New Developments in Urogynecology. Sharon K. Knight, MD Associate Clinical Professor University of California, Department of Ob, Gyn & RS
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1 New Developments in Urogynecology Sharon K. Knight, MD Associate Clinical Professor University of California, Department of Ob, Gyn & RS
2 Presentation Overview Urogynecology Background and New Treatment Options: Overactive Bladder Stress Urinary Incontinence Pelvic Organ Prolapse
3 Overactive Bladder (OAB) Urinary urgency, frequency, nocturia Dry: No incontinence Wet: Urge incontinence Treatment Options: Behavioral-bladder training, diet Physical Therapy/Biofeedback Medications
4 Phamacologic Therapy Ditropan (oxybutinin) Detrol (tolteradine) Ditropan XL Detrol LA Oxytrol patch Vesicare (solefenacin) Enablex (darefenacin) Sanctura (trospium) Sanctura XR
5 Botox Botulinum Toxin Type A MOA: blocks release of acetylcholine at the neuromuscular junction which results in temporary paralysis of the muscle (chemodenervation)
6 Botox U injected into detrusor 2 RCTs in IDO (idiopathic detrusor overactivity) Significant improvement in urgency, frequency and incontinence vs. placebo (50-60% with Botox) Onset 2d-4weeks Duration 1) mean 373d 2)complete sx resolution 44% 4w, 25% 24w Risks 1Brubaker J Urol 2008, 2Sahai J Urol 2007
7 Urgent PC PTNS Percutaneous Posterior Tibial Nerve Stimulation 60% positive response (van Balken)
8 InterStim Sacral Nerve Stimulation INDICATIONS: urge incontinence urgency-frequency urinary retention
9 Stress Incontinence (SUI) Involuntary loss of urine with increased abdominal pressure in the absence of detrusor contraction Treatment Options: PME +/- PT, Biofeedback, E-stim Pessary, Femsoft Surgery
10 Operations for Urinary Incontinence Suburethral Slings: Traditional (1907) Mid-urethral: Retropubic (1995) Transobturator (2001) Mini Slings (2006) Colposuspension (1949/1968)
11 Burch Colposuspension
12 Rectus Fascia Sling
13 From TVT Lithograph;Ethicon
14
15 RCT of Burch vs.. TVT 14 centers in UK 175 TVT, 169 Burch Objective cure rate at 2 years: Burch 51% TVT 63% ~20% in each group lost to f/u: considered failures OR= 1.7 (95%CI: ) Ward. Am J Obstet Gynecol 2004;190:
16 RCT of Burch vs.. TVT Only 20-25% 25% of each group reported no incontinence under any 2 years: More cystocele in TVT group (63 vs.. 39%) More cervical / apical prolapse in Burch group (60 vs.. 29%) Ward. Am J Obstet Gynecol 2004;190:
17 RCT of Burch vs.. TVT: results by center n y w v p u q t r o l m Hilton. BJOG 2002;109: TVT Burch
18 RCT of Burch vs.. TVT: results by surgical volume of center < >30 Hilton. BJOG 2002;109: TVT Burch
19 TVT Complications Vascular injury ~1: 10k Bowel injury ~1: 17k Urethral erosion ~1: 25k Hematoma ~1: 25k Nerve injury ~1:125k % Minor voiding difficulty 7.6 UTI 4.1 Bladder perforation 3.8 Post-op urinary retention 2.3 Retropubic hematoma 2.4 Wound infection 0.8 Mesh exposure 0.7 Kuuva Actya Obstet Gynecol Scand 2002;81:72-7.
20 Transobturator Tape (TOT)
21
22 TOT Complications (MAUDE) 1/04-7/05: 173 complications in 140 reports Erosions (60%)- 1 urethral Infections (15%)- 2 ischiorectal fossa 2 adductor muscle Neuropathy (2%) Excess bleeding (3%) Urethral & Bladder Injury (4%) Boyles. Int Urogynecol J 2007;95:19-22.
23 Review 13 RCTs through Sept TVT, 931 TOT cure rate various time points and definitions: TVT 896/972= 92.2% (95% CI= ) 93.7) TOT 832/931= 89.4% (95% CI= ) OR= 1.40 (95% CI= ) 1.92)
24 TOT: in women with poor urethral function Varying study design VLPP<60 or MUCP < Objective outcome (varies) Normal urethra: 224 cured / 250 total 89.6% (95% CI= ) Poor urethral function: 161/ % (95% CI= ) OR= 4.8 (95% CI= )
25 Ready or Not? TVT-Secur
26 FDA Approval of Surgical Devices Devices unregulated until 1976 (drugs regulated in 1902) Premarket Notification Process: 510k Device does not require premarket approval if shown to be substantially equivalent to an existing device
27 501 K for TVT-Secur Application received by FDA: 11/17/2005 Thanksgiving: 11/24/2005 FDA approval given: 11/28/2005
28 Published Data for TVT-Secur Nearly 3 years since FDA approval.
29 Published Data for TVT-Secur
30 MiniArc
31 POP-Q Stage 0: no prolapse Stage I: >1cm above level of hymen Stage II: <1cm above and < 1cm below hymen Stage III: >1cm below hymen but <TVL-2cm Stage IV: complete protrusion
32 Prolift Pinnacle Apogee Perigee Avaulta
33 Anterior Repair: Synthetic Mesh Hiltunen 2007: randomized to traditional AR or AR with polypropylene graft (n=202) -Recurrence: 38.5% vs. 6% w/graft -Mesh exposure 17.3% -No difference in post-op symptoms Nguyen 2008: randomized to traditional AR or AR with polypropylene graft (n=75) -Recurrence: 45 vs 13% w/graft -Mesh exposure 5%
34 Non-absorbable Synthetic Mesh Complications Reported complications: infection, hemorrhage, dyspareunia, bladder injury, voiding dysfunction, ureteric obstruction, chronic pelvic pain, mesh erosion (bladder/urethra), mesh extrusion (vagina), VVF Overall mesh erosion/extrusion rate: 0-29% Altman 2007: 4.4% serious (10/11 visceral injury); 14.5% minor (UTI,retention, fever)
35 Mesh Complications Case #1 Case #2 59yoP2 TVH,BSO, APR w/prolene mesh 10/06 -postop pain, SUI -12/06 TOT -2/07,4/07 mesh removal -multiple pain meds, trigger point injections -7/08 removal of small amt remaining prolene -persistent pain, considering spinal implant 78yo P APR with mesh; 2001 mesh removed (infection) -3 surgeries for rectovaginal/perineal fistula; persistent FI/purulent discharge colostomy, persistent anal discharge removal of mesh transrectal (obliterated vagina)
36 Sacrocolpopexy Vaginal Vault Prolapse Sacrocolpopexy with Mesh
37 Operating Room Configuration 4 th arm on LEFT side to retract sigmoid laterally Assistant stands to RIGHT side of OR table Role of Assistant -Access and exchange da Vinci instruments -Use conventional laparoscopic instruments for retraction/countertraction, suction/irrigation, introducing suture and mesh, cutting -Uterine/vaginal manipulation Intuitive Surgical
38 Intuitive Surgical da Vinci 5 cm 1 cm
39 Potential Benefits over Traditional Surgery Less postoperative pain Less scarring Less blood loss Fewer transfusions Less risk of infection Faster recovery time Shorter hospital stay Open Sacrocolpopexy Incision da Vinci Sacrocolpopexy Incisions
40 Robotic ASC 2 published studies (30,15 total n=42) Short-term outcomes: 3-6 months n=13: mean POP-Q stage 0 (C-8.28,Ba-2.29) 12 months n=21: 19/20 (95%) successful apical repair at 24mos OR time, Learning curve Complications Elliott 2006, Daneshgari 2007
41 Direct Hospital Based Costs 25, , , , $ 5, Robotic LSC Open 24, , , Patel 2008 AUGS Abstract
42 Robotic ASC: Short Term Outcomes Robotic vs. Open OR Time 328min 225 min Stay 1.3 days 2.7days Fever 4.1% 0% EBL 103ml 255cc No clinical difference in POP-Q outcomes No difference in other secondary outcomes Geller 2008 AUGS Abstract
43 Conclusions OAB: Botox and neuromodulation are promising options in refractory cases Volume and site/surgeon are factors in surgical outcomes New devices/kits: minimal data on complications and long-term outcomes, some data for short-term success
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