Systematic reviews of health promotion and public health interventions
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1 Systematic reviews of health promotion and public health interventions Rebecca Armstrong Elizabeth Waters Cochrane Health Promotion & Public Health Field Overview Overview of systematic reviews Outline of The Cochrane Collaboration Role of the HPPH Field Function of systematic reviews in informing policy and practice Key elements of systematic reviews Asking answerable questions Searching for evidence Assessing quality Synthesising results Applicability and transferability 1
2 Types of reviews Reviews (narrative/literature/ traditional) Systematic reviews Meta-analysis Narrative reviews Usually written by experts in the field Use informal and subjective methods to collect and interpret information Usually narrative summaries of the evidence Read: Klassen et al. Guides for Reading and Interpreting Systematic Reviews. Arch Pediatr Adolesc Med 1998;152:
3 What is a systematic review? A review of the evidence on a clearly formulated question that uses systematic and explicit methods to identify, select and critically appraise relevant primary research, and to extract and analyse data from the studies that are included in the review* *Undertaking Systematic Reviews of Research on Effectiveness. CRD s Guidance for those Carrying Out or Commissioning Reviews. CRD Report Number 4 (2nd Edition). NHS Centre for Reviews and Dissemination, University of York. March Key elements of a systematic review Structured, systematic process involving several steps : 1. Formulate the question 2. Plan the review 3. Comprehensive search 4. Unbiased selection and abstraction process 5. Critical appraisal of data 6. Synthesis of data (may include meta-analysis) 7. Interpretation of results All steps described explicitly in the review 3
4 Systematic vs. Narrative reviews Scientific approach to a review article Criteria determined at outset Comprehensive search for relevant articles Explicit methods of appraisal and synthesis Meta-analysis may be used to combine data Depend on authors inclination (bias) Author gets to pick any criteria Search any databases Methods not usually specified Vote count or narrative summary Can t replicate review Advantages of systematic reviews Reduce bias Replicability Resolve controversy between conflicting studies Identify gaps in current research Provide reliable basis for decision making 4
5 Limitations of systematic reviews specific to health promotion Results may still be inconclusive There may be no trials/evidence The trials may be of poor quality The intervention may be too complex to be tested by a trial Practice does not change just because you have the evidence of effect/effectiveness Consider these interventions Interventions to promote smoke alarm ownership and function School-based driver education for the prevention of traffic crashes Helmets for preventing head and facial injuries in bicyclists Do you think the results identified in SRs will be good, promising or absent (and potentially harmful)? 5
6 Results from systematic reviews Helmets reduce bicycle-related head and facial injuries for bicyclists of all ages involved in all types of crashes including those involving motor vehicles. The results provide no evidence that drive education reduces road crash involvement, and suggest that it may lead to a modest but potentially important increase in the proportion of teenagers involved in traffic crashes. Results from this review suggest that area-wide traffic calming in towns and cities may be a promising intervention for reducing the number of road traffic injuries and deaths. However, further rigorous evaluations of this intervention are needed. The Cochrane Collaboration International non-profit organisation that prepares, maintains, and disseminates systematic up-to-date reviews of health care interventions 6
7 Cochrane Collaboration Named in honour of Archie Cochrane, a British researcher In 1979: It is surely a great criticism of our profession that we have not organised a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomised controlled trials The Cochrane Library Cochrane Systematic reviews : Cochrane reviews and protocols Database of Reviews of Effects: Other systematic reviews appraised by the Centre for Reviews and Dissemination. Cochrane Central Register of Controlled Trials: Bibliography of controlled trials (some not indexed in MEDLINE). Health Technology Assessment Database: HTA reports NHS Economic evaluation database: Economic evaluations of health care interventions. 7
8 The Cochrane Library 8
9 Cochrane HPPH Field Represent the needs and interests of those in health promotion and public health in Cochrane matters Represent Cochrane in health promotion and public health forums In transition from Field to Review Group Will edit PH reviews for the Cochrane Library Cochrane Collaboration Structure Steering Group Review Groups Centres Fields Consumer Network Methods Groups 9
10 Collaborative Review Groups (50) Produce systematic reviews relevant to a particular disease or health issue for inclusion in the Cochrane Library Examples Airways Group Drug and Alcohol Group Heart Group Injuries Group Skin Group Pregnancy and Childbirth Group Stroke Group Breast Cancer Group Methods Groups (12) Provide advice and support in the development of the methods of systematic reviews Examples Non-Randomised Studies Screening and Diagnostic Tests Empirical Methodological Studies Qualitative Methods 10
11 Cochrane Centres (14) Work to assist all Cochrane entities within a specific geographical area Examples Australasian Cochrane Centre (at Monash) South African Cochrane Centre Italian Cochrane Centre Chinese Cochrane Centre Cochrane Fields/Networks (9) Represent an area of interest which spans a number of health problems - and hence a number of Review Groups Examples Health Promotion and Public Health Field Primary Health Care Field Cancer Network Child Health Field 11
12 Cochrane HPPH Field Cochrane Fields represent a population group, or type of care that overlaps multiple Review Group areas HPPH Field Registered in 1996 Administered from Melbourne Funded by VicHealth Over 400 members on contact database across >30 countries Staff Elizabeth Waters (Director) Jodie Doyle (Coordinator) Rebecca Armstrong (Senior Research Fellow) Naomi Priest (Research Fellow) 12
13 Asking an answerable question Questions of interest Effectiveness: Does the intervention work/not work? Who does it work/not work for? Other important questions: How does the intervention work? Is the intervention appropriate? Is the intervention feasible? Is the intervention and comparison relevant? 13
14 Answerable questions EFFECTIVENESS A description of the populations P An identified intervention I An explicit comparison C Relevant outcomes O A PICO question Time-consuming question: What is the best strategy to prevent smoking in young people? 14
15 An answerable question Q. Are mass media (or school-based or community-based) interventions effective in preventing smoking in young people? The PICO(T) chart Problem, population Intervention Comparison Outcome Types of studies Young people under 25 years of age a) Television b) Radio c) Newspapers d) Bill boards e) Posters f) Leaflets g) Booklets a) School-based interventions b) No intervention a) objective measures of smoking (saliva thiocyanate levels, alveolar CO) b) self-reported smoking behaviour c) Intermediate measures (intentions, attitude, knowledge, skills) d) Media reach a) RCT b) Controlled before and after studies c) Time series designs 15
16 Finding the evidence 16
17 Systematic review process 1. Well formulated question 2. Comprehensive data search 3. Unbiased selection and abstraction process 4. Critical appraisal of data 5. Synthesis of data 6. Interpretation of results A good search Clear research question Comprehensive search All domains, no language restriction, unpublished and published literature, up-to-date Document the search (replicability) 17
18 Components of electronic searching 1. Describe each PICO component 2. Start with primary concept 3. Find synonyms a) Identify MeSH / descriptors / subject headings b) Add textwords 4. Add other components of PICO question to narrow citations (may use study filter) 5. Examine abstracts 6. Use search strategy in other databases (may need adapting) So you want to do a quick & dirty? DARE CENTRAL PubMed (clinical queries, related records) CDC NICE Organisations who do work in your area google 18
19 The Cochrane Library: Cochrane HPPH Field 19
20 Health-evidence.ca The Guide to Community Preventive Services 20
21 National Institute for Health and Clinical Excellence Evidence for Policy and Practice Information and Coordinating Centre (EPPI-Centre) 21
22 Effective Public Health Practice Project (EPHPP) vernment/healthandsocialservices/research/e PHPP/ Centre for Reviews and Dissemination 22
23 Other sources of primary research Searching The order of terms will effect the results so start with the obvious or key concept No need for and Google will ignore common words If they are important use + (e.g. policy + 3) Phrase searching is useful eg suicide prevention Google searches for variations on words eg diet, dietary 23
24 Searching Where terms have multiple meanings you can direct google to remove sites you want to avoid (e.g. bass music) Keep your search strings brief Mental health promotion initiatives to prevent suicide in young people Compartmentalise your search strings mental health promotion suicide Suicide prevention young people Prevention and suicide and youth Searching Use the same principles for google keep it short and sweet. Key features Journals Database MeSH Database Single Citation Matcher Clinical Queries 24
25 Searching Searching 25
26 Searching Select the Limits tab just under the search string Searching 26
27 These next few slides show you how to search MeSH terms in PubMed. Useful if you don t have access to electronic databases. You combine this method with the one for text words outlined above. The process for combining text words and MeSH terms is outlines below. 27
28 28
29 Example Mass media interventions to prevent smoking in young people P= Young people STEP ONE: Find MeSH and textwords to describe young people Example Mass media interventions to prevent smoking in young people P= Young people MeSH: Adolescent Child Minors 29
30 Example Mass media interventions to prevent smoking in young people P= Young people Textwords: Adolescent Child Juvenile Young people Student Girl Boy Teenager Young adult Youth Textwords Truncation $: To pick up various forms of a word Teen$.tw Smok$.tw Teenage Smoke Teenager Smoking Teenagers Smokes Teens Smoker Teen Smokers 30
31 Textwords Wild cards? and #: To pick up different spellings Colo?r.tw (? Can be substituted for one or no characters) Colour Color Wom#n.tw (# Substitutes for one character) Woman Women Textwords Adjacent ADJn: retrieves two or more query terms within n words of each other, and in any order Great when you are not sure of phraseology Eg sport adj1 policy Sport policy Policy for sport Eg mental adj2 health Mental health Mental and physical health 31
32 Example continued Mass media interventions to prevent smoking in young people I = Mass media interventions STEP TWO: Find MeSH and textwords to describe mass media interventions Example continued MeSH Mass media Audiovisual aids Television Motion pictures Radio Telecommunications Newspapers Videotape recording Advertising 32
33 Example continued Mass media interventions to prevent smoking in young people O = Prevention of smoking STEP THREE: Find MeSH and textwords to describe prevention of smoking Example of search P = YOUNG PEOPLE MeSH... I = MASS MEDIA MeSH... C = (if required) O = PREVENTION OF SMOKING MeSH... OR OR OR Textwords... Textwords... Textwords... P AND I AND C AND O 33
34 Different bibliographic databases Databases use different types of controlled vocabulary Same citations indexed differently on different databases Medline and EMBASE use a different indexing system for study type PsycINFO and ERIC do not have specific terms to identify study types Need to develop search strategy for each database Study design filters RCTs See Cochrane Reviewer s Handbook Non-RCTs Not yet developed, research in progress Qualitative research Specific subject headings used in CINAHL, qualitative research used in Medline CINAHL Filter: Edward Miner Library Cinahl_eb_filters.pdf Systematic reviews/meta-analyses CINAHL: as above Medline OVID_eb_filters.pdf Medline and Embase PubMed 34
35 2. Unpublished literature Not all known published trials are identifiable in Medline (depending on topic) Only 25% of all medical journals in Medline Non-English language articles are underrepresented in Medline (and developing countries) Publication bias tendency for investigators to submit manuscripts and of editors to accept them, based on strength and direction of results (Olsen 2001) 2. Unpublished literature Hand searching of key journals and conference proceedings Scanning bibliographies/reference lists of primary studies and reviews Contacting individuals/agencies/ academic institutions Neglecting certain sources may result in reviews being biased 35
36 Librarians are your friends! Principles of critical appraisal 36
37 Critical appraisal The process of systematically examining research evidence to assess its validity, results and relevance before using it to inform a decision. Alison Hill, Critical Appraisal Skills Programme, Institute of Health Sciences, Oxford Critical appraisal I: Quantitative studies 37
38 Why appraise validity? Not all published and unpublished literature is of satisfactory methodological rigour Just because it is in a journal does not mean it is sound! Onus is on you to assess validity! Quality may be used as an explanation for differences in study results Guide the interpretation of findings and aid in determining the strength of inferences Bias quality assessment tool 1. Selection bias 2. Allocation bias 3. Confounding 4. Blinding (detection bias) 5. Data collection methods 6. Withdrawals and drop-outs 7. Statistical analysis 8. Intervention integrity 38
39 Selection bias Recruit participants Intervention Allocation Allocation of concealment Control Exposed to intervention Confounding Integrity of intervention Not exposed to intervention Follow-up Outcome Analysis Intention-to-treat Withdrawals Blinding of outcome assessment Data collection methods Statistical analysis Follow-up Outcome Analysis Critical appraisal tools RCTs The Quality Assessment Tool for Quantitative Studies ( Non-RCTs Cochrane Effective Practice and Organisation of Care Group ( The Berkeley Systematic Reviews Group ( 39
40 Critical appraisal II: Qualitative studies Qualitative research explores the subjective world. It attempts to understand why people behave the way they do and what meaning experiences have for people. Qualitative studies of experience Process evaluation Undertaking Systematic Reviews of Research on Effectiveness. CRD s Guidance for those Carrying Out or Commissioning Reviews. CRD Report Number 4 (2nd Edition). NHS Centre for Reviews and Dissemination, University of York. March
41 CASP appraisal checklist 1. Clear aims of research (goals, why it is important, relevance) 2. Appropriate methodology (what, how, why) 3. Sampling strategy 4. Data collection 5. Relationship between researcher and participants 6. Ethical issues 7. Data analysis 8. Findings 9. Value of research (context dependent) Other qualitative checklist Quality framework Government Chief Social Researcher s Office, UK ork.pdf 19 question checklist for process evaluations (EPPI-Centre) 41
42 Appraisal of a systematic review 10 questions 1. Clearly-focused question 2. The right type of study included 3. Identifying all relevant studies 4. Assessment of quality of studies 5. Reasonable to combine studies 6. What were the results 7. Preciseness of results 8. Application of results to local population 9. Consideration of all outcomes 10. Policy or practice change as a result of evidence CASP Interpretation of results 42
43 Factors influencing effectiveness Type III error (integrity of intervention) Theoretical framework of intervention Context For whom did the intervention work, why, in what circumstances, at what cost Difficulties addressing inequalities Studies rarely present information on differential effects of interventions Cannot locate studies addressing inequalities May need original data from authors Low power to detect subgroup differences 43
44 Integration of evidence into practice Assessing the applicability and transferability of interventions Applicability whether the intervention process could be implemented in the local setting, no matter what the outcome is. Is it possible to run this intervention in this local setting? Eg. provision of condoms in area where they are not acceptable for religious reasons Wang et al
45 Assessing the applicability and transferability of interventions Transferability if the intervention were to be implemented in the local setting, would the effectiveness of the program be similar to the level detected in the study setting? E.g. if the interventionists lack experience and have few skills in delivering the intervention then its effectiveness in the local setting may be lower than that demonstrated in the study setting Wang et al 2005 Review of questions proposed by Wang et al 45
46 Contact details Rebecca Armstrong If I can t help you I might be able to point you in the right direction. If you are interested in training and support for conducting SRs or increasing uptake within your organisation, region, state please let me know 46
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