Click to edit Master title style

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Click to edit Master title style"

Transcription

1 O ral Cancer - so much research, Click to edit Master title style so little progress-why? Click to edit Master text styles Second Level Christopher Squier Third Level Department of O ral Pathology Fourth Level University of Iowa, Iowa City, USA Fifth Level

2 What are we going to talk about? Oro-pharyngeal cancer Epidemiology how much of it is there? Etiology what causes it? Diagnosis and screening how good are we at finding it? What has research contributed The future what is to be done?

3 Oral and Pharyngeal cancer: world-wide epidemiology The eighth most frequent cancer world-wide Accounts for almost 6% of all cancers 400, 000 new cases each year, representing 5% of all cancer deaths Warnakulasuriya, S Global epidemiology of oral and oropharyngeal cancer O ral Oncology 45 (2009)

4 O ro-pharyngeal cancer in Europe (men): top twenty countries *

5 What are the trends? Unfortunately, upwards in the C E E C! Hungary Ukraine 15 Romania Poland 10 Bulgaria M ale mortality rates I A R C, UK USA

6 O ral and Pharyngeal cancer -survival Five year survival rate has improved only marginally over the past 40 years, and averages about 50%. Survival rates range from 80% for individuals diagnosed with Stage 1 lesions to only 15% with those presenting with Stage 4 disease Warnakulasuriya, S Global epidemiology of oral and oropharyngeal cancer Oral Oncology 45 (2009)

7 Etiology we know what causes oral cancer Tobacco Alcohol Micro-organisms (HPV) Age Nutrition Previous oral carcinoma Genetic susceptibility

8 Tobacco -Cigarettes Relative risk of oral cancer cigarettes per day cigarettes per day cigarettes per day 5.0

9 Prevalence of smoking in Europe * Prevalence (%) Tendency to higher rates in C E E C 5 0 * The Tobacco Atlas, 2006

10 Alcohol Relative risk of oral cancer and alcohol consumption Minimal consumption 1.0 Less than 6 drinks*/day drinks/day or more drinks/day oz of wine or 12oz of beer

11 Per capita alcohol consumption (litres) among adults (WHO data; 2003) No clear distinctions between western Europe and the CEEC

12 Synergy between tobacco and alcohol in the etiology of oral cancer A multiplicative effect such that the combined relative risk far exceeds that of the sum of the individual risks for tobacco use or alcohol use alone Relative Risk Heavy drinking (10+ drinks a day) Heavy smoking (40+ cigarettes a day) Heavy drinking and smoking

13 Diagnosis -How do we recognise oral cancer? A major problem in diagnosing oral cancer is that the small lesion which is most easily treated is generally asymptomatic and therefore the patient is unaware of its presence.

14 Diagnosis -How do we recognize oral cancer? But symptoms are not necessarily related to the until advanced in size M. McGurk, C. Chan, J. Jones, E. and M. Sherriff. Br. J. Oral and Maxillofacial Surgery, 43, , 2005 Rindum and Pindborg* have reported that 15% of asymptomatic tumors were greater than 4cm in size * Tandlaegebladet, 93, , 1989

15 Diagnosis -how do we recognize oral cancer? Diagnostic delay time between onset of a symptom and a definitive diagnosis 80% of delay is due to the patient - even when the patient does recognize a change, there is on average a delay of more than three months before they seek professional advice (Silverman, 1998).

16 Diagnosis -how do we recognize oral cancer? What about routine screening? -Given the overall low frequency (7 cases per 100,000 individuals per year in Europe) and the difficulty of detecting the asymptomatic lesion, this is not likely to be effective (M. McGurk and S. E. Scott. The reality of identifying early oral cancer in the general dental practice. British Dental J ,2010) Rather, we should focus on screening high risk individuals

17 O ral and Pharyngeal cancer so much research! In 2009, the National Institute of Dental and Craniofacial Research (USA) devoted over 10% of its budget ($40 million) to oral and pharyngeal cancer research. In there were over 3600 citations in Pubmed to oro-pharyngeal cancer U.S. National Library of Medicine National Institutes of Health

18 What has research contributed? Oral cance represents disruption of a number of genetic or epigenetic events involving changes in up to 100 genes* These changes affect, among others: Cell division, cell adhesion and cell migration (oncogenes and cytokines) Control of cell death (apoptosis tumor suppressor genes) Growth of blood vessels (angiogenesis) Extra-cellular matrix degradation (metalloproteinases) * Scully, C and Bagan, JV. Oral Squamous Cell Carcinoma. Oral Diseases, 15, (2009)

19 What has research contributed? Diagnosis and prognosis at the molecular level molecular markers* Non invasive -use of rinses/swabs to collect DNA from exfoliated buccal cells Use of techniques such as microarrays and the polymerase chain reaction (PCR) that have sensitivities 500x that of histopathology *Ha, PH et al; Molecular techniques and genetic alterations in head and neck cancer. Oral Oncology, 45, , 2009 Gold, KA and Kim ES; Role of molecular markers and gene profiling in head and neck cancers. Curr Opin Oncol. 21, (2009) Zheng, M; Biomarkers in tongue cancer. Postgraduate Med J., 86, ,2010

20 What has research contributed? Examples of diagnosis and prognosis at the molecular level Tumor suppressor genes The p53 gene is mutated in 20-80% of head and neck cancers Changes in the gene and protein may serve as a detection marker and a predictor of poor response to radiotherapy (Koch, Curr Oncol Rep, 1, 129,1999)

21 What has research contributed? Examples of diagnosis and prognosis at the molecular level Cytokines Epidermal growth factor and its receptor (EGFR) is activated and induces cell proliferation and blocks apoptosis during carcinogenesis - Cetuximab is a monoclonal against EGFR that prolongs survival in advanced and metastatic disease* * Vermorken, JB et al. Platinum based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 359, , 2008.

22 What has research contributed? Examples of diagnosis and prognosis at the molecular level Markers of Angiogenesis Vascular endothelial growth factors (VEGF) increase with progression from a premalignant to an invasive lesion* *Koch, Curr Oncol Rep, 1, 129,1999

23 What has research contributed? Examples of diagnosis and prognosis at the molecular level However, few biomarkers presently exist that are: Reliable Convenient Economical This makes them impractical for large scale screening!

24 Diagnosis and Detection what is to be done? Screening of high risk individuals M. McGurk and S. E. Scott. The reality of identifying early oral cancer in the general dental practice. British Dental J ,2010

25 Diagnosis and Detection what is to be done? The importance of the dental health professional awareness of patients habits such as tobacco and alcohol use education of patients about tobacco and alcohol use early detection of oral disease by identifying high risk patients and screening for mucosal alterations

26 Questions? College of Dentistry, University of Iowa, Iowa City

Diagnosis and Treatment of Common Oral Lesions Causing Pain

Diagnosis and Treatment of Common Oral Lesions Causing Pain Diagnosis and Treatment of Common Oral Lesions Causing Pain John D. McDowell, DDS, MS University of Colorado School of Dentistry Chair, Oral Diagnosis, Medicine and Radiology Director, Oral Medicine and

More information

Lung cancer is not just one disease. There are two main types of lung cancer:

Lung cancer is not just one disease. There are two main types of lung cancer: 1. What is lung cancer? 2. How common is lung cancer? 3. What are the risk factors for lung cancer? 4. What are the signs and symptoms of lung cancer? 5. How is lung cancer diagnosed? 6. What are the available

More information

Developments in Biomarker Identification and Validation for Lung Cancer

Developments in Biomarker Identification and Validation for Lung Cancer Developments in Biomarker Identification and Validation for Lung Cancer Alexandre Passioukov, MD, PhD Alexandre.Passioukov@eortc.be Contents Introduction Lung cancer pathogenesis NSCLC treatment options

More information

NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA)

NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA) NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA) Merat Esfahani, MD Medical Oncologist, Hematologist Cancer Liaison Physician SwedishAmerican Regional Cancer Center

More information

Department of BioScience Technology Chung Yuan Christian University 2015/08/13

Department of BioScience Technology Chung Yuan Christian University 2015/08/13 Department of BioScience Technology Chung Yuan Christian University 2015/08/13 Cancer Cells Cancer, the 1st leading cause of death, is an example of a disease that arises from abnormalities in cell function

More information

Guideline Development The American Society of Clinical Oncology

Guideline Development The American Society of Clinical Oncology Assessing Genomic Sequencing Information for Health Care Decision Making Decision Making Once Evidence is Assessed/Graded Evaluated Guideline Development The American Society of Clinical Oncology Gary

More information

The following information is only meant for people who have been diagnosed with advanced non-small cell

The following information is only meant for people who have been diagnosed with advanced non-small cell Important information for people with advanced non-small cell lung cancer The following information is only meant for people who have been diagnosed with advanced non-small cell lung cancer (NSCLC). NSCLC

More information

Human Papillomavirus Infection and Oropharyngeal Cancer

Human Papillomavirus Infection and Oropharyngeal Cancer Human Papillomavirus Infection and Oropharyngeal Cancer Robert I. Haddad, MD Introduction Squamous cell carcinoma of the head and neck (SCCHN), which affects close to 40,000 individuals each year in the

More information

Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022

Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022 Brochure More information from http://www.researchandmarkets.com/reports/2228475/ Avastin (Renal Cell Carcinoma) - Analysis and Forecasts to 2022 Description: Avastin (Renal Cell Carcinoma) Analysis and

More information

New Insights into Merkel Cell Carcinoma

New Insights into Merkel Cell Carcinoma New Insights into Merkel Cell Carcinoma Bruce R. Smoller, MD Professor and Chair, Department of Pathology Professor, Department of Dermatology University of Arkansas for Medical Sciences Merkel cell carcinoma

More information

What is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function:

What is Cancer? Cancer is a genetic disease: Cancer typically involves a change in gene expression/function: Cancer is a genetic disease: Inherited cancer Sporadic cancer What is Cancer? Cancer typically involves a change in gene expression/function: Qualitative change Quantitative change Any cancer causing genetic

More information

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials)

ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) 3 Integrated Trials Testing Targeted Therapy in Early Stage Lung Cancer Part of NCI s Precision Medicine Effort in

More information

Targeted Therapy What the Surgeon Needs to Know

Targeted Therapy What the Surgeon Needs to Know Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures

More information

Non-Small Cell Lung Cancer Therapies

Non-Small Cell Lung Cancer Therapies Non-Small Cell Lung Cancer Therapies Guest Expert: Roy, MD, PhD Assistant Professor of Therapeutic Radiology Scott, MD Assistant Professor of Medical Oncology www.wnpr.org www.yalecancercenter.org Welcome

More information

Report series: General cancer information

Report series: General cancer information Fighting cancer with information Report series: General cancer information Eastern Cancer Registration and Information Centre ECRIC report series: General cancer information Cancer is a general term for

More information

Cancer patients waiting for potentially live-saving treatments in UK

Cancer patients waiting for potentially live-saving treatments in UK Cancer patients waiting for potentially live-saving treatments in UK 29 May 2005 UK patients are waiting too long for new treatments, according to a 'Dossier of Delay' compiled by information charity CancerBACUP.

More information

REPORT PERSPECTIVES IN LUNG CANCER 2010 AMSTERDAM

REPORT PERSPECTIVES IN LUNG CANCER 2010 AMSTERDAM REPORT PERSPECTIVES IN LUNG CANCER 2010 AMSTERDAM Valerie Van Damme, Isabelle Wauters, Johan Vansteenkiste Univ. Hospital Leuven and Leuven Lung Cancer Group Introduction Perspectives in Lung Cancer (PILC)

More information

Breast cancer. A guide for journalists on breast cancer and its treatment

Breast cancer. A guide for journalists on breast cancer and its treatment Breast cancer A guide for journalists on breast cancer and its treatment Contents Contents 2 3 Section 1: Breast Cancer 4 i. What is breast cancer? 4 ii. Types of breast cancer 4 iii. Causes and risk factors

More information

Introduction to Pathology and Diagnostic Medicine

Introduction to Pathology and Diagnostic Medicine Harvard-MIT Division of Health Sciences and Technology HST.035: Principle and Practice of Human Pathology Dr. Badizadegan Introduction to Pathology and Diagnostic Medicine Spring 2003 What is pathology?

More information

Genomic Medicine The Future of Cancer Care. Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America

Genomic Medicine The Future of Cancer Care. Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America Genomic Medicine The Future of Cancer Care Shayma Master Kazmi, M.D. Medical Oncology/Hematology Cancer Treatment Centers of America Personalized Medicine Personalized health care is a broad term for interventions

More information

targeted therapy a guide for the patient

targeted therapy a guide for the patient targeted therapy FOR LUNG CANCER a guide for the patient TABLE OF CONTENTS lung cancer basics... 2-3 Gene changes... 4-5 Testing... 7-8 Targeted therapy... 9-11 Drugs Targeting EGFR... 12 Drugs Targeting

More information

Individualizing Your Lung Cancer Care: Informing Decisions Through Biomarker Testing

Individualizing Your Lung Cancer Care: Informing Decisions Through Biomarker Testing Individualizing Your Lung Cancer Care: Informing Decisions Through Biomarker Testing These Are Hopeful Times for Lung Cancer Survivors When people first learn they have cancer, they are often afraid. But

More information

Future Oncology: Technology, Products, Market and Service Opportunities

Future Oncology: Technology, Products, Market and Service Opportunities Brochure More information from http://www.researchandmarkets.com/reports/296370/ Future Oncology: Technology, Products, Market and Service Opportunities Description: Future Oncology is an analytical newsletter

More information

Prognostic and Predictive Factors in Oncology. Mustafa Benekli, M.D.

Prognostic and Predictive Factors in Oncology. Mustafa Benekli, M.D. Prognostic and Predictive Factors in Oncology Mustafa Benekli, M.D. NCI Definitions ESMO Course -Essentials of Medical Oncology -Istanbul 2 Prognostic factor: NCI Definition A situation or condition, or

More information

Non Small Cell Lung Cancer: Scientific Discoveries and the Pursuit of Progress

Non Small Cell Lung Cancer: Scientific Discoveries and the Pursuit of Progress Non Small Cell Lung Cancer: Scientific Discoveries and the Pursuit of Progress Lung Cancer Accounts for 14% of All New Cancer Diagnoses in the United States 1 Lung cancer is the second most common malignancy

More information

Avastin in breast cancer: Summary of clinical data

Avastin in breast cancer: Summary of clinical data Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading

More information

Targeted Therapies in Lung Cancer

Targeted Therapies in Lung Cancer Targeted Therapies in Lung Cancer I Edited by: Simona Carnio Thoracic Oncology Division - St Luigi Hospital Orbassano (TO) - Italy Silvia Novello Department of Oncology - University of Torino - Italy Why

More information

GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE

GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE GENETIC PROFILES AND TARGETED TREATMENT OF CANCER - PERSONALIZED MEDICINE Branko Zakotnik MD, PhD Department of Medical Oncology Institute of Oncology Ljubljana 1 I have no conflict of interest to declare

More information

Digital Health: Catapulting Personalised Medicine Forward STRATIFIED MEDICINE

Digital Health: Catapulting Personalised Medicine Forward STRATIFIED MEDICINE Digital Health: Catapulting Personalised Medicine Forward STRATIFIED MEDICINE CRUK Stratified Medicine Initiative Somatic mutation testing for prediction of treatment response in patients with solid tumours:

More information

One out of every two men and one out of every three women will have some type of cancer at some point during their lifetime. 3

One out of every two men and one out of every three women will have some type of cancer at some point during their lifetime. 3 1. What is cancer? 2. What causes cancer?. What causes cancer? 3. Can cancer be prevented? The Facts One out of every two men and one out of every three women will have some type of cancer at some point

More information

Successes and Limitations of Targeted Therapies in Renal Cell Carcinoma

Successes and Limitations of Targeted Therapies in Renal Cell Carcinoma g Tumor Res. Basel, Karger, 2014, vol 41, pp 98 112 (DOI: 10.1159/000355906) Successes and Limitations of Targeted Therapies in Renal Cell Carcinoma Marc Pracht Dominik Berthold Medical Oncology Unit,

More information

The Biological Basis of Cancer. Annie Young, Professor of Nursing, University of Warwick, University Hospitals Coventry and Warwickshire

The Biological Basis of Cancer. Annie Young, Professor of Nursing, University of Warwick, University Hospitals Coventry and Warwickshire The Biological Basis of Cancer Annie Young, Professor of Nursing, University of Warwick, University Hospitals Coventry and Warwickshire Aim of Presentation By the end of this presentation you will: Be

More information

No. prev. doc.: 8770/08 SAN 64 Subject: EMPLOYMENT, SOCIAL POLICY, HEALTH AND CONSUMER AFFAIRS COUNCIL MEETING ON 9 AND 10 JUNE 2008

No. prev. doc.: 8770/08 SAN 64 Subject: EMPLOYMENT, SOCIAL POLICY, HEALTH AND CONSUMER AFFAIRS COUNCIL MEETING ON 9 AND 10 JUNE 2008 COUNCIL OF THE EUROPEAN UNION Brussels, 22 May 2008 9636/08 SAN 87 NOTE from: Committee of Permanent Representatives (Part 1) to: Council No. prev. doc.: 8770/08 SAN 64 Subject: EMPLOYMENT, SOCIAL POLICY,

More information

Understanding series. new. directions. 1-800-298-2436 LungCancerAlliance.org. A guide for the patient

Understanding series. new. directions. 1-800-298-2436 LungCancerAlliance.org. A guide for the patient Understanding series LUNG CANCER: new treatment directions 1-800-298-2436 LungCancerAlliance.org A guide for the patient TABLE OF CONTENTS What s New in lung cancer? Advancements...4 Changes in genes that

More information

Avastin in breast cancer: Summary of clinical data

Avastin in breast cancer: Summary of clinical data Avastin in breast cancer: Summary of clinical data Worldwide, over one million people are diagnosed with breast cancer every year 1. It is the most frequently diagnosed cancer in women 1,2, and the leading

More information

A disease of populations of cells that live, divide, invade and spread without regard to normal limits

A disease of populations of cells that live, divide, invade and spread without regard to normal limits 1 Targeted Cancer Therapies Mark McKeage Medical Oncology Specialist Professor in Clinical Pharmacology 2 Cancer Definition- A disease of populations of cells that live, divide, invade and spread without

More information

A Publication of the National Registry of Diseases Office, Singapore. Trends of Colorectal Cancer in Singapore,

A Publication of the National Registry of Diseases Office, Singapore. Trends of Colorectal Cancer in Singapore, Health Factsheet February 27, 2013, INP-13-1 A Publication of the National Registry of Diseases Office, Singapore Trends of Colorectal Cancer in Singapore, 2007-2011 1. Introduction The large intestine

More information

Update in Hematology Oncology Targeted Therapies. Mark Holguin

Update in Hematology Oncology Targeted Therapies. Mark Holguin Update in Hematology Oncology Targeted Therapies Mark Holguin 25 years ago Why I chose oncology People How to help people with possibly the most difficult thing they may have to deal with Science Turning

More information

Breast and Lung Cancer Biomarker Research at ASCO: Changing Treatment Patterns

Breast and Lung Cancer Biomarker Research at ASCO: Changing Treatment Patterns July 2013 Edition Vol. 7, Issue 7 Breast and Lung Cancer Biomarker Research at ASCO: Changing Treatment Patterns By Julie Katz, MPH, MPhil Biomarkers played a prominent role in the research presented in

More information

Spirometry, COPD and lung cancer

Spirometry, COPD and lung cancer Spirometry, COPD and lung cancer Associate Professor Robert Young BMedSc, MBChB, DPhil (Oxon), FRACP, FRCP University of Auckland, New Zealand Spirometry for those with smoking and dust exposures Risk

More information

Systems for the Provision of Oral Health Care in the Black Sea Countries. Part 7. Hungary

Systems for the Provision of Oral Health Care in the Black Sea Countries. Part 7. Hungary Systems for the Provision of Oral Health Care in the Black Sea Countries. Part 7. Hungary Peter Kivovics 1, Kinga Csado 2 1 D.M.D., B.D.S., M.D.Sc., Ph.D. Associate Professor, Semmelweis University, Department

More information

CHAPTER 2: UNDERSTANDING CANCER

CHAPTER 2: UNDERSTANDING CANCER CHAPTER 2: UNDERSTANDING CANCER INTRODUCTION We are witnessing an era of great discovery in the field of cancer research. New insights into the causes and development of cancer are emerging. These discoveries

More information

Master Online Study Program @dvanced Oncology. Study part time team up internationally!

Master Online Study Program @dvanced Oncology. Study part time team up internationally! Master Online Study Program @dvanced Oncology Study part time team up internationally! Ulm University is developing an innovative international postgraduate study program @dvanced Oncology addressing clinical

More information

JESSE HUANG ( 黄 建 始 ),MD,MHPE,MPH,MBA Professor of Epidemiology Assistant President

JESSE HUANG ( 黄 建 始 ),MD,MHPE,MPH,MBA Professor of Epidemiology Assistant President Breast Cancer Epidemiology i in China JESSE HUANG ( 黄 建 始 ),MD,MHPE,MPH,MBA Professor of Epidemiology Assistant President Chinese Academy of Medical Sciences Peking Union Medical College Medical Center

More information

LIVER TUMORS PROFF. S.FLORET

LIVER TUMORS PROFF. S.FLORET LIVER TUMORS PROFF. S.FLORET NEOPLASM OF LIVER PRIMARY 1)BENIGN 2)MALIGNANT METASTATIC/SECONDARY LIVER Primary Liver Cancer the Second Killer among tumors high morbidity and mortality(20.40/100,000) etiology

More information

CLINICAL POLICY Department: Medical Management Document Name: Opdivo Reference Number: CP.PHAR.121 Effective Date: 07/15

CLINICAL POLICY Department: Medical Management Document Name: Opdivo Reference Number: CP.PHAR.121 Effective Date: 07/15 Page: 1 of 6 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted

More information

Early detection of breast cancer

Early detection of breast cancer Early detection of breast cancer Professor Denise Kendrick Division of Primary Care 1 5/26/2016 Average Number of New Cases Per Year and Age-Specific Incidence Rates per 100,000 Population Females, UK

More information

BREAST CANCER AWARENESS FOR WOMEN AND MEN by Samar Ali A. Kader. Two years ago, I was working as a bedside nurse. One of my colleagues felt

BREAST CANCER AWARENESS FOR WOMEN AND MEN by Samar Ali A. Kader. Two years ago, I was working as a bedside nurse. One of my colleagues felt Ali A. Kader, S. (2010). Breast cancer awareness for women and men. UCQ Nursing Journal of Academic Writing, Winter 2010, 70 76. BREAST CANCER AWARENESS FOR WOMEN AND MEN by Samar Ali A. Kader Two years

More information

Lung Cancer Research: From Prevention to Cure!

Lung Cancer Research: From Prevention to Cure! Lung Cancer Research: From Prevention to Cure! Ravi Salgia, M.D, Ph.D Associate Professor of Medicine Director, Thoracic Oncology Research Program Department of Medicine Section of Hematology/Oncology

More information

Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry

Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry The Master Degree in Medical Laboratory Sciences /Clinical Biochemistry, is awarded by the Faculty of Graduate Studies

More information

Cellular, Molecular, and Biochemical Targets in Breast Cancer

Cellular, Molecular, and Biochemical Targets in Breast Cancer Cellular, Molecular, and Biochemical Targets in Breast Cancer Kristy Kummerow Ingrid Meszoely December 12, 2012 VUMC Resident Bonus Conference One size fits all surgical treatment of breast cancer Wilhelm

More information

Learning about Mouth Cancer

Learning about Mouth Cancer Learning about Mouth Cancer Creation of this material was made possible in part by a pioneering grant from CBCC-USA. Distributed by India Cancer Initiative What is mouth cancer? Our bodies are made up

More information

National Horizon Scanning Centre. Vandetanib (Zactima) for advanced or metastatic non-small cell lung cancer. December 2007

National Horizon Scanning Centre. Vandetanib (Zactima) for advanced or metastatic non-small cell lung cancer. December 2007 Vandetanib (Zactima) for advanced or metastatic non-small cell lung cancer December 2007 This technology summary is based on information available at the time of research and a limited literature search.

More information

MULTIPLE MYELOMA. Dr Malkit S Riyat. MBChB, FRCPath(UK) Consultant Haematologist

MULTIPLE MYELOMA. Dr Malkit S Riyat. MBChB, FRCPath(UK) Consultant Haematologist MULTIPLE MYELOMA Dr Malkit S Riyat MBChB, FRCPath(UK) Consultant Haematologist Multiple myeloma is an incurable malignancy that arises from postgerminal centre, somatically hypermutated B cells.

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Molecular Analysis for Targeted Therapy for Non-Small Cell Lung File Name: Origination: Last CAP Review: Next CAP Review: Last Review: molecular_analysis_for_targeted_therapy_for_non_small_cell_lung_cancer

More information

Lung cancer. A guide for journalists on Non-Small Cell Lung Cancer (NSCLC) and its treatment

Lung cancer. A guide for journalists on Non-Small Cell Lung Cancer (NSCLC) and its treatment Lung cancer A guide for journalists on Non-Small Cell Lung Cancer (NSCLC) and its treatment Contents Contents 2 3 Section 1: Lung Cancer 4 i. Types of lung cancer 4 ii. Causes and risk factors 5 iii. Symptoms

More information

Oral HPV: An Overview of the Infection and its Role in the Development of Oral Cancer

Oral HPV: An Overview of the Infection and its Role in the Development of Oral Cancer Oral HPV: An Overview of the Infection and its Role in the Development of Oral Cancer PL-000238-A 7400 Flying Cloud Drive / Eden Prairie, MN 55347 855-ORALDNA (672-5362) / Fax: 952-942-0703 / OralDNA.com

More information

Progress and Prospects in Ovarian Cancer Screening and Prevention

Progress and Prospects in Ovarian Cancer Screening and Prevention Progress and Prospects in Ovarian Cancer Screening and Prevention Rebecca Stone, MD MS Assistant Professor Kelly Gynecologic Oncology Service The Johns Hopkins Hospital 1 No Disclosures 4/12/2016 2 Ovarian

More information

Hosts. New Methods for Treating Colorectal Cancer

Hosts. New Methods for Treating Colorectal Cancer Hosts Anees Chagpar MD Associate Professor of Surgical Oncology Francine MD Professor of Medical Oncology New Methods for Treating Colorectal Cancer Guest Expert: Scott, MD Associate Professor in the Department

More information

Gastric Cancer. Brochure More information from http://www.researchandmarkets.com/reports/2228929/

Gastric Cancer. Brochure More information from http://www.researchandmarkets.com/reports/2228929/ Brochure More information from http://www.researchandmarkets.com/reports/2228929/ Gastric Cancer Description: Gastric cancer (GC) is one of the most common malignancies in terms of incidence and the second

More information

LCFA/IASLC LORI MONROE SCHOLARSHIP IN TRANSLATIONAL LUNG CANCER RESEARCH

LCFA/IASLC LORI MONROE SCHOLARSHIP IN TRANSLATIONAL LUNG CANCER RESEARCH LCFA/IASLC LORI MONROE SCHOLARSHIP IN TRANSLATIONAL LUNG CANCER RESEARCH FUNDING OPPORTUNITY DESCRIPTION 2016 REQUEST FOR APPLICATION (RFA) Lung Cancer Foundation of America (LCFA) and the International

More information

Alaska Comprehensive Cancer Control Plan 2011-15

Alaska Comprehensive Cancer Control Plan 2011-15 Alaska Comprehensive Cancer Control Plan 2011-15 Alaska Comprehensive Cancer Plan 2011-2015 STATE of ALASKA Department of Health and Social Services ALASKA Comprehensive Cancer Partnership Prevention Promotion

More information

Colorectal cancer. A guide for journalists on colorectal cancer and its treatment

Colorectal cancer. A guide for journalists on colorectal cancer and its treatment Colorectal cancer A guide for journalists on colorectal cancer and its treatment Contents Contents 2 3 Section 1: Colorectal cancer 4 i. What is colorectal cancer? 4 ii. Causes and risk factors 4 iii.

More information

Clinical Cancer Research: Alternative IRB Models and Enhancing Progress

Clinical Cancer Research: Alternative IRB Models and Enhancing Progress Clinical Cancer Research: Alternative IRB Models and Enhancing Progress Lowell E. Schnipper, M.D. Berenson Professor of Medicine Chief, Hematology-Oncology Beth Israel Deaconess Medical Dynamics of Clinical

More information

Medical Therapies Limited EGM Presentation

Medical Therapies Limited EGM Presentation Medical Therapies Limited EGM Presentation Maria Halasz Chief Executive Officer 5 May 2009 1 Agenda 1. Company information 2. Recent developments 3. Business strategy 4. Key value inflection points for

More information

ALK+ lung cancer and the Blood-Brain Barrier (BBB) A concise guide

ALK+ lung cancer and the Blood-Brain Barrier (BBB) A concise guide ALK+ lung cancer and the Blood-Brain Barrier (BBB) A concise guide Contents Section Page number Section 1: Lung cancer and ALK+ NSCLC 3 Section 2: The Blood-Brain Barrier (BBB): What and why? 4 Section

More information

Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Microbiology, Immunology and Serology

Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Microbiology, Immunology and Serology Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Microbiology, Immunology and Serology The Master Degree in Medical Laboratory Sciences / Clinical Microbiology, Immunology or

More information

Breast Imaging Made Brief and Simple. Jane Clayton MD Associate Professor Department of Radiology LSUHSC New Orleans, LA

Breast Imaging Made Brief and Simple. Jane Clayton MD Associate Professor Department of Radiology LSUHSC New Orleans, LA Breast Imaging Made Brief and Simple Jane Clayton MD Associate Professor Department of Radiology LSUHSC New Orleans, LA What women are referred for breast imaging? Two groups of women are referred for

More information

HCC: Risk factors, surveillance and the importance of a multidisciplinary team

HCC: Risk factors, surveillance and the importance of a multidisciplinary team HCC: Risk factors, surveillance and the importance of a multidisciplinary team Anjana Pillai MD Assistant Professor of Medicine Director, Emory University Hospital Liver Tumor Clinic Division of Digestive

More information

HER2 Status: What is the Difference Between Breast and Gastric Cancer?

HER2 Status: What is the Difference Between Breast and Gastric Cancer? Ask the Experts HER2 Status: What is the Difference Between Breast and Gastric Cancer? Bharat Jasani MBChB, PhD, FRCPath Marco Novelli MBChB, PhD, FRCPath Josef Rüschoff, MD Robert Y. Osamura, MD, FIAC

More information

FastTest. You ve read the book... ... now test yourself

FastTest. You ve read the book... ... now test yourself FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. Please refer back to relevant sections

More information

For Yourself and Loved Ones. A Colorectal Cancer Kit from NFCR

For Yourself and Loved Ones. A Colorectal Cancer Kit from NFCR For Yourself and Loved Ones A Colorectal Cancer Kit from NFCR ABOUT THE NFCR COLORECTAL CANCER PREVENTION AND DETECTION KIT Colorectal cancer, also called colon cancer or large bowel cancer, includes cancerous

More information

Biomedical Engineering for Global Health. Lecture Thirteen

Biomedical Engineering for Global Health. Lecture Thirteen Biomedical Engineering for Global Health Lecture Thirteen Outline The burden of cancer How does cancer develop? Why is early detection so important? Strategies for early detection Example cancers/technologies

More information

An overview of CLL care and treatment. Dr Dean Smith Haematology Consultant City Hospital Nottingham

An overview of CLL care and treatment. Dr Dean Smith Haematology Consultant City Hospital Nottingham An overview of CLL care and treatment Dr Dean Smith Haematology Consultant City Hospital Nottingham What is CLL? CLL (Chronic Lymphocytic Leukaemia) is a type of cancer in which the bone marrow makes too

More information

Examples of good screening tests include: mammography for breast cancer screening and Pap smears for cervical cancer screening.

Examples of good screening tests include: mammography for breast cancer screening and Pap smears for cervical cancer screening. CANCER SCREENING Dr. Tracy Sexton (updated July 2010) What is screening? Screening is the identification of asymptomatic disease or risk factors by history taking, physical examination, laboratory tests

More information

Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle

Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle Sommaire projets sélectionnés mesure 29: Soutien à la recherche translationnelle TITLE PROJET NOM HOPITAL Assessment of tumor angiogenesis using PET/CT with 18 F-Galacto- RGD. (PNC_29_001) Division of

More information

Technology Assisting Cancer Outcomes: Automated Biomarker Abstraction Overcoming Textual Data-Silos

Technology Assisting Cancer Outcomes: Automated Biomarker Abstraction Overcoming Textual Data-Silos Technology Assisting Cancer Outcomes: Automated Biomarker Abstraction Overcoming Textual Data-Silos Patrick Mergler, MBA PMP CPHIMS DISCLAIMER: The views and opinions expressed in this presentation are

More information

Nuevas tecnologías basadas en biomarcadores para oncología

Nuevas tecnologías basadas en biomarcadores para oncología Nuevas tecnologías basadas en biomarcadores para oncología Simposio ASEBIO 14 de marzo 2013, PCB Jose Jimeno, MD, PhD Co-Founder / Vice Chairman Pangaea Biotech SL Barcelona, Spain PANGAEA BIOTECH BUSINESS

More information

Florida Breast Health Specialists Breast Cancer Information and Facts

Florida Breast Health Specialists Breast Cancer Information and Facts Definition Breast cancer is a cancer that starts in the tissues of the breast. There are two main types of breast cancer: Ductal carcinoma starts in the tubes (ducts) that move milk from the breast to

More information

LESSON 3.5 WORKBOOK. How do cancer cells evolve? Workbook Lesson 3.5

LESSON 3.5 WORKBOOK. How do cancer cells evolve? Workbook Lesson 3.5 LESSON 3.5 WORKBOOK How do cancer cells evolve? In this unit we have learned how normal cells can be transformed so that they stop behaving as part of a tissue community and become unresponsive to regulation.

More information

OVARIAN CANCER 101 7/16/14 FAST FACTS

OVARIAN CANCER 101 7/16/14 FAST FACTS OVARIAN CANCER 101 Victoria L Chiou, MD Women s Malignancies Branch National Cancer Institute, National Institutes of Health July 11, 2014 FAST FACTS Approximately 22,000 women will be diagnosed with ovarian

More information

micrornas Non protein coding, endogenous RNAs of 21-22nt length Evolutionarily conserved

micrornas Non protein coding, endogenous RNAs of 21-22nt length Evolutionarily conserved microrna 2 micrornas Non protein coding, endogenous RNAs of 21-22nt length Evolutionarily conserved Regulate gene expression by binding complementary regions at 3 regions of target mrnas Act as negative

More information

Cancer can occur at almost any organ in the body

Cancer can occur at almost any organ in the body Cancer can occur at almost any organ in the body There are many different types of cancers affecting different parts of the body. A cancer, or tumor, can occur in any organ or tissue of the human body.

More information

Recommendations for cross-sectional imaging in cancer management, Second edition

Recommendations for cross-sectional imaging in cancer management, Second edition www.rcr.ac.uk Recommendations for cross-sectional imaging in cancer management, Second edition Breast cancer Faculty of Clinical Radiology www.rcr.ac.uk Contents Breast cancer 2 Clinical background 2 Who

More information

Lesson 3 Reading Material: Oncogenes and Tumor Suppressor Genes

Lesson 3 Reading Material: Oncogenes and Tumor Suppressor Genes Lesson 3 Reading Material: Oncogenes and Tumor Suppressor Genes Becoming a cancer cell isn t easy One of the fundamental molecular characteristics of cancer is that it does not develop all at once, but

More information

Lung Cancer & Mesothelioma 2011-2015

Lung Cancer & Mesothelioma 2011-2015 Lung Cancer & Mesothelioma 2011-2015 Annex G Mesothelioma 1. The vision for mesothelioma services is set out in the Mesothelioma Framework issued by DH on 26 February 2007 (supported by the British Thoracic

More information

Breakthrough Lung Cancer Treatment Approved Webcast September 9, 2011 Renato Martins, M.D., M.P.H. Introduction

Breakthrough Lung Cancer Treatment Approved Webcast September 9, 2011 Renato Martins, M.D., M.P.H. Introduction Breakthrough Lung Cancer Treatment Approved Webcast September 9, 2011 Renato Martins, M.D., M.P.H. Please remember the opinions expressed on Patient Power are not necessarily the views of Seattle Cancer

More information

BRAF in the diagnostic evaluation of thyroid nodules

BRAF in the diagnostic evaluation of thyroid nodules Symposium 13 Molecular markers in thyroid cancer: current role in clinical practice BRAF in the diagnostic evaluation of thyroid nodules Laura Fugazzola University of Milan, Italy Papillary carcinoma BRAF

More information

Il percorso diagnostico del nodulo tiroideo: il ruolo dell analisi molecolare

Il percorso diagnostico del nodulo tiroideo: il ruolo dell analisi molecolare Il percorso diagnostico del nodulo tiroideo: il ruolo dell analisi molecolare Maria Chiara Zatelli Sezione di Endocrinologia Direttore: Prof. Ettore degli Uberti Dipartimento di Scienze Mediche Università

More information

THYROID CANCER. I. Introduction

THYROID CANCER. I. Introduction THYROID CANCER I. Introduction There are over 11,000 new cases of thyroid cancer each year in the US. Females are more likely to have thyroid cancer than men by a ratio of 3:1, and it is more common in

More information

Immune Therapy for Pancreatic Cancer

Immune Therapy for Pancreatic Cancer Immune Therapy for Pancreatic Cancer December 16, 2014 If you experience technical difficulty during the presentation: Contact WebEx Technical Support directly at: US Toll Free: 1-866-229-3239 Toll Only:

More information

New strategies in anticancer therapy

New strategies in anticancer therapy 癌 症 診 療 指 引 簡 介 及 臨 床 應 用 New strategies in anticancer therapy 中 山 醫 學 大 學 附 設 醫 院 腫 瘤 內 科 蔡 明 宏 醫 師 2014/3/29 Anti-Cancer Therapy Surgical Treatment Radiotherapy Chemotherapy Target Therapy Supportive

More information

Glioblastoma (cancer affecting the brain) A guide for journalists on glioblastoma and its treatment

Glioblastoma (cancer affecting the brain) A guide for journalists on glioblastoma and its treatment Glioblastoma (cancer affecting the brain) A guide for journalists on glioblastoma and its treatment Section 1 Glioblastoma Section 2 Epidemiology and prognosis Section 3 Treatment Contents Contents 2 3

More information

New Treatment Advances for Breast Cancer

New Treatment Advances for Breast Cancer New Treatment Advances for Breast Cancer Guest Expert: Lyndsay, MD Director of the Yale Cancer Center Breast Cancer Program Gina ng, MD www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center

More information

Epi procolon The Blood Test for Colorectal Cancer Screening

Epi procolon The Blood Test for Colorectal Cancer Screening Epi procolon The Blood Test for Colorectal Cancer Screening Epi procolon is an approved blood test for colorectal cancer screening. The US Preventive Services Task Force, the American Cancer Society and

More information

BRAF as a prognostic marker in papillary thyroid cancer

BRAF as a prognostic marker in papillary thyroid cancer 12 Congresso Nazionale AME Molecular markers in thyroid cancer: current role in clinical practice BRAF as a prognostic marker in papillary thyroid cancer Dott. ssa Cristina Romei Sezione di Endocrinologia

More information

Cetuximab plus radiotherapy for the treatment of locally advanced squamous cell carcinoma of the head and neck

Cetuximab plus radiotherapy for the treatment of locally advanced squamous cell carcinoma of the head and neck DOI: 10.3310/hta13suppl1/08 Health Technology Assessment 2009; Vol. 13: Suppl. 1 Cetuximab plus radiotherapy for the treatment of locally advanced squamous cell carcinoma of the head and neck S Griffin,*

More information

Using Family History to Improve Your Health Web Quest Abstract

Using Family History to Improve Your Health Web Quest Abstract Web Quest Abstract Students explore the Using Family History to Improve Your Health module on the Genetic Science Learning Center website to complete a web quest. Learning Objectives Chronic diseases such

More information

Spread the Word, Once and for All. The Lung Cancer Prevention & Detection Kit

Spread the Word, Once and for All. The Lung Cancer Prevention & Detection Kit Spread the Word, Once and for All The Lung Cancer Prevention & Detection Kit About Spread the Word, Once and for All The NFCR Lung Cancer Prevention and Detection Kit Lung cancer is the leading killer

More information

Determinants, Key Players and Possible Interventions

Determinants, Key Players and Possible Interventions Major in Human Health, Nutrition and Environment, FS 2010 Public Health Concepts Determinants, Key Players and Possible Interventions David Fäh Aims Have an idea about which parameters can influence health

More information