Think Tank Meeting : Colon Capsule Endoscopy. 3 rd International colon capsule expert meeting: Status update and future opportunities

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1 Think Tank Meeting : Colon Capsule Endoscopy. 3 rd International colon capsule expert meeting: Status update and future opportunities March 30-31, 2015 : / Italy Chairmen: Guido Costamagna / Deirdre McNamara Secretary: Cesare Hassan / Cristiano Spada Background: The ESGE published the first guideline on Colon Capsule Endoscopy (CCE) in 2012 to guide new users about indications, bowel prep and reporting, based on results of the first expert meeting. In the same year, there was the second meeting focusing on running clinical trials to understand which data are planned and which are still missing Goal: Show current status of evidence and elaborate barriers and future opportunities of Colon Capsule Endoscopy. Understand what is needed to increase the acceptance of CCE in different fields/indications. Style: Mixture of a pre-discussion per working group (prepare overview about current situation, evidence and barriers, if possible per country), presentations and workshops / discussions during the meeting. Participants: Experts Physicians from Europe, Israel, USA. Hotels : Via Aurelia Vecchia km IT (VT=Viterbo) - Italy Tel : +39/ Fax : +39/ Hotel Villa Via Benedetto Croce, 2 - IT (VT) - Italy Tel : +39/ Fax : +39/ del Via San Pancrazio, 41 IT (VT) - Italy Tel/fax: +39/ Cell:+39/ Hotel Etruscan Woman sort Duomo - Piazza Duomo, 2 IT ( Tel : +39/ (Only Covidien GI Italy) Meeting venue : (Palazzo Comunale di ). Piazza Giacomo Matteotti, 6 IT (VT, Viterbo) - Italy Transport/shuttles timetable in : see page Travel : Airports of FCO Fiumicino Rome (±80 km drive) or CIA Ciampino Rome (±105 km) Depending on availability of flights : arrivals Sunday March 29 or morning Monday March 30. COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 1 of 8

2 Day before the event = Sunday March 29, 2015 (for those arriving that day). Time Topic Speaker/Chair 20:00 Dinner. All Departure from hotels, Le Camare del, Valle See page 6 for the shuttles timetable. 20:15-23:00 Dinner 23:00 Departure to, Le Camare del, Valle All Scientific program Day 1 = Monday March 30, 2015 Time Topic Speaker/Chair 12:15 Departure Hotel + Le del to Valle. See page 7 for the shuttles timetable. 12:30-13:30 Lunch in 13:35 Departure from to meeting venue See page 7 for the shuttles timetable. 14:00-14:15 Welcome and Introduction Guido Costamagna Deirdre McNamara Tanja Nowak 14:15-14:30 Colon Capsule Endoscopy: what did we learn? Deirdre McNamara 14:30-14:45 The FDA trial (pitfalls, follow-up, diminutive polyps). Doug x 14:45-16:15 INDICATION 1: Patients with incomplete colonoscopy or unable or unwilling to undergo optical colonoscopy (OC) Facts and figures (5 min) (current situation; new evidence since ESGE/ECCO guideline was published) Barriers and opportunities Planned and/or running trials Action Items (if possible per country) Open discussion 16:15-16h30 Coffee Break 16:30-18:00 INDICATION 2: CRC Screening (familial syndromes; surveillance; filter after FIT+, others) Facts and figures (5min) (current situation; new evidence since ESGE/ECCO guideline was published) Barriers and opportunities Planned and/or running trials Action Items (if possible per country) Open discussion 18:00 Departure from meeting venue to hotels See page 7 for the shuttles timetable. 18:45 Departure from hotels, Le Camare del to Valle See page 7 for the shuttles timetable. 19:00-19h30 Get together : welcome drink/coffee break before start of the working group. 19:30-20:30 Discussion in working groups 20:30-22:15 Dinner in 22:15 Departure from hotel Valle to &Le Camare del. See page 7 for the shuttles timetable. COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 2 of 8 Coordinator : André Van Gossum Working group : Jean-Christophe Saurin Martin Keuchel Andrea Laghi Cristiano Spada Ignacio Fernández-Urién Simon Panter Seth Gross Coordinator : Cesare Hassan Working group : Gunnar Baatrup Robert Benamouzig Carlo Senore Ernst Kuipers Evelien Dekker Juan Egea Valenzuela Felice Schnoll Sussman

3 Scientific program Day 2 = Tuesday March 31, 2015 Time Topic Speaker/Chair 8:45 Departure from Hotels to meeting venue See page 8 for the shuttles timetable. 09:00-10:45 INDICATION 3: Pan-enteric work-up (IBD/IBS; bleeding; IDA; surveillance; others) Facts and figures (5min) (current situation; new evidence since ESGE/ECCO guideline was published) Barriers and opportunities Planned and/or running trials Action Items (if possible per country) Open discussion 10:45-11:00 Coffee Break 11:00-12:45 missing links and open questions - Bowel Prep - Quality indicators and training in CCE Round table discussion - Expand indications? More publications? Big trial? New recommendations (country-wise?)? Cost-effectiveness data? Others? - Priorities of action items Coordinator : Rami Eliakim Working group : Philippe Ducrotté Jörg Albert Mark Löwenberg Begoña González Suárez Owen Epstein Jonathan Leighton Sam Adler Ignacio Fernández-Urién Coordinators/Chairmen Lars Aabakken 12:45-13:15 Is the (diagnostic) future wireless? Owen Epstein 13:15-13:30 Conclusion Guido Costamagna Deirdre McNamara Tanja Nowak 13:30-14:00 Lunch in the premises of the meeting venue = Between 14:00 and 15:00 Departures from meeting venue to Rome Fiumicino Airport Departures from meeting venue to Valle and and Le del hotels --> for those not having flights back home that day. See page 8 for the shuttles timetable. COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 3 of 8

4 List of participants Healthcare Professionals (Physicians) NR Title Family name First name Country 1 Prof. Dr. Van Gossum André Belgium 2 Prof. Dr. Baatrup Gunnar Denmark 3 Prof. Dr. Benamouzig Robert France 4 Prof. Dr. Ducrotté Philippe France 5 Prof. Dr. Saurin Jean-Christophe France 6 PD Dr. Albert Jörg Gerhard Germany 7 Dr. habil. Keuchel Martin Germany 8 Prof. Dr. McNamara Deirdre Ireland 9 Prof. Dr. Costamagna Guido Italy 10 Dr. Hassan Cesare Italy 11 Prof. Dr. Laghi Andrea Italy 12 Dr. Senore Carlo Italy 13 Dr. Spada Cristiano Italy 14 Prof. Dr. Dekker Evelien Netherlands 15 Prof. Dr. Kuipers Ernst J. Netherlands 16 Dr. Löwenberg Mark Netherlands 17 Prof. Dr. Aabakken Lars Norway 18 Prof. Dr. Egea Valenzuela Juan Spain 19 Dr. Fernández-Urién Sainz Ignacio Spain 20 Dr. González Suárez Maria Begoña Spain 21 Prof. Dr. Epstein Owen UK 22 Dr. Panter Simon UK 23 Prof. Dr. Adler Samuel Israel 24 Prof. Dr. Eliakim Rami Israel 25 Prof. Dr. x Douglas K. USA 26 Prof. Dr. Leighton Jonathan A. USA 27 Prof. Dr. Schnoll-Sussman Felice USA 28 Prof. Dr. Gross Seth Andrew USA COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 4 of 8

5 List of participants Covidien staff : attending meeting and meals. NR Title Family name First name Country 1 Mr. Ambor Iddo Israel 2 Mrs. Brophy Bronwyn EMEA 3 Mr. Brynelsen Chuck USA 4 Mr Deretz Luis-Miguel Europe 5 Mrs. Fang nee Europe 6 Mrs. Fox Sherry USA 7 Mr. Franzi Cristiano EMEA 8 Dr. Garcia Lorda Pilar Europe 9 Mr. Huber Jonathan USA 10 Mr. Jamali Vafa USA 11 Dr. Nowak Tanja Europe 12 Dr. Price Robin USA 13 Dr. Rabinovitz Raphael Israel 14 Mr. Rudolph Thomas Europe 15 Mrs. Sherry Tania Europe 16 Mrs. Sullivan Michelle Europe 17 Ms. Vonckx Lieve Europe List of participants Covidien staff : only attending meals. NR Title Family name First name Country 1 Mr. Angrisani Vincenzo Italy 2 Mr. Pagliusi Umberto Italy COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 5 of 8

6 Shuttles DAY BEFORE EVENT = Sunday March 29, 2015 (for those arrived by flight that day). Bus 1 Bus 3 Date Hour On foot From To mark 20seats 8seats 29/03/ h00 x To have dinner. 29/03/ h00 x del del 29/03/ h00 x Hotel 29/03/ h10 x turn to the hotels 29/03/ h00 x 29/03/ h00 x Dr. Spada - Via della Gabelletta, 9 - Dr. Spada - Via della Gabelletta, 9-29/03/ h10 x Hotel Hotel + Dr. Spada - Via della Gabelletta, 9 - Dr. Spada - Via della Gabelletta, 9 - del Hotel 1 person = Lieve Vonckx in order to check details in the hotels 2 persons 7 persons and drive to Valle 11 persons Valle del Marta 3 persons 9 persons to and then drive to Valle 11 persons COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 6 of 8

7 Shuttles DAY 1 = Monday March 30, 2015 (max. 10 hours per day per bus) Bus 1 Bus 2 Bus 3 Date Hour On foot From To mark 20seats 20seats 8seats To have lunch at Valle 30/03/ h30 x 30/03/ h15 x del del 30/03/ h15 x Hotel To attend the meeting 30/03/ h35 x x x To the hotels at end of the meeting - part 1 30/03/ h00 x 30/03/ h00 x 30/03/ h00 x 30/03/ h00 x To Valle Del Marta for meeting - part 2 + dinner 30/03/ h45 x 30/03/ h45 x Etruscan sort Duomo Del 30/03/ h45 x Hotel turn to hotels 30/03/ h15 x 30/03/ h15 x 30/03/ h15 x Hotel Del Etruscan sort Duomo Etruscan sort Duomo Del Hotel 1 person = Lieve Vonckx 9 persons 13 persons 47 persons 19 persons 14 persons Le del is walking distance from. Etruscan sort Duomo is walking distance from. 2 persons 10 persons 14 persons 2 persons 10 persons 14 persons COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 7 of 8

8 Shuttles DAY 2 = Tuesday March 31, 2015 (max. 10 hours per day per bus) Bus 1 Bus 2 Bus 3 Date Hour On foot From To mark 20seats 20seats 8seats To attend the meeting 31/03/2015 8h45 x 31/03/2015 8h45 x Hotel 31/03/2015 8h45 x 31/03/2015 8h45 x Del Etruscan sort Duomo Le del is walking distance from. Etruscan sort Duomo is walking distance from. 31/03/2015 9h00-18h30 x x x End of the meeting : those having flights; see schedule taxi pick ups to Rome Airport Buses stay available for any other trip in e.g. persons who - for any reason - need a transfer to at e.g. 10h00 31/03/ h00 x For debriefing meeting with Covidien staff. ± 19 persons to meeting room in Valle 31/03/ h30 x 31/03/ h00 x Dinner at Valle Del Marta for those returning April 1, /03/ h45 x Del 31/03/ h50 x turn to the hotels 31/03/ h30 x 31/03/ h35 x del Del 6 persons (having flights back on March 31 late evening or April 1, 2015). 1 person = Lieve Vonck 2 persons and drive to 4 persons 6 persons and drive to Le del COVIDIEN AG VICTOR VON BRUNS-STRASSE [T] Page 8 of 8

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