laboratory of genetic diagnostic and preventive medicine_ Total Health Care _Personalised Report and Advice on Genetic Tests _

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1 laboratory of genetic diagnostic and preventive medicine_ Total Health Care _Personalised Report and Advice on Genetic Tests _

2 Introduction_Personalised genetic tests for your health, body weight, nutrition status and fitness_ Some people have higher tendency to develop some kind of disease compared to others depending on their genetic profile. Our genetic tests provide valuable information of individual genetic profiles, taking into account how they are influenced by environment and risk factors involved in the onset of most diseases, such as age, diet and life style. Early detection of potential genetic variants allow to get more insights on your health, lifestyle and eating habits. Genetic analysis would help you how preventing or delaying development of complex pathologies including cardiovascular diseases, and non-hereditary chronic diseases such as obesity or diabetes. Our genetic testing provides a specific genetic profile for each patient. It is necessary, under supervision of our specialist physicians team, for proper nutritional counseling and planning of preventive programs to help you for improving your lifestyle, to feel better and in fit. Individual data from our genetic tests will help to our expert physicians to practice a preventive and personalised medicine on each individual patient, through a more effective diagnosis and appropriate therapeutics while minimizing the risk from those potential adverse genetic variants.

3 Onco-Genetic_: LF1000 Components of the Onco-Genetic preventive program Onco-Genetic I: Hereditary and/or familial cancer Breast and ovary cancer Prostate cancer Nonpolyposis colon cancer LF1110 LF1120 LF1130 LF Familial adenomatous polyposis 1 (APC gene) LF Familial adenomatous polyposis 2 (MYH gene) LF Hereditary diffuse gastric cancer (CDH1 gene) LF Colon cancer LF Breast cancer LF1220 Onco-Genetic II: Individual genetic risk Skin cancer LF1230 LF Prostate cancer Lung cancer LF1240 LF Thyroid cancer LF Bladder cancer LF1270 Onco-Genetic III: Early detection program Colon cancer ( m Sept9 gene) Prostate cancer (mpca3 gene) LF1310 LF1320 LF Lung cancer ( m Sox2 gene) LF1330 Onco-Genetic IV: Drug resistance Tamoxifen resistance LF1410 LF1400

4 Cardio-Genetic_: LF2000 Components of the Cardio-Genetic preventive program Ischemic cardiopathy LF Hemochromatosis LF Thrombophilia LF2300 Cardio-Genetic I: Cardiovascular disease risk Abdominal aortic aneurysm LF2400 LF Intracranial aortic aneurysm LF Peripheral arterial disease Hypertension LF Atherosclerosis LF2700 LF2800

5 Nutri-Genetic_: LF3000 Components of the Nutri-Genetic preventive program Nutri-Genetic I: Trends in eating behavior LF3100 Snacking Feeling hungry Satiety Dietary disinhibition Food desire Sweet tooth LF3100 Nutri-Genetic II: Dietary recommendations LF3200 Individual dietary recommendations Monounsaturated-fat tolerance Polyunsaturated-fat tolerance Omega-3 and omega-6 levels LF3200 Nutri-Genetic III: Genetic intolerances LF Intolerance to lactose Intolerance to fructose Intolerance to gluten Intolerance to histamine LF3300 Nutri-Genetic IV: Vitamin metabolism LF3400 Vitamin A Vitamin B 2 Vitamin B 6 Vitamin B 12 Vitamin C Vitamin D Folate/Folic acid LF3400

6 Sport-Genetic_: LF4000 Components of the Sport-Genetic preventive program Sport-Genetic I: Exercise LF4100 Resistance training Strength training Aerobic capacity (V0 2 max) Muscle strength LF4100 Sport-Genetic II: Exercise Benefits LF4200 Increased HDL levels Body weight loss by exercise Body fat loss Reduced arterial pressure Increased sensitivity to insulin LF4200 Sport-Genetic III: Injuries caused by exercise LF Achilles tendinopathy Knee osteoarthritis LF4300 Sport-Genetic IV: Body and weight LF Obesity Regain lost body weight Metabolism Adiponectin levels LF4400 Sport-Genetic V: Metabolic health LF4500 Increased LDL levels Decreased HDL levels Increased TAG levels Increased glucose levels LF4500 Sport-Genetic VI: Cardiovascular risk LF Myocardial infarction Stroke Deep vein thrombosis LF4600

7 Detoxi-Genetic_: LF5000 Components of the Detoxi-Genetic preventive program Detoxi-Genetic I: Heavy metals detoxification Mercury detoxification LF5110 LF5100 Detoxi-Genetic II: Phase I hepatic detoxification Phase I detoxification LF5210 LF5200 Detoxi-Genetic III: Phase II hepatic detoxification Phase II detoxification LF5310 LF5300 Detoxi-Genetic IV: Premature aging LF5400 Oxidative stress and cellular aging Telomere length LF5410 LF5420

8 Skin-Genetic_: LF6000 Components of the Skin-Genetic preventive program Skin-Genetic I: Facial health LF6100 Sensitivity and inflammation Sun exposure and pigmentation LF6110 LF6120 Skin-Genetic II: Facial aging Premature wrinkles LF6210 LF6200 Skin elasticity and firmness LF6220

9 Dental-Genetic: LF7000_Personalised genetic tests for your dental health_ Our Dental-Genetic preventive program includes several packs. You can ask for them all together or separately as follows: o Individualized microbiological study of most commonly associated bacteria to periodontal disease and further design of specific antibiotic treatment. o Personalized genetic analysis including analysis of different genetic polymorphisms associated to periodontal disease risk and individual susceptibility of implant rejection. The Dental-Genetic tests are recommended to patients who meet one of the following criteria : Childhood periodontitis. Acute periodontitis or generalised severe periodontitis. High-risk dental detachment previous to dental implantation. Dental-Genetic I: Identification of periodontal bacteria LF Identification of 5 pathogenic bacteria. Identification of 11 pathogenic bacteria. LF7110 LF7120 Dental-Genetic II: Identification of inflammation markers Interleukins LF7200 LF7200

10 Prenatal-Genetic_: LF8000 Components of the Prenatal-Genetic preventive program Male infertility Detection of 6 STSs (Sequence Tagged Sites) on chromosome Y related to azoospermia LF8100 Baby gender prediction Fetal DNA in maternal plasma LF8200

11 Commercial office Marbella Malaga

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