WELCOME TO THE 13 TH LURN RETREAT APRIL 14-15, 2016 YSTAD SALTSJÖBAD, YSTAD

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1 WELCOME TO THE 13 TH LURN RETREAT APRIL 14-15, 2016 YSTAD SALTSJÖBAD, YSTAD

2 ORGANIZING COMMITTEE: Ellen Tufvesson, Annika Andersson Sjöland, Michiko Mori, Irma Mahmutovic Persson, Eva Körner-Muhrbeck, Lena Uller, Marianne Person, Leif Bjermer, Jonas Erjefält, Gunilla Westergren-Thorsson, Arne Egesten SUPPORTED BY: The Sandberg foundation, AstraZeneca, Takeda and Boston Scientific ALUMNI HONORARY SANDBERG LECTURERS 2015 Professor Magnus Sköld (Stockholm, Sweden), Professor Sven-Erik Dahlén (Stockholm, Sweden), Stephanie Königshoff, PhD (Munich, Germany) and Professor Reinoud Gosens (Groningen, the Netherlands) 2014 Professor Rachel Chambers (London, UK), Professor Gunnar Nilsson (Stockholm, Sweden), Professor Peter Sterk (Amsterdam, the Netherlands) and Patrick Mallia, PhD (London, UK) 2013 Professor Oliver Eickelberg (Munich, Germany), Professor Pieter S. Hiemstra (Leiden, the Netherlands), Professor Guy G. Brusselle (Ghent, Belgium) and Andrew McKenzie, PhD (Cambridge, UK) 2012 Professor James C. Hogg (Vancouver, Canada) 2011 Professor Dirkje Postma (Groningen, the Netherlands) SANDBERG AWARDEES 2014 Professor Michael Benson (Linköping, Sweden) 2012 Professors Anders Blomberg and Thomas Sandström (Umeå, Sweden) 2011 Professors Anders Eklund and Johan Grünewald (Stockholm, Sweden) YOUNG INVESTIGATOR AWARDEES 2015 Irma Mahmutovic-Persson (Lund, Sweden), Sara Rolandsson (Lund, Sweden) and Rita Costa, (Munich, Germany) 2014 Mandy Menzel (Lund, Sweden), Henning Svensson (Lund, Sweden) and Maria Weitoft (Lund, Sweden) 2013 Yuan Xu (Stockholm, Sweden), Michiko Mori (Lund, Sweden), Sara Rolandsson (Lund, Sweden) and Jenny Calvén (Lund, Sweden) 2012 Emil Tykesson (Lund, Sweden) 2011 Abraham Roos (Stockholm, Sweden)

3 DAY 1 THURSDAY 14 TH APRIL Arrival and Coffee Welcome and Introduction, Professor Jonas Erjefält (Lund) Session 1 New treatment targets for respiratory diseases CHAIRMEN: OSKAR HALLGREN, PHD AND LINNEA JARENBÄCK HONORARY LURN LECTURE: Professor Clive Page (London), Research strategies for finding new targets for respiratory diseases Discussion HONORARY LURN LECTURE: Janette Burgess, PhD (Groningen), The extracellular matrix remodelling as a therapeutic target in asthma and COPD Discussion Irma Mahmutovic Persson (Lund), Targeting cytokines in asthma therapy using an in vivo model Discussion Lunch Session 2 New treatment options for respiratory diseases CHAIRMEN: EMMA ÅHRMAN, PHD AND PREMKUMAR SIDDHURAJ HONORARY LURN LECTURE: Professor Michel Aubier (Paris), Endobronchial thermoplasty, who fits for this therapy Discussion Anders Bergqvist, PhD (Lund), Lung pathology and mechanisms after endobronchial thermoplasty Discussion Professor Gunilla Westergren-Thorsson (Lund), Stem cell therapy to target repair Discussion

4 Session 3 Poster presentations with coffee Session 4 Diagnostic biomarkers CHAIRMEN: DAVID ARONSSON, PHD AND CECILIA HAGMAN HONORARY LURN LECTURE: Professor Anna-Carin Olin (Gothenburg), Particles in exhaled air - a clinical tool to monitor small airways? Discussion Professor Per Wollmer (Malmö), Nanoparticle diffusion in the lung Discussion Ellen Tufvesson, PhD (Lund), Biomarkers in different asthma phenotypes Discussion Dinner

5 DAY 2 FRIDAY 15 TH APRIL Breakfast Session 5 Innate immunity and infection in lung diseases CHAIRMEN: GOPINATH KASETTY, PHD AND HAMID AKBARSHAHI, PHD Christopher McCrae, PhD (Mölndal), Beta defensin 2 levels in the COPD airways and risk of acute exacerbations Discussion Ravi Bhongir (Lund), Small DNA-fragments generated from extracellular DNA in vitro and in vivo are bactericidal against Pseudomonas aeruginosa Discussion Cecilia Andersson, PhD (London), RSV infection of bronchial epithelial cells Discussion Coffee (check out time) Session 6 Asthma targets CHAIRMEN: CATHARINA MÜLLER, PHD AND MARIAM BAGHER HONORARY LURN LECTURE: Apostolos Bossios, PhD (Stockholm), Adipokines as therapeutic targets in severe asthma Discussion Anna-Karin Larsson-Callerfelt, PhD (Lund), Prostaglandins in asthma and COPD Discussion Professor Matt Thomas (Mölndal), Lung-targeted dual PI3Kγδ inhibition: Evidence for a novel therapeutic strategy for multiple severe asthma phenotypes Discussion Lunch

6 LURN Årsmöte Session 7 How to target the cells? CHAIRMEN: JULIE WEIDNER, PHD AND PRAJAKTA JOGDAND, PHD HONORARY LURN LECTURE: Professor Martina Schmidt (Groningen), Being in the right place in the right time: Targeting COPD Discussion Shameem Ladak (Newcastle), MicroRNA-200b represses TGF-β1 induced EMT in BEAS-2B and primary bronchial epithelial cells Discussion Åsa Wheelock, PhD (Stockholm), Systems medicine approaches to investigate molecular gender differences in COPD Discussion Concluding remarks, Professor Leif Bjermer (Lund) Price ceremony. Thank you and good bye! Coffee and departure PARTICIPANTS Hamid Akbarshahi Respiratory Immunopharmacology, Lund University Mohamad Ali Respiratory Medicine and Allergology, Lund University Cecilia Andersson Imperial College, London Annika Andersson Sjöland Lungbiology, Lund University

7 Jaro Ankerst Lung and Allergy Research Unit, SUS Lund David Aronsson Lung and Allergy Clinic, SUS Lund Helena Arozenius AnaMar AB, Lund Michel Aubier Hopitaux de Paris, France Vibeke Backer Bispebjerg Hospital, Copenhagen Mariam Bagher Lungbiology, Lund University Kinga Balogh Sivars AstraZeneca, Mölndal Engin Baturcam AstraZeneca, Mölndal Anders Bergqvist Airway Inflammation, Lund University Ravi Bhongir Respiratory Medicine and Allergology, Lund University Leif Bjermer Lung and Allergy Research Unit, SUS Lund Apostolos Bossios Karolinska Institute Janette Burgess UMCG, Groningen Lena Bülow Boston Scientific Nordic AB Samuel Cerps Respiratory Immunopharmacology, Lund University Ib Groth Clausen AstraZeneca, Mölndal Danen Cunoosamy AstraZeneca, Mölndal Zuzana Diamant Respiratory Medicine and Allergology, Lund University Arne Egesten Respiratory Medicine and Allergology, Lund University Jonas Geir Einarsson Lung and Allergy Clinic, SUS Lund Sandra Ekstedt Karolinska Institute, Stockholm Gunilla Ekström AnaMar AB, Lund Linda Elowsson Lungbiology, Lund University Gunnar Engström Cardiovascular Epidemiology, Lund University Leif Eriksson Lungbiology, Lund University Jonas Erjefält Airway Inflammation, Lund University Susann Ferm Lung and Allergy Research Unit, SUS Lund Anele Gela Respiratory Medicine and Allergology, Lund University Susanna Georen Karolinska Institute, Stockholm Cecilia Hagman Neonatal Clinic, SUS Oskar Hallgren Lungbiology, Lund University Kerstin Hansson Lung and Allergy Research Unit, SUS Lund Ulf Hedström AstraZeneca, Mölndal Paula Heinke Lungbiology, Lund University Leif Hultin AstraZeneca, Mölndal Morten Hvidtfeldt Bispebjerg Hospital, Copenhagen Linnea Jarenbäck Respiratory Medicine and Allergology, Lund University Fanyi Jiang AstraZeneca, Mölndal Prajakta Jogdand Airway Inflammation, Lund University Christina Jungar AstraZeneca, Mölndal Lisa Karlsson Lungbiology, Lund University Gopinath Kasetty Respiratory Medicine and Allergology, Lund University Olga Kelemen Oncology and Pathology, Lund University Shameem Ladak Newcastle University Anna-Karin Larsson Callerfelt Lungbiology, Lund University Hakon Leffler Microbiology, Immunology and Glycobiology, Lund University

8 Evelina Lidén Airway Inflammation, Lund University Anna Löfdahl Lungbiology, Lund University Irma Mahmutovic Persson Respiratory Immunopharmacology, Lund University Anders Malmström Matrix Biology, Lund University Christopher McCrae AstraZeneca, Mölndal Mandy Menzel Respiratory Immunopharmacology, Lund University Subhabrata Moitra Respiratory Medicine and Allergology, Lund University Michiko Mori Airway Inflammation, Lund University Catharina Müller Lungbiology, Lund University Matthias Mörgelin Infection Medicine, Lund University Ulf Nihlén AstraZeneca, Mölndal Britt-Marie Nilsson Airway Inflammation, Lund University Maria Nordberg AstraZeneca, Mölndal Annika Nybom Lungbiology, Lund University Anna-Carin Olin Occupational and Environmental Medicine, Sahlgrenska Academy Jonas Olsson Lung and Allergy Research Unit, SUS Lund Tina Olsson Lung and Allergy Research Unit, SUS Lund Clive Page King s College, London Marianne Person Knowledge Center for Allergy, Asthma and COPD, SUS Lund Celeste Porsbjerg Bispebjerg Hospital, Copenhagen Sangeetha Ramu Respiratory Immunopharmacology, Lund University Kristian Riesbeck Clinical Microbiology, Lund University Sara Rolandsson Enes Lungbiology, Lund University Abraham Roos AstraZeneca, Mölndal Martina Schmidt UMCG, Groningen Premkumar Siddhuraj Airway Inflammation, Lund University Anna Sikesjö Lung and Allergy Research Unit, SUS Lund Mette Solum Lung and Allergy Research Unit, SUS Lund Georgios Stratelis AstraZeneca, Södertälje Lena Thiman Lungbiology, Lund University Matt Thomas AstraZeneca, Mölndal Göran Tornling Karolinska Institute, Stockholm Ellen Tufvesson Respiratory Medicine and Allergology, Lund University Alf Tunsäter Knowledge Center for Allergy, Asthma and COPD, SUS Lund Lena Uller Respiratory Immunopharmacology, Lund University Julie Weidner Respiratory Medicine and Allergology, Lund University Christina Wenglén AnaMar AB, Lund Gunilla Westergren-Thorsson Lungbiology, Lund University Åsa Wheelock Respiratory Medicine Unit, Karolinska Institute, Stockholm Elisabet Wieslander Oncology and Pathology, Lund University Per Wollmer Clinical Physiology, Lund University Suneela Zaigham Cardiovascular Epidemiology, Lund University Ida Åberg Respiratory Medicine and Allergology, Lund University Emma Åhrman Lungbiology, Lund University Jörgen Östling AstraZeneca, Mölndal

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