GLOBAL MARKETS FOR NANOPARTICLE SIZE ANALYSIS INSTRUMENTATION IN THE LIFE SCIENCES. BIO114B August Jackson Highsmith Project Analyst

Transcription

1 GLOBAL MARKETS FOR NANOPARTICLE SIZE ANALYSIS IN THE LIFE SCIENCES BIO114B August 2014 Jackson Highsmith Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA USA (toll-free within the USA), or (+1) information@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THE STUDY 2 SCOPE OF REPORT 3 INTENDED AUDIENCE 3 METHODOLOGY AND INFORMATION SOURCES 4 ANALYST'S CREDENTIALS 5 RELATED BCC RESEARCH REPORTS 5 BCC RESEARCH WEBSITE 5 DISCLAIMER 5 CHAPTER 2 SUMMARY 7 SUMMARY TABLE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS EQUIPMENT, THROUGH 2019 ($ MILLIONS) SUMMARY FIGURE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS EQUIPMENT, ($ MILLIONS) 8 8 CHAPTER 3 OVERVIEW 11 BASICS OF IN THE LIFE SCIENCES 11 BASICS OF PARTICLE ANALYSIS FOR BIOACTIVE 12 PARTICLE SIZE ANALYSIS 13 PARTICLE SHAPE ANALYSIS 14 DRUG RELEASE FROM 15 PARTICLE MOLECULAR WEIGHT ANALYSIS 15 PARTICLE ZETA POTENTIAL ANALYSIS 16 PARTICLE RHEOLOGY ANALYSIS 16 PARTICLE IMAGING ANALYSIS 16 SCANNING ELECTRON MICROSCOPE 17 TRANSMISSION ELECTRON MICROSCOPE 17 PARTICLE MOLECULAR STRUCTURE 17 ATOMIC FOCUS MICROSCOPE 18 SCANNING TUNNELING ELECTRON MICROSCOPE 19 FLOW CYTOMETRY 19 COMPANIES USING NANOPARTICLE SIZING 20 TABLE 1 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE TABLE 2 BIOPHARMA AND BIOTECHNOLOGY COMPANIES APPLYING NANOPARTICLE TECHNOLOGY CHAPTER 4 GLOBAL LIFE SCIENCES MARKET FOR NANOPARTICLE ANALYSIS NANOPARTICLE ANALYSIS MARKET 25 TABLE 3 MARKET FOR ANALYSIS EQUIPMENT, THROUGH 2019 ($ MILLIONS) GROWTH OF NANOPARTICLE BY INDUSTRY SEGMENT 27 TABLE 4 PROJECTED GROWTH OF ANALYTICAL SEGMENTS, (%)

3 GROWTH OF NANOPARTICLE BY GLOBAL REGION 28 TABLE 5 GLOBAL GROWTH RATE FOR ANALYTICAL/LIFE SCIENCES BY REGION, (%) COMPANIES USING NANOPARTICLE ANALYSIS 29 TABLE 6 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE TABLE 7 COMPANIES SUPPORTING NANOPARTICLE USE IN THE LIFE SCIENCES CHAPTER 5 PARTICLE SIZE ANALYSIS 32 INTRODUCTION 32 REVENUE FROM NANOPARTICLE IDENTIFICATION 33 TABLE 8 REVENUE FROM NANOPARTICLE IDENTIFICATION, THROUGH 2019 ($ MILLIONS) PARTICLE TYPE, SIZE AND SHAPE 33 TABLE 9 CURRENTLY USED IN DRUG DELIVERY AND DIAGNOSTIC IMAGING TABLE 10 SPHERICITY LEVELS FOR NANOPARTICLE 35 TABLE 11 GOLD NANOPARTICLE SHAPES IN RESPONSE TO DNA BASES 36 PARTICLE SIZE ANALYSIS 36 TABLE 12 NANOPARTICLE SIZING METHODS USED IN PHARMACEUTICAL INDUSTRY 38 PARTICLE SIZING BY STATIC LIGHT SCATTERING 38 PARTICLE SIZING BY DYNAMIC LIGHT SCATTERING 39 NONINVASIVE BACK SCATTER METHOD 40 PHOTON CORRELATION SPECTROSCOPY 41 CONDENSATION PARTICLE COUNTER (CPC) 41 NANOPARTICLE TRACKING ANALYSIS 42 STRENGTHS AND WEAKNESSES OF INDIVIDUAL TYPES 44 TABLE 13 STRENGTHS AND WEAKNESSES OF SOME NANOPARTICLE SIZING METHODS APPLICATION OF PARTICLE SIZE INFORMATION 45 NANOPARTICLE SIZING 47 TABLE 14 NANOPARTICLE SIZING 48 NANOPARTICLE SIZING INSTRUMENT MAJOR PLAYERS 50 TABLE 15 NANOPARTICLE SIZING MAJOR PLAYERS CHAPTER 6 NANOPARTICLE SHAPE ANALYSIS IN LIFE SCIENCES 53 NANOPARTICLE SHAPE ANALYSIS 53 TABLE 16 CHARACTERISTICS OF VARIOUS FORMS OF 54 GOLD AND SILVER NANOPARTICLE SHAPES 55 TABLE 17 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR GOLD TABLE 18 GOLD NANOPARTICLE SHAPES FORMED IN RESPONSE TO SPECIFIC DNA BASES TABLE 19 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR SILVER NANOPARTICLE SHAPE ANALYSIS METHODS 57 TABLE 20 ASPECT RATIOS FOR CERTAIN NANOPARTICLE SHAPES 58 ELECTRON IMAGING METHODS FOR PARTICLE SHAPE ANALYSIS 60 TRANSMISSION ELECTRON MICROSCOPY

4 TABLE 21 COMPARISON OF SPECIFICATION OF OPTICAL MICROSCOPE AND TEM 61 SCANNING ELECTRON MICROSCOPE 62 X-RAY DETECTORS 63 APPLICATION OF NANOPARTICLE SIZE INFORMATION 64 FOR NANOPARTICLE SHAPE ANALYSIS 65 TABLE 22 COMPARISON OF SPECIFICATION OF A SEM TO OPTICAL MICROSCOPE 66 TABLE 23 NANOPARTICLE SHAPE INSTRUMENTS 67 TABLE 24 TEM AND SEM FOR NANOPARTICLE ANALYSIS 69 CHAPTER 7 MOLECULAR WEIGHT ANALYSIS IN THE LIFE SCIENCES 72 DYNAMIC LIGHT SCATTERING METHOD 72 GEL PERMEATION CHROMATOGRAPHY 72 ZETA POTENTIAL 73 ULTRACENTRIFUGATION 73 REVENUE FROM ULTRACENTRIFUGATION ANALYSIS 74 TABLE 25 REVENUES FROM ULTRACENTRIFUGATION ANALYSIS OF, THROUGH 2019 ($ MILLIONS) APPLICATIONS OF MOLECULAR WEIGHT INFORMATION 75 NANOPARTICLE MOLECULAR WEIGHT 76 TABLE 26 INSTRUMENTS FOR NANOPARTICLE MOLECULAR WEIGHT ANALYSIS 76 TABLE 27 ULTRACENTRIFUGATION FOR DETERMINATION OF PARTICLE MOLECULAR WEIGHT MAJOR PLAYERS IN MOLECULAR WEIGHT 78 TABLE 28 MAJOR PLAYERS IN NANOPARTICLE MOLECULAR WEIGHT CHAPTER 8 FLOW PROPERTIES OF IN THE LIFE SCIENCES 80 APPLICATION OF VISCOSITY INFORMATION 81 MEASUREMENT OF RHEOLOGY/VISCOMETRY 82 TABLE 29 RHEOLOGY/VISCOSITY INSTRUMENTS IN THE LIFE SCIENCES 82 MAJOR PLAYERS IN THE RHEOLOGY/VISCOSITY MEASUREMENT 82 TABLE 30 MAJOR PLAYERS IN THE RHEOLOGY/VISCOSITY INSTRUMENT FOR THE LIFE SCIENCES 83 CHAPTER 9 MOLECULAR STRUCTURE/IMAGING OF NANOPARTICLE IN THE LIFE SCIENCES SCANNING ELECTRON MICROSCOPE 85 TRANSMISSION ELECTRON MICROSCOPE 88 TABLE 31 REVENUES FROM TEM AND SEM FOR NANOPARTICLE ANALYSIS, THROUGH 2019 ($ MILLIONS) TABLE 32 COMPARISON OF SPECIFICATIONS FOR TEM, SEM AND OPTICAL MICROSCOPES SCANNING TUNNELING ELECTRON MICROSCOPE 90 ATOMIC FOCUS MICROSCOPE 91 Contact Mode 92 Lateral Force Mode 93 Tapping Mode 93 Noncontact Mode 93 Force Modulation Mode

5 CRYO-ELECTRON TOMOGRAPHY MICROSCOPY 94 REVENUE FROM AFM AND SPM ANALYSIS 95 TABLE 33 REVENUE FROM AFM AND SPM INSTRUMENTS FOR NANOPARTICLE ANALYSIS, THROUGH 2019 ($ MILLIONS) APPLICATION OF MOLECULAR STRUCTURE/ IMAGING INFORMATION 96 MOLECULAR STRUCTURE AND IMAGING 97 TABLE 34 FOR NANOPARTICLE ANALYSIS BY SEM AND TEM 97 TABLE 35 AFM INSTRUMENTS FOR NANOPARTICLE IMAGING ANALYSIS 100 MAJOR PLAYERS 101 TABLE 36 MAJOR PLAYERS IN THE TEM AND SEM INSTRUMENT MARKET 101 TABLE 37 MAJOR PLAYERS IN THE AFM INSTRUMENT MARKET 103 SCANNING TUNNELING MICROSCOPY 104 TABLE 38 SCANNING TUNNELING ELECTRON MICROSCOPES USED IN NANOPARTICLE IDENTIFICATION MAJOR PLAYERS IN STEM INSTRUMENT MARKET 106 TABLE 39 MAJOR PLAYERS IN STEM INSTRUMENT MARKET CHAPTER 10 TRENDS AND OPPORTUNITIES IN NANOPARTICLE 108 ADVANCES IN NANOPARTICLE ANALYSIS IN LIFE SCIENCES 108 INDUSTRY DRIVERS 108 INDUSTRY INHIBITORS 109 FUTURE OPPORTUNITIES FOR IN LIFE SCIENCES 109 CHAPTER 11 GLOBAL DEMAND FOR NANOPARTICLE ANALYSIS IN LIFE SCIENCES COUNTRIES INVOLVED IN NANOPARTICLE LIFE SCIENCE ACTIVITIES 112 TABLE 40 TOP COUNTRIES/REGIONS INVOLVED IN NANOPARTICLE LIFE SCIENCE ACTIVITY TABLE 41 NANOPARTICLE REVENUES AS PART OF TOTAL LIFE SCIENCES NANOPARTICLE REVENUES, THROUGH 2019 ($ MILLIONS) CHAPTER 12 NANOPARTICLE INSTRUMENT AND ASSOCIATED PATENTS 117 TABLE 42 RECENT U.S. PATENTS FOR NANOPARTICLE ANALYSIS AND DETECTION METHODS 117 CHAPTER 13 DRUG CLINICAL TRIALS WITH NANOPARTICLE DRUGS 120 TABLE 43 NANOPARTICLE DRUG CLINICAL TRIALS WITHIN DISEASE CATEGORIES 120 TABLE 44 CLINICAL TRIALS WITH NANOPARTICLE CANCER DRUGS/PROCEDURES 121 TABLE 45 CLINICAL TRIALS FOR NANOPARTICLE NON-CANCER DRUGS/PROCEDURES TABLE 46 CLINICAL TRIALS WITH NANOPARTICLE DRUGS (MISCELLANEOUS) 135 TABLE 47 CLINICAL TRIALS FOR RESPIRATORY SYNCYTIAL VIRUS (RSV) NANOPARTICLE VACCINE TABLE 48 CLINICAL TRIALS FOR NANOPARTICLE FOR DIAGNOSTIC IMAGING CHAPTER 14 NANOPARTICLE MERGERS AND ACQUISITIONS 138 CHAPTER 15 COMPANY PROFILES 144 ACCURION GMBH 144

6 PRODUCTS 144 TABLE 49 ACCURION INSTRUMENTS FOR NANOPARTICLE 145 STRATEGY 145 AGILENT TECHNOLOGIES INC. 145 PRODUCTS 146 TABLE 50 AGILENT TECHNOLOGIES INSTRUMENTS FOR NANOPARTICLE STRATEGY 146 ASPEX CORP. 147 PRODUCTS 147 TABLE 51 ASPEX USED FOR NANOPARTICLE ANALYSIS IN LIFE SCIENCES STRATEGY 148 ASYLUM RESEARCH 148 PRODUCTS 148 TABLE 52 ASYLUM RESEARCH AFM INSTRUMENTS USED IN NANOPARTICLE STRATEGY 149 BECKMAN-COULTER INC. 149 PRODUCTS 150 TABLE 53 BECKMAN COULTER PRODUCTS FOR NANOPARTICLE STRATEGY 150 BRUKER AXS INC. 151 PRODUCTS 151 TABLE 54 BRUKER AXS INSTRUMENTS FOR NANOPARTICLE AND IDENTIFICATION STRATEGY 152 CARL ZEISS SMT GMBH 152 PRODUCTS 153 TABLE 55 CARL ZEISS TEM AND SEM INSTRUMENTS USED FOR NANOPARTICLE STRATEGY 153 DME-DANISH MICRO ENGINEERING A/S 153 PRODUCTS 154 TABLE 56 DME PRODUCTS FOR NANOPARTICLE AND IDENTIFICATION STRATEGY 154 FEI CO. 155 PRODUCTS 155 TABLE 57 FEI ELECTRON MICROSCOPY PRODUCTS FOR NANOPARTICLE EVALUATION STRATEGY 156 FLUID IMAGING TECHNOLOGIES INC. 156 PRODUCTS 157 TABLE 58 FLUID IMAGING TECHNOLOGIES PRODUCTS FOR PHARMACEUTICAL MONITORING STRATEGY 157 HITACHI HIGH-TECHNOLOGIES CORP

7 PRODUCTS 158 TABLE 59 HITACHI INSTRUMENTS FOR TEM AND SEM ANALYSIS OF STRATEGY 159 HORIBA LTD. 159 PRODUCTS 160 TABLE 60 HORIBA INSTRUMENTS FOR NANOPARTICLE AND IDENTIFICATION STRATEGY 161 JEOL LTD. 161 PRODUCTS 161 TABLE 61 JEOL SEM AND TEM INSTRUMENTS FOR NANOPARTICLE AND IDENTIFICATION STRATEGY 162 MALVERN INSTRUMENTS LTD. 162 PRODUCTS 163 TABLE 62 MALVERN INSTRUMENTS EQUIPMENT THAT IS USED FOR NANOPARTICLE STRATEGY 164 MICROMERITICS INSTRUMENT CORP. 164 PRODUCTS 165 TABLE 63 NANOPARTICLE INSTRUMENTS FROM MICROMERITICS STRATEGY 165 NANOSIGHT LTD. 166 PRODUCTS 166 TABLE 64 NANOSIGHT NTA INSTRUMENTS 166 STRATEGY 167 NANOSURF AG 167 PRODUCTS 167 TABLE 65 NANOSURF INSTRUMENTS FOR AFM AND STM ANALYSIS OF STRATEGY 168 OCCHIO SA 168 PRODUCTS 168 TABLE 66 OCCHIO SA INSTRUMENTS FOR NANOPARTICLE 169 STRATEGY 169 OMICRON NANOTECHNOLOGY GMBH 169 PRODUCTS 170 TABLE 67 OMICRON SCANNING TUNNELING MICROSCOPY INSTRUMENTS 170 STRATEGY 170 PARK SYSTEMS CORP. 170 PRODUCTS 171 TABLE 68 PARK SYSTEMS' AFM INSTRUMENTS FOR NANOPARTICLE STRATEGY 171 PARTICLE SIZING SYSTEMS INC. 171 PRODUCTS

8 TABLE 69 PARTICLE SIZING SYSTEMS NANOPARTICLE STRATEGY 172 PHENOM WORLD BV 173 PRODUCTS 173 TABLE 70 PHENOM WORLD SEM INSTRUMENTS FOR NANOPARTICLE ANALYSIS 173 STRATEGY 174 PHYSICA MCR 174 PRODUCTS 174 TABLE 71 PHYSICA MCR VISCOSITY USED FOR NANOPARTICLE IN THE LIFE SCIENCES STRATEGY 175 PHYSIK INSTRUMENTS GMBH 175 PRODUCTS 176 TABLE 72 PHYSIK INSTRUMENTS AFM MICROSCOPY ACCESSORIES 176 STRATEGY 176 TESCAN A.S. 176 PRODUCTS 177 TABLE 73 TESCAN INSTRUMENTS FOR NANOPARTICLE 177 STRATEGY 177 THERMO SORVALL DIVISION 177 PRODUCTS 178 TABLE 74 THERMO SORVALL ULTRACENTRIFUGES USED IN NANOPARTICLE INVESTIGATIONS STRATEGY 179 TSI INC. 179 PRODUCTS 180 TABLE 75 TSI INSTRUMENTS USED FOR NANOPARTICLE DETECTION 180 STRATEGY 180 UNISOKU CO. LTD. 180 PRODUCTS 181 TABLE 76 UNISOKU STEM INSTRUMENTS ON THE MARKET 181 STRATEGY

9 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS EQUIPMENT, THROUGH 2019 ($ MILLIONS) TABLE 1 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE TABLE 2 BIOPHARMA AND BIOTECHNOLOGY COMPANIES APPLYING NANOPARTICLE TECHNOLOGY TABLE 3 MARKET FOR ANALYSIS EQUIPMENT, THROUGH 2019 ($ MILLIONS) TABLE 4 PROJECTED GROWTH OF ANALYTICAL SEGMENTS, (%) TABLE 5 GLOBAL GROWTH RATE FOR ANALYTICAL/LIFE SCIENCES BY REGION, (%) TABLE 6 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE TABLE 7 COMPANIES SUPPORTING NANOPARTICLE USE IN THE LIFE SCIENCES 29 TABLE 8 REVENUE FROM NANOPARTICLE IDENTIFICATION, THROUGH 2019 ($ MILLIONS) TABLE 9 CURRENTLY USED IN DRUG DELIVERY AND DIAGNOSTIC IMAGING TABLE 10 SPHERICITY LEVELS FOR NANOPARTICLE 35 TABLE 11 GOLD NANOPARTICLE SHAPES IN RESPONSE TO DNA BASES 36 TABLE 12 NANOPARTICLE SIZING METHODS USED IN PHARMACEUTICAL INDUSTRY 38 TABLE 13 STRENGTHS AND WEAKNESSES OF SOME NANOPARTICLE SIZING METHODS TABLE 14 NANOPARTICLE SIZING 48 TABLE 15 NANOPARTICLE SIZING MAJOR PLAYERS 50 TABLE 16 CHARACTERISTICS OF VARIOUS FORMS OF 54 TABLE 17 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR GOLD TABLE 18 GOLD NANOPARTICLE SHAPES FORMED IN RESPONSE TO SPECIFIC DNA BASES TABLE 19 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR SILVER TABLE 20 ASPECT RATIOS FOR CERTAIN NANOPARTICLE SHAPES 58 TABLE 21 COMPARISON OF SPECIFICATION OF OPTICAL MICROSCOPE AND TEM 61 TABLE 22 COMPARISON OF SPECIFICATION OF A SEM TO OPTICAL MICROSCOPE 66 TABLE 23 NANOPARTICLE SHAPE INSTRUMENTS 67 TABLE 24 TEM AND SEM FOR NANOPARTICLE ANALYSIS 69 TABLE 25 REVENUES FROM ULTRACENTRIFUGATION ANALYSIS OF, THROUGH 2019 ($ MILLIONS) TABLE 26 INSTRUMENTS FOR NANOPARTICLE MOLECULAR WEIGHT ANALYSIS 76 TABLE 27 ULTRACENTRIFUGATION FOR DETERMINATION OF PARTICLE MOLECULAR WEIGHT TABLE 28 MAJOR PLAYERS IN NANOPARTICLE MOLECULAR WEIGHT TABLE 29 RHEOLOGY/VISCOSITY INSTRUMENTS IN THE LIFE SCIENCES 82 TABLE 30 MAJOR PLAYERS IN THE RHEOLOGY/VISCOSITY INSTRUMENT FOR THE LIFE SCIENCES TABLE 31 REVENUES FROM TEM AND SEM FOR NANOPARTICLE ANALYSIS, THROUGH 2019 ($ MILLIONS)

10 TABLE HEADING TABLE 32 COMPARISON OF SPECIFICATIONS FOR TEM, SEM AND OPTICAL MICROSCOPES TABLE 33 REVENUE FROM AFM AND SPM INSTRUMENTS FOR NANOPARTICLE ANALYSIS, THROUGH 2019 ($ MILLIONS) TABLE 34 FOR NANOPARTICLE ANALYSIS BY SEM AND TEM 97 TABLE 35 AFM INSTRUMENTS FOR NANOPARTICLE IMAGING ANALYSIS 100 TABLE 36 MAJOR PLAYERS IN THE TEM AND SEM INSTRUMENT MARKET 101 TABLE 37 MAJOR PLAYERS IN THE AFM INSTRUMENT MARKET 103 TABLE 38 SCANNING TUNNELING ELECTRON MICROSCOPES USED IN NANOPARTICLE IDENTIFICATION TABLE 39 MAJOR PLAYERS IN STEM INSTRUMENT MARKET 106 TABLE 40 TOP COUNTRIES/REGIONS INVOLVED IN NANOPARTICLE LIFE SCIENCE ACTIVITY TABLE 41 NANOPARTICLE REVENUES AS PART OF TOTAL LIFE SCIENCES NANOPARTICLE REVENUES, THROUGH 2019 ($ MILLIONS) TABLE 42 RECENT U.S. PATENTS FOR NANOPARTICLE ANALYSIS AND DETECTION METHODS TABLE 43 NANOPARTICLE DRUG CLINICAL TRIALS WITHIN DISEASE CATEGORIES 120 TABLE 44 CLINICAL TRIALS WITH NANOPARTICLE CANCER DRUGS/PROCEDURES 121 TABLE 45 CLINICAL TRIALS FOR NANOPARTICLE NON-CANCER DRUGS/PROCEDURES 132 TABLE 46 CLINICAL TRIALS WITH NANOPARTICLE DRUGS (MISCELLANEOUS) 135 TABLE 47 CLINICAL TRIALS FOR RESPIRATORY SYNCYTIAL VIRUS (RSV) NANOPARTICLE VACCINE TABLE 48 CLINICAL TRIALS FOR NANOPARTICLE FOR DIAGNOSTIC IMAGING 136 TABLE 49 ACCURION INSTRUMENTS FOR NANOPARTICLE 145 TABLE 50 AGILENT TECHNOLOGIES INSTRUMENTS FOR NANOPARTICLE TABLE 51 ASPEX USED FOR NANOPARTICLE ANALYSIS IN LIFE SCIENCES TABLE 52 ASYLUM RESEARCH AFM INSTRUMENTS USED IN NANOPARTICLE TABLE 53 BECKMAN COULTER PRODUCTS FOR NANOPARTICLE 150 TABLE 54 BRUKER AXS INSTRUMENTS FOR NANOPARTICLE AND IDENTIFICATION TABLE 55 CARL ZEISS TEM AND SEM INSTRUMENTS USED FOR NANOPARTICLE TABLE 56 DME PRODUCTS FOR NANOPARTICLE AND IDENTIFICATION TABLE 57 FEI ELECTRON MICROSCOPY PRODUCTS FOR NANOPARTICLE EVALUATION 156 TABLE 58 FLUID IMAGING TECHNOLOGIES PRODUCTS FOR PHARMACEUTICAL MONITORING TABLE 59 HITACHI INSTRUMENTS FOR TEM AND SEM ANALYSIS OF 159 TABLE 60 HORIBA INSTRUMENTS FOR NANOPARTICLE AND IDENTIFICATION TABLE 61 JEOL SEM AND TEM INSTRUMENTS FOR NANOPARTICLE AND IDENTIFICATION TABLE 62 MALVERN INSTRUMENTS EQUIPMENT THAT IS USED FOR NANOPARTICLE TABLE 63 NANOPARTICLE INSTRUMENTS FROM MICROMERITICS TABLE 64 NANOSIGHT NTA INSTRUMENTS

11 TABLE HEADING TABLE 65 NANOSURF INSTRUMENTS FOR AFM AND STM ANALYSIS OF TABLE 66 OCCHIO SA INSTRUMENTS FOR NANOPARTICLE 169 TABLE 67 OMICRON SCANNING TUNNELING MICROSCOPY INSTRUMENTS 170 TABLE 68 PARK SYSTEMS' AFM INSTRUMENTS FOR NANOPARTICLE TABLE 69 PARTICLE SIZING SYSTEMS NANOPARTICLE TABLE 70 PHENOM WORLD SEM INSTRUMENTS FOR NANOPARTICLE ANALYSIS 173 TABLE 71 PHYSICA MCR VISCOSITY USED FOR NANOPARTICLE IN THE LIFE SCIENCES TABLE 72 PHYSIK INSTRUMENTS AFM MICROSCOPY ACCESSORIES 176 TABLE 73 TESCAN INSTRUMENTS FOR NANOPARTICLE 177 TABLE 74 THERMO SORVALL ULTRACENTRIFUGES USED IN NANOPARTICLE INVESTIGATIONS TABLE 75 TSI INSTRUMENTS USED FOR NANOPARTICLE DETECTION 180 TABLE 76 UNISOKU STEM INSTRUMENTS ON THE MARKET

12 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS EQUIPMENT, ($ MILLIONS) 8