SUN & ENVIRONMENT: GET CONNECTED, GET PROTECTED

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1 SUN & ENVIRONMENT: GET CONNECTED, GET PROTECTED

2 L O R É A L R E S E A R C H & I N N O V A T I O N S Y M P O S I U M EDITORIAL The mission of the L Oréal Group is to offer the best of beauty to all women and men on the planet and Innovation has been a driving force for L Oréal growth. The diversity of hair and skin types and the diversity of beauty needs are a vital part of the creative processes at L Oréal Research & Innovation. Our commitment to better understanding skin and hair diversity can be fully appreciated in technological advances in hair care and coloration and in photoprotection. Furthermore, L Oréal Research endeavors to identify mechanisms of skin sensitivity to the light, in particular to UVA light, in different parts of the world. Thanks to in vitro skin models, we have deciphered the biological influences of UV light and of different environmental factors on this particular tissue. Today, given the diversity of skin types and the variations of environmental conditions, a personalized monitoring of environmental risks is indispensable. In relevant prevention strategies, new technologies, like flexible sensors, are paving the way for individualized connected environmental protection. Michèle VERSCHOORE, MD Medical Director, L Oréal Research and Innovation, S U N & E N V I R O N M E N T : G E T C O N N E C T E D, G E T P R O T E C T E D

3 L O R É A L R E S E A R C H & I N N O V A T I O N S Y M P O S I U M Chairman Mark SHRIVER, PhD Associate Professor of Anthropology and Genetics at Penn State University, State College, USA Co-Chairman Françoise BERNERD, PhD L Oréal Research & Innovation Fellow, Head of Light and Pigmentation Research Group. Advanced Research, France SUN & ENVIRONMENT: GET CONNECTED, GET PROTECTED VANCOUVER CONVENTION CENTER: ROOM: WEST TUESDAY, JUNE 9 TH - 5PM - 7PM 5.00 PM Opening Remarks Françoise BERNERD 5.05 PM Evolutionary Adaptation of the Skin to the Environment Mark SHRIVER 5.30 PM Effect of Sunlight and Pollution on the Skin Henry W. LIM 6.00 PM An Integrated Strategy Against Environmental Stress Didier CANDAU 6.30 PM Stretchable Bioelectronics for Continuous Characterization and Monitoring of Skin Health Roozbeh GHAFFARI 6.55 PM Closing Remarks Mark SHRIVER S U N & E N V I R O N M E N T : G E T C O N N E C T E D, G E T P R O T E C T E D

5 L O R É A L R E S E A R C H & I N N O V A T I O N S Y M P O S I U M Mark SHRIVER, PhD Associate Professor of Anthropology and Genetics at Penn State University, State College, USA EVOLUTIONARY ADAPTATION OF THE SKIN TO THE ENVIRONMENT There are many sources of information regarding the physiology and pathophysiology of the human skin and its responses to environmental exposures. Human evolution has provided a series of natural experiments as humans first spread across the natal continent Africa and then across the rest of the world. Although human populations can differ substantially in superficial traits such as skin pigmentation, skin response to UVR, hair texture, and facial features, the levels of genetic diversity genome-wide are very low. Race as a means to organize and conceptualize human genetic and phenotypic variation is thus only of limited utility. A more useful model within which to investigate human diversity, the population-genomic model explicitly recognizes that the genome is a composite of many local regions with diverse evolutionary histories. Dermatological differences among populations can provide the means to investigate the physiology of skin biology. Admixture mapping methods, some of the most statistically powerful approaches to gene discovery, are ideally suited to identifying the genetic factors underlying phenotypic differences among populations. Given many of the skin differences across the world s populations are the result of local adaptation to the environment, locating and investigating these genes can and should give us many insights into the interaction of skin and the sun. Examples of will be given using the discoveries of the genes that have lightened the skin of Europeans and physical differences in skin pigmentation and skin responses across several populations. S U N & E N V I R O N M E N T : G E T C O N N E C T E D, G E T P R O T E C T E D

7 L O R É A L R E S E A R C H & I N N O V A T I O N S Y M P O S I U M Henry W. LIM, MD C.S. Livingood Chair and Chairman Department of Dermatology Henry Ford Hospital Detroit, Michigan, USA EFFECT OF SUNLIGHT AND POLLUTION ON THE SKIN Sunlight as it reaches the surface of the earth consists of ultraviolet (UV)-B, UVA, visible light and infrared. The major biologic effects of acute exposure to UVB radiation are cutaneous erythema and vitamin D synthesis, while UVA, tanning. Chronic effect of UVB is photocarcinogenesis, and UVA, photocarcinogenesis and photoaging. Recent studies have also pointed out that longwaves UVA1 are more harmful than previously thought with huge impact in DNA lesions formation, photoimmunosuppression and alterations of many biological functions. Other radiations can also be deleterious and have to be taken into account such as Visible light which is needed for general illumination but now shown to be responsible for induced pigmentation lasting up to 3 months, and more pronounced in dark skinned individuals. Infrared A radiation has been shown to contribute to photoaging. Emerging data also show that air pollution has detrimental effects on human skin. Therefore, development of better and global protective measures against all these environmental injuries, UV rays and beyond, have to be considered for the future. S U N & E N V I R O N M E N T : G E T C O N N E C T E D, G E T P R O T E C T E D

9 L O R É A L R E S E A R C H & I N N O V A T I O N S Y M P O S I U M Didier CANDAU, PhD Senior Research Associate, Applied Research Anti-ageing and Photoprotection Department L Oréal Research and Innovation, Chevilly-Larue, France AN INTEGRATED STRATEGY AGAINST ENVIRONMENTAL STRESS Diversity of populations and skin colors, as well as variety of external stress require a broad and integrated strategy of protection in each product and each use. To face this challenge, we will see, from the usual ones to the more innovative ones, technologies that allow us to broaden the scope of protection and to give an appropriate response. 1. A broad and overall protection based on our current tool box for short-term developments. 2. Identification of innovative systems using all technical tools from filters to biological protective molecules. Altogether these approaches will aim at offering a broader photoprotection by i) a physical surface photoprotection able to cover long UVA between 370 and 400 nm and ii) a biological photoprotection with appropriate anti-oxidants (AOX). AOX being no longer considered as formulation aids, but really as auxiliary of photoprotection, associated with the filters system and formulated so that their complementarity is expressed. 3. Evaluation of photoprotection efficacy provided by the overall system using biological and clinical end points including pigmentation. 4. The final dimension from efficacy to efficiency with a finished product combining photoprotection performance and an adequate texture for optimal conditions of use. S U N & E N V I R O N M E N T : G E T C O N N E C T E D, G E T P R O T E C T E D

11 L O R É A L R E S E A R C H & I N N O V A T I O N S Y M P O S I U M Roozbeh GHAFFARI, PhD MC10 Technology Inc Co-Founder & Vice President, MIT Research Laboratory of Electronics, Los Angeles, USA STRETCHABLE BIOELECTRONICS FOR CONTINUOUS CHARACTERIZATION AND MONITORING OF SKIN HEALTH Human skin is a living organ with soft, stretchable and dynamically changing characteristics; whereas wearable devices are largely planar, rigid and non-deformable. Here, we present novel materials, mechanics and designs for ultrathin skin-coupled sensors and microelectronics systems, called epidermal electronics, which can mechanically match the physical properties and curvilinear geometries of skin. We demonstrate microfabricated arrays of sensors configured in ultrathin, flexible formats for continuous monitoring of skin temperature, thermal and electrical conductivity, skin modulus, ph, and movement. Quantitative analyses of strain over various anatomical locations and electronics performance under stress illustrate the utility of these systems to laminate on skin, for clinical diagnostics and continuous health monitoring applications. Sleep study analysis, continuous monitoring of sweat, physiology, and dermatologic analysis of skin mechanical properties are all enabled using this platform, thus highlighting promising new directions in skin health enabled with epidermal electronics. S U N & E N V I R O N M E N T : G E T C O N N E C T E D, G E T P R O T E C T E D

12 DIAMOND SPONSOR

HUMAN SKIN COLOR: EVIDENCE FOR SELECTION

OVERVIEW HUMAN SKIN COLOR: EVIDENCE FOR SELECTION This activity supports the viewing of the short film The Biology of Skin Color. Students watch the film in segments and use real data to propose hypotheses,