99 學年度中醫系免疫學第二次期中考. Dr. Hsi-Hsien Lin (40%) I. Terminology: (12 %) 1. Immunoproteasome 2. ITAM. 3. Invariant chain. 4. Anchor residues 5.

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1 99 學年度中醫系免疫學第二次期中考 學號 姓名 Dr. Hsi-Hsien Lin (40%) I. Terminology: (12 %) 1. Immunoproteasome 2. ITAM 3. Invariant chain 4. Anchor residues 5. SMAC 6. Cross-presentation of Ag II. Single Choice (12%). Please choose the one that is most relevant to the described terminology below. 1. Professional APC (A) Th cells (B) Mast cells (C) Dendritic cells (D) Basophils. 2. Chemokine (A) TNF receptor (B) Bax (C) TLR4 (D) GPCR. 3. Superantigen (A) endotoxin (B) staphylococcal enterotoxins (C) diphtheria toxin (D) neurotoxin. 4. ITIM (A) CD28 (B) FcγRIII (C) CTLA-4 (D) CD3 complex. 5. The cytosolic Ag processing pathway (A) MHC-class II (B) invariant chain (C) HLA-DM (D) 1

2 proteasome 6. SH2 domain (A) phosphoinositides (B) phosphoserine/threonine (C) phosphotyrosine (D) proline 7. Glycolipid Ag (A) B cell receptor (B) proteasome (C) CD4 (D) CD1. 8. β 2 -microglobulin (A) MHC-class II (B) MHC-class I (C) somatic hypermutation (D) congenic mice. 9. Naïve T cell activation (A) Macrophages (B) Neutrophils (C) B cells (D) Dendritic cells. 10. MHC-class II molecules (A) CD8 (B) CD4 (C) CD1 (D) CD3 11. c-smac (A) LFA-1 (B) ICAM-1 (C) TCR (D) talin. 12. Src-family kinase (A) Ras (B) MAPK (C) PLC-γ (D) Lyn. III. Essays (16%) 1. Please give 2 examples of immunoevasins and describe how do they work to escape immune detection? (6%) 2. Please explain in detail how an extracelluar antigen is processed by antigen presenting cells (APC) and presented to what type of T cells?? (5%) 3. Please explain how the diversity of MHC molecules is maintained in a population? (5%) 2

3 周開平老師 (60%) I. Fill-in (12%) 1. Please identify the B cell developmental stages (from stem cells to mature B cells) that (a) allelic exclusion (b) possible cell apoptosis (c) self tolerance takes place. (6%) (a) (b) (c) 2. Immune cells are prepared from an immune organ and immunostained for CD4 and CD8. In the flow cytometirc analysis, please (a) identify the possible organ, (b) label the marker (CD4 or CD8) on the x-axis and Y-axis, and (c) the most likely location of γδt cells in the diagram. (4%) (a) (b) X: Y: (c) 3. Give two types of immune cells that bear IL7R. (2%) II. True and false (12%) 1. A pluripotent hematopoietic stem cell generates all the cells of the immune system. 2. The early stages of B cell development are dependent on bone marrow stromal cells. 3. Both nude and RAG1-deficient mice lack T and B cells. 4. T cell progenitors are produced by thymus. 5. Negative selection in central lymphoid organs is to select the cells with productive BCR/TCR gene rearrangement. 6. The transfer of bone marrow cells of SCID mice into nude mice can reconstitute T cells in the recipients. 7. MHC class II mutant mice could not produce mature CD4 T cells. 8. T cells that react strongly with ubiquitous self antigens are deleted in the thymus. 9. The homing of lymphocytes and dendritic cells to specific regions (i.e. B cell zone or T cell zone) of peripheral lymphoid tissues is mediated by chemokines. 10. Activation of selectins by chemokines is responsible for the entry of naïve T cells into lymph nodes. 11. S1P receptor is upregulated in T cells undergone activation. 3

4 12. Dendritic cells are the major phagocytes in the inflammatory site. III. Single choice (20%) 1. The cells express AIRE are: (A) Bone marrow stromal cells. (C) Thymic medullary epithelial cells. (B) Thymic cortical epithelial cells. (D) Thymic dendritic cells. 2. T cell MHC restriction is: (A) Determined at the single-positive stage. (C) Resulted from the positive selection. (B) Determined at the cortex. (D) Resulted from the negative selection. 3. Which of the following bone marrow transplantation can generate functional T effectors that restricted to MHC b in the recipients? (A) Donor (MHC a ) to recipient (MHC b ). (B) Donor (MHC b ) to recipient (MHC a ). (C) Donor (MHC a ) to recipient (MHC axb ). (D) Donor (MHC axb ) to recipient (MHC b ). 4. Which of the following cells have the longest life span? (A) CD5 B cells. (B) IgM + IgD + B cells. (C) B cells that migrate into medullary cord of lymph node. (D) IgG +, IgA + or IgE + B cells. 5. Priming is: (A) The activation and differentiation of naïve T cells. (B) The maturation of dendritic cells to APC. (C) T cells in the blood enter lymphoid tissue by crossing the walls of HEV. (D) The activation of macrophages by IFNγ. 6. Which of the following molecules on APCs determines clonal expansion or anergy of T cells? (A) CD28. (B) Β7. (C) CTLA4. (D) CD Which of the following cytokine condition promotes the generation of T effector cells that migrate into the acute inflammatory site at the early stage? (A) IL17. (B) TGFβ, IL6, IL23. (C) IL12. (D) GM-CSF, G-CSF. 8. Self tolerance is generated: (A) At central lymphoid organs. (C) At the inflammatory sites. (B) At peripheral lymphoid organs. (D) All of above. 4

5 9. The type of T cells that are responsible for the recruitment of neutrophils is: (A) Th17. (B) Th1. (C) Th2. (D) Treg. 10. IL4 producer is: (A) Th17. (C) Th2. (B) Th1. (D) Treg. IV. Essay (20%) 1. Describe how tissue dendritic cells become potent antigen-presenting cells in peripheral lymphoid tissue. (5%) 2. What is the contribution of CD4 T cells and CD40L to CTL response? (5%) 3. Describe the regulation among Th17, Th1, Th2 and Treg. (10%) 5

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