 Fall 2011 Final Exam. JDS Draft with correct answers noted. 1 Identify oxidation. A) Increase in oxidation number. B) Loss of electrons. C) Gain of electrons. D) Decrease in oxidation number.

More information

University of Missouri and MU Research Reactor Center

University of Missouri and MU Research Reactor Center University of Missouri and MU Research Reactor Center DOE Isotope Workshop August 2008 University of Missouri Research Reactor Center The MURR Center a Global Resource A 10 MW reactor that operates 24

More information

Tableting Punch Performance Can Be Improved With Precision Coatings

Tableting Punch Performance Can Be Improved With Precision Coatings Tableting Punch Performance Can Be Improved With Precision Coatings by Arnold H. Deutchman, Ph. D. Director of Research and Development (614) 873-4529 X 114 adeutchman@beamalloy.net Mr. Dale C. Natoli

More information

Atomic Structure Practice Test

Atomic Structure Practice Test Atomic Structure Practice Test Multiple Choice Identify the choice that best completes the statement or answers the question. 1. If 6.0 g of element K combine with 17 g of element L, how many grams of

More information

Radioactivity and Balancing Nuclear Reactions: Balancing Nuclear Reactions and Understanding which Particles are Involves

Radioactivity and Balancing Nuclear Reactions: Balancing Nuclear Reactions and Understanding which Particles are Involves 1 General Chemistry II Jasperse Nuclear Chemistry. Extra Practice Problems Radioactivity and Balancing Nuclear Reactions: Balancing Nuclear Reactions and Understanding which Particles are Involved The

More information

Basics of Nuclear Physics and Fission

Basics of Nuclear Physics and Fission Basics of Nuclear Physics and Fission A basic background in nuclear physics for those who want to start at the beginning. Some of the terms used in this factsheet can be found in IEER s on-line glossary.

More information

COST / BENEFIT COMPARISON 45 MEV AND 70 MEV CYCLOTRONS MAY 26, 2005 FOR

COST / BENEFIT COMPARISON 45 MEV AND 70 MEV CYCLOTRONS MAY 26, 2005 FOR COST / BENEFIT COMPARISON FOR 45 MEV AND 70 MEV CYCLOTRONS MAY 26, 2005 Conducted for: Conducted by: U.S. Department of Energy Suite 900, Westfield North Office of Nuclear Energy, Science, and Technology

More information

U.S. D!PARTM!NT OJI!N!RGY OFFICE OF SCIENCE- CHICAGO OFFICE

U.S. D!PARTM!NT OJI!N!RGY OFFICE OF SCIENCE- CHICAGO OFFICE sc.cu ~ g;o.ar.n (1 I!WI Pr.W.W ~.,.on~'- U.S.!PARTM!NT OJI!N!RGY OFFICE OF SCIENCE- CHICAGO OFFICE NATIONAL ENVIRONMENTAL POLICY ACT (NEPAl ENVIRONMENTAl. EVALUATION NOTIFICATION FORM To be completed

More information

K O M A C. Beam Commissioning of 100-MeV KOMAC Linac. Korea Multi-purpose Accelerator Complex 양 성 자 가 속 기 연 구 센 터

K O M A C. Beam Commissioning of 100-MeV KOMAC Linac. Korea Multi-purpose Accelerator Complex 양 성 자 가 속 기 연 구 센 터 LINAC14, Geneva Beam Commissioning of 100-MeV KOMAC Linac Yong-Sub Cho for KOMAC accelerator team September 2, 2014 KOMAC, KAERI 0 Outline KOrea Multi-purpose Accelerator Complex Facility Introduction

More information

Noble Gases. Outline Nobel Gas Elements Radon and Health Chemistry Homework

Noble Gases. Outline Nobel Gas Elements Radon and Health Chemistry Homework Radon and Other Noble Gases The elements in the last column of the periodic table are all very stable, mono-atomic gases. Until 1962, they were called inert gases because they did not react with other

More information

NUCLEAR SERVICES & TECHNOLOGY

NUCLEAR SERVICES & TECHNOLOGY The Most Important Substance You ve Never Heard Of (Probably) The story of Molybdenum-99 Michael Washer, PE, Merrick and Company Martin Biggs, Chief Engineer, Phoenix Engineering NUCLEAR SERVICES & TECHNOLOGY

More information

Radioactivity III: Measurement of Half Life.

Radioactivity III: Measurement of Half Life. PHY 192 Half Life 1 Radioactivity III: Measurement of Half Life. Introduction This experiment will once again use the apparatus of the first experiment, this time to measure radiation intensity as a function

More information

PERSONNEL MONITORING AND DOSIMETRY POLICIES

PERSONNEL MONITORING AND DOSIMETRY POLICIES PERSONNEL MONITORING AND DOSIMETRY POLICIES All individuals who are required to have their exposure to ionizing radiation monitored must be trained prior to using the source(s) of radiation. The radioactive

More information

Nuclear Structure. particle relative charge relative mass proton +1 1 atomic mass unit neutron 0 1 atomic mass unit electron -1 negligible mass

Nuclear Structure. particle relative charge relative mass proton +1 1 atomic mass unit neutron 0 1 atomic mass unit electron -1 negligible mass Protons, neutrons and electrons Nuclear Structure particle relative charge relative mass proton 1 1 atomic mass unit neutron 0 1 atomic mass unit electron -1 negligible mass Protons and neutrons make up

More information

1) NUCLEONS AND ISOTOPES HOMEWORK A) Multiple-Choice Questions: place your answers in the space to the left of each question.

1) NUCLEONS AND ISOTOPES HOMEWORK A) Multiple-Choice Questions: place your answers in the space to the left of each question. Name: 1) NUCLEONS AND ISOTOPES HOMEWORK A) Multiple-Choice Questions: place your answers in the space to the left of each question. 1) One atomic mass unit is defined as weighing a) 1/16 the mass of O-16b)

More information

Section 3.1 Properties of Matter

Section 3.1 Properties of Matter Section 3.1 Properties of Matter In your textbook, read about physical properties and chemical properties of matter. Use each of the terms below just once to complete the passage. chemical mass physical

More information

Atomic Theory and Bonding

Atomic Theory and Bonding Atomic Theory and Bonding Textbook pages 168 183 Section 4.1 Summary Before You Read What do you already know about Bohr diagrams? Record your answer in the lines below. What are atoms? An atom is the

More information

Radiation Detection and Measurement

Radiation Detection and Measurement Radiation Detection and Measurement June 2008 Tom Lewellen Tkldog@u.washington.edu Types of radiation relevant to Nuclear Medicine Particle Symbol Mass (MeV/c 2 ) Charge Electron e-,! - 0.511-1 Positron

More information

Atoms, Ions and Molecules The Building Blocks of Matter

Atoms, Ions and Molecules The Building Blocks of Matter Atoms, Ions and Molecules The Building Blocks of Matter Chapter 2 1 Chapter Outline 2.1 The Rutherford Model of Atomic Structure 2.2 Nuclides and Their Symbols 2.3 Navigating the Periodic Table 2.4 The

More information

2. John Dalton did his research work in which of the following countries? a. France b. Greece c. Russia d. England

2. John Dalton did his research work in which of the following countries? a. France b. Greece c. Russia d. England CHAPTER 3 1. Which combination of individual and contribution is not correct? a. Antoine Lavoisier - clarified confusion over cause of burning b. John Dalton - proposed atomic theory c. Marie Curie - discovered

More information

Chap. 2 Interaction of Radiation with Matter

Chap. 2 Interaction of Radiation with Matter Chap. 2 Interaction of Radiation with Matter Classes of Radiation to consider Electromagnetic Gamma rays Neutrons Nuclear Coulombic Electrons +/- Nuclear Charged Particles Neutrons are special, only interact

More information

Radiation Strip Thickness Measurement Systems

Radiation Strip Thickness Measurement Systems Radiation Strip Thickness Measurement Systems During the past years we have increased our sales of radiometric Vollmer strip thickness measurement systems, i.e. X-ray or isotope gauges, dramatically. Now,

More information

Radioactivity & Particles

Radioactivity & Particles Radioactivity & Particles Introduction... 2 Atomic structure... 2 How are these particles arranged?... 2 Atomic notation... 4 Isotopes... 4 What is radioactivity?... 5 Types of Radiation: alpha, beta and

More information

Homework #8 203-1-1721 Physics 2 for Students of Mechanical Engineering. Part A

Homework #8 203-1-1721 Physics 2 for Students of Mechanical Engineering. Part A Homework #8 203-1-1721 Physics 2 for Students of Mechanical Engineering Part A 1. Four particles follow the paths shown in Fig. 32-33 below as they pass through the magnetic field there. What can one conclude

More information

Electrons in Atoms & Periodic Table Chapter 13 & 14 Assignment & Problem Set

Electrons in Atoms & Periodic Table Chapter 13 & 14 Assignment & Problem Set Electrons in Atoms & Periodic Table Name Warm-Ups (Show your work for credit) Date 1. Date 2. Date 3. Date 4. Date 5. Date 6. Date 7. Date 8. Electrons in Atoms & Periodic Table 2 Study Guide: Things You

More information

The ithemba LABS Radioactive Beam Project. R A Bark

The ithemba LABS Radioactive Beam Project. R A Bark The ithemba LABS Radioactive Beam Project R A Bark Scientific Committee Local Committee Rob Bark Krish Bharuth-Ram Pete Jones Steve Karataglidis Kobus Lawrie Rudzani Nemutudi Rudolf Nchodu Paul Papka Carlos

More information

Radiation Monitoring System DLMon

Radiation Monitoring System DLMon Radiation Monitoring System DLMon Fields of Application: Dose rate monitoring system for use in nuclear medicine Area monitoring ( e.g. manufacturing of radionuclides, laboratories, nuclear power plants,

More information

ATOMIC THEORY. Name Symbol Mass (approx.; kg) Charge

ATOMIC THEORY. Name Symbol Mass (approx.; kg) Charge ATOMIC THEORY The smallest component of an element that uniquely defines the identity of that element is called an atom. Individual atoms are extremely small. It would take about fifty million atoms in

More information

PHYA5/1. General Certificate of Education Advanced Level Examination June 2012. Unit 5 Nuclear and Thermal Physics Section A

PHYA5/1. General Certificate of Education Advanced Level Examination June 2012. Unit 5 Nuclear and Thermal Physics Section A Centre Number Surname Candidate Number For Examinerʼs Use Other Names Candidate Signature Examinerʼs Initials General Certificate of Education Advanced Level Examination June 2012 Question 1 2 Mark Physics

More information

Atomic Theory: The Nuclear Model of the Atom

Atomic Theory: The Nuclear Model of the Atom Chapter 5 Atomic Theory: The Nuclear Model of the Atom Section 5.1 Dalton s Atomic Theory Goal 1 Precursors to John Dalton s atomic theory Law of Definite Composition The percentage by mass of the elements

More information

Case Study: Fission Yield Module and the Oklo Nuclear Geyser

Case Study: Fission Yield Module and the Oklo Nuclear Geyser Radioactivity - Radionuclides - Radiation 8th Multi-Media Training Course with Nuclides.net (Institute Josžef Stefan, Ljubljana, 13 th -15 th September 2006) Thursday, 14 th September 2006 Case Study:

More information

Chapter 4 & 25 Notes Atomic Structure and Nuclear Chemistry Page 1

Chapter 4 & 25 Notes Atomic Structure and Nuclear Chemistry Page 1 Chapter 4 & 25 Notes Atomic Structure and Nuclear Chemistry Page 1 DEFINING THE ATOM Early Models of the Atom In this chapter, we will look into the tiny fundamental particles that make up matter. An atom

More information

Radioactive waste managment in Estonia past, present and future

Radioactive waste managment in Estonia past, present and future Radioactive waste managment in Estonia past, present and future Ivo Tatrik ivo.tatrik@alara.ee Content 1. Status of ALARA 2. Decomission of Paldiski Former Navy Submarine Training Centre 3. Decomission

More information

Chapter 5 TREATMENT MACHINES FOR EXTERNAL BEAM RADIOTHERAPY

Chapter 5 TREATMENT MACHINES FOR EXTERNAL BEAM RADIOTHERAPY Chapter 5 TREATMENT MACHINES FOR EXTERNAL BEAM RADIOTHERAPY E.B. PODGORSAK Department of Medical Physics, McGill University Health Centre, Montreal, Quebec, Canada 5.1. INTRODUCTION Since the inception

More information

MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.

MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 971015 Exam Name MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) Which of the following has the lowest % w/w oxygen composition? A) Al2O3 B) KMnO4

More information

Period 18 Solutions: Consequences of Nuclear Energy Use

Period 18 Solutions: Consequences of Nuclear Energy Use Period 18 Solutions: Consequences of Nuclear Energy Use 12/22/12 As you watch the videos in class today, look for a pro-nuclear or anti-nuclear bias on the part of the video producers, narrators, and interviewers.

More information

Tutorial 4.6 Gamma Spectrum Analysis

Tutorial 4.6 Gamma Spectrum Analysis Tutorial 4.6 Gamma Spectrum Analysis Slide 1. Gamma Spectrum Analysis In this module, we will apply the concepts that were discussed in Tutorial 4.1, Interactions of Radiation with Matter. Slide 2. Learning

More information

Standardized Test Preparation. Chapter 3. Preview. Multiple Choice Short Answer Extended Response

Standardized Test Preparation. Chapter 3. Preview. Multiple Choice Short Answer Extended Response Preview Short Answer Extended Response 1. A chemical compound always has the same elements in the same proportions by mass regardless of the source of the compound. This is a statement of A. the law of

More information

Mars Atmosphere and Volatile EvolutioN (MAVEN) Mission

Mars Atmosphere and Volatile EvolutioN (MAVEN) Mission Mars Atmosphere and Volatile EvolutioN (MAVEN) Mission MAVEN Science Community Workshop December 2, 2012 Particles and Fields Package Solar Energetic Particle Instrument (SEP) Davin Larson and the SEP

More information

Guidance for the Transport of Radioactive Material by Road

Guidance for the Transport of Radioactive Material by Road Safety Office Reviewed: Aug 2013 Safety Office November 2012 Guidance for the Transport of Radioactive Material by Road The transport of radioactive material between different premises, for example between

More information

RESPIRATION AND FERMENTATION: AEROBIC AND ANAEROBIC OXIDATION OF ORGANIC MOLECULES. Bio 171 Week 6

RESPIRATION AND FERMENTATION: AEROBIC AND ANAEROBIC OXIDATION OF ORGANIC MOLECULES. Bio 171 Week 6 RESPIRATION AND FERMENTATION: AEROBIC AND ANAEROBIC OXIDATION OF ORGANIC MOLECULES Bio 171 Week 6 Procedure Label test tubes well, including group name 1) Add solutions listed to small test tubes 2) For

More information

What does DXA mean and why is it important? Principles of operation of DXA systems. How can we measure bone mineral density? What is radiation?

What does DXA mean and why is it important? Principles of operation of DXA systems. How can we measure bone mineral density? What is radiation? What does DXA mean and why is it important? Principles of operation of DXA systems Dr Wil Evans Head of Medical Physics University Hospital of Wales, Cardiff DXA stands for Dual energy X-ray Absorptiometry

More information

Radiation Safety Handbook

Radiation Safety Handbook Northwestern University Radiation Safety Handbook February 2010 Office for Research Safety Office for Research This page is intentionally blank Contents I. Foreword II. General Policies and Procedures

More information

NOTES ON The Structure of the Atom

NOTES ON The Structure of the Atom NOTES ON The Structure of the Atom Chemistry is the study of matter and its properties. Those properties can be explained by examining the atoms that compose the matter. An atom is the smallest particle

More information

Spezifikation für Freigabe / specification for release

Spezifikation für Freigabe / specification for release Artikelnummer / part number : 82550350 Datum / Date : 31.07.06 description : 0805 SMD VARISTOR Lead Free SMD size: 0805 ROHS Compliant A Mechanische Abmessungen / dimensions : SIZE SIZE W L T a 0402 0.5

More information

Radium-223 Therapy: Handling & Radiation Safety Issues

Radium-223 Therapy: Handling & Radiation Safety Issues Nuclear Physics Enterprises Radium-223 Therapy: Handling & Radiation Safety Issues Jeffry A. Siegel, Ph.D. President & CEO 2014 Meeting Mid-Atlantic States Radiation Control Programs Malvern, PA NRC s

More information