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1 Definition Essential tremor is a disorder of the nervous system that causes a rhythmic shaking. Essential tremor can affect almost any part of your body, but the trembling occurs most often in your hands especially when you try to do simple tasks, such as drinking from a glass, tying shoelaces, writing or shaving. Essential tremor also may affect your head, voice, arms or legs. Although usually not a dangerous condition, essential tremor worsens over time and can be severe in some people. It isn't caused by other diseases, although it's sometimes confused with Parkinson's disease. Essential tremor can occur at any age but is most common in older adults. Symptoms Essential tremor signs and symptoms: Begin gradually Worsen with movement Usually occur in the hands first, affecting one hand or both hands Can include a "yes-yes" or "no-no" motion of the head Are aggravated by emotional stress, fatigue, caffeine or extremes of temperature Essential tremor vs. Parkinson's disease Many people associate tremors with Parkinson's disease, but the two conditions differ in key ways: When tremors occur. Essential tremor of the hands typically occurs when you use your hands. Tremors from Parkinson's are most prominent when your hands are at your sides or resting in your lap. Associated conditions. Essential tremor doesn't cause other health problems, whereas Parkinson's is associated with a stooped posture, slow movement and a shuffling gait. However, people with essential tremor may sometimes develop other neurological signs and symptoms such as an unsteady gait (ataxia). Parts of body affected. Essential tremor can involve your hands, head, voice and legs. Tremors from Parkinson's typically affect your hands but not your head or voice.

2 Causes About half of essential tremor cases appear to occur because of a genetic mutation. This is referred to as familial tremor. What causes essential tremor in people without a known genetic mutation isn't clear. Risk factors There are two known risk factors for essential tremor: Genetic mutation. The inherited variety of essential tremor is an autosomal dominant disorder, which means that a defective gene from just one parent is needed to pass on the condition. If you have a parent with a genetic mutation for essential tremor, you have a 50 percent chance of developing the disorder yourself. Age. Essential tremor is more common in middle age and older. Complications Essential tremor is not life-threatening, but symptoms often worsen over time. If the tremors become severe, you may find it difficult to: Hold a cup or glass without spilling Eat normally Put on makeup or shave Talk, if your voice box or tongue is affected Write handwriting may become increasingly large, shaky and illegible Tests and diagnosis There is no specific test for essential tremor. Determining the diagnosis includes ruling out other conditions that could be causing your symptoms which may require the following: Neurological exam: surveys your nervous system functioning, including checking your: Tendon reflexes Muscle strength and tone Ability to feel certain sensations Posture and coordination Gait Laboratory tests: Your blood and urine may be tested for problems such as: Thyroid disease Drug side effects

3 Tests and diagnosis There is no specific test for essential tremor. Determining the diagnosis is often a matter of ruling out other conditions that could be causing your symptoms. To do this, your doctor may suggest the following: Neurological exam: surveys your nervous system functioning, including checking your: Tendon reflexes Muscle strength and tone Ability to feel certain sensations Posture and coordination Gait Laboratory tests: Your blood and urine may be tested for problems such as: Thyroid disease Drug side effects Some people with essential tremor may not require treatment if their symptoms are mild. But if your essential tremor is making it difficult to work or perform daily activities, you may want to discuss treatment options with your doctor. Medications Beta blockers. Normally used to treat high blood pressure, beta blockers such as propranolol (Inderal), atenolol, metoprolol and nadolol help relieve tremors in some people. They may not be an option if you also have asthma, diabetes or certain heart problems. Anti-seizure medications. Epilepsy drugs including primidone (Mysoline), gabapentin (Neurontin) and topiramate (Topamax) may be effective in people who don't respond to beta blockers. The main side effects are drowsiness and flu-like symptoms, which usually disappear within a short time. Tranquilizers. Doctors sometimes use drugs such as diazepam (Valium) and alprazolam (Xanax) to treat people whose tremors are made much worse by tension or anxiety. Side effects can include confusion and memory loss. Additionally, these medications should be used with caution because they can be habit-forming. OnabotulinumtoxinA (Botox) injections. You're probably familiar with Botox as a treatment for facial wrinkles, but it can also be useful in treating some types of tremors, especially of the head and voice. Botox injections can improve problems for up to three months at a time. But if it's used to treat hand tremors, it can sometimes cause weakness in your fingers.

4 Therapy Physical therapy exercises can sometimes reduce tremor and improve coordination and muscle control. Occupational therapists may suggest some of the following adaptive devices to reduce the effect of your tremors on your daily activities: Heavier plates, glasses and utensils Wrist weights Wider writing implements Surgery Surgery may be an option for people whose tremors are severely disabling and who don't respond to medications. The type of surgery performed is known as deep brain stimulation. Deep brain stimulation involves inserting a long, thin electrical probe into your thalamus the portion of your brain responsible for causing your tremors. A wire from the probe is tunneled under your skin to your chest, where a pacemaker-like device has been inserted. This device transmits painless electrical pulses to interrupt signals from your thalamus that may be causing your tremors. Side effects of surgery may include problems with motor control or speech, problems with balance and temporary or permanent cognitive impairment, such as learning difficulties, or problems with your vision. Deep brain stimulation, however, is very effective for severe essential tremor, and these side effects are rare. Lifestyle and home remedies The following suggestions can sometimes help reduce or relieve tremors: Avoid caffeine. Caffeine can cause your body to produce more adrenaline, which may make your tremors worse. Avoid other stimulants as well. Use alcohol sparingly. Some people notice that their tremors improve slightly after they drink alcohol, but drinking isn't a good solution for people with essential tremor. That's because tremors tend to worsen once the effects of alcohol wear off. What's more, larger amounts of alcohol eventually are needed to relieve tremors, which can lead to chronic alcoholism. If you have essential tremor, it's best to drink sparingly or not at all. Learn to relax. Stress tends to worsen tremors and a relaxed state often improves them. Although it's not possible to eliminate all stress from your life, you can change how you react to stressful situations using a range of relaxation techniques. Many people also find that physical exercise walking, jogging, swimming or biking is a great stress reliever. Rest well. Fatigue can exacerbate tremors. Try to get at least seven hours of sound sleep every night. If you have trouble falling asleep, wake up repeatedly, or awaken early and can't go back to sleep, talk to your doctor.

5 Alternative medicine Although there have been no scientific studies to confirm their benefit in those with essential tremor, the following treatments may be helpful: Acupuncture. This treatment involves inserting extremely thin needles in your skin at strategic points on your body. It's used for symptomatic relief of a variety of conditions. Hypnosis. This involves being put into a trance-like state in which you have heightened focus and concentration. Hypnosis is designed to help you gain control over certain behaviors or to cope with a range of medical conditions. Massage. This involves manipulating your muscles, tendons and ligaments to help you relieve stress. Biofeedback. This technique uses electrical sensors to help you learn to use your mind to control bodily functions. Coping and support For many people, essential tremor can have serious social and psychological consequences. If the effects of essential tremor are making it hard to live your life as fully as you once did, consider joining a support group for people with the disorder. Support groups aren't for everyone, but you may find it helpful to have the encouragement of people who understand what you're going through. Or you might want to consider seeing a counselor or social worker who can help you meet the challenges of living with essential tremor. DS00367 Aug. 12, Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

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