Pharmacokinetics in Toxicology Research


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1 Pharmacokinetics in Toxicology Research Center for Human Health Assessment A Course on Physiologically Based Pharmacokinetic (PBPK) Modeling and Risk Assessment February 11 February 15, 2008 Copyright 2008 by The Hamner Institutes for Health Sciences. May not be reproduced without permission
2 External exposure Pharmacokinetics Absorbed dose Target dose Tissue interaction Early effect Pharmacodynamics Adverse effect Disease/injury
3 Pharmacokinetics Studies of the change in chemical distribution over time in the body Explores the quantitative relationship between Absorption, Distribution, Metabolism, and Excretion of a given chemical Classical models Databased, empirical compartments Describes movement of chemicals with fitted rate constants Physiologicallybased models: Compartments are based on real tissue volumes Mechanistically based description of chemical movement using tissue blood flow and simulated in vivo transport processes.
4 Example of Simple Kinetic Model: Onecompartment model with bolus dose Dose Volume? Purpose: In a simple (1compartment) system, determine volume of distribution Terminology: Compartment = a theoretical volume for chemical Steadystate = no net change of concentration Bolus dose = instantaneous input into compartment Method: 1. Dose: Add known amount (A) of chemical 2. Experiment: Measure concentration of chemical (C) in compartment 3. Calculate: A compartmental Volume (V)
5 Example of Simple Kinetic Model: Onecompartment model with bolus dose Basic assumption: Well stirred, instant equal distribution within entire compartment Volume of distribution = A/C In this classical model, V is an operational volume V depends on site of measurement This simple calculation only works IF: Compound is rapidly and uniformly distributed The amount of chemical is known The concentration of the solution is known. What happens if the chemical is able to leave the container?
6 Describing the Rates of Chemical Processes  1 Chemical in the System Rate equations: Describe movement of chemical between compartments The previous example had instantaneous dosing Now, we need to describe the rate of loss from the compartment Zeroorder process: rate is constant, does not depend on chemical concentration rate = k x C 0 = k Firstorder process: rate is proportional to concentration of ONE chemical rate = k x C 1
7 Describing the Rates of Chemical Processes  2 Chemical Systems Secondorder process: rate is proportional to concentration of both chemicals Rate = k x C 1 x C 2 Saturable processes*: Rate is dependent on interaction of two chemicals One reactant, the enzyme, is constant Described using MichaelisMenten* equation Rate = (V max x C) / ( C + K m ) 10 MM kinetics *MichaelisMenten kinetics can describe: Metabolism Carriermediated transport across membranes Excretion Rate C
8 1Comp model with bolus dose and 1 st order elimination Dose Conc? Concentration; Purpose: Examine how concentration changes with time Massbalance equation (change in C over time): da/dt=k e x A, or dc/dt=k e x C where k e = elimination rate constant  Rearrange and integrate above rate equation C = C 0 x e ke t, or ln C = ln C 0 k e t Halflife (t 1/2 ):  to reduce concentration by 50% replace C with C 0 /2 and solve for t t 1/2 = (ln 2)/k e = 0.693/k e
9 1Comp model with bolus dose and 1 st order elimination Dose Conc Clearance: volume cleared per time unit  if k e = fraction of volume cleared per time unit, k e = CL/V (CL=ke ke*v) Calculating Clearance using Area Under the Curve (AUC): AUC = average concentration  integral of the concentration  C dt 10 CL = volume cleared over time (L/min) da/dt =  k e A = k e V C da/dt =  CL C da =  CL C dt Dose = CL AUC CL = Dose / AUC 5 0 AUC
10 1Comp model with continuous infusion and 1st order elimination Calculating Clearance at Steady State: At steady state, there is no net change in concentration: dc/dt = k 0 /V k e C = 0 Rearrange above equation: k 0 /V = k e C ss Steady State Since CL = k e V, CL = k 0 /C ss
11 2Comp model with bolus dose and 1 st order elimination k k 21 k e Calculating Rate of Change in Chemical: Central Compartment (C1): dc1/dt = k 21 C 2  k 12 C 1  k e C 1 Peripheral (Deep) Compartment (C2): dc2/dt = k 12 C 1  k 21 C 2
12 Linear: Linear and Nonlinear Kinetics All elimination and distribution kinetics are 1 st order Double dose double concentration AUC Nonlinear: At least one process is NOT 1 st order Dose No direct proportionality between dose and compartment concentration
13 PBPK Models Building a PBPK Model: 1. Define model compartments Represent tissues 2. Write differential equation for each compartment 3. Assign parameter values to compartments Compartments have defined volumes, blood flows 4. Solve equations for concentration Numerical integration software (e.g. Berkeley Madonna, ACSL) Venous side Chemical in air Lungs Other Fat tissues Liver Elimination Simple model for inhalation Arterial side
14 PBPK Model Compartment Types  Storage compartment Chemical in air QT CVT QT CA Same as 1compartment model with continuous infusion Lungs Other Fat tissues Liver Rate in = Q T C A where Q T = tissue blood flow, C A = arterial blood conc Elimination Rate out = Q T C VT = Q T C T /P T where C VT = conc in tissue blood, C T = conc in tissue, P T = partition coefficient Assume Wellstirred compartment, so that, C VT = C T /P T
15 PBPK Model Compartment Types  Storage compartment Chemical in air QT CVT QT CA Same as 1compartment model with continuous infusion Lungs Other Fat tissues Liver Calculating Change in Amount: Change in amount = rate in rate out E lim ination da/dt = Q T x (C A C T /P T ) dc/dt = Q T x (C A C T /P T ) /V C A Dose C VT
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