StrokeNet. Recovery & Rehabilitation Working Group Update. February 9, Steven C. Cramer, MD
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1 StrokeNet Recovery & Rehabilitation Working Group Update February 9, 2015 Steven C. Cramer, MD
2 Increased focus on stroke recovery is a true paradigm shift
3 Increased focus on stroke recovery is a true paradigm shift
4 Increased focus on stroke recovery is a true paradigm shift Most patients with ischemic stroke do not receive acute reperfusion therapy; many who do are nonetheless disabled. Once stroke injury is fixed, biological pathways related to recovery upregulate these represent therapeutic targets.
5 Increased focus on stroke recovery is a true paradigm shift Most patients with ischemic stroke do not receive acute reperfusion therapy; many who do are nonetheless disabled. Once stroke injury is fixed, biological pathways related to recovery upregulate these represent therapeutic targets. There is no standard higher than the assent of the relevant community... Thomas S. Kuhn The Structure of Scientific Revolutions
6 Current Summary There have been many proposals submitted to NINDS, but most were not at the stage where appropriate for StrokeNet 1 active trial 1 proposal under review
7 Current Summary There have been many proposals submitted to NINDS, but most were not at the stage where appropriate for StrokeNet 1 active trial 1 proposal under review Stroke recovery and rehabilitation trials differ from acute and preventative stroke studies in key ways Current focus is to address these differences
8 Stroke recovery and rehabilitation trials: some complexities The study of new therapies is complicated by the fact that many drugs and therapies are commonly prescribed during stroke rehabilitation despite limited evidence.
9 Stroke recovery and rehabilitation trials: some complexities The study of new therapies is complicated by the fact that many drugs and therapies are commonly prescribed during stroke rehabilitation despite limited evidence. Therapy and training (OT/PT/ST) are standard of care, but --this is provided inconsistently --the dose of therapy is often very low --therapeutic decision-making is frequently guided by non-neurological factors such as cost or access
10 Stroke recovery and rehabilitation trials: some complexities The study of new therapies is complicated by the fact that many drugs and therapies are commonly prescribed during stroke rehabilitation despite limited evidence. Therapy and training (OT/PT/ST) are standard of care, but --this is provided inconsistently --the dose of therapy is often very low --therapeutic decision-making is frequently guided by non-neurological factors such as cost or access This is a complex baseline scenario for starting a clinical trial
11 Stroke recovery and rehabilitation trials: some complexities Structural issues --Which facility --Who is the attending
12 Stroke recovery and rehabilitation trials: some complexities Structural issues --Which facility --Who is the attending Cultural issues --Acute stroke team in a stroke center vs. patient recruitment in a stroke rehabilitation hospital --Recovery vs. compensation
13 Stroke recovery and rehabilitation trials: some complexities Structural issues --Which facility --Who is the attending Cultural issues --Acute stroke team in a stroke center vs. patient recruitment in a stroke rehabilitation hospital --Recovery vs. compensation Major cultural exchanges are needed to derive maximal results
14 Stroke recovery and rehabilitation trials: some complexities Structural issues --Which facility --Who is the attending Cultural issues --Acute stroke team in a stroke center vs. patient recruitment in a stroke rehabilitation hospital --Recovery vs. compensation Scientific issues --Many fundamental questions still need major guidance, e.g., the optimal timing and dose of post-stroke therapy. --Published recovery/rehabilitation studies are often small, uncontrolled, focused on subjects with mild deficits, etc.
15 Stroke recovery and rehabilitation trials: some complexities In acute stroke and preventative stroke studies, treatment generally targets a clot, platelets, an artery, the heart, serum glucose or cholesterol levels, etc.
16 Stroke recovery and rehabilitation trials: some complexities In acute stroke and preventative stroke studies, treatment generally targets a clot, platelets, an artery, the heart, serum glucose or cholesterol levels, etc. In stroke recovery and rehabilitation studies, treatment often directly targets the brain.
17 Stroke recovery and rehabilitation trials: some complexities In acute stroke and preventative stroke studies, treatment generally targets a clot, platelets, an artery, the heart, serum glucose or cholesterol levels, etc. In stroke recovery and rehabilitation studies, treatment often directly targets the brain. --activity-dependent neural plasticity --need for increased granularity: neural systems approach
18 Many submissions to NINDS, but only 3 reached the Recovery & Rehabilitation Group thus far: 1 funded Telerehabilitation in the Home versus Therapy In-Clinic for Patients with Stroke 1 under consideration Optimizing Motor Training Dose In the Early Post-Stroke Period 1 returned to the PI with constructive feedback
19 Next steps Articulate the key questions: white paper Spread the word: a new dawn Promote StrokeNet at meetings related to recovery and rehabilitation; meetings attended by StrokeNet Recovery & Rehabilitation Group members include ISC, AAN, ANA, ASNR, SfN, APTA, AOTA, and ACRM. Explore synergy with the VA system Promote standardized post stroke physiotherapy and treatment protocols Encourage and nurture new submissions
20 Next steps Articulate the key questions: white paper Spread the word: a new dawn Promote StrokeNet at meetings related to recovery and rehabilitation; meetings attended by StrokeNet Recovery & Rehabilitation Group members include ISC, AAN, ANA, ASNR, SfN, APTA, AOTA, and ACRM. Explore synergy with the VA system Promote standardized post stroke physiotherapy and treatment protocols Encourage and nurture new submissions The therapeutic time windows in recovery & rehabilitation trials are wide--nearly all patients should be offered study enrollment.
21 StrokeNet Recovery & Rehabilitation Working Group Update February 9, 2015 Steven C. Cramer, MD
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