WHAT S THE DIFFERENCE? A B12 tablet that is effective at normalizing B12 levels without the need for any accompanying injections

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1 WHAT S THE DIFFERENCE? A B12 tablet that is effective at normalizing B12 levels without the need for any accompanying injections

2 THAT S WHERE ELIGEN B12 IS DIFFERENT Eligen B12 has a special technology that makes sure your body gets the B12 it needs by taking a pill just once a day without the need for any accompanying injections. It s called Eligen Technology, and once it s attached to the B12 molecules in the pills, it: How is Eligen B12 different? It s about absorption In many people with low B12 levels, vitamin B12 supplements aren t enough. If your doctor has recommended other B12 therapies, it could be because your digestive system doesn t absorb the B12 very well through your diet or oral supplements. CARRIES Vitamin B12 through the digestive system TRANSPORTS Vitamin B12 across the lining of the intestine DELIVERS Vitamin B12 into the blood stream 2 Please see page 6 for full Important Safety Information. 3

3 PRESCRIPTION-STRENGTH B12 WITHOUT THE NEEDLE In a clinical study, patients received either Eligen B12 or B12 injections, and both reached normal B12 levels. Why not just take a regular over-the-counter vitamin? If you re one of those people who doesn t absorb vitamin B12 well, over-the-counter vitamin B12 pills are just not going to be enough to bring your B12 up to a normal level. In clinical studies with healthy patients, twice as much of the vitamin B12 in Eligen B12 was absorbed as over-the-counter vitamin B12. Actual size CONVENIENT ONCE-DAILY DOSING Take 1 Eligen B12 tablet once daily on an empty stomach at least 1 hour before a meal, with about a quarter cup of water. Your doctor may decide to adjust this dose after testing your B12 levels. In clinical trials, there were no serious side effects 4 Please see page 6 for full Important Safety Information. 5

4 Indication Eligen B12 TM is indicated for the dietary management of patients who have a diagnosed vitamin B12 deficiency that cannot be managed by a modification of the normal diet alone. This deficiency can be caused by a range of conditions in which there is an impaired capacity to absorb vitamin B12. Important Safety Information You should not take Eligen B12 TM if you are allergic to vitamin B12, cobalt, or any ingredient of Eligen B12 TM. You should not take Eligen B12 TM if you have Leber s disease, which your doctor may refer to as heredity optic nerve atrophy. Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber s disease. Before using Eligen B12 TM, tell your doctor or pharmacist if you: Are or may be allergic to cyanocobalamin (vitamin B12) or cobalt Have an iron or folic acid deficiency Have kidney or liver disease Have low potassium blood levels (hypokalemia) or gout Have a blood disorder called polycythemia vera Have an eye disease called heredity optic nerve atrophy (Leber s disease) Are receiving any medication or treatment that affects bone marrow Have other vitamin/mineral deficiencies (especially folic acid and iron) Get emergency medical help if you have any of these signs of a serious reaction: muscle cramps, weakness or irregular heartbeat, hives, difficulty breathing, swelling of your face, lips, tongue or throat. Call your doctor at once if you have a serious side effect, such as feeling short of breath, even with mild exertion, sudden vision changes or slurred speech. Less serious side effects may include diarrhea, itching or rash. Before using Eligen B12 TM tell your doctor or pharmacist all of the medicines you are taking, especially methotrexate, pyrimethamine, any antibiotics, and any vitamins. You are encouraged to report negative side effects of medical foods to the FDA. Visit or call FDA

5 Priced with you in mind PLUS: YOU COULD BE SAVING Pay no more than $ 45 per prescription* Eligible patients could pay no more than $45 per month on their prescription for Eligen B12. Visit EligenB12.com/patient to learn more. *Eligibility Requirements: Eligible patients pay no more than $45 for each 30-day prescription. Maximum benefits may apply. Offer is limited to 1 prescription fill per month. Keep this coupon, which can be used for additional refills. This coupon is not valid for prescription costs that are reimbursed entirely by your insurance plan or if your prescriptions are purchased under any federal or state healthcare program (including, but not limited to Medicare, Medicaid, Medigap, VA, DOD, or TriCare) or any federal or state patient assistance program. Offer not valid for persons under 18 years of age. Offer not valid in the State of Vermont. This offer cannot be combined with any other promotional offer. Emisphere Technologies reserves the right to rescind, revoke or amend this offer without notice, at any time. Offer good only in the USA and Puerto Rico and void where prohibited or otherwise restricted by law. No cash value Emisphere Technologies All Rights Reserved 4 Becker Farm Road, Suite 103 Roseland NJ February 2015 ELB017

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