Phenomenome Discoveries. Cutting Edge Disease Prevention Research 1
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1 Cutting Edge Disease Prevention Research 1
2 Phenomenome Discoveries Inc. Phenomenome Discoveries Inc (PDI) is a life science company focused on the discovery and development of simple blood chemistry tests for disease. PDI s Mission: Become the world s leading disease prevention company. Key focus products include blood tests for colorectal cancer (CRC), ovarian cancer, prostate cancer, pancreatic cancer, and Alzheimer s disease (AD). 2
3 CORPORATE BACKGROUND 3 Phenomenome Discoveries
4 Historic Highlights Founding Diagnostic discovery research begins Key biomarkers discovered in 12 major diseases First diagnostic clinical trial begins in CRC First diagnostic patent issues, in Alzheimer s disease CRC trial results announced: 86% sensitivity, 90% specificity CRC rights out-licensed in the US market CRC trial results paper CRC market launch Canada Ag clients secured before doors open 7 of top 10 global pharma companies are contract research clients Patents issue for platform technology in Can & US First outlicensing deal, for CRC screening rights in Can CRC trial concludes SK gov t licenses CRC test for use Advances in validation of pancreatic cancer test IA research collaborations with global Dx companies established in CRC CRC submission for FDA approval 2006 to patent families filed
5 THE SCIENCE 5 Phenomenome Discoveries
6 Our Research Advantage Our discoveries come out of our patented metabolomics research platform. What is metabolomics? Genomics & proteomics study the interaction of genes and proteins in biological systems Very few diseases are the direct result of only genetics, however Metabolomics measures the impact of environment and lifestyle on your genetics and biology This means metabolomics can find biological markers to measure the risk for disease, or to diagnose disease, that take into account the whole biological picture, from genetics to daily living choices. These markers are similar to cholesterol or blood glucose; they can change over time and should be monitored in the same way. 6
7 Our Discoveries Have Biological Stories Behind Them Metabolomics discoveries aren t just markers for disease; they lead us to understand what is going wrong in the underlying biochemistry of disease. Disease Marker Biological Story Colorectal cancer GTA-446 Long chain fatty acids These compounds have anti-cancer and antiinflammatory properties; they are low in people at risk for CRC; they are one of your body s natural cancer-fighting mechanisms, and have never been discovered before. Alzheimer s disease Plasmalogens Membrane lipids These are chemicals produced in your liver that are important parts of every cell membrane in your body; when they are low, they affect how your cells communicate, and this especially effects brain cells; they ve never been measured in blood before. 7
8 PDI Research Approach Samples from clinical populations for discovery Identify diseasespecific metabolic imbalances Build research models to investigate the physiological effects of the imbalance 8
9 Disease Develops Over Time 9
10 PDI s tests identify disease-specific metabolic problems before the onset of clinical symptoms Restoration 10
11 Product Research and Development Workflow Discover Verify Translate Serum Biomarker Tests TARGETED 2 MIN TRIPLE-QUAD CLINICALLY READY Therapeutics FTICR-MS HPLC MSMS QUAD TOF NMR RESTORATION OF ENDOGENOUS COMPOUNDS
12 DIAGNOSTICS RESEARCH AND DEVELOPMENT 12
13 Deaths per 100,000 Phenomenome Discoveries Causes of Death Canada All Cause Circulatory System Disease Cancer Respiratory Diseases Nervous System Diseases Endocrine/Metabolic Unintentional Injuries < >65 AGE (Years) 13
14 Deaths per 100,000 Phenomenome Discoveries Causes of Death Canada All Cause Circulatory System Disease Cancer Respiratory Diseases Nervous System Diseases Endocrine/Metabolic Unintentional Injuries < >65 AGE (Years) Yearly Screening Programs Needed for Early Detection 14
15 What Does This Mean? Age is the most significant risk factor for ALL chronic diseases Age affects all of us differently Aging is a complex process affecting ALL of our biosystems BUT not all systems in all people AND NOT at the same time Accurate monitoring and targeted intervention is the key to disease prevention and healthy longevity PDI s technology reduces the complexity of aging by accurately linking specific metabolic changes with specific diseases 15
16 TRADITIONAL RISK SCREENING TESTS 16 Phenomenome Discoveries
17 Effect of Diabetes on Cardiovascular Disease Risk (Next 10 Years) Lifetime Risk of CVD (Next 10 Years) Relative Risk < 2X 0 Average (50-90) Male Female Diabetic 17
18 Effect of Serum Cholesterol on Lifetime Risk of Coronary Heart Disease Relative Risk < 2X 18
19 Effect of High Blood Pressure on Lifetime Risk of Stroke Lifetime Risk of Stroke Relative Risk < 2X Average Risk High blood pressure (High Risk) Low blood pressure (Low Risk) 19
20 PDI S RISK SCREENING TESTS 20 Phenomenome Discoveries
21 Effect of Serum DHA-PlsEtn Levels (PDI s Alzheimer s Blood Test) 40 On Lifetime Risk Risk of Dementia of (Age Dementia 65) 35 Relative Risk > 8X! Age 65 Average Risk Low Plasmalogen (High Risk) Normal Plasmalogen (Low Risk) Male Female
22 Effect of Low Serum PC-594 Levels (PDI s Pancreatic Cancer Blood Test) on Lifetime Risk of Pancreatic Cancer Relative Risk > 20X! Average Risk Low PC-594 Normal PC
23 Effect of Low Serum GTA Levels (PDI S CRC Blood Test) on Lifetime Risk of Colon Cancer Lifetime Risk of CRC Age Relative Risk > 10X! Average Risk Low CRC-446 (High Risk) Normal CRC-446 (Low Risk) 23
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