Test Value Comments Bicarbonate (Total CO2) <10 or >40 mmol/l Bilirubin, Total. Test Value Comments

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1 Page: 1 of 5 Chemistry Critical Values List Bicarbonate (Total CO2) <10 or >40 mmol/l Bilirubin, Total >15 mg/dl Calcium, Ionized 0.78 or 1.58 mmol/l Calcium, Total <6.0 or >13.0 mg/dl Glucose <40 or >450 mg/dl Iron >500 ug/dl Glucose, WB POC <60 or >450 mg/dl Glucose, WB, neonatal POC <40 or >200 mg/dl Magnesium <1.0 or >9.0 mg/dl Phosphorus <1.0 or >9.0 mg/dl Potassium <3.0 or >6.1 mmol/l Sodium <120 or >160 mmol/l Troponin I 0.30 ng/ml Coagulation Prothrombin Time 46.3 seconds INR 5.0 PTT 85 seconds Fibrinogen <100 mg/dl Factors 2, 5, 8, 9, 11 5% Factor 7 6% Factor 10 7% Factor 13, Activity 5%

2 Page: 2 of 5 Infectious Disease Detection of any infectious By: agent: Positive Culture, Smear or Rapid AFB, bacterial, fungal, Antigen Bone Marrow Positive Culture or Smear AFB, bacterial, fungal, viral, Body Fluid (Except gastrointestinal fluid or Positive Culture or Smear AFB, bacterial, fungal, viral, urine sources) CSF or other Central Nervous Positive Culture, Smear, or AFB, bacterial, fungal, viral System specimen CSF or other Central Nervous System specimen Antigen detection Nucleic Acid Testing (NAT) (except Enterovirus), All pathogens except Enterovirus, EBV, HIV, JC virus, and Parvovirus. Eye / Ocular Positive Culture, Smear, or NAT AFB, bacterial, fungal, viral, Tissue Positive Culture or Smear AFB, bacterial, fungal, viral, Detection of specific infectious agent Mycobacterium sp., Acid Fast Bacillus (AFB) (M. tuberculosis) By Positive stain, culture, NAT, and/or resistance to primary antituberculosis agents Zygomycete Positive Culture Nasal, Sinus Select Agents and other highly pathogenic organisms (Bacillus anthracis, Brucella spp., Burkholderia mallei, Burkholderia pseudomallei, Coccidiodes immitis, Francisella tularensis, Yersinia pestis, and C. diphtheriae, Salmonella typhi, Vibrio cholera) Positive Culture and/or positive probe for C. immitis 5- fluorocytosine 100 µg/ml In

3 Page: 3 of 5 Acetone >100 mg/dl Acetaminophen >150 4 hours post ingestion >40 hours post ingestion Amiodarone >3 g/ml >30 g/ml Peak - draw 30 min post infusion. Amikacin Trough - draw 30 min before >8 g/ml infusion Amitriptyline+Nortriptyline Bupropion Caffeine (Neonate) >20 g/ml Carbamazepine Epoxide >15 g/ml Carbamazepine, Total >15 g/ml Trough Carbamazepine, Free >3.8 g/ml Choramphenicol >25 g/ml Chlorpromazine (12 and older) >750 ng/ml Chlorpromazine (0-12 years) >200 ng/ml Clomipramine+Norclomipramine >900 ng/ml Clozapine >2000 ng/ml Cyanide >100 g/ml Desipramine Cyclosporine A >700 ng/ml Digitoxin >45 ng/ml Digoxin >2.4 ng/ml Trough - draw 8-12 hr. post dose. Minimum post dose 6 hours Disopyramide >6 g/ml Doxepin+Nordoxepin Ethanol >250 mg/dl Ethosuximide >150 µg/ml Ethylene Glycol >20 mg/dl Everolimus >15 ng/ml Felbamate >200 g/ml >12 g/ml Peak - draw 30 min. post infusion. Gentamicin Trough - draw 30 min. before infusion.

4 Page: 4 of 5 Flecainide Imipramine+Desipramine Isopropanol Methanol >1.5 g/ml >50 mg/dl >20 mg/dl Lidocaine >9 g/ml > 30 min. post IV dose after steady state (5-10 hours) Lithium 1.6 mmol/l Trough Mexiletine Mycophenolic Acid (MPA) >25 g/ml Nortriptyline Pentobarbital >10 g/ml Phenytoin, Total >30 g/ml Trough, 3 months adult >14 g/ml Trough, 0-3 months Phenobarbital >50 g/ml Trough, 3 months adult >40 g/ml Trough, 0-3 months Phenytoin, Free >3.0 g/ml Primidone > 15 g/ml Propafenone Protriptyline Procainamide NAPA >12 g/ml >35 g/ml Trough Quinidine >10 g/ml Trough Salicylate >300 g/ml or >30 mg/dl Sirolimus >25 ng/ml Theophylline >25 g/ml Trough, 6 months adult >20 g/ml Trough, 0-6 months TCA - Tricyclics >12 g/ml Peak draw 30 min post infusion. Tobramycin Trough draw 30 min. before >2 ug/ml infusion Valproic Acid (VPA), Free >30 g/ml Valproic Acid (VPA), Total >150 g/ml Trough Voriconazole >6.0 g/ml Vancomycin >80 g/ml Trough >80 g/ml Peak (not recommended)

5 Page: 5 of 5 Zonisamide Trace and Toxic Elements >80 g/ml Lead Arterial Gases 45 g/dl (birth thru 18 yr) 70 g/dl (>19 years) ph 7.25 or 7.6 PCO 2 20 or 60 mm Hg PO 2 40 mm Hg Hemoglobin 7.0g/dL Transfusion Service Antibody Screen Positive DAT (Direct Coombs) Positive Hematology Hematocrit 21% or 65% Hemoglobin 7 or >21.0 g/dl Platelet Count 20 or 1000 x 10 3 /µl White Cell Count 2.0 or 40 x 10 3 /µl

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