Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No. 6

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1 P = P = P = ± μmol /L ± μmol /L ± 177 μmol /L P = ± μmol /L ± μmol /L ± μmol /L 6. 2 ± 5. 2 μmol /L 5. 0 ± 4. 2 μmol /L 4. 8 ± 3. 4 μmol /L P = P = P = P = Study on relationship between serum uric acid and bilirubin level with carotid plaque in acute cerebral infarction patients YOU Shou-jiangHAN Qiao CAO Yong-jun ZHANG Xia LU Tao-sheng LIU Hui-hui LIU Chun-feng. Department of Neurology the Second Affiliated Hospital of Soochow University Suzhou China yahoo. com. cn

2 475 Corresponding author CAO Yong-jun yahoo. com. cn Abstract Objective To study the relationship between serum uric acid and bilirubin level with carotid plaque in acute cerebral infarction patients. Methods 165 patients with acute cerebral infarction from October 2010 to July 2011 in our hospital were screened for carotid plaque by duplex color Doppler and firstly classified into no plaque group n = 47 and plaque group n = 118 secondly divided into no plaque group n = 47 stable plaque group n = 70 and unstable plaque group n = 35. Compare the difference of serum uric acid and bilirubin level in each group. Results 1 The level of serum uric acid in plaque group mild higher then no plaque group while no statistically significant difference in the two group P = The level of total serum bilirubin P = and direct serum bilirubin P = in plaque group significant lower than no plaque group. 2 The level of serum uric acid in no plaque group stable plaque group and unstable plaque group were ± μmol /L ± μmol /L and ± 177 μmol /L respectively. And the level of serum uric acid in unstable plaque group significant higher than stable plaque group P = The level of total serum bilirubin in no plaque group stable plaque group and unstable plaque group were ± μmol /L ± μmol / L and ± μmol /L respectively. The level of direct serum bilirubin in no plaque group stable plaque group and unstable plaque group were 6. 2 ± 5. 2 μmol /L 5. 0 ± 4. 2 μmol /L and 4. 8 ± 3. 4 μmol /L respectively. The level of total serum bilirubin P = and direct serum bilirubin P = in unstable plaque group significant lower than no plaque group. The level of total serum bilirubin P = and direct serum bilirubin P = in stable plaque group significant lower than no plaque group. The level of total serum bilirubin P = and direct serum bilirubin P = in unstable plaque group lower than stable plaque group. Conclusions The higher serum uric acid lower total serum bilirubin and lower direct serum bilirubin have a significant relationship with unstable plaque in in acute cerebral infarction patients. Key words Acute cerebral infarction Serum uric acid Serum bilirubin Carotid plaque 1 2-3

3 d MRI 2. common carotid artery CCA carotid artery bifurcation BIF internal carotid arteries ICA IMT 1 cm 3 IMT IMT IMT < 1. 0 cm IMT > 1. 2 cm 4 3. SPSS16. 0 x 珋 ± s t P < % % 32 ~ ± % % % TIA % % % % % μmol /L μmol /L

4 477 P = P > μmol /L 6. 2 μmol /L μmol /L 4. 9 μmol /L P = P < P = P < μmol /L x 珋 ± s ± ± ± ± ± ± 3. 8 P μmol /L μmol /L μmol /L P < P > μmol /L 6. 2 μmol /L μmol 5. 0 μmol /L μmol 4. 8 μmol /L P = P < P = P < P = P < P = P < μmol /L x 珋 ± s ± ± ± ± a ± b 5. 0 ± 4. 2 b ± 177 b ± b 4. 8 ± 3. 4 b P < P < 0. 01

5 Karagiannis P

6 479 LDL HO Longo-Mbenza B Luila EL Mbete P et al. Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans. Int J Cardiol Schwertner HA Jackson WG Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem Hopkins PN Wu LL Hunt SC et al. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. Arterioscler Thromb Vasc Biol Squadrito GL Cueto R Splenser AE et al. Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. Arch Biochem Biophys Hink HU Santanam N Dikalov S et al. Peroxidase properties of extracellular superoxide dismutase role of uric acid in modulating in vivo activity. Arterioscler Thromb Vasc Biol Milionis HJ Kalantzi KJ Goudevenos JAet al. Serum uric acid levels and risk for acute ischaemic non-embolic stroke in elderly subjects. J Intern Med Weir CJ Muir SW Walters MR et al. Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke Karagiannis A Mikhailidis DP Tziomalos K et al. Serum uric acid as an independent predictor of early death after acute stroke. Circ J Abuja PM. Ascorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein. FEBS Lett

7 Madhavan M Wattigney WA Srinivasan SR et al. Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults. Atherosclerosis J /CD

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