NIH Asthma Guidelines. Versus. Asthma: Cost Beyond Non-Compliance
|
|
- Leslie Thomas
- 7 years ago
- Views:
Transcription
1 Asthma: Cost Beyond Non-Compliance WILLIAM CRAWFORD, MD OCTOBER 24, 2014 Outpatient Management of Asthma NIH Asthma Guidelines-Based Care Stepping Up Controller Therapy Newer Treatments for Severe Asthma Measuring Asthma Quality of Care NIH Asthma Guidelines Established by Expert Panel Review Created in 1991 Revised in 1997 (EPR-2) Updated in 2002 Revised Again in 2007 (EPR-3) Fourth Revision Under Consideration Versus 1
2 Classifying Asthma Severity and Initiating Therapy in Adults Components of Severity Intermittent Persistent Mild Moderate Severe Symptoms Nighttime awakenings 2 days/week 2x/month >2 days/week but not daily 3-4x/month Daily >1x/week but not nightly Throughout the day Often 7x/week Short-acting beta2-agonist use for symptom control (not prevention of EIB) Interference with normal activity Lung Function >2 days/week but Several times per 2 days/week not daily and not >1 Daily day day None Minor limitation Some limitation Extremely limited Versus Normal FEV1 FEV1 > 80% FEV1 /FEC normal FEV1 > 80% predicted FEV1 /FEC Normal FEV1 >60% but <80% predicted FEV1 /FEC reduced 5% FEV1 <60% predicted FEV1 /FEC reduced >5% Exacerbations requiring oral systemic corticosteroids 0-1/year 2x/year Recommended Step for Initiating Therapy Step 1 Step 2 Step 3 Step 4 Assessing Asthma Control and Adjusting Therapy in Adults Classification of Asthma Control Components of Control WELL- CONTROLLED NOT WELL- CONTROLLED VERY POORLY CONTROLLED Symptoms 2 days/week >2 days/week but not daily Throughout the day Impairment Normal FEV1/FVC: 8-19 yr 85% yr 80% yr 75% yr 70% Nighttime awakenings 2x/month 1-3x/week 4x/week SABA Use for symptoms 2 days/week >2 days/week Several times per day Interference with normal None Some limitation Extremely limited activity FEV1 or peak flow >80% 60-80% <60% ACT Questionnaire Exacerbations requiring oral steroids 0-1/year 2x/year Risk Progressive loss of lung function Evaluation requires long-term follow-up care. Treatment-related adverse effects Intensity of medication side effects does not correlate to specific levels of control, but should be considered in the overall assessment of risk. 2
3 Intermittent Asthma Step 1: Preferred: SABA PRN Step 2: Preferred: Low-dose ICS Alternative: Cromolyn, LTRA, or Theophylline Step 3: Preferred: Low-dose ICS plus LABA OR Medium-dose ICS Alternative: Low-dose ICS plus either LTRA, Theophylline, or Zileuton Persistent Asthma: Daily Medication Step 4: Preferred: Medium-dose ICS plus LABA Alternative: Medium-dose ICS plus either LTRA, Theophylline, or Zileuton Step 5: Preferred: High-dose ICS plus LABA AND Consider Omalizumab for patients who have allergies Step 6: Preferred: High-dose ICS plus LABA plus oral corticosteroid AND Consider Omalizumab for patients who have allergies Stepwise Approach to Asthma Therapy Step 1: PRN Albuterol Step 2: Low Dose ICS vs. LTRA Step 3: Low Dose ICS/LABA vs. Low Dose ICS + LTRA vs. Medium Dose ICS Step 4: Medium Dose ICS/LABA Step 5: High Dose ICS/LABA Step 6: High Dose ICS/LABA + PO Corticosteroid Patient Education and Environmental Control at Each Step Dosage Guide for Inhaled Corticosteroids Age 12 and Up Exacerbations requiring oral steroids 0-1/year 2x/year Progressive loss of lung Risk function Treatment-related adverse effects Recommended Action for Treatment Assessing Asthma Control and Adjusting Therapy in Adults Classification of Asthma Control Components of Control WELL- NOT WELL- VERY POORLY CONTROLLED CONTROLLED CONTROLLED >2 days/week but not Symptoms 2 days/week Throughout the day daily Impairment Nighttime awakenings 2x/month 1-3x/week 4x/week Normal FEV1/FVC: SABA Use for symptoms 2 days/week >2 days/week Several times per day 8-19 yr 85% Interference with normal None Some limitation Extremely limited yr 80% activity yr 75% FEV1 or peak flow >80% 60-80% <60% yr 70% ACT Questionnaire Evaluation requires long-term follow-up care. Intensity of medication side effects does not correlate to specific levels of control, but should be considered in the overall assessment of risk. Maintain Step up 1 step. Consider oral current step. Re-evaluate in 2-6 steroids. Regular weeks. Step up 1-2 follow-up steps. every 1-6 Re-evaluate in 2 mos. weeks. Consider step down if wellcontrolled for 3 mos. 3
4 Versus ICS/LABA vs ICS + LTRA Clinical Trials Favor ICS/LABA Over ICS + LTRA Early Clinical Trials Clearly Favored ICS/LABA Concern and Controversy Regarding LABA s Real World Studies Suggest That LTRA s May Work Better Than Originally Thought LTRA Monotherapy = ICS Monotherapy ICS + LTRA = ICS/LABA Meta-Analysis of 18 Studies with > 7000 Subjects Patients Inadequately Controlled with ICS Randomized to Add LABA or Add LTRA Modest Reduction of Exacerbation Risk with ICS/LABA vs ICS + LTRA 13% vs 11% (p < 0.05) NNT to Prevent One Exacerbation: 62 Better FEV1 Modest Improvement in Symptom Scores, Rescue Inhaler Use and Quality of Life Cochrane Database Syst Rev Jan 24;1:CD
5 Real World Studies Suggest Equivalence Between ICS/LABA and ICS + LTRA LABA Risks 352 Primary Care Patients Inadequately Controlled with ICS Randomly Assigned to Open Label Add LABA or Add LTRA Under Care of PCP Outcomes at 2 Months and 2 Years No Difference in Asthma Exacerbations No Difference in Symptom Scores Similar Results for ICS vs LTRA as Initial Therapy Price D et al. N Engl J Med. 2011;364(18): : FDA announces on 1/23/03 that Salmeterol may be associated with an increased risk of life-threatening asthma episodes or asthma-related deaths GlaxoSmithKline simultaneously halts large safety trial of Salmeterol (SMART study) SMART Study Halted 1/23/03 GlaxoSmithKline statement indicates that interim study results were inconclusive Findings suggest that two sub-groups may be at increased risk of respiratory adverse events with Salmeterol Patients not on concomitant IAI African-Americans FDA Advisory 2005: FDA issues Public Health Advisory regarding LABAs on 11/23/05 Salmeterol, Formoterol, and Fluticasone/Salmeterol are included FDA Advisory states: these medicines may increase the chance of severe asthma episodes, and death when those episodes occur 5
6 Black Box Warning 2006: Black box warning added to the labels of Salmeterol and Fluticasone/Salmeterol on 3/2/06 WARNING Long-acting beta2-adrenergic agonists, such as salmeterol, one of the active ingredients in ADVAIR DISKUS, may increase the risk of asthma-related death. Therefore, when treating patients with asthma, physicians should only prescribe ADVAIR DISKUS for patients not adequately controlled on other asthma-controller medications (e.g., low- to medium-dose inhaled corticosteroids) or whose disease severity clearly warrants initiation of treatment with 2 maintenance therapies. Data from a large placebo-controlled US study that compared the safety of salmeterol (SEREVENT Inhalation Aerosol) or placebo added to usual asthma therapy showed an increase in asthma-related deaths in patients receiving salmeterol (13 deaths out of 13,176 patients treated for 28 weeks on salmeterol versus 3 deaths out of 13,179 patients on placebo) (see WARNINGS). Gly/Gly, Gly/Arg, or Arg/Arg Human Beta 2 -Adrenergic Receptor LABA Monotherapy and Beta 2 -Adrenergic Receptor Polymorphism Gly-Gly Arg-Arg Caucasian: 13% African-American: 28% Wechsler et al; AJRCCM; Mar
7 Isopreterenol Sales in the UK During the 1960 s Asthma Deaths Lancet October, 1969 Ongoing stimulation of the beta2-adrenergic receptor: beneficial or detrimental? Yes! Take Home Message ICS/LABA Likely to Be Most Effective Step-Up Be Vigilant for Worsening Asthma After Adding LABA More Likely in African-Americans than in Other Ethnic Groups Adding LTRA Is Reasonable Steroid Phobic Cost Conscious No LABA Monotherapy No! 7
8 Assess for Comorbidities Consider Masqueraders Cigarette Smoking Rhinosinusitis GERD CHF Pulmonary Embolism Vocal Cord Dysfunction ACE Inhibitor-Induced Cough Newer Therapies in Asthma Omalizumab Omalizumab Bronchial Thermoplasty Humanized Mouse IgG Anti-Human IgE Antibody Binds to the Constant Region of the IgE Molecule Produces 89 99% Reduction in Free Circulating IgE Induces Downregulation of IgE Receptors on Mast Cells and Basophils Studied for Use in Patients with Allergic Asthma 8
9 Clinical Effectiveness of Omalizumab 4 Trials of Patients on Medium to High Dose ICS Reduced Exacerbations in 3 of 4 Trials Reduced Dose of ICS Needed to Control Symptoms One Trial of Patients on High Dose ICS + LABA Reduced Exacerbations by 25% Improved Symptom Scores, Rescue Inhaler Use Hanania NA et al. Ann Intern Med. 2011;154(9):573 Potential Adverse Effects of Omalizumab Omalizumab s Place in Therapy? Increased Cancer Risk Anaphylaxis Must Be Administered in Monitored Setting Patients Must Have Epi-Pens Increased Risk of Cardiovascular and Cerebrovascular Events Step 5 or Step 6 Therapy per NIH Guidelines Variable Response to Treatment 12-Week s of Treatment Before Gauging Response 30 50% of Patients Respond Optimum Duration of Treatment Not Known Cost of Therapy Is a Consideration $4,000 $20,000 per Year Depending on Dose $12,000 per Year Average Cost 9
10 Bronchial Thermoplasty FDA Approved in 2010 Uses a Radiofrequency Probe to Apply Heat to the Airways During Bronchoscopy Reduces the Increased Smooth Muscle Mass Associated with Asthma Findings Demonstrated in Dogs Requires 3 Separate Bronchoscopies; 3 Weeks Apart 10
11 Clinical Effectiveness of Bronchial Thermoplasty Asthma Intervention Research (AIR2) Trial 3 Clinical Trials with 429 Participants Only 1 Trial Included a Sham Treatment Arm Meta-Analysis of the 3 Trials Showed: Modest Improvement in Quality of Life Reduced Asthma Exacerbations No Change in Asthma Symptom Scores Increased Risk of Asthma Exacerbations and Hospitalization During the Treatment Period 288 Patients Randomized to BT or Sham Treatment Statistically (But Not Clinically) Significant Improvement in Asthma Symptom Scores Increased Risk for BT During 6-Week Treatment Period: 16 BT Subjects (8%) Required 19 Hospitalizations 2 Sham Subjects (2%) Required 2 Hospitalizations Cochrane Database Syst Rev. 2014;3:CD Asthma Intervention Research (AIR2) Trial Bronchial Thermoplasty s Place in Therapy 5-Year Follow-Up of 162 Subjects in the BT Arm Average 44% Reduction in Exacerbations for Post- BT Years 1 5 Compared to the Pre-BT Year Average 78% Reduction in ED Visits for Post-BT Years 1 5 Compared to the Pre-BT Year 18% Reduction in Average Daily ICS Use Stable FEV1 No Data for the Sham Treatment Group Wechsler ME et al. J Allergy Clin Immunol Dec;132(6):
12 Bronchial Thermoplasty s Place in Therapy Not Addressed in NIH Asthma Guidelines Marketed to Patients Who Are Over 18 and Having Little Success Controlling Their Asthma Symptoms with ICS/LABA Active Debate in the Scientific Community Perhaps Best Undertaken in the Context of a Clinical Trial HEDIS Asthma Quality of Care Measures HEDIS Measure Data Collection Began First Publicly Reported Year Any Controller Asthma Medication Adherence Asthma Medication Ratio
13 Appropriate Medication for People with Asthma Did you dispense at least one canister of controller medication during the measurement year? The following medications are considered valid controller medications: Inhaled corticosteroids Oral leukotriene modifier and theophylline medications HEDIS One Controller Per Year Measure Is Associated With Increased Risk % ED/ Hosp Controller No Controller Berger, et al. Ann Allergy Asthma Immunol 2004; 93:538 Asthma Medication Ratio Relationship of Medication Ratio to Asthma ED/Hospital Care % ED or 5 Hospital P < < 0.5 > 0.5 Medication Ratio Schatz, et al. Chest 2005; 128:
14 Relationship of Ratio >0.5 to Poor Symptom Control Medication Management for People with Asthma % AQLQ < 3.9 ATAQ > 1 AOMS > 3 Patient-Reported Outcome Tool Schatz, et al. Chest 2006; 130:43 Ratio < 0.5 Ratio > 0.5 All p < Percentage of Persistent Asthma Patients Who Remained on Asthma Controller Medications for at Least 75% of the Treatment Period Adherence Determined by the Number of Canisters of Asthma Controllers Dispensed and the Dosing Instructions The HEDIS MMA Measure: Conceptual Concerns Penalizes Appropriate Step-Down of Asthma Controller Therapy per NIH Guidelines Penalizes Appropriate Management of Seasonal Asthma Relationship Between the HEDIS MMA Measure and Improved Asthma Outcomes Is Unknown Percent of Population 35% 30% 25% 20% 15% 10% 5% 0% 75% Adherent in 2012 Not 75% Adherent in 2012 Hospitalization ED Visit >6 SABA Canisters Asthma Outcomes in 2013 Oral Corticosteroid Dispensing 14
15 6% 75% Adherent in 2012 Not 75% Adherent but Ratio 0.5 in % Percent of Population 4% 3% 2% 1% 0% Hospitalization ED Visit >6 SABA Canisters Asthma Outcomes in 2013 HEDIS One Controller per Year Measure Is Associated With Increased Risk 49,637 patients with HEDIS-defined persistent asthma in health plans in 3 regions Outcome: Asthma-related ED visit or hospitalization (ED/Hosp) in 6 months following first medication % ED/ Hosp Controller No Controller Berger, et al. Ann Allergy Asthma Immunol 2004; 93:538 Relationship of Medication Ratio to Acute Episodes 38,433 Southern California Kaiser Permanente patients with persistent asthma Medication ratio determined in 2002 Acute episodes (one or more asthma emergency department visits or hospitalizations) determined in 2003 Schatz, et al. Chest 2005; 128:
16 Relation of Medication Ratio to Patient-Reported Outcomes Random sample of 2250 adult patients (aged 18-56) with persistent asthma (1999) Northern California, Southern California, and Northwest Kaiser Permanente Survey completed in Fall, 2000 Survey included quality of life (AQLQ), control (ATAQ) and symptom severity (AOMS) Medication ratio from year 2000 computerized pharmacy records Schatz, et al. Chest 2006; 130:43 Medication Management for People with Asthma (MMA) Index dispensing event = In measurement year, earliest dispensing event of a controller medication identified Treatment period = time between index dispensing event and end of calendar year Number of days covered = total controller amount dispensed daily dose Percentage of days covered (PDC) = number of days covered total number of days in treatment period 75% MMA adherent = patients who have a PDC of at least 75% 50% MMA adherent = patients who have a PDC of at least 50% Asthma controller medications = inhaled corticosteroids, inhaled corticosteroid/long acting beta 2 agonist combination agents, leukotriene modifiers, theophylline, and cromolyn sodium Methods 30,040 KPSC patients met persistent asthma criteria for ,750 patients had oral steroid dispensing data available for 2013 MMA status for 2012 assessed Asthma outcomes for 2013 tracked asthma related hospitalizations asthma related ED visits oral steroid dispensing > 6 SABA canisters dispensed 16
Classifying Asthma Severity and Initiating Treatment in Children 0 4 Years of Age
Classifying Asthma Severity and Initiating Treatment in Children 0 4 Years of Age Components of Severity Symptoms Intermittent 2 days/week Classification of Asthma Severity (0 4 years of age) Persistent
More informationManaging Asthma Long Term
Managing Asthma Long Term TARGET POPULATION Eligibility Inclusion Criterion Exclusion Criterion RECOMMENDATIONS F I G U R E 4 2 a. CLASSIFYING ASTHMA SEVERITY AND INITIATING TREATME N T IN CHILDREN 0 4
More informationAnnotated from the NAEPP/NHLBI Updated Asthma Guidelines and Developed Through Expert Consensus
Asthma Pocket Guide for Primary Care Annotated from the NAEPP/NHLBI Updated Asthma Guidelines and Developed Through Expert Consensus POSITION STATEMENT Despite advances in therapy, asthma remains a disease
More informationTraining Manual & Speaker s Guide
Training Manual & Speaker s Guide Based on National Asthma Education and Prevention Program (NAEPP) Guidelines including the NAEPP s Guidelines Implementation Panel (GIP) Priority Messages. Funded in part
More informationDear Provider: Sincerely,
Asthma Toolkit Dear Provider: L.A. Care is pleased to present this updated asthma toolkit. Our goal is to promote the highest level of asthma care, based on the 2007 National Asthma Education and Prevention
More informationHow to Manage Asthma in Children
Clinical Guideline for the Diagnosis, Evaluation and Management of Adults and Children with Asthma Color Key n Four Components of Asthma Care n Classifying Asthma Severity, Assessing Asthma Control and
More informationCOPD and Asthma Differential Diagnosis
COPD and Asthma Differential Diagnosis Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in America. Learning Objectives Use tools to effectively diagnose chronic obstructive
More informationObjectives. Asthma Management
Objectives Asthma Management BREATHE Conference Allergy and Asthma Specialists PC Christine Malloy MD March 22, 2013 Review the role of inflammation in asthma Discuss the components of the EPR-3 management
More informationGlucocorticoids, Inhaled Therapeutic Class Review (TCR) February 7, 2012
Glucocorticoids, Inhaled Therapeutic Class Review (TCR) February 7, 2012 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying,
More informationGuidance to support the stepwise review of combination inhaled corticosteroid therapy for adults ( 18yrs) in asthma
Guidance to support the stepwise review of combination inhaled corticosteroid therapy for adults ( 18yrs) in asthma Important Complete asthma control needs to be achieved for at least 12 weeks before attempting
More informationStacie L. Penkova, PharmD, MHSA, BCPS Clinical Pharmacy Manager Critical Care Pharmacy Specialist Drug Information Coordinator Pharmacology Summit
Stacie L. Penkova, PharmD, MHSA, BCPS Clinical Pharmacy Manager Critical Care Pharmacy Specialist Drug Information Coordinator Pharmacology Summit July 26, 2014 Objectives Classify asthma by severity Prescribe
More informationPrevention of Acute COPD exacerbations
December 3, 2015 Prevention of Acute COPD exacerbations George Pyrgos MD 1 Disclosures No funding received for this presentation I have previously conducted clinical trials with Boehringer Ingelheim. Principal
More informationSevere asthma Definition, epidemiology and risk factors. Mina Gaga Athens Chest Hospital
Severe asthma Definition, epidemiology and risk factors Mina Gaga Athens Chest Hospital Difficult asthma Defined as asthma, poorly controlled in terms of chronic symptoms, with episodic exacerbations,
More informationGlucocorticoids, Inhaled Therapeutic Class Review (TCR)
Glucocorticoids, Inhaled Therapeutic Class Review (TCR) July 31, 2015 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying,
More informationManagement of Asthma
Federal Bureau of Prisons Clinical Practice Guidelines May 2013 Clinical guidelines are made available to the public for informational purposes only. The Federal Bureau of Prisons (BOP) does not warrant
More informationSpirometry Workshop for Primary Care Nurse Practitioners
Spirometry Workshop for Primary Care Nurse Practitioners Catherine Casey S. Jones PhD, RN, AE-C, ANP-C Certified Adult Nurse Practitioner Texas Pulmonary & Critical Care Consultants P.A. and Visiting Assistant
More informationBronchodilators in COPD
TSANZSRS Gold Coast 2015 Can average outcomes in COPD clinical trials guide treatment strategies? Long live the FEV1? Christine McDonald Dept of Respiratory and Sleep Medicine Austin Health Institute for
More informationBackground information
Background information Asthma Asthma is a complex disease affecting the lungs that can be managed but cannot be cured. 1 Asthma can be controlled well in most people most of the time, although some people
More informationAn Overview of Asthma - Diagnosis and Treatment
An Overview of Asthma - Diagnosis and Treatment Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness,
More information5. Treatment of Asthma in Children
Treatment of sthma in hildren 5. Treatment of sthma in hildren 5.1 Maintenance Treatment 5.1.1 rugs Inhaled Glucocorticoids. Persistent wheezing in children under the age of three can be controlled with
More informationClinical Research Pediatric Pulmonary Division
Clinical Research Pediatric Pulmonary Division Hengameh H. Raissy, PharmD Research Associate Professor, Pediatric Pulmonary UNM HSC Director of Clinical Trials Presented at Envision NM Asthma / Pulmonary
More informationunderstanding the professional guidelines
SEVERE ASTHMA understanding the professional guidelines This guide includes information on what the European Respiratory Society (ERS) and the American Thoracic Society (ATS) have said about severe asthma.
More informationPathway for Diagnosing COPD
Pathway for Diagnosing Visit 1 Registry Clients at Risk Patient presents with symptoms suggestive of Exertional breathlessness Chronic cough Regular sputum production Frequent bronchitis ; wheeze Occupational
More informationIn the last few decades, asthma has become epidemic. As the most common
Licensed School Nurse/ Public Health Nurse/ Registered Nurse In the last few decades, asthma has become epidemic. As the most common chronic childhood disease, asthma affects more than six million children
More informationEVIDENCE-BASED BEST PRACTICES FOR THE MANAGEMENT OF ASTHMA IN PEDIATRIC PRIMARY CARE IN SOUTH CAROLINA
EVIDENCE-BASED BEST PRACTICES FOR THE MANAGEMENT OF ASTHMA IN PEDIATRIC PRIMARY CARE IN SOUTH CAROLINA Sarah Ball, PharmD Mike Bowman, MD Sandra Garner, PharmD Nancy Hahn, PharmD Sophie Robert, PharmD
More informationCCHCS Care Guide: Asthma
GOALS SHORTNESS OF BREATH, WHEEZE, COUGH NIGHT TIME AWAKENINGS ACTIVITY INTERFERENCE SABA* USE FOR SYMPTOM CONTROL FEV1* OR PEAK FLOW EXACERBATIONS REQUIRING ORAL STEROIDS < 2 DAYS / WEEK 2 TIMES / MONTH
More informationThe National Asthma Education. Overview of Changes to Asthma Guidelines: Diagnosis and Screening
Overview of Changes to Asthma Guidelines: Diagnosis and Screening SUSAN M. POLLART, MD, MS, and KURTIS S. ELWARD, MD, MPH Department of Family Medicine, University of Virginia School of Medicine, Charlottesville,
More informationPre-Operative Services Teaching Rounds 2 Jan 2011
Pre-Operative Services Teaching Rounds 2 Jan 2011 Deborah Richman MBChB FFA(SA) Director Pre-Operative Services Department of Anesthesia Stony Brook University Medical Center, NY drichman@notes.cc.sunysb.edu
More informationRES/006/APR16/AR. Speaker : Dr. Pither Sandy Tulak SpP
RES/006/APR16/AR Speaker : Dr. Pither Sandy Tulak SpP Definition of Asthma (GINA 2015) Asthma is a common and potentially serious chronic disease that imposes a substantial burden on patients, their families
More informationStandardizing the measurement of drug exposure
Standardizing the measurement of drug exposure The ability to determine drug exposure in real-world clinical practice enables important insights for the optimal use of medicines and healthcare resources.
More informationAsthma POEMs. Patient Orientated Evidence that Matters
ASTHMA POEMs Asthma POEMs Patient Orientated Evidence that Matters Developed by the Best Practice Advocacy Centre Level 8, 10 George Street PO Box 6032 Dunedin Phone 03 4775418 Fax 03 4772622 Acknowledgement
More informationExploratory data: COPD and blood eosinophils. David Price: 9.23-9.35am
Exploratory data: COPD and blood eosinophils David Price: 9.23-9.35am Blood Eosinophilia in COPD The reliability and utility of blood eosinophils as a marker of disease burden, healthcare resource utilisation
More informationMontelukast Sodium. -A new class of seasonal allergic rhinitis therapy
Montelukast Sodium -A new class of seasonal allergic rhinitis therapy Symptoms of Seasonal Allergic Rhinitis Nasal itch Sneezing Rhinorrhoea Nasal stuffiness Pathogenesis of Allergic Rhinitis Mast cells,
More informationAsthma. Micah Long, MD
Asthma Micah Long, MD Goals Define the two components of asthma. Describe the method of action and uses for: Steroids (inhaled and IV) Quick Beta Agonists (Nebs and MDIs) The "Others" Magnesium, Epi IM,
More information9/16/2014. Anti-Immunoglobulin E (IgE) Omalizumab (Xolair ) Dosing Guidance
Disclosure Statement of Financial Interest New Therapies for Asthma Including Omalizumab and Anti-Cytokine Therapies Marsha Dangler, PharmD, BCACP Clinical Pharmacy Specialist James H. Quillen VA Medical
More informationMedicaid Health Plans of America Center for Best Practices. Best Practices Compendium in Childhood Asthma Care
Medicaid Health Plans of America Center for Best Practices Best Practices Compendium in Childhood Asthma Care 2 Childhood Asthma Care Best Practices Compendium table of contents 3 Table of Contents President
More informationmedicineupdate to find out more about this medicine
medicineupdate Asking the right questions about new medicines Seretide for chronic obstructive pulmonary disease What this medicine is 1 What this medicine treats 2 Other medicines available for this condition
More informationCompare the physiologic responses of the respiratory system to emphysema, chronic bronchitis, and asthma
Chapter 31 Drugs Used to Treat Lower Respiratory Disease Learning Objectives Describe the physiology of respirations Compare the physiologic responses of the respiratory system to emphysema, chronic bronchitis,
More informationPulmonary Rehabilitation in Newark and Sherwood
Pulmonary Rehabilitation in Newark and Sherwood With exception of smoking cessation pulmonary rehabilitation is the single most effective intervention for any patient with COPD. A Cochrane review published
More informationInformation for Behavioral Health Providers in Primary Care. Asthma
What is Asthma? Information for Behavioral Health Providers in Primary Care Asthma Asthma (AZ-ma) is a chronic (long-term) lung disease that inflames and narrows the airways. Asthma causes recurring periods
More informationThe Problem with Asthma. Ruth McArthur, Practice Nurse/Trainer
The Problem with Asthma Ruth McArthur, Practice Nurse/Trainer Getting the diagnosis right! Asthma or COPD? History taking is key Both are inflammatory conditions with different mechanisms & mediators Diagnostic
More informationStanley J. Szefler, MD National Jewish Medical and Research Center
New Asthma Guidelines: Special Attention to Infant Wheezers Stanley J. Szefler, MD Helen Wohlberg & Herman Lambert Chair in Pharmacokinetics, & Professor of Pediatrics and Pharmacology, University of Colorado
More informationAsthma (With a little SCID to start) Disclosures Outline Starting with the Immune System The Innate Immune System The Adaptive Immune System
1 2 3 4 5 6 7 8 9 Asthma (With a little SCID to start) Lauren Smith, MD CHKD Pediatric Allergy/Immunology Disclosures None Will be discussing some medications that are not yet FDA approved Outline SCID
More informationPediatric. Updated 2008
A S T H M A P R O V I D E R M A N U A L Pediatric Updated 2008 Asthma 2 Causes of Asthma 3 Utah Prevalence 3 Diagnosis 7 Managing Asthma 9 Education for Partnership in Care 11 Control of Environmental
More informationYOU VE BEEN REFERRED TO AN ASTHMA SPECIALIST...
YOU VE BEEN REFERRED TO AN ASTHMA SPECIALIST... ...HERE S WHAT TO EXPECT You have been referred to an allergist because you have or may have asthma. The health professional who referred you wants you to
More informationAsthma in Infancy, Childhood and Adolescence. Presented by Frederick Lloyd, MD Palo Alto Medical Foundation Palo Alto, California
Asthma in Infancy, Childhood and Adolescence Presented by Frederick Lloyd, MD Palo Alto Medical Foundation Palo Alto, California Major Health Problem in Childhood Afflicts 2.7 million children in the USA
More informationTreatment of Asthma. Talk to your doctor about the various medications available to treat asthma.
Please call 911 if you think you have a medical emergency. Treatment of Asthma The goals of asthma therapy are to prevent your child from having chronic and troublesome symptoms, to maintain your child's
More informationPATIENT INFORMATION ABOUT TREATMENTS FOR ASTHMA AND ALLERGIC RHINITIS, PRESCRIPTIONS & OVER THE COUNTER MEDICINE
PATIENT INFORMATION ABOUT TREATMENTS FOR ASTHMA AND ALLERGIC RHINITIS, PRESCRIPTIONS & OVER THE COUNTER MEDICINE The content of this booklet was developed by Allergy UK. MSD reviewed this booklet to comment
More informationThe Annual Direct Care of Asthma
The Annual Direct Care of Asthma The annual direct health care cost of asthma in the United States is approximately $11.5 billion; indirect costs (e.g. lost productivity) add another $4.6 billion for a
More informationBefore prescribing for COPD management, the patient should have had appropriate assessment, including spirometry, as per NICE guidelines.
Formulary Guidance for Management of COPD patients Before prescribing for COPD management, the patient should have had appropriate assessment, including spirometry, as per NICE guidelines. For inhaler
More informationinability to take a deep breath)
Algorithm for the diagnosis and management of asthma: a practice parameter update These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy,
More informationTests. Pulmonary Functions
Pulmonary Functions Tests Static lung functions volumes Dynamic lung functions volume and velocity Dynamic Tests Velocity dependent on Airway resistance Resistance of lung tissue to change in shape Dynamic
More informationSponsor Novartis Pharmaceuticals
Clinical Trial Results Database Page 1 Sponsor Novartis Pharmaceuticals Generic Drug Name Indacaterol Therapeutic Area of Trial Chronic Obstructive Pulmonary Disease (COPD) Indication studied: COPD Study
More informationDrug therapy SHORT-ACTING BETA AGONISTS SHORT-ACTING ANTICHOLINERGICS LONG-ACTING BETA AGONISTS LONG-ACTING ANTICHOLINERGICS
Drug therapy 6 6.1 What is the role of bronchodilators in COPD? 52 SHORT-ACTING BETA AGONISTS 6.2 How do short-acting beta agonists work? 52 6.3 What are the indications for their use? 52 6.4 What is the
More informationMEDICATION GUIDE. SYMBICORT 80/4.5 (budesonide 80 mcg and formoterol fumarate dihydrate 4.5 mcg) Inhalation Aerosol
MEDICATION GUIDE SYMBICORT 80/4.5 (budesonide 80 mcg and formoterol fumarate dihydrate 4.5 mcg) Inhalation Aerosol SYMBICORT 160/4.5 (budesonide 160 mcg and formoterol fumarate dihydrate 4.5 mcg) Inhalation
More informationMedicines Use Review Supporting Information for Asthma Patients
Medicines Use Review Supporting Information for Asthma Patients What is asthma? Asthma is a chronic inflammatory disorder of the airways. The inflammation causes an associated increase in airway hyper-responsiveness,
More informationBreathe With Ease. Asthma Disease Management Program
Breathe With Ease Asthma Disease Management Program MOLINA Breathe With Ease Pediatric and Adult Asthma Disease Management Program Background According to the National Asthma Education and Prevention Program
More informationManagement of exacerbations in chronic obstructive pulmonary disease in Primary Care
Management of exacerbations in chronic obstructive pulmonary disease in Primary Care Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with significant morbidity and mortality.
More informationUnderstanding Asthma Patients in the Dental Office
Understanding Asthma Patients in the Dental Office Barbara Fried, RDH, MBA Continuing Education Units: 1 hour Online Course: www.dentalcare.com/en-us/dental-education/continuing-education/ce408/ce408.aspx
More information4 Pharmacological management
4 Pharmacological management The aim of asthma management is control of the disease. Control of asthma is defined as: no daytime symptoms no night time awakening due to asthma no need for rescue medication
More informationCOPD MANAGEMENT PROTOCOL STANFORD COORDINATED CARE
I. PURPOSE To establish guidelines f the collabative management of patients with a diagnosis of chronic obstructive pulmonary disease (COPD) who are not adequately controlled and to define the roles and
More informationIrish Association for Emergency Medicine (IAEM) submission to the National COPD Strategy
31 st Irish Association for Emergency Medicine (IAEM) submission to the National COPD Strategy 1 Introduction Chronic obstructive pulmonary disease (COPD) is an important disease for patients, the health
More informationDRUG UTILISATION STUDY IN BRONCHIAL ASTHMA IN A TERTIARY CARE HOSPITAL
International Journal of Pharmaceutical Applications ISSN 0976-2639, Online ISSN 2278 6023 Vol 3, Issue 2, 2012, pp 297-305 http://www.bipublication.com DRUG UTILISATION STUDY IN BRONCHIAL ASTHMA IN A
More informationSTATISTICAL BRIEF #378
STATISTICAL BRIEF #378 July 212 Asthma Medication Use among Adults with Reported Treatment for Asthma, United States, and 28-29 Frances M. Chevarley, PhD Introduction Asthma is a chronic respiratory disease
More informationUS Food and Drug Administration
US Food and Drug Administration Meeting of the Pulmonary-Allergy Drugs Advisory Committee November 18, 2009 Badrul A. Chowdhury, MD, PhD Director, Division of Pulmonary and Allergy Products, Office of
More informationLogistics. Registration for free continuing education (CE) hours or certificate of attendance through TRAIN at: https://tx.train.
. DSHS Grand Rounds Logistics Registration for free continuing education (CE) hours or certificate of attendance through TRAIN at: https://tx.train.org Streamlined registration for individuals not requesting
More informationOn completion of this chapter you should be able to: discuss the stepwise approach to the pharmacological management of asthma in children
7 Asthma Asthma is a common disease in children and its incidence has been increasing in recent years. Between 10-15% of children have been diagnosed with asthma. It is therefore a condition that pharmacists
More informationElectronic patient diaries in clinical research
Topics Electronic diaries in Clinical Trials Electronic diaries versus Paper Electronic patient diaries in clinical research Case Study: Novel detection of exacerbations of COPD with patient reported outcome
More informationThe Right Medicines Can Help You Get Control of Asthma. BlueCare SM TennCareSelect
The Right Medicines Can Help You Get Control of Asthma BlueCare SM TennCareSelect WHEEZING. COUGHING. SHORTNESS OF BREATH. CHEST TIGHTNESS. If you or a family member has asthma, you know these symptoms
More informationAdrenaline autoinjector (EpiPen) for acute allergic anaphylaxis
for acute allergic anaphylaxis This review of adrenaline autoinjector was first published in December 2003. This update describes the change to the PBS listing to allow prescribing immediately after hospital
More informationThe patient s response to therapy within the first hour in the Emergency Room is one of the most reliable ways to predict need for hospitalization.
Emergency Room Asthma Management Algorithm The Emergency Room Asthma Management Algorithm is to be used for any patient seen in the Emergency Room with the diagnosis of asthma. (The initial history should
More informationAsthma Intervention. An Independent Licensee of the Blue Cross and Blue Shield Association.
Asthma Intervention 1. Primary disease education Member will have an increased understanding of asthma and the classification by severity, the risks and the complications. Define asthma Explain how lungs
More informationCOPD PROTOCOL CELLO. Leiden
COPD PROTOCOL CELLO Leiden May 2011 1 Introduction This protocol includes an explanation of the clinical picture, diagnosis, objectives and medication of COPD. The Cello way of working can be viewed on
More informationSEREVENT DISKUS (salmeterol xinafoate inhalation powder) FOR ORAL INHALATION USE Initial U.S. Approval: 1994
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use SEREVENT DISKUS safely and effectively. See full prescribing information for SEREVENT DISKUS. SEREVENT
More informationT HE ROLE OF THE PHARMACIST IN IMPROVING ASTHMA CARE NIH PUBLICATION NO. 95-3280 JULY 1995 NATIONAL INSTITUTES. National Heart, Lung,
T HE ROLE OF THE PHARMACIST IN IMPROVING ASTHMA CARE NIH PUBLICATION NO. 95-3280 JULY 1995 NATIONAL INSTITUTES OF HEALTH National Heart, Lung, and Blood Institute TABLE OF CONTENTS Preface.................................i
More informationClinical Guideline. Recommendation 3: For stable COPD patients with respiratory symptoms
Clinical Guideline Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians,
More informationClinical Guideline. Recommendation 3: For stable COPD patients with respiratory symptoms
Clinical Guideline Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians,
More informationHow to use FENO-guided asthma control in routine clinical practice
How to use FENO-guided asthma control in routine clinical practice Asthma is a chronic inflammatory disease of the airways. This has implications for the diagnosis, management and potential prevention
More informationHow Can We Get the Best Medication History?
How Can We Get the Best Medication History? Stephen Shalansky, Pharm.D., FCSHP Pharmacy Department, St. Paul s Hospital Faculty of Pharmaceutical Sciences, UBC How Are We Doing Now? Completeness of Medication
More informationThe pharmacist s role in controlling asthma American Pharmacists Association
CPE The pharmacist s role in controlling asthma American Pharmacists Association Abstract Objective: To provide a review of the asthma management guidelines issued by the National Asthma Education and
More information"Respiratory Problems in Swimmers: How to keep Swimmers Afloat" and in the Pool!
"Respiratory Problems in Swimmers: How to keep Swimmers Afloat" and in the Pool! Charles Siegel, MD Associate Clinical Professor University of Missouri @ Kansas City School of Medicine USA Swimming does
More informationASTHMA IN INFANTS AND YOUNG CHILDREN
ASTHMA IN INFANTS AND YOUNG CHILDREN What is Asthma? Asthma is a chronic inflammatory disease of the airways. Symptoms of asthma are variable. That means that they can be mild to severe, intermittent to
More informationPosition Statement from the Irish Thoracic Society on the treatment of Idiopathic Pulmonary Fibrosis
BACKGROUND Position Statement from the Irish Thoracic Society on the treatment of Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis (IPF) is a rare, chronic and fatal disease characterised by
More informationMontelukast 10mg film-coated tablets PL 17907/0474
Montelukast 10mg film-coated tablets PL 17907/0474 UKPAR TABLE OF CONTENTS Lay Summary Page 2 Scientific Discussion Page 4 Steps Taken for Assessment Page 11 Steps Taken After Initial Authorisation Page
More informationCOPD Prescribing Guidelines
South Staffordshire Area Prescribing Group COPD Prescribing Guidelines Inhaler choices in this guideline are different from previous versions produced by the APG. It is not expected patients controlled
More informationU.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER)
Guidance for Industry Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease: Developing Antimicrobial Drugs for Treatment U.S. Department of Health
More informationPOCKET GUIDE FOR ASTHMA MANAGEMENT AND PREVENTION
POCKET GUIDE FOR ASTHMA MANAGEMENT AND PREVENTION (for Adults and Children Older than 5 Years) A Pocket Guide for Physicians and Nurses Updated 2015 BASED ON THE GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND
More informationPLAN OF ACTION FOR. Physician Name Signature License Date
PLAN OF ACTION FOR Patient s copy (patient s name) I Feel Well Lignes I feel short directrices of breath: I cough up sputum daily. No Yes, colour: I cough regularly. No Yes I Feel Worse I have changes
More informationCCHP/CCRMC 2006 Clinical Practice Guideline Outpatient Management of Asthma in Children and Adults
Clinical Practice Guideline Outpatient Management of ASTHMA in Children and Adults 2007 Contra Costa Health Plan and Contra Costa Regional Medical Center TABLE OF CONTENTS SECTION PAGE ASTHMA GUIDELINE
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
Afrezza Page 1 of 6 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Afrezza (human insulin) Prime Therapeutics will review Prior Authorization requests Prior Authorization
More informationESCMID Online Lecture Library. by author
Do statins improve outcomes of patients with sepsis and pneumonia? Jordi Carratalà Department of Infectious Diseases Statins for sepsis & community-acquired pneumonia Sepsis and CAP are major healthcare
More informationPragmatic Seamless Design for Efficacy Trial of Asthma Management with reduced Cost. Mei Lu, PhD Christine Joseph, Ph.D
Pragmatic Seamless Design for Efficacy Trial of Asthma Management with reduced Cost Mei Lu, PhD Christine Joseph, Ph.D Henry Ford Health System May 19, 2013 Puff City Pragmatic RCT: Partners HFHS Clinical
More informationadrenoceptor agonists and the Olympic Games in Turin
Beta 2 adrenoceptor agonists and the Olympic Games in Turin 1. INTRODUCTION Article 4 of the World Anti-Doping Code refers to the Prohibited List as the international standard. This List, which came into
More informationSingle-Inhaler Maintenance AND Reliever Therapy for Asthma Control: A Primer for Pharmacists
A FREE CONTINUING EDUCATION LESSON OBJECTIVES Upon successful completion of this lesson, the pharmacist will be able to: 1. assess asthma control and asthma severity in patients with asthma 2. discuss
More informationGuideline on the clinical investigation of medicinal products for the treatment of asthma
22 October 2015 CHMP/EWP/2922/01 Rev.1 Committee for Medicinal Products for Human Use (CHMP) Guideline on the clinical investigation of medicinal products for the treatment of Draft Agreed by Respiratory
More informationOutcome of Drug Counseling of Outpatients in Chronic Obstructive Pulmonary Disease Clinic at Thawangpha Hospital
Mahidol University Journal of Pharmaceutical Sciences 008; 35(14): 81. Original Article Outcome of Drug Counseling of Outpatients in Chronic Obstructive Pulmonary Disease Clinic at Thawangpha Hospital
More informationCLINICAL PATHWAY. Acute Medicine. Chronic Obstructive Pulmonary Disease
CLINICAL PATHWAY Acute Medicine Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Table of Contents (tap to jump to page) INTRODUCTION 1 Scope of this Pathway 1 Pathway Contacts
More informationAmerican Thoracic Society Documents
American Thoracic Society Documents An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations Standardizing Endpoints for Clinical Asthma Trials and
More information