YOUR LOGO. Tissue Adhesive. Welcome. to the. wound closure.

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1 Tissue Adhesive Welcome to the art of wound closure.

2 Quick. Effective. Safe. INDERMIL is a synthetic tissue adhesive that closes wounds painlessly within seconds, leaving minimal scarring. It reduces treatment time and may eliminate the need for anaesthetic injections, sutures or staples, resulting in less trauma for your patients. As long as the adhesive film remains intact, INDERMIL also seals the wound against microbial penetration*. The new product family enhances the innate advantages of the premium tissue adhesive INDERMIL by bringing it together with innovative application concepts concepts specifically developed to meet the needs of your practice. A new generation of Tissue Adhesives. Minimize with Indermil Minimize pain & anxiety Usually no anaesthetic injections May eliminate the need for needles, sutures or staples Wound closure is quick and less painful than suturing No need for return visit to remove sutures or staples Minimize scarring After application After three months No invasive skin punctures Causes no discoloration of the wound site Minimize treatment time Clean strong bond in seconds, reducing time required for treatment One ampoule allows closure of multiple lacerations on the same patient Usually no further treatment required

3 Maximize with Indermil Maximize safety Sterile product, ideal for operating theatre No risk of needle-stick injury Seals against microbial penetration* * The microbial barrier properties of INDERMIL were demonstrated by in-vitro studies and are dependent on the adhesive film remaining intact. Maximize efficiency Easy to use Usually no patient rescheduling Aids in haemostasis

4 The new product family INDERMIL tissue adhesive is supplied in plastic ampoules for single patient use. The ampoules are individually sealed into pouches, ensuring that the exterior of the ampoule is also sterile. Simple & quick Open outer foil pouch. Remove contents. 12 pouches, each containing one 0.5g INDERMIL ampoule fast, safe and effective treatment of topical incisions and lacerations less pain and anxiety for the patient protection against microbial penetration* INDERMIL regular: 0.5g ampoule 10 pouches, each containing one 0.35g INDERMIL ampoule ideal solution for small wounds requiring little adhesive minimizes wastage of adhesive INDERMIL xsmall: 0.35g ampoule 10 pouches, each containing one 0.5g INDERMIL ampoule plus a soft bristle silicone flow control applicator optimized flow control through soft silicone applicator improved safety through elimination of runs and drips even and accurate application INDERMIL xcontrol: 0.5g ampoule and silicone applicator for optimal control of the adhesive flow 10 pouches, each containing one 0.5g INDERMIL ampoule plus a fine tip precision cannula precise dosage and application greater reach and better visibility for hard-to-reach areas such as the hairy scalp more convenient treatment of small wounds and zig zag wounds INDERMIL xfine: 0.5g ampoule and fine tip precision cannula for precise dosage and application * The microbial barrier properties of INDERMIL were demonstrated by in-vitro studies and are dependent on the adhesive film remaining intact.

5 application** Flick a finger against the ampoule to ready the contents. Carefully twist off cap and open ampoule. Affix applicator to ampoule tip. INDERMIL is now ready to use. Hold edges of wound together. Apply INDERMIL sparingly along the length of the wound site. Turn cap around and close ampoule. Ampoule can be re-used with same patient. INDERMIL ampoule without applicator INDERMIL regular INDERMIL xsmall ampoule without applicator INDERMIL xsmall Affixing INDERMIL xcontrol soft bristle silicone flow control applicator INDERMIL ampoule with xcontrol applicator INDERMIL xcontrol INDERMIL xcontrol applicator has to be removed before closing the ampoule. Affixing INDERMIL xfine fine tip precision cannula INDERMIL ampoule with xfine precision cannula INDERMIL xfine INDERMIL xfine precision cannula has to be removed before closing the ampoule. **For additional product information, warnings, precautions and contra-indications, refer to the instructions for use leaflet supplied with the product.

6 Tissue Adhesive less pain clean bond Tissue Adhesive MUSTER-FIRMA Iureminisse Road Sedioeuiscin Ersectefaccumm ildelendreetlorperam Tel.: Fax: dit in henibh exercil incil Product Ordering Information Product Description Product Reference No Unit of Sale INDERMIL Tissue Adhesive XXXYYY 0.5 g x 12 INDERMIL xsmall Tissue Adhesive XXXYYY 0.35 g x 10 INDERMIL xcontrol Tissue Adhesive XXXYYY 0.5 g x 10 INDERMIL xfine Tissue Adhesive XXXYYY 0.5 g x 10 References: The following References refer to INDERMIL and the procedure for its use in wound closure. Certificate young Boy Certificate young Girl 1. The Tissue Adhesive Indermil and its use in Surgery. Roberts AC, Acta Chirurgiae Plasticae 1998, 40 (1): A Single Blind, Prospective, Randomised Trial Comparing n-butyl 2-cyanoacrylate Tissue Adhesive (Indermil) and Sutures for Skin Closure in Hand Surgery. Sinha S, Naik M, Wright V, Timmons J, Campbell AC, Journal of Hand Surgery (Br) 2001, 26 (3): Use of Indermil Tissue Adhesive for Closure of Superficial Skin Lacerations in Children. Schonauer F, Pereira J, La Rusca I, Harris J, Cullen K, Minerva Chirurgica 2001, 56: Treating the Child with Minor Scalp Wounds. Eckersley E, Emergency Nurse 1998, 6, No.5 5. Which Tissue Adhesive for Wounds? Doraiswamy NV, Baig H, Hammett S, Hutton M, Injury 2003, 34 (8): Evaluation of Long-term Outcome of Wounds Closed with Indermil Adhesive. Jaibaji M, Liddington M, Geary P, Darcy C, Batchelor AG, Roberts AC, Eur J Plast Surg 2000, 23: n-butyl cyanoacrylate Adhesive for Skin Closure of Abdominal Wounds: Preliminary Results. Qureshi A, Roberts AC, Monson JRT, Drew PJ, Duthie GS, Ann R Coll Surg Engl 1997, 79: Preliminary Experience with Twenty Perineal Repairs using Indermil Tissue Adhesive. Rogerson L, Mason GC, Roberts AC, Eur J Obstet Gynecol and Reprod Biol 2000, 88: The Use of Indermil (n-butyl cyanoacrylate) in Otorhinolaryngology and Head and Neck Surgery. A Preliminary Report on the First 33 Patients. Samual PR, Roberts AC, Nigam A, Journal of Laryngology and Otology 1997, III: Does Indermil Glue Improve Success Rates in Myringoplasty? Interim Analysis of a Prospective Trial. England RJ, Roberts AC, Raines CH, Rev. Laryngol Otol Rhinol Bord 2000, 121 (2): 91-3 INDERMIL is a Registered Trademark of Henkel Corporation Certificate Boy INDERMIL Sticker young Boy + young Girl INDERMIL Sticker Boy + Girl INDERMIL Presentation Welcome to thear t of wound Product Support Ordering Information Certificate Girl INDERMIL Patient Advice Sheet Product Description Product Reference No Unit of Sale Certificate young Boy XXXYYY xxx Certificate young Girl XXXYYY xxx Certificate Boy XXXYYY xxx Certificate Girl XXXYYY xxx INDERMIL Sticker young Girl + Boy XXXYYY xxx INDERMIL Sticker Girl + Boy XXXYYY xxx INDERMIL Presentation XXXYYY xxx INDERMIL Patient Advice Sheet XXXYYY xxx of Welcome to thea a r t wound

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